目的:评估左心室舒张末期压力(LVEDP)对新发ST段抬高型心肌梗死(STEMI)患者行急诊经皮冠状动脉(冠脉)介入治疗(PCI)后死亡率的影响。方法:该研究为回顾性分析。入选255例行急诊PCI的新发STEMI患者,术中均在冠脉血管开通前测量LVEDP,根据...目的:评估左心室舒张末期压力(LVEDP)对新发ST段抬高型心肌梗死(STEMI)患者行急诊经皮冠状动脉(冠脉)介入治疗(PCI)后死亡率的影响。方法:该研究为回顾性分析。入选255例行急诊PCI的新发STEMI患者,术中均在冠脉血管开通前测量LVEDP,根据LVEDP的均值[14 mm Hg(1 mm Hg=0.133 k Pa)]分为LVEDP≤14 mm Hg组和LVEDP>14 mm Hg组,观察术后6个月死亡率。运用Cox回归分析LVEDP对死亡率的影响。结果:相对LVEDP≤14 mm Hg组,LVEDP>14 mm Hg组患者术后6个月死亡的风险比(HR)为4.26(P=0.03)。相关分析显示,LVEDP与左心室射血分数(r=-0.267,P=0.001)和B型利钠肽(r=0.154,P=0.041)呈轻度相关。多因素分析显示,在调整左心室射血分数及B型利钠肽后,LVEDP是术后6个月死亡的独立预测因素(每增加5 mm Hg,HR=1.22,P=0.04)。结论:急诊PCI术中测量的LVEDP是新发STEMI患者术后死亡的独立预测因素。展开更多
目的:探讨三维斑点追踪超声心动图(3D-STE)评估冠心病患者的左心室整体舒张功能的临床应用价值。方法:前瞻性纳入68例左心室射血分数正常的冠心病患者。据左心室舒张末期压(LVEDP),将68例冠心病患者分为两组:舒张功能正常组[LVEDP≤15 m...目的:探讨三维斑点追踪超声心动图(3D-STE)评估冠心病患者的左心室整体舒张功能的临床应用价值。方法:前瞻性纳入68例左心室射血分数正常的冠心病患者。据左心室舒张末期压(LVEDP),将68例冠心病患者分为两组:舒张功能正常组[LVEDP≤15 mm Hg,(1 mm Hg=0.133 k Pa)]31例,舒张功能不全组(LVEDP>15 mm Hg)37例。采集心尖四腔全容积图像,运用4D Auto LVQ软件进行离线分析,得到左心室整体(四项三维应变指标)纵向应变(GLS)、圆周应变(GCS)、面积应变(GAS)及径向应变(GRS)。结果:左心室舒张功能不全组GLS、GCS、GAS、GRS较舒张功能正常组均明显减低(P<0.001)。Pearson相关性分析显示四项三维应变指标与LVEDP中度相关:GLS(r=0.585,P<0.001),GCS(r=0.589,P<0.001),GAS(r=0.674,P<0.001)及GRS(r=-0.643,P<0.001)。受试者工作特征(ROC)曲线分析显示GLS在-15.5%时预测左心室舒张功能不全的灵敏度和特异度均为68%;GCS在-17.5%时预测左心室舒张功能不全的灵敏度和特异度分别为76%和81%,GAS在-29.5%时预测左心室舒张功能不全的灵敏度和特异度分别为84%和68%。结论:3D-STE的相关应变参数可用来预测左心室射血分数正常冠心病患者的LVEDP,并能作为新的超声诊断指标来评估患者的左心室舒张功能。展开更多
We sought to determine whether the echocardiographic Doppler parameters of left ventricular diastolic dysfunction predict future heart failure(HF) events and, if so, which parameters best predict HF. We also examined ...We sought to determine whether the echocardiographic Doppler parameters of left ventricular diastolic dysfunction predict future heart failure(HF) events and, if so, which parameters best predict HF. We also examined whether the predictive ability of echocardiographic Doppler parameters was related to their prediction of left ventricular end-diastolic pressure(LVEDP). We studied patients who underwent cardiac catheterization and echocardiography performed within a 30-day period. The end point was HF, defined as new-onset or recurrent HF diagnosed by a physician and requiring the initiation or modification of treatment of HF. We identified 289 patients(mean age 63.5± 12.6 years) with a mean follow-up of 10.9± 10.2 months. A total of 24 HF events occurred. LVEDP was a significant predictor of HF univariately and independently in multiple regression models after adjustment for ejection fraction. In Cox models adjusted for age, gender, LVEDP, and ejection fraction, only the left atrial volume index and early mitral inflow to early diastolic tissue velocity(E/e′ ) ratio remained predictive of HF. A multiple regression model, including all echocardiographic variables, showed a persistent, although attenuated, relation of early to late mitral inflow velocity(E/A) ratio and E/e′ with LVEDP(p=0.06 and p=0.002, respectively). The addition of E/e′ or the left atrial volume indexed to body surface area, but not E/A, to the clinical history and left ventricular ejection fraction provided incremental prognostic information.A LVEDP of< 20 mm Hg, E/e′ ratio of< 15, and left atrial volume index of< 23 ml/m2 identified those with a higher risk of HF. In conclusion, invasively determined LVEDP is an independent predictor of future HF events. E/e′ and the left atrial volume indexed to body surface area are the best independent predictors of future HF and provide prognostic information incremental to the clinical history and left ventricular ejection fraction.展开更多
