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西夏文《菩提心及常作法事》研究 被引量:1
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作者 孙伯君 胡进杉 《西夏学》 2019年第1期244-294,共51页
俄罗斯科学院东方文献研究所收藏的Инв.№6510,为藏传佛教"发菩提心"实修仪轨的西夏文译本,刊行于夏襄宗应天元年(1206年)。该本是黑水城出土同类藏传佛典译本中罕见的存有明确刊行年代的刻本,为确定俄藏、英藏等其他残卷... 俄罗斯科学院东方文献研究所收藏的Инв.№6510,为藏传佛教"发菩提心"实修仪轨的西夏文译本,刊行于夏襄宗应天元年(1206年)。该本是黑水城出土同类藏传佛典译本中罕见的存有明确刊行年代的刻本,为确定俄藏、英藏等其他残卷的内容以及研究西夏晚期藏传佛教的流行情况提供了极有价值的参考。 展开更多
关键词 《发菩提心及常作法事》 发菩提心 西夏学 藏传佛教
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三维石油遥感应用中多时相影像数据管理 被引量:3
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作者 郭红燕 邹立群 +2 位作者 董文彤 刘杨 周红英 《遥感信息》 CSCD 北大核心 2016年第4期129-133,共5页
针对目前多时相影像数据管理主要是面向影像产品管理,仅考虑影像产品本身的信息作为管理要素,无法满足石油行业遥感应用要求这一问题,提出一种面向三维石油遥感应用的多时相数据管理方法,通过采用数据组织目录结构与瓦片存储目录结构相... 针对目前多时相影像数据管理主要是面向影像产品管理,仅考虑影像产品本身的信息作为管理要素,无法满足石油行业遥感应用要求这一问题,提出一种面向三维石油遥感应用的多时相数据管理方法,通过采用数据组织目录结构与瓦片存储目录结构相结合的方式,建立了多时相影像数据的分级管理与访问。该方法满足石油遥感应用多样性、应用的油区范围分散、多数据源组合、油区变化性检测的要求,并以鄱阳湖三角洲环境变化中多时相数据管理为例进行了软件实现。 展开更多
关键词 三维石油遥感应用 多时相影像管理 数据组织结构 影像瓦片 数据存储
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积蓄力量“再出发”——卢新华访谈 被引量:4
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作者 卢新华 王冬梅 《中国现代文学论丛》 2015年第1期132-149,共18页
《伤痕》之前:'偶得佳句便为乐,常作玄想也能醉'王冬梅(以下简称王):1978年8月11日,短篇小说《伤痕》在上海《文汇报》公开发表。您一跃而成为众人关注的焦点人物,很多人由此知道了您的名字。能谈谈《伤痕》之前您所受到的文学... 《伤痕》之前:'偶得佳句便为乐,常作玄想也能醉'王冬梅(以下简称王):1978年8月11日,短篇小说《伤痕》在上海《文汇报》公开发表。您一跃而成为众人关注的焦点人物,很多人由此知道了您的名字。能谈谈《伤痕》之前您所受到的文学教育或者文学启蒙吗?或者说,最初亲近文学是始于什么时候?卢新华(以下简称卢):真正亲近文学,应该还是从插队落户的时候开始的吧。那时劳动很辛苦,也看不到有改变当一辈子农民命运的可能。 展开更多
关键词 命运 文学 积蓄 插队落户 伤痕 焦点人物 谈谈 常作
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Effects of IQ_23 on the Repolarization and Both Components of the Delayed Rectifier Potassium Current in Guinea Pig Ventricular Myocytcs
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作者 李新华 阎升 +4 位作者 姚伟星 夏国瑾 江明性 黄文龙 彭司勋 《Journal of Chinese Pharmaceutical Sciences》 CAS 1999年第1期48-52,共5页
Using patch clamp whole cell recording techiques, we examined the effects ofIQ_23, a benzyl-isoquinoline derivative with antiarrhythmic activities, on the action potential (AP) andpotassium currents in single guinea p... Using patch clamp whole cell recording techiques, we examined the effects ofIQ_23, a benzyl-isoquinoline derivative with antiarrhythmic activities, on the action potential (AP) andpotassium currents in single guinea pig ventricular myocytes. The results showed that IQ_23 at 10, 30and 100 μmol ·L_-1 slowed the repolarization in AP dose-dependently. The APD_90 were prolonged by15%, 28% and 31% respectively. This effect did not depend on the extracellular Ca^2+. In voltageclamp mode, IQ_23 effectively blocked both the components of the delayed rectifier potassium current(I_k), i.e., I_ks and I_kr. At concentrations of 30 and 100 μmol· L^-1, IQ_23 suppressed I_ks by 21% and 26%and suppressed I_kr by 67% and 86% respectively. But even at 100 μmol·L^-1, IQ_23 had little effect onthe inward rectifier potassium current (I_k1). It is concluded: 1. IQ_23 can dose-dependently prolongAPD in the ventriculas myocytes of guinea pig, the effect does not depend on the extracellular Ca^2+; 2.IQ_23 blocks both I_ks and Ikr in the ventricular myocytes without obvious specificities between them. 展开更多
关键词 IQ_13 Antiarrhythmic drug Patch clamp technic Action potential Potassiumchannel Ventricular myocyte Guinea pig
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Transarterial chemoembolization with drug-eluting beads in hepatocellular carcinoma 被引量:5
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作者 Hee Chul Nam Bohyun Jang Myeong Jun Song 《World Journal of Gastroenterology》 SCIE CAS 2016年第40期8853-8861,共9页
