Increasing time-spent online has amplified users＇ exposure to tile tilreat oI miormanon leakage. Although existing security systems （such as firewalls and intrusion detection systems） can satisfy most of the securi...Increasing time-spent online has amplified users＇ exposure to tile tilreat oI miormanon leakage. Although existing security systems （such as firewalls and intrusion detection systems） can satisfy most of the security requirements of network administrators, they are not suitable for detecting the activities of applying the HTTP-tunnel technique to steal users＇ private information. This paper focuses on a network behavior-based method to address the limitations of the existing protection systems. At first, it analyzes the normal network behavior pattern over HTI＇P traffic and select four features. Then, it pres- ents an anomaly-based detection model that applies a hierarchical clustering technique and a scoring mechanism. It also uses real-world data to validate that the selected features are useful. The experiments have demonstrated that the model could achieve over 93% hit-rate with only about 3% false- positive rate. It is regarded confidently that the approach is a complementary technique to the existing security systems.展开更多
The security evaluation for an information network system is an important management tool to insure its normal operation. We must realize the significance of the comprehensive network security risks. A network evaluat...The security evaluation for an information network system is an important management tool to insure its normal operation. We must realize the significance of the comprehensive network security risks. A network evaluation model and the algorithm are presented and adapt the hierarchical method to characterize the security risk situation. The evaluation method is used to evaluate the key nodes and the mathematics is used to analyze the whole network security situation. Compared with others, the method can automatically create a rule-based security evaluation model to evaluate the security threat from the individual security elements and the combination of security elements, and then evaluation the network situation. It is shown that this system provides a valuable model and algorithms to help to find the security rules, adjust the security展开更多
1104 patients with Secondary Dyslipidemia and CKD （Chronic Kidney Disease） （females： 387; males： 717; aged： 70 4- 11 years） were given Diflstat with diet to evaluate efficacy and safety. The study lasted two ye...1104 patients with Secondary Dyslipidemia and CKD （Chronic Kidney Disease） （females： 387; males： 717; aged： 70 4- 11 years） were given Diflstat with diet to evaluate efficacy and safety. The study lasted two years. Patients were assigned to three groups （A, B, C） based upon basal renal function. Group A consisted of 180 patients with GFR （glomerular filtration rate） of 67 4- 16 mL/min/m2. TC （Total-Cholesterol） （-31%）, LDLC （LDL-Cholesterol） （-42%）, TG （triglycerides） （-36.8%） levels, and nonHDLC （non HDLC holesterol） （-41%） and TC/HDLC ratio （-40%） were significantly reduced （P 〈 0.001）. GFR （＋2.5%） increased significantly. No significant changes were observed in HDLC （＋13%）. Group B was of 744 patients, 69% （males： 514）, 31% （females： 230） （median age： 70 ± 13 years）, and moderate stage Ill CKD （GFR： 38 ± 12 mL/min/l.73m2）. After 24 months the change of HDLC （＋3.5%） was not significant, while TC （-27%）, TG （-32%）, LDLC （-33%）, non-HDLC （33.4%）, TC/HDLC （-30%）, and GFR （＋2.1%） were statistically significant （P 〈 0.001）. Group C consisted of 180 patients, 51.6% （males： 93）, 48.3% （females： 87） （median age： 72±11 years）, with severe stage IV CKD （GFR： 19 mL/min/l.73m2）. HDLC （＋13%） was not significant, while TC （-32%）, TG （-38%）, LDLC （-35%）, non-HDLC （-38.5%）, TC/HDLC （-40%）, and GFR （＋2.1%） were statistically significant （P 〈 0.001）. An effective but safe lipid-lowering therapy in patients with CKD, may be crucial to prevent cardiovascular events. The treatment with Dill stat~ combined with diet is to be started as soon as possible in patients with CKD in order of improving lipid and lipoprotein profile, and reducing the progression of renal damage.展开更多
