This article reports the discussion about the multiple relations between architectural design and ＂place＂ using two different approaches in order to characterize the interfaces of design challenges. The first is qua...This article reports the discussion about the multiple relations between architectural design and ＂place＂ using two different approaches in order to characterize the interfaces of design challenges. The first is qualitative, highlighting the lack of dialogue between the standard-project architecture, the guidelines recommended by the COEDI （Coordenagao Geral de Educao Infantil （General Coordination of Early Childhood Education）） of the Ministry of Education, socio-technical and cultural-environmental context and pedagogy. The second, more quantitative, addresses the problems generated by dissociation between the constructive solutions and the bioclimatic demands of different insertion contexts of architectural design in the Brazilian Bioclimatic Zone 2. Initially planned to use a conventional building system, it was transposed to the Wall System, developed by MVC Componentes Pl^tsticos Ltda. The simulation evaluates and compares the level of thermal comfort of the building with two envelope systems. The study reports the analysis of the thermal comfort of a Type C unit, based on thermodynamic simulation, through the software Design Builder （version 4.2.0.054）. The analysis of the building simulation results was based on the adaptive comfort model ASHRAE 55/2010. Later, three optimization measures of the thermal comfort level of the building were tested, based on thermal insulation and absorptance coverage, in addition to sun protection system design for the window frames. Preliminary results for the level of comfort of long permanence environments indicate a tow level of thermal comfort, the 50% in MVC system and around 60% in the conventional system, and also that the greater discomfort comes from the heat. Based on performance optimization measures of building, the MVC system reached 66.4% of thermal comfort compared to 62% in the conventional system. The results show the importance of adapting the standard project to the local climatic context.展开更多
The paper deals with the energy and indoor comfort on buildings of UPF （University ofPasso Fundo）, located in southern Brazil, in order to improve the eco-efficiency concepts in the university＇s building stock, rei...The paper deals with the energy and indoor comfort on buildings of UPF （University ofPasso Fundo）, located in southern Brazil, in order to improve the eco-efficiency concepts in the university＇s building stock, reinforcing its responsibility towards sustainable development. The factors that affect thermal performance and the energy consumption of two case studies were identified, including the general characteristics of the envelope and the indoor conditions. The simulations with DesignBuilder software compare the energy and thermal performance of both cases： those results allow the identification of their positive and negative aspects, as well as making a co-relation with the students＇ sensations of comfort--obtained through PMV （predicted mean vote）. The research indicates that it will be possible to improve eco-efficiency of existing and new buildings and campuses by retrofitting and upgrading it with regard to better indoor conditions that really correspond to climate conditions （hot and humid summers, and cold and damp winters）, using passive strategies for heating and cooling and at the same time to improve rational use of natural resources and to reduce the environmental impact. Probably, giving comfortable conditions to the users will increase energy consumption, but there is a potential reduction of lighting and equipment that could minimize this impact.展开更多
The expansion of social housing in Brazil is solving the great demand among low-income populations, ltowever, these projects are not considering climatic factors and thermal comfort strategies. There is a standardizat...The expansion of social housing in Brazil is solving the great demand among low-income populations, ltowever, these projects are not considering climatic factors and thermal comfort strategies. There is a standardization of architectural projects, which leads to the user discomfort. Bioclimatic solutions that improve the thermal performance of buildings should be valued in the projects of buildings. This paper presents a comparative study noticing the thermal comfort provided by a earth tube ventilation system with a natural ventilation system based in the opening of the windows. In this study, three Brazilian bioclimatic zones defined by NBR （Brazilian Standard） 15220 （2005）, Zone 1 （Curitiba）, 2 （Camaqu~,） and 7 （Cuiabfi）, were considered. To make this comparison, computer simulation was used to observe the thermal confort conditions in RTQ-R （Quality Technical Standard for Energy Efficiency Level in Residential Buildings） （2010）, with the help of Energy Plus software and Schektch Up with the plug in Open Studio for modeling the residence. After the energy modeling, the results were analyzed with the Analisys Bio software in order to obtain the percentage of hours of comfort for the year （8,760 h）. The conclusion is drawn that the natural ventilation strategy with the opening and closing of the windows is more efficient in Bioclimatic Zone 1. For the Bioclimatic Zone 2, the earth tubes should be used only in the summer and, in Bioclimatic Zone 7, earth tubes are efficient throughout the year because of the high temperatures in the exterior environment.展开更多
Herpes simplex virus type 1 （HSV-1）, a neurotropic member of the alphaherpes virus family, is among the most prevalent and successful human pathogens. HSV-1 can cause serious diseases at every stage of life includin...Herpes simplex virus type 1 （HSV-1）, a neurotropic member of the alphaherpes virus family, is among the most prevalent and successful human pathogens. HSV-1 can cause serious diseases at every stage of life including fatal disseminated disease in newborns, cold sores, eye disease, and fatal encephalitis in adults. HSV-1 infection can trigger rapid immune responses, and efficient inhibition and clearance of HSV-1 infection rely on both the innate and adaptive immune responses of the host. Multiple strategies have been used to restrict host innate immune responses by HSV-1 to facilitate its infection in host cells. The adaptive immunity of the host plays an important role in inhibiting HSV-1 infections. The activation and regulation of T cells are the important aspects of the adaptive immunity. They play a crucial role in host-mediated immunity and are important for clearing HSV-1. In this review, we examine the findings on T cell immune responses during HSV-1 infection, which hold promise in the design of new vaccine can- didates for HSV-I.展开更多