Transarterial chemoembolization(TACE) is a widely used standard treatment for patients with hepatocellular carcinoma(HCC) who are not suitable candidates for curative treatments. The rationale for TACE is that intra-a... Transarterial chemoembolization(TACE) is a widely used standard treatment for patients with hepatocellular carcinoma(HCC) who are not suitable candidates for curative treatments. The rationale for TACE is that intra-arterial chemotherapy using lipiodol and chemotherapeutic agents, followed by selective vascular embolization, results in a strong cytotoxic effect as well as ischemia(conventional TACE). Recently, drugeluting beads(DC Beads?) have been developed for transcatheter treatment of HCC to deliver higher doses of the chemotherapeutic agent and to prolong contact time with the tumor. DC Beads? can actively sequester doxorubicin hydrochloride from solution and release it in a controlled sustained fashion. Treatment with DC Beads? substantially reduced the amount of chemotherapeutic agent that reached the systemic circulation compared with conventional, lipiodol-based regimens, significantly reducing drug-related adverse events. In this article, we describe the treatment response, survival, and safety of TACE used with drugeluting beads for the treatment of HCC and discuss future therapeutic possibilities. 展开更多
关键词 Hepatocellular carcinoma Transarterial chemoembolization Conventional TACE Drug-eluting beads Treatment response
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Azoxymethane-induced rat aberrant crypt foci:Relevance in studying chemoprevention of colon cancer 被引量:5
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作者 Jayadev Raju 《World Journal of Gastroenterology》 SCIE CAS CSCD 2008年第43期6632-6635,共4页
The pathogenesis of colon cancer involves sequential and multistep progression of epithelial cells initiated to a cancerous state with defined precancerous intermediaries. Aberrant crypt foci (ACF) represent the ear... The pathogenesis of colon cancer involves sequential and multistep progression of epithelial cells initiated to a cancerous state with defined precancerous intermediaries. Aberrant crypt foci (ACF) represent the earliest identifiable intermediate precancerous lesions during colon carcinogenesis in both laboratory animals and humans. ACF are easily induced by colon-specific carcinogens in rodents and can be used to learn more about the process of colon carcinogenesis. For over two decades, since its first discovery, azoxymethane (AOM)-induced rodent ACF have served as surrogate biomarkers in the screening of various anticarcinogens and carcinogens. Several dietary constituents and phytochemicals have been tested for their colon cancer chemopreventive efficacy using the ACF system. There has been substantial effort in defining and refining ACF in terms of understanding their molecular make-up, and extensive research in this field is currently in progress. In chemoprevention studies, AOM-induced rat ACF have been very successful as biomarkers, and have provided several standardized analyses of data. There have been several studies that have reported that ACF data do not correlate to actual colon tumor outcome, however, and hence there has been an ambiguity about their role as biomarkers. The scope of this mini-review is to provide valuable insights and limitations of AOM-induced rat ACF as biomarkers in colon cancer chemoprevention studies. The role of the dynamics and biological heterogeneity of ACF is critical in understanding them as biomarkers in chemoprevention studies. 展开更多
关键词 Aberrant crypt foci AZOXYMETHANE Biological markers CARCINOGENESIS CHEMOPREVENTION Colon cancer
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Effects of IQ23 on the Repolarization and Both Components of the Delayed Rectifier Potassium Current in Guinea Pig Ventricular Myocytcs
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作者 李新华 阎升 +4 位作者 姚伟星 夏国瑾 江明性 黄文龙 彭司勋 《Journal of Chinese Pharmaceutical Sciences》 CAS 1999年第1期48-52,共页
