γ-aminobutyric acid (GABA) is an inhibitory neurotransmitter in the brain and its degradation is mainly caused by GABA-transaminase (GABA-T). γ-vinyl GABA (GVG), which was recently found to act as a specific inhibit...γ-aminobutyric acid (GABA) is an inhibitory neurotransmitter in the brain and its degradation is mainly caused by GABA-transaminase (GABA-T). γ-vinyl GABA (GVG), which was recently found to act as a specific inhibitor of GABA-T in vivo, can greatly increase the GABA content in brain for several days after ip injection and last for several days. In the present work we studied the effect of the increase in brain GABA content induced by intracerebroventricular (icv) GVG injection on electroacupuncture (EA) and morphine analgesia.展开更多
基金Project supported by the Science Fund of the Chinese Academy of Sciences.
文摘γ-aminobutyric acid (GABA) is an inhibitory neurotransmitter in the brain and its degradation is mainly caused by GABA-transaminase (GABA-T). γ-vinyl GABA (GVG), which was recently found to act as a specific inhibitor of GABA-T in vivo, can greatly increase the GABA content in brain for several days after ip injection and last for several days. In the present work we studied the effect of the increase in brain GABA content induced by intracerebroventricular (icv) GVG injection on electroacupuncture (EA) and morphine analgesia.