文摘目的:评估左心室舒张末期压力(LVEDP)对新发ST段抬高型心肌梗死(STEMI)患者行急诊经皮冠状动脉(冠脉)介入治疗(PCI)后死亡率的影响。方法:该研究为回顾性分析。入选255例行急诊PCI的新发STEMI患者,术中均在冠脉血管开通前测量LVEDP,根据LVEDP的均值[14 mm Hg(1 mm Hg=0.133 k Pa)]分为LVEDP≤14 mm Hg组和LVEDP>14 mm Hg组,观察术后6个月死亡率。运用Cox回归分析LVEDP对死亡率的影响。结果:相对LVEDP≤14 mm Hg组,LVEDP>14 mm Hg组患者术后6个月死亡的风险比(HR)为4.26(P=0.03)。相关分析显示,LVEDP与左心室射血分数(r=-0.267,P=0.001)和B型利钠肽(r=0.154,P=0.041)呈轻度相关。多因素分析显示,在调整左心室射血分数及B型利钠肽后,LVEDP是术后6个月死亡的独立预测因素(每增加5 mm Hg,HR=1.22,P=0.04)。结论:急诊PCI术中测量的LVEDP是新发STEMI患者术后死亡的独立预测因素。
文摘目的:探讨三维斑点追踪超声心动图(3D-STE)评估冠心病患者的左心室整体舒张功能的临床应用价值。方法:前瞻性纳入68例左心室射血分数正常的冠心病患者。据左心室舒张末期压(LVEDP),将68例冠心病患者分为两组:舒张功能正常组[LVEDP≤15 mm Hg,(1 mm Hg=0.133 k Pa)]31例,舒张功能不全组(LVEDP>15 mm Hg)37例。采集心尖四腔全容积图像,运用4D Auto LVQ软件进行离线分析,得到左心室整体(四项三维应变指标)纵向应变(GLS)、圆周应变(GCS)、面积应变(GAS)及径向应变(GRS)。结果:左心室舒张功能不全组GLS、GCS、GAS、GRS较舒张功能正常组均明显减低(P<0.001)。Pearson相关性分析显示四项三维应变指标与LVEDP中度相关:GLS(r=0.585,P<0.001),GCS(r=0.589,P<0.001),GAS(r=0.674,P<0.001)及GRS(r=-0.643,P<0.001)。受试者工作特征(ROC)曲线分析显示GLS在-15.5%时预测左心室舒张功能不全的灵敏度和特异度均为68%;GCS在-17.5%时预测左心室舒张功能不全的灵敏度和特异度分别为76%和81%,GAS在-29.5%时预测左心室舒张功能不全的灵敏度和特异度分别为84%和68%。结论:3D-STE的相关应变参数可用来预测左心室射血分数正常冠心病患者的LVEDP,并能作为新的超声诊断指标来评估患者的左心室舒张功能。
文摘We sought to determine whether the echocardiographic Doppler parameters of left ventricular diastolic dysfunction predict future heart failure(HF) events and, if so, which parameters best predict HF. We also examined whether the predictive ability of echocardiographic Doppler parameters was related to their prediction of left ventricular end-diastolic pressure(LVEDP). We studied patients who underwent cardiac catheterization and echocardiography performed within a 30-day period. The end point was HF, defined as new-onset or recurrent HF diagnosed by a physician and requiring the initiation or modification of treatment of HF. We identified 289 patients(mean age 63.5± 12.6 years) with a mean follow-up of 10.9± 10.2 months. A total of 24 HF events occurred. LVEDP was a significant predictor of HF univariately and independently in multiple regression models after adjustment for ejection fraction. In Cox models adjusted for age, gender, LVEDP, and ejection fraction, only the left atrial volume index and early mitral inflow to early diastolic tissue velocity(E/e′ ) ratio remained predictive of HF. A multiple regression model, including all echocardiographic variables, showed a persistent, although attenuated, relation of early to late mitral inflow velocity(E/A) ratio and E/e′ with LVEDP(p=0.06 and p=0.002, respectively). The addition of E/e′ or the left atrial volume indexed to body surface area, but not E/A, to the clinical history and left ventricular ejection fraction provided incremental prognostic information.A LVEDP of< 20 mm Hg, E/e′ ratio of< 15, and left atrial volume index of< 23 ml/m2 identified those with a higher risk of HF. In conclusion, invasively determined LVEDP is an independent predictor of future HF events. E/e′ and the left atrial volume indexed to body surface area are the best independent predictors of future HF and provide prognostic information incremental to the clinical history and left ventricular ejection fraction.