Using patch clamp whole cell recording techiques, we examined the effects ofIQ<sub>2</sub>3, a benzyl-isoquinoline derivative with antiarrhythmic activities, on the action potential (AP) andpotassium cur... Using patch clamp whole cell recording techiques, we examined the effects ofIQ<sub>2</sub>3, a benzyl-isoquinoline derivative with antiarrhythmic activities, on the action potential (AP) andpotassium currents in single guinea pig ventricular myocytes. The results showed that IQ<sub>2</sub>3 at 10, 30and 100 μmol ·L<sub>-</sub>1 slowed the repolarization in AP dose-dependently. The APD<sub>9</sub>0 were prolonged by15%, 28% and 31% respectively. This effect did not depend on the extracellular Ca<sup>2</sup>+. In voltageclamp mode, IQ<sub>2</sub>3 effectively blocked both the components of the delayed rectifier potassium current(I<sub>k</sub>), i.e., I<sub>k</sub>s and I<sub>k</sub>r. At concentrations of 30 and 100 μmol· L<sup>-</sup>1, IQ<sub>2</sub>3 suppressed I<sub>k</sub>s by 21% and 26%and suppressed I<sub>k</sub>r by 67% and 86% respectively. But even at 100 μmol·L<sup>-</sup>1, IQ<sub>2</sub>3 had little effect onthe inward rectifier potassium current (I<sub>k</sub>1). It is concluded: 1. IQ<sub>2</sub>3 can dose-dependently prolongAPD in the ventriculas myocytes of guinea pig, the effect does not depend on the extracellular Ca<sup>2</sup>+; 2.IQ<sub>2</sub>3 blocks both I<sub>k</sub>s and Ikr in the ventricular myocytes without obvious specificities between them. 展开更多
关键词 IQ13 Antiarrhythmic drug Patch clamp technic Action potential Potassiumchannel Ventricular myocyte Guinea pig
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Density, Viscosity, and Excess Properties for Binary Mixture of Diethylene Glycol Monoethyl Ether + Water from 293.15 to 333.15 K at Atmospheric Pressure 被引量:5
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作者 李新学 徐国民 +1 位作者 王彦伟 胡一江 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2009年第6期1009-1013,共5页
Densities and viscosities were measured as a function of composition for binary liquid mixture of diethylerie glycol monoethyl ether [CH3CH2O(CH2)2O(CH2)2OH] + water from 293.15 to 333.15 K at atmospheric pressur... Densities and viscosities were measured as a function of composition for binary liquid mixture of diethylerie glycol monoethyl ether [CH3CH2O(CH2)2O(CH2)2OH] + water from 293.15 to 333.15 K at atmospheric pressure, with a capillary pycnometer and Ubbelohde capillary viscometer respectively. From the experimental data, the excess molar volume V^E, viscosity deviation △η, and the excess energy of activation for viscous flow △G^*E were calculated. These data were correlated by the Redlich-Kister type equations to obtain the coefficients and standard deviations. The results showed a strong molecular interaction between diethylene glycol monoethyl ether and water. 展开更多
关键词 DENSITY VISCOSITY diethylene glycol monoethyl ether binary mixture excess molar volume viscosity deviation
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Multiverse Theory 被引量:1
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作者 Khaled 《Journal of Energy and Power Engineering》 2018年第4期186-191,共6页
In this paper it is answered why the imaginary number is not used in the equal operator presented earlier by Ahiobani. The life criterion is presented here. The concept of energy conservation is assumed to be held wit... In this paper it is answered why the imaginary number is not used in the equal operator presented earlier by Ahiobani. The life criterion is presented here. The concept of energy conservation is assumed to be held within the gates between verses. The Hamiltonian for entry is the some when exiting, this concept is discussed. Within this concept suvat equations are discussed. Ahiobani' s generalized factor is presented instead of Planck's constant as proportionality factor between energy and frequency. A closer physical look for multiverse mathematics as tensor product is performed. 展开更多
关键词 TIME MASS multiverse.
