目的:探析左侧额叶CT值在评估偏执型精神分裂症病情中的临床意义。方法:以我院50例偏执型精神分裂症患者(研究组)、50例健康体检者(参照组)为研究对象,均给予CT检测,比较两组CT值、不同类型患者CT值,分析CT值与患者年龄、阳性和阴性症...目的:探析左侧额叶CT值在评估偏执型精神分裂症病情中的临床意义。方法:以我院50例偏执型精神分裂症患者(研究组)、50例健康体检者(参照组)为研究对象,均给予CT检测,比较两组CT值、不同类型患者CT值,分析CT值与患者年龄、阳性和阴性症状量表(postive and negative syndrome scadle,PANSS)评分、病程的关系。结果:研究组CT值明显低于参照组(P<0.05)。不同年龄、阳性和阴性症状量表、病程患者CT值相比,均无统计学差异(P>0.05)。CT值与患者PANSS评分、病程表现为负相关(r=-0.405、-0.467,P=0.036、0.013)。结论:在偏执型精神分裂症病情评估中左侧额叶CT值的应用,可提高临床病情判断客观性与准确性。展开更多
Background: The intracarotid amobarbital procedure (IAP) is widely used in the preoperative evaluation for epilepsy surgery to lateralize language dominance and memory functions. However, language mapping has most oft...Background: The intracarotid amobarbital procedure (IAP) is widely used in the preoperative evaluation for epilepsy surgery to lateralize language dominance and memory functions. However, language mapping has most often been accomplished with cortical brain stimulation. Objective: To examine left temporal lobe language cortex representation using this technique in patients with bilateral language (BL) as compared with patients with left language dominance (LD). Methods: The language maps of each patient were reviewed retrospectively. Group I consisted of 10 patients with BL and Group II consisted of 10 matched control patients with LD. Each stimulation trial included a brief assessment of confrontation naming, automatic speech, reading, repetition, and comprehension. Clusters of errors that included comprehension, repetition, and naming defined primary temporal lobe language areas. Results: Mapping revealed two distinct language areas in 60% of patients in Group I and 10% in Group II (p = 0.019). In Group I, two patients had both language areas in the same gyrus (either the superior or the middle temporal gyrus), whereas two showed one language area each in the superior and middle temporal gyri and the remaining two had one in the superior temporal gyrus and the other intermixed between the superior and middle temporal gyri. In Group II, both language areas were intermixed between the superior and middle temporal gyri. Conclusions: Bilateral language (BL) representation in the intracarotid amobarbital procedure is frequently associated with more than one noncontiguous language area in the left temporal lobe. A careful search for multiple language areas, particularly in patients with BL, is prudent prior to surgical resection.展开更多
Background: Frontotemporal lobar degeneration (FTLD)-is an uncommon degenerative dementia that presents with focal cognitive and behavioral deficits. Objective: To determine the correlation of the different presentati...Background: Frontotemporal lobar degeneration (FTLD)-is an uncommon degenerative dementia that presents with focal cognitive and behavioral deficits. Objective: To determine the correlation of the different presentations of FTLD with structural neuroimaging findings. Design and Patients: In a blinded study, we retrospectively evaluated the clinical presentations and magnetic resonance imaging (MRI) patterns of atrophy in 59 patients with FTLD and 26 patients with probable Alzheimer disease at a memory disorders clinic. Results: Analysis of variance revealed a significant difference in the patterns of atrophy in the FTLD and Alzheimer disease groups. Patients with FTLD presenting with altered personal conduct had significant bifrontal atrophy, whereas patients presenting with semantic dementia had significant left temporal and bifrontal atrophy compared with other groups. Disinhibited behavior and hyperphagia correlated with right frontal atrophy, and fluent, anomic aphasia correlated with left temporal atrophy. Conclusions: We found that the type of clinical presentation of FTLD correlates with specific areas of atrophy. Our method of analysis may be useful to elicit further anatomic-behavioral relationships in degenerative brain disorders.展开更多
文摘目的:探析左侧额叶CT值在评估偏执型精神分裂症病情中的临床意义。方法:以我院50例偏执型精神分裂症患者(研究组)、50例健康体检者(参照组)为研究对象,均给予CT检测,比较两组CT值、不同类型患者CT值,分析CT值与患者年龄、阳性和阴性症状量表(postive and negative syndrome scadle,PANSS)评分、病程的关系。结果:研究组CT值明显低于参照组(P<0.05)。不同年龄、阳性和阴性症状量表、病程患者CT值相比,均无统计学差异(P>0.05)。CT值与患者PANSS评分、病程表现为负相关(r=-0.405、-0.467,P=0.036、0.013)。结论:在偏执型精神分裂症病情评估中左侧额叶CT值的应用,可提高临床病情判断客观性与准确性。
文摘Background: The intracarotid amobarbital procedure (IAP) is widely used in the preoperative evaluation for epilepsy surgery to lateralize language dominance and memory functions. However, language mapping has most often been accomplished with cortical brain stimulation. Objective: To examine left temporal lobe language cortex representation using this technique in patients with bilateral language (BL) as compared with patients with left language dominance (LD). Methods: The language maps of each patient were reviewed retrospectively. Group I consisted of 10 patients with BL and Group II consisted of 10 matched control patients with LD. Each stimulation trial included a brief assessment of confrontation naming, automatic speech, reading, repetition, and comprehension. Clusters of errors that included comprehension, repetition, and naming defined primary temporal lobe language areas. Results: Mapping revealed two distinct language areas in 60% of patients in Group I and 10% in Group II (p = 0.019). In Group I, two patients had both language areas in the same gyrus (either the superior or the middle temporal gyrus), whereas two showed one language area each in the superior and middle temporal gyri and the remaining two had one in the superior temporal gyrus and the other intermixed between the superior and middle temporal gyri. In Group II, both language areas were intermixed between the superior and middle temporal gyri. Conclusions: Bilateral language (BL) representation in the intracarotid amobarbital procedure is frequently associated with more than one noncontiguous language area in the left temporal lobe. A careful search for multiple language areas, particularly in patients with BL, is prudent prior to surgical resection.
文摘Background: Frontotemporal lobar degeneration (FTLD)-is an uncommon degenerative dementia that presents with focal cognitive and behavioral deficits. Objective: To determine the correlation of the different presentations of FTLD with structural neuroimaging findings. Design and Patients: In a blinded study, we retrospectively evaluated the clinical presentations and magnetic resonance imaging (MRI) patterns of atrophy in 59 patients with FTLD and 26 patients with probable Alzheimer disease at a memory disorders clinic. Results: Analysis of variance revealed a significant difference in the patterns of atrophy in the FTLD and Alzheimer disease groups. Patients with FTLD presenting with altered personal conduct had significant bifrontal atrophy, whereas patients presenting with semantic dementia had significant left temporal and bifrontal atrophy compared with other groups. Disinhibited behavior and hyperphagia correlated with right frontal atrophy, and fluent, anomic aphasia correlated with left temporal atrophy. Conclusions: We found that the type of clinical presentation of FTLD correlates with specific areas of atrophy. Our method of analysis may be useful to elicit further anatomic-behavioral relationships in degenerative brain disorders.
