本文报道采自广东热带地区的15种半知菌,其中有4个新种和2个中国新记录种:寄生在毛麝香 Adenosma glutinosum (L.) Druce上的毛麝香假尾孢 Pseudocercospora adenosmae Y. L. Guo,生于柑橘属Citrus sp.植物上的柑橘假尾孢 P. citri Y. L...本文报道采自广东热带地区的15种半知菌,其中有4个新种和2个中国新记录种:寄生在毛麝香 Adenosma glutinosum (L.) Druce上的毛麝香假尾孢 Pseudocercospora adenosmae Y. L. Guo,生于柑橘属Citrus sp.植物上的柑橘假尾孢 P. citri Y. L. Guo,生于木防己属Cocculus sp.植物上的木防己生假尾孢 P. cocculigena Y. L. Guo,生于腺萼木属Mycetia sp.植物上的腺萼木假尾孢P. mycetiae Y. L. Guo,生于西番莲Passiflora coerulea L.上的西番莲生尾孢Cercospora passifloricola Chupp和生于吴茱萸属Evodia sp.植物锈菌春孢子器上的春孢器生枝孢Cladosporium aecidiicola Th黰.。文中为新种提供了拉丁文简介、英文描述并附图,研究的标本保存在中国科学院微生物研究所菌物标本馆(HMAS)。展开更多
Objective To study the effects of tetrandrine, a Chinese herbal medicine, on the action potential (AP),contraction as well as sarcoplasmic reticulum (SR) calcium uptake of myocardium in guinea-pigs and dogs.Methods C...Objective To study the effects of tetrandrine, a Chinese herbal medicine, on the action potential (AP),contraction as well as sarcoplasmic reticulum (SR) calcium uptake of myocardium in guinea-pigs and dogs.Methods Changes in AP, dV/dt, peak tension (PT) and dT/dt of myocardial cells were studied using the technique of glass electrode. Changes of the calcium uptake rate by sarcoplasmic reticulum and release of inorganic phosphate from sarcoplasmic reticulum were assessed with biochemical techniques.Results Tetrandrine exerts a concentration-dependent and frequency-dependent negative inotropic effect and shortens action potential duration. Tetrandrine depresses both dT(E)/dt and dT(L)/dt as well as the tension of myocardium, and reduces dV/dt and amplitude only in the slow action potential, thus implying that tetrandrine blocks the slow calcium channel. In addition, compared with thapsigargin, a specific inhibitor of Ca2+-ATPase on SR, tetrandrine more apparently suppresses the contraction of the myocardium.Conclusions Tetrandrine is a wide-range calcium antagonist of plant origin. Not only it blocks the voltageoperated calcium channels as other authors reported, but also may play an important role in affecting the function of Ca2+ -ATPase and calcium release channels on SR. From this study, we also suggest that the calcium channel appears to be more critical than SR for the contraction of my ocardium.展开更多
基金Supported by the National Science Foundation of China (Approved No. 39730020)
文摘本文报道采自广东热带地区的15种半知菌,其中有4个新种和2个中国新记录种:寄生在毛麝香 Adenosma glutinosum (L.) Druce上的毛麝香假尾孢 Pseudocercospora adenosmae Y. L. Guo,生于柑橘属Citrus sp.植物上的柑橘假尾孢 P. citri Y. L. Guo,生于木防己属Cocculus sp.植物上的木防己生假尾孢 P. cocculigena Y. L. Guo,生于腺萼木属Mycetia sp.植物上的腺萼木假尾孢P. mycetiae Y. L. Guo,生于西番莲Passiflora coerulea L.上的西番莲生尾孢Cercospora passifloricola Chupp和生于吴茱萸属Evodia sp.植物锈菌春孢子器上的春孢器生枝孢Cladosporium aecidiicola Th黰.。文中为新种提供了拉丁文简介、英文描述并附图,研究的标本保存在中国科学院微生物研究所菌物标本馆(HMAS)。
文摘Objective To study the effects of tetrandrine, a Chinese herbal medicine, on the action potential (AP),contraction as well as sarcoplasmic reticulum (SR) calcium uptake of myocardium in guinea-pigs and dogs.Methods Changes in AP, dV/dt, peak tension (PT) and dT/dt of myocardial cells were studied using the technique of glass electrode. Changes of the calcium uptake rate by sarcoplasmic reticulum and release of inorganic phosphate from sarcoplasmic reticulum were assessed with biochemical techniques.Results Tetrandrine exerts a concentration-dependent and frequency-dependent negative inotropic effect and shortens action potential duration. Tetrandrine depresses both dT(E)/dt and dT(L)/dt as well as the tension of myocardium, and reduces dV/dt and amplitude only in the slow action potential, thus implying that tetrandrine blocks the slow calcium channel. In addition, compared with thapsigargin, a specific inhibitor of Ca2+-ATPase on SR, tetrandrine more apparently suppresses the contraction of the myocardium.Conclusions Tetrandrine is a wide-range calcium antagonist of plant origin. Not only it blocks the voltageoperated calcium channels as other authors reported, but also may play an important role in affecting the function of Ca2+ -ATPase and calcium release channels on SR. From this study, we also suggest that the calcium channel appears to be more critical than SR for the contraction of my ocardium.