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Planation Surfaces on the Tibet Plateau,China 被引量:2
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作者 ZHANG Xinbao HE Xiubin +1 位作者 WANG Yangchun LONG Yi 《Journal of Mountain Science》 SCIE CSCD 2008年第4期310-317,共8页
A planation hypothesis is proposed to explain landform evolution of the Tibet Plateau. A denudation threshold (T), the maximum potential denudation rate for a certain type of rock, is introduced to explain the combi... A planation hypothesis is proposed to explain landform evolution of the Tibet Plateau. A denudation threshold (T), the maximum potential denudation rate for a certain type of rock, is introduced to explain the combined effects of lithology and tectonics on landform evolution. If the tectonic uplifting rate (U) is equal to or less than the threshold rate (U ≤ T), the tectonic uplifting and terrain denudation are in dynamic equilibrium, and landforms are in a steady state. The end product should be planation surfaces whether the original landforms are flat plains or deeply dissected mountains. If U 〉 T, uplift and denudation are not able to reach a dynamic equilibrium state. The plateau surface is mostly underlain by soft rocks, such as the Mesozoic epimetamorphic argillites and Tertiary sedimentary rocks, while the mountain ranges comprise hard rocks, such as granite, gneiss and limestone. In soft rock regions, hills are low with a relative relief of mostly less than 100 m and the slopes are gentle at a gradient of 〈200. In contrast, hills can maintain steep slopes in hard rock regions. The Tibet Plateau has been under an equilibrium condition between tectonic uplifting and denudation except for the mountain ranges. The plateau might have reached the present altitudes before the Quaternary. 展开更多
关键词 planation denudation threshold landform evolution Tibet Plateau China
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The Development of a New Anti-electromagnetic Radiation Fabric
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作者 赵书林 王恩清 《Journal of Donghua University(English Edition)》 EI CAS 2009年第2期200-203,共4页
By the study of electromagnetic shielding principle,we have designed some new style fabrics for anti-electromagnetic radiation through the research of raw materials and fabric texture,and solved the key technical prob... By the study of electromagnetic shielding principle,we have designed some new style fabrics for anti-electromagnetic radiation through the research of raw materials and fabric texture,and solved the key technical problems such as the manufacture of composite yarn which composed of stainless steel filament and cotton yarn.As a newly developed high technology material,the new style anti-electromagnetic radiation fabric was woven by the special yarn composed of stainless filament and nature fiber.The new fabric overcomes the defect in the production and service of the shielding fabrics at present and satisfies the people's requirement the routine job and life.With further improvement,it can be widely used in aviation,navigation and military project,underground project and so on. 展开更多
关键词 electromagnetic radiation stainless steel filament anti-electromagnetic radiation fabric
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Magnetic and Magneto-Optical Properties in Paramagnetic NdF3 Under High Magnetic Field
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作者 WANGWei LIUGong-Qiang 《Communications in Theoretical Physics》 SCIE CAS CSCD 2005年第5期948-952,共5页
In this paper, we first theoretically report the magnetic and magneto-opticalproperties in paramagnetic media under high external magnetic field. Considering the action of theexternal magnetic Geld H_e and indirect ex... In this paper, we first theoretically report the magnetic and magneto-opticalproperties in paramagnetic media under high external magnetic field. Considering the action of theexternal magnetic Geld H_e and indirect exchange interaction H_v, the characteristic of the magneticsaturation and the property of the Faraday rotation to be nonlinear with external magnetic Geld arepresented in paramagnetic NdF_3. In terms of our theory, the indirect exchange interaction plays auimportant role in the magnetization M and the Faraday rotation θ in NdF_3 under high externalmagnetic Geld. The theory is in good agreement with experimental results. On the other hand, areasonable explanation for the temperature dependence of the ratio of the Verdet constant to themagnetic susceptibility V/x is obtained. 展开更多
