目的探讨高血压患者左室整体长轴收缩期峰值应变(GLPS)与动态血压水平及血压变异性(BPV)的关系。方法选取原发性高血压既往未行降压治疗患者79例,以GLPS绝对值20%为界分为GLPS下降组42例和GLPS正常组37例。采用全自动生化分析仪、彩色...目的探讨高血压患者左室整体长轴收缩期峰值应变(GLPS)与动态血压水平及血压变异性(BPV)的关系。方法选取原发性高血压既往未行降压治疗患者79例,以GLPS绝对值20%为界分为GLPS下降组42例和GLPS正常组37例。采用全自动生化分析仪、彩色多普勒超声、动态血压监测仪分别检测两组血清生化指标、心脏功能、左侧肱动脉24 h血压;采用多元线性逐步回归分析方法明确GLPS的独立相关因素。结果两组比较,血清甘油三酯、总胆固醇(TC)、低密度脂蛋白胆固醇水平、心脏舒张末期室间隔厚度、左室重量指数以及全天平均收缩压(24 h SBP)、日间平均收缩压、全天收缩压变异系数、全天舒张压变异系数、夜间舒张压变异系数(n DBPCV)差异均有统计学意义(P<0.05或<0.01)。多元线性逐步回归分析显示,24 h SBP(β=-0.083,P<0.01)、n DBPCV(β=-8.730,P<0.05)、TC(β=-0.366,P<0.05)与GLPS独立相关。结论高血压GLPS下降患者24 h SBP、n DBPCV升高,此种变化可引起左室早期收缩功能障碍。展开更多
Background: The purpose of this study is to assess the impact of hypertension on systolic function and diastolic function using 2-dimensional echocardiography, conventional Doppler imaging of the transmitral inflow, a...Background: The purpose of this study is to assess the impact of hypertension on systolic function and diastolic function using 2-dimensional echocardiography, conventional Doppler imaging of the transmitral inflow, and tissue Doppler imaging(TDI) of the mitral annulus. Methods: From an outpatient clinic population, 414 consecutive patients underwent 2-dimensional echocardiography, conventional Doppler imaging of the transmitral inflow, and TDI of the septal, lateral, inferior, and posterior walls near the mitral annulus. Parameters of systolic left ventricular(LV) function and diastolic LV function were assessed. Patients were divided according to the presence or absence of systemic hypertension(blood pressure ≥140/90mm Hg on ≥3 measurements or treatment with antihypertensive medication). Results: A complete echocardiographic evaluation was obtained in 397 patients. Among these, 269(68%) had hypertension. There was no difference with respect to age between patients with and without hypertension. Patients with hypertension had higher LV mass index and relative wall thickness and lower TDI peak systolic velocity(VS) when compared with patients without hypertension. In addition, indices of diastolic LV function were significantly impaired in hypertensive patients. Conclusions: Quantitative echocardiography using TDI reveals that hypertensive patients with preserved global LV systolic function often have combined impairment of systolic function and diastolic function.展开更多
文摘目的探讨高血压患者左室整体长轴收缩期峰值应变(GLPS)与动态血压水平及血压变异性(BPV)的关系。方法选取原发性高血压既往未行降压治疗患者79例,以GLPS绝对值20%为界分为GLPS下降组42例和GLPS正常组37例。采用全自动生化分析仪、彩色多普勒超声、动态血压监测仪分别检测两组血清生化指标、心脏功能、左侧肱动脉24 h血压;采用多元线性逐步回归分析方法明确GLPS的独立相关因素。结果两组比较,血清甘油三酯、总胆固醇(TC)、低密度脂蛋白胆固醇水平、心脏舒张末期室间隔厚度、左室重量指数以及全天平均收缩压(24 h SBP)、日间平均收缩压、全天收缩压变异系数、全天舒张压变异系数、夜间舒张压变异系数(n DBPCV)差异均有统计学意义(P<0.05或<0.01)。多元线性逐步回归分析显示,24 h SBP(β=-0.083,P<0.01)、n DBPCV(β=-8.730,P<0.05)、TC(β=-0.366,P<0.05)与GLPS独立相关。结论高血压GLPS下降患者24 h SBP、n DBPCV升高,此种变化可引起左室早期收缩功能障碍。
文摘Background: The purpose of this study is to assess the impact of hypertension on systolic function and diastolic function using 2-dimensional echocardiography, conventional Doppler imaging of the transmitral inflow, and tissue Doppler imaging(TDI) of the mitral annulus. Methods: From an outpatient clinic population, 414 consecutive patients underwent 2-dimensional echocardiography, conventional Doppler imaging of the transmitral inflow, and TDI of the septal, lateral, inferior, and posterior walls near the mitral annulus. Parameters of systolic left ventricular(LV) function and diastolic LV function were assessed. Patients were divided according to the presence or absence of systemic hypertension(blood pressure ≥140/90mm Hg on ≥3 measurements or treatment with antihypertensive medication). Results: A complete echocardiographic evaluation was obtained in 397 patients. Among these, 269(68%) had hypertension. There was no difference with respect to age between patients with and without hypertension. Patients with hypertension had higher LV mass index and relative wall thickness and lower TDI peak systolic velocity(VS) when compared with patients without hypertension. In addition, indices of diastolic LV function were significantly impaired in hypertensive patients. Conclusions: Quantitative echocardiography using TDI reveals that hypertensive patients with preserved global LV systolic function often have combined impairment of systolic function and diastolic function.