Chile is a very important country that forms part of the Andean metallogenic belts. The Atacama and Domeyko fault systems in northern Chile control the tectonic- magmatic activities that migrate eastward and the types...Chile is a very important country that forms part of the Andean metallogenic belts. The Atacama and Domeyko fault systems in northern Chile control the tectonic- magmatic activities that migrate eastward and the types of mineral resources. In this paper, we processed and interpreted aeromagnetic data from northern Chile using reduction to pole, upward field continuation, the second derivative calculation in the vertical direction, inclination angle calculation, and analytical signal amplitude analysis. We revealed the locations and planar distribution characteristics of the regional deep faults along the NNE and NS directions. Furthermore, we observed that the major reasons for the formation of the tectonic-magmatic rocks belts were the nearly parallel deep faults distributed from west to east and multiple magmatic activities along these faults. We ascertained the locations of volcanic mechanisms and the relationships between them using these regional deep faults. We deduced the spatial distributions of the basic-intermediate, basic, and acidic igneous rocks, intrusive rocks, and sedimentary sequences. We showed the linear positive magnetic anomalies and magnetic anomaly gradient zones by slowly varying the background, negative magnetic anomaly field, which indicated the presence of strong magmatic activities in these regional deep faults; it also revealed the favorable areas of copper and polymetallic mineralization. This study provides some basic information for further research on the geology, structural characteristics, and mineral resource prospecting in northern Chile.展开更多
Inflammatory bowel disease (IBD), in particular Crohn's disease refractory to conventional therapy, fistulizing Crohn's disease and chronic active ulcerative colitis, generally respond well to anti-tumor necro...Inflammatory bowel disease (IBD), in particular Crohn's disease refractory to conventional therapy, fistulizing Crohn's disease and chronic active ulcerative colitis, generally respond well to anti-tumor necrosis factor (TNF) therapy. However, serious side effects do occur, necessitating careful monitoring of therapy. Potential side effects of anti-TNF therapy include opportunistic infections, which show a higher incidence when concomitant immunosuppression is used. Furthermore, antibody formation against anti-TNF is associated with decreased efficacy and an increased frequency of infusion reactions. The hypothesis of a slightly increased risk of lymphomas in IBD patients treated with anti TNF-therapy is debatable, since most studies lack the specific design to properly address this issue. Alarmingly, the occurrence of hepatosplenic T-cell lymphomas coincides with combined immunosuppressive therapy. Despite the potential serious side effects, anti-TNF therapy is an effective and relatively safe treatment option for refractory IBD. Future research is needed to answer important questions, such as the long-term risk of malignancies, safety during pregnancy, when to discontinue and when to switch anti-TNF therapy, as well as to determine the balance between therapeutic and toxic effects.展开更多
An earthquake measuring 5.1 on the Richter scale struck Wen'an county,Hebei Province on July 4,2006. No casualties have been reported,with only slight damage. The disaster level of this event is the slightest on t...An earthquake measuring 5.1 on the Richter scale struck Wen'an county,Hebei Province on July 4,2006. No casualties have been reported,with only slight damage. The disaster level of this event is the slightest on the M4.9～5.1 events record tally since the CCDSN (China Center of Digital Seismic Network) was built in 1999. The epicenter intensity of this earthquake was low,while in areas like Beijing,which is 100km far away,abnormal high intensity zones appeared. This article discusses the reasons behind this abnormal phenomenon,with the diagrams of intensity isolines drawn by the intense seismic stations and networks in the capital circle area as references,as well as the seismogenic mechanism in the source,the seismic histories,the geological structures and the ray pathways of seismic waves in areas within 150km around the epicenter. It was concluded that the special dynamic and geological situations were the main causes for the lower intensity degree and slight damage in the epicenter area,but higher intensity in the surrounding areas.展开更多