文摘This article reports the discussion about the multiple relations between architectural design and ＂place＂ using two different approaches in order to characterize the interfaces of design challenges. The first is qualitative, highlighting the lack of dialogue between the standard-project architecture, the guidelines recommended by the COEDI （Coordenagao Geral de Educao Infantil （General Coordination of Early Childhood Education）） of the Ministry of Education, socio-technical and cultural-environmental context and pedagogy. The second, more quantitative, addresses the problems generated by dissociation between the constructive solutions and the bioclimatic demands of different insertion contexts of architectural design in the Brazilian Bioclimatic Zone 2. Initially planned to use a conventional building system, it was transposed to the Wall System, developed by MVC Componentes Pl^tsticos Ltda. The simulation evaluates and compares the level of thermal comfort of the building with two envelope systems. The study reports the analysis of the thermal comfort of a Type C unit, based on thermodynamic simulation, through the software Design Builder （version 4.2.0.054）. The analysis of the building simulation results was based on the adaptive comfort model ASHRAE 55/2010. Later, three optimization measures of the thermal comfort level of the building were tested, based on thermal insulation and absorptance coverage, in addition to sun protection system design for the window frames. Preliminary results for the level of comfort of long permanence environments indicate a tow level of thermal comfort, the 50% in MVC system and around 60% in the conventional system, and also that the greater discomfort comes from the heat. Based on performance optimization measures of building, the MVC system reached 66.4% of thermal comfort compared to 62% in the conventional system. The results show the importance of adapting the standard project to the local climatic context.
文摘The paper deals with the energy and indoor comfort on buildings of UPF （University ofPasso Fundo）, located in southern Brazil, in order to improve the eco-efficiency concepts in the university＇s building stock, reinforcing its responsibility towards sustainable development. The factors that affect thermal performance and the energy consumption of two case studies were identified, including the general characteristics of the envelope and the indoor conditions. The simulations with DesignBuilder software compare the energy and thermal performance of both cases： those results allow the identification of their positive and negative aspects, as well as making a co-relation with the students＇ sensations of comfort--obtained through PMV （predicted mean vote）. The research indicates that it will be possible to improve eco-efficiency of existing and new buildings and campuses by retrofitting and upgrading it with regard to better indoor conditions that really correspond to climate conditions （hot and humid summers, and cold and damp winters）, using passive strategies for heating and cooling and at the same time to improve rational use of natural resources and to reduce the environmental impact. Probably, giving comfortable conditions to the users will increase energy consumption, but there is a potential reduction of lighting and equipment that could minimize this impact.
文摘The expansion of social housing in Brazil is solving the great demand among low-income populations, ltowever, these projects are not considering climatic factors and thermal comfort strategies. There is a standardization of architectural projects, which leads to the user discomfort. Bioclimatic solutions that improve the thermal performance of buildings should be valued in the projects of buildings. This paper presents a comparative study noticing the thermal comfort provided by a earth tube ventilation system with a natural ventilation system based in the opening of the windows. In this study, three Brazilian bioclimatic zones defined by NBR （Brazilian Standard） 15220 （2005）, Zone 1 （Curitiba）, 2 （Camaqu~,） and 7 （Cuiabfi）, were considered. To make this comparison, computer simulation was used to observe the thermal confort conditions in RTQ-R （Quality Technical Standard for Energy Efficiency Level in Residential Buildings） （2010）, with the help of Energy Plus software and Schektch Up with the plug in Open Studio for modeling the residence. After the energy modeling, the results were analyzed with the Analisys Bio software in order to obtain the percentage of hours of comfort for the year （8,760 h）. The conclusion is drawn that the natural ventilation strategy with the opening and closing of the windows is more efficient in Bioclimatic Zone 1. For the Bioclimatic Zone 2, the earth tubes should be used only in the summer and, in Bioclimatic Zone 7, earth tubes are efficient throughout the year because of the high temperatures in the exterior environment.
基金supported by the Wuhan Institute of Virology (WIV) “One-Three-Five” Strategic Programs,China
文摘Herpes simplex virus type 1 （HSV-1）, a neurotropic member of the alphaherpes virus family, is among the most prevalent and successful human pathogens. HSV-1 can cause serious diseases at every stage of life including fatal disseminated disease in newborns, cold sores, eye disease, and fatal encephalitis in adults. HSV-1 infection can trigger rapid immune responses, and efficient inhibition and clearance of HSV-1 infection rely on both the innate and adaptive immune responses of the host. Multiple strategies have been used to restrict host innate immune responses by HSV-1 to facilitate its infection in host cells. The adaptive immunity of the host plays an important role in inhibiting HSV-1 infections. The activation and regulation of T cells are the important aspects of the adaptive immunity. They play a crucial role in host-mediated immunity and are important for clearing HSV-1. In this review, we examine the findings on T cell immune responses during HSV-1 infection, which hold promise in the design of new vaccine can- didates for HSV-I.