关键词 magneto-optical property verdet constant exchange interaction highmagnetic field NONLINEAR
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Extraction of rubidium by t-BAMBP in cyclohexane 被引量:9
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作者 王嘉伟 车德华 秦炜 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2015年第7期1110-1113,共4页
4-Tert-butyl-2-(α-methylbenzyl) phenol (t-BAMBP) was used in cyclohexane in the extraction of rubidium from brine sources containing lithium. The effect of t-BAMBP concentration and aqueous phase pH on the rubidi... 4-Tert-butyl-2-(α-methylbenzyl) phenol (t-BAMBP) was used in cyclohexane in the extraction of rubidium from brine sources containing lithium. The effect of t-BAMBP concentration and aqueous phase pH on the rubidium and lithium extraction equilibrium was studied, t-BAMBP/cyclohexane was efficient and selective for rubidium extraction with optimal operating conditions being pH of 13.0 and initial t-BAMBP concentration of 1.0 mol.L-1. The stoichiometry of the complex of α-BAMBP with rubidium is 4:1. The apparent extraction equilibrium constant of rubidium was calculated by fitting the experimental data. 展开更多
关键词 Solvent extractionSelectivityRubidiumc-BAMBPCydohexane
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First-principles lattice stability of Fe, Ru and Os
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作者 陶辉锦 尹健 《Journal of Central South University》 SCIE EI CAS 2009年第2期177-183,共7页
Lattice constants, total energies and densities of states of transition metals Fe, Ru and Os with BCC, FCC and HCP structures were calculated by the GGA+PBE functional and the ultrasoft pseudo-potential plane wave met... Lattice constants, total energies and densities of states of transition metals Fe, Ru and Os with BCC, FCC and HCP structures were calculated by the GGA+PBE functional and the ultrasoft pseudo-potential plane wave method, and compared with those of the first-principles projector augmented wave (PAW) method, CALPHAD method and experimental data. The results show that the lattice stability of this work is △GBCC-HCP>△GFCC-HCP>0, agreeing well with those of PAW method in the first-principles and CALPHAD method except for BCC-Fe. And the densities of state of HCP-Ru and Os have an obvious character of stable phase, agreeing completely with the results of the total energy calculations. Further analyses of atomic population show that the transition rate of electrons from s to p state for HCP, FCC and BCC crystals increases from Fe to Os, and a stronger cohesion, a higher cohesive energy or a more stable lattice between atoms of heavier metals are formed. 展开更多
关键词 FE RU OS lattice stability FIRST-PRINCIPLES
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Application of Workflow Technology to Cabinet Dyeing
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作者 Maderi Sivalingam Saravanan Ratakonda Janakiram Rama Sree 《Computer Technology and Application》 2011年第1期62-66,共5页
In this paper, workflow technology is firstly applied to the cabinet dyeing order system for cabinet dyeing unit. The system setup workflow models which conform to the existing system and resource and the system adopt... In this paper, workflow technology is firstly applied to the cabinet dyeing order system for cabinet dyeing unit. The system setup workflow models which conform to the existing system and resource and the system adopts flexible workflow process mechanism to enhance the adaptability and opening and solve the exception and abnormality manipulation. The results show that it can not only provide the better dyeing order process, but also set dyer free from the fussy daily business and predigest task flow and heighten production efficiency. 展开更多
关键词 Workflow technology cabinet dyeing exception.