The relation between the United States and the Democratic People＇s Republic of Korea （DPRK） is of substantial strategic prominence in the security landscape of Northeast Asia. The longstanding incompatibility betwe...The relation between the United States and the Democratic People＇s Republic of Korea （DPRK） is of substantial strategic prominence in the security landscape of Northeast Asia. The longstanding incompatibility between the two countries can be illuminated by drawing on three factors： the conflict of interest in the DPRK-ROK unification; the strategic interests of the nuclearization and the denuclearization-normalization dilemma; the Sino-U.S. dual power structure in Northeast Asia. In addressing these issues, this paper discusses the possibility of achieving diplomatic normalization between the U.S. and DPRK by examining in a comparative framework the feasibility of existing mechanisms. The paper concludes that unconventional mechanism is required to establish the initial momentum for a necessary political breakthrough, especially in light of the Trump phenomenon. Specifically, the author proposes a stepwise model to assist the diplomatic reconciliation and to further promote the restoration of peace, security and stability in Northeast Asia.展开更多
It has been found in our past studies that the installation of asymmetric plate at the inlet of inducer is effective for the suppression of cavitation surge phenomenon.In the present study,the suction performance of 2...It has been found in our past studies that the installation of asymmetric plate at the inlet of inducer is effective for the suppression of cavitation surge phenomenon.In the present study,the suction performance of 2-bladed helical inducer with an inlet asymmetric plate is experimentally investigated.It is observed that the suction performance in large flow rate conditions is not significantly influenced by the asymmetric plate,whereas the head of inducer with the asymmetric plate increases just before the head breakdown in partial flow conditions.To understand the mechanism of this additional head,the flow measurements and the numerical simulations are carried out.It is found that the circumferential component of absolute velocity at the exit of inducer slightly increases with the development of cavitation in both cases with and without the inlet asymmetric plate,indicating the increase of the theoretical head.The theoretical head increase with the inlet asymmetric plate is also confirmed by the unsteady numerical simulations,suggesting that the additional head is achieved through the increase of the theoretical head with the change of the exiting flow from the inducer associated with some amount of cavitation.展开更多
基金Supported by the National Natural Science Foundation of China(No.61070185,61003261)the Knowledge Innovation Program of the Chinese Academy of Sciences(No.XDA06030200)
文摘Increasing time-spent online has amplified users＇ exposure to tile tilreat oI miormanon leakage. Although existing security systems （such as firewalls and intrusion detection systems） can satisfy most of the security requirements of network administrators, they are not suitable for detecting the activities of applying the HTTP-tunnel technique to steal users＇ private information. This paper focuses on a network behavior-based method to address the limitations of the existing protection systems. At first, it analyzes the normal network behavior pattern over HTI＇P traffic and select four features. Then, it pres- ents an anomaly-based detection model that applies a hierarchical clustering technique and a scoring mechanism. It also uses real-world data to validate that the selected features are useful. The experiments have demonstrated that the model could achieve over 93% hit-rate with only about 3% false- positive rate. It is regarded confidently that the approach is a complementary technique to the existing security systems.
文摘The security evaluation for an information network system is an important management tool to insure its normal operation. We must realize the significance of the comprehensive network security risks. A network evaluation model and the algorithm are presented and adapt the hierarchical method to characterize the security risk situation. The evaluation method is used to evaluate the key nodes and the mathematics is used to analyze the whole network security situation. Compared with others, the method can automatically create a rule-based security evaluation model to evaluate the security threat from the individual security elements and the combination of security elements, and then evaluation the network situation. It is shown that this system provides a valuable model and algorithms to help to find the security rules, adjust the security
文摘1104 patients with Secondary Dyslipidemia and CKD （Chronic Kidney Disease） （females： 387; males： 717; aged： 70 4- 11 years） were given Diflstat with diet to evaluate efficacy and safety. The study lasted two years. Patients were assigned to three groups （A, B, C） based upon basal renal function. Group A consisted of 180 patients with GFR （glomerular filtration rate） of 67 4- 16 mL