Free aldopentoses and aldohexoses reacted respectively with (EtO) 2P(O)CHNaCOAr to give the five stereospecific free hydroxyl \%β\% C glycosides in one step. The reaction take place under a mild condition. The proced...Free aldopentoses and aldohexoses reacted respectively with (EtO) 2P(O)CHNaCOAr to give the five stereospecific free hydroxyl \%β\% C glycosides in one step. The reaction take place under a mild condition. The procedures are simple and convenient. The prices of starting materials are cheap. The method can be applied universally for aldopentoses and aldohexoses. The application scope of Wittig Horner reaction has also been expanded. The synthesis of free hydroxyl \%β\% C glycosides from free aldoses directly using Witting\|Horner reaction has not been reported so far.展开更多
Objective: To investigate the effect of arsenic trioxide(As_2O_3)with three different concentration groups on the distribution and recruitment of dendritic cells(DCs)in the conducting airways of asthmatic mice. Metho...Objective: To investigate the effect of arsenic trioxide(As_2O_3)with three different concentration groups on the distribution and recruitment of dendritic cells(DCs)in the conducting airways of asthmatic mice. Methods: Fifty BALB/c mice were divided into 5 groups at random:control group,asthmatic group,therapeutic groups with low dose(1 mg/kg),moderate dose(5 mg/kg)and high dose(10 mg/kg)of As_2O_3.The immunohistochemistry,scanning electron microscope and computerized image analysis were applied to detect airway DCs,respectively. Results: We demonstrated from the control mice that all intraepithelial NLDC-145 + DCs throughout the respiratory tree could be accounted for a network of cells with dendritic cell morphology,and the density of DCs varied from(500±50)cells/mm 2 epithelial surface in the large airways,to(60±10)cells/mm 2 epithelial surface in the small airways(P<0.05).The DCs characteristic of spiny and long processes were impressively observed by the scanning electron microscope.Compared with the control mice,the density,but not the distribution of NLDC-145 + DCs was significantly upregulated in the conducting airways of asthmatic mice(P<0.01).Compared with the asthmatic mice,the densities,but not the distributions of NLDC-145 + DCs were significantly down regulated in the conducting airways of the therapeutic groups with three varying concentrations of As_2O_3(P<0.01)while there were no statistical differences between each other(P>0.05). Conclusion: Our findings suggest that it might be an important therapeutic mechanism of As_2O_3 to downregulate not the distribution but the density of DCs in the conducting airways of asthmatic mice,and low dose of As_2O_3 has potential value in treating asthma.展开更多
文摘Free aldopentoses and aldohexoses reacted respectively with (EtO) 2P(O)CHNaCOAr to give the five stereospecific free hydroxyl \%β\% C glycosides in one step. The reaction take place under a mild condition. The procedures are simple and convenient. The prices of starting materials are cheap. The method can be applied universally for aldopentoses and aldohexoses. The application scope of Wittig Horner reaction has also been expanded. The synthesis of free hydroxyl \%β\% C glycosides from free aldoses directly using Witting\|Horner reaction has not been reported so far.
文摘Objective: To investigate the effect of arsenic trioxide(As_2O_3)with three different concentration groups on the distribution and recruitment of dendritic cells(DCs)in the conducting airways of asthmatic mice. Methods: Fifty BALB/c mice were divided into 5 groups at random:control group,asthmatic group,therapeutic groups with low dose(1 mg/kg),moderate dose(5 mg/kg)and high dose(10 mg/kg)of As_2O_3.The immunohistochemistry,scanning electron microscope and computerized image analysis were applied to detect airway DCs,respectively. Results: We demonstrated from the control mice that all intraepithelial NLDC-145 + DCs throughout the respiratory tree could be accounted for a network of cells with dendritic cell morphology,and the density of DCs varied from(500±50)cells/mm 2 epithelial surface in the large airways,to(60±10)cells/mm 2 epithelial surface in the small airways(P<0.05).The DCs characteristic of spiny and long processes were impressively observed by the scanning electron microscope.Compared with the control mice,the density,but not the distribution of NLDC-145 + DCs was significantly upregulated in the conducting airways of asthmatic mice(P<0.01).Compared with the asthmatic mice,the densities,but not the distributions of NLDC-145 + DCs were significantly down regulated in the conducting airways of the therapeutic groups with three varying concentrations of As_2O_3(P<0.01)while there were no statistical differences between each other(P>0.05). Conclusion: Our findings suggest that it might be an important therapeutic mechanism of As_2O_3 to downregulate not the distribution but the density of DCs in the conducting airways of asthmatic mice,and low dose of As_2O_3 has potential value in treating asthma.