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Quantum to Classical Transition by a Classically Small Interaction
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作者 赵文垒 揭泉林 周波 《Communications in Theoretical Physics》 SCIE CAS CSCD 2010年第8期247-252,共6页
We investigate the quantum-classical transition of a kicked rotor (KR) under perturbation by a second one. The influence of such a chaotic KR makes decoherence of the first one, resulting in the emergence of classic... We investigate the quantum-classical transition of a kicked rotor (KR) under perturbation by a second one. The influence of such a chaotic KR makes decoherence of the first one, resulting in the emergence of classical diffusion from its quantum dynamics. Such quantum-classical transition persists by decreasing the effective Planck's constant h, and at the same time, decreasing the mass of the second KR and the interaction strength proportionally. In the limit of h → 0, due to vanishing small mass and interaction, the second KR has almost no effect on the classieal dynamics of the first one. We demonstrate this via two different coupling potentials. 展开更多
关键词 DECOHERENCE ENTANGLEMENT quantum chaos kicked rotor
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Reactive Extraction of Nicotinic Acid with Trialkylamine in n-Octanol 被引量:2
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作者 李德亮 于飞 常志显 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2012年第5期843-848,共6页
The distributions of nicotinic acid (NA) between water and trialkylamine (N235) dissolved in n-octanol was studied. The complexes of N235 and NA were investigated by Fourier transformation infrared spectrometry to ded... The distributions of nicotinic acid (NA) between water and trialkylamine (N235) dissolved in n-octanol was studied. The complexes of N235 and NA were investigated by Fourier transformation infrared spectrometry to deduce the reaction mechanism. It was found that N235/n-octanol was an efficient extractant for extracting nicotinic acid. The favorable operation conditions were equilibrium aqueous pH 4.2 to 5.5 and initial N235 concentration<0.42 mol·L-1 . The reaction processes included the reaction between neutral N235 and neutral NA and the reaction between protonated N235 and anionic NA. Based on the mass action law and some assumptions, an expression for distribution coefficient D was proposed. The apparent extraction equilibrium constants were calculated by fitting the experimental data and the results were satisfactory. 展开更多
关键词 nicotinic acid reactive extraction trlalkylamlne proton-transter
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The Risk Identification and Corresponding Strategy of Transnational Financial Accounting Outsourcing
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作者 Meng WU Lei YANG 《International Journal of Technology Management》 2015年第6期36-38,共3页
Financial Accounting outsourcing in recent years has been the development of new outsourcing model with more and more enterprises management and CFOs of all ages. With the development of financial accounting outsourci... Financial Accounting outsourcing in recent years has been the development of new outsourcing model with more and more enterprises management and CFOs of all ages. With the development of financial accounting outsourcing services, it will lead to economic, social and development prospects that are also widely recognized. Not only small and medium companies are keen to own non-core financial accounting processes outsourced to agencies, large group has the entire basis of accounting processes tend to be outsourced to a qualified and experienced outsourcing service. Group companies or large multinationals are gradually re-integration of the financial sector, the basic financial accounting processes separate from the daily work out for outsourcing to focus resources on the development of core competencies. 展开更多
关键词 International Financial Accounting Risk Identification Corresponding Strategy
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Anti-tumor effect of bufalin on the orthotopic transplantation tumor model of human hepatocellular carcinoma in nude mice 被引量:1
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作者 韩克起 顾伟 +5 位作者 苏永华 张亚妮 黄雪强 刘岭 王喜 凌昌全 《Journal of Medical Colleges of PLA(China)》 CAS 2004年第6期338-341,345,共5页
Objective: To investigate anti-tumor effect of bufalin on the orthotopic transplantation tumor model of human hepatocellular carcinoma in nude mice. Methods: BEL-7402 cells of human hepatocellular carcinoma were inocu... Objective: To investigate anti-tumor effect of bufalin on the orthotopic transplantation tumor model of human hepatocellular carcinoma in nude mice. Methods: BEL-7402 cells of human hepatocellular carcinoma were inoculated to form subcutaneous tumors in nude mice by subcutaneous injection. Then the subcutaneous tumors were implanted into the liver of nude mice, and the orthotopic transplantation tumor models of human hepatocellular carcinoma were established. Seventy-five models were randomized into 5 groups ( n = 15) . Bufalin was injected intraperitoneally into the 3 groups at dose of 1.5,1 and 0.5 mg/kg for day 15 - 24, respectively. NS group were injected equal volume saline as above and adriamycin were injected intraperitoneally into ADM group at dose of 8.0 mg/kg for day 15. Ten mice in each group were killed at day 25 and detected on morphological and ultrastructural changes in myocardium, brain, liver, kidney and tumor tissues by pathology and electron microscope. The survival time in each group were observed. Results: The tumor volumes in each group of bufalin were reduced significantly compared with NS group (P < 0.01), the survival time were prolonged in group Bu 1 and Bu 2 compared with NS group ( P < 0.05), and tumor tissues were mainly necrosis in severe or moderate degree in Bu 1, Bu 2 groups, and mild degree or moderate degree in Bu 3 group. No morphological changes were detected in myocardium, brain, liver and kidney tissues, respectively. Apoptotic characteristics could be seen in tumor tissues of group Bu 1 and group Bu 2. Conclusion: Bufalin has significant anti-tumor effects on the orthotopic transplantation tumor model of human hepatocellular carcinoma in nude mice without marked toxicity. To guide cell apoptosis may be one of its anti-tumor mechanism of bufalin. 展开更多
关键词 BUFALIN hepatocellular carcinoma orthotopic transplantation nude mice model TREATMENT
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Effects of allocryptopine on outward potassium current and slow delayed rectifier potassium current in rabbit myocardium
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作者 Yi-Cheng FU Yu ZHANG +5 位作者 Liu-Yang TIAN Nan LI Xi CHEN Zhong-Qi CAI Chao ZHU Yang LI 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2016年第4期316-325,共10页
Objective Allocryptopine (ALL) is an effective alkaloid of Corydalis decumbens (Thunb.) Pers. Papaveraceae and has proved to be an- ti-arrhythmic. The purpose of our study is to investigate the effects of ALL on t... Objective Allocryptopine (ALL) is an effective alkaloid of Corydalis decumbens (Thunb.) Pers. Papaveraceae and has proved to be an- ti-arrhythmic. The purpose of our study is to investigate the effects of ALL on transmural repolarizing ionic ingredients of outward potassium current (Ito) and slow delayed rectifier potassium current (IKs). Methods The monophasic action potential (MAP) technique was used to record the MAP duration of the epicardium (Epi), myocardium (M) and endocardium (Endo) of the rabbit heart and the whole cell patch clamp was used to record/to and IKs in cardiomyocytes of Epi, M and Endo layers that were isolated from rabbit ventricles. Results The effects of ALL on MAP of Epi, M and Endo layers were disequilibrium. ALL could effectively reduce the transmural dispersion of repolarization (TDR) in rabbit transmural ventricular wall. ALL decreased the current densities of/to and IKs in a voltage and concentration dependent way and narrowed the repolarizing differences among three layers. The analysis of gating kinetics showed ALL accelerated the channel activation ofIto in M layers and partly inhibit the channel openings of/to in Epi, M and Endo cells. On the other hand, ALL mainly slowed channel deactivation of IKs channel in Epi and Endo layers without affecting its activation. Conclusions Our study gives partially explanation about the mechanisms of tmnsmural inhibition of/to and IKs channels by ALL in rabbit myocardium. These findings provide novel perspective regarding the anti-arrhythmogenesis application of ALL in clinical settings. 展开更多
关键词 Allocryptopine ENDOCARDIUM EPICARDIUM Midcardium Slow delayed rectifier potassium channel Transient outward potassiumcurrent
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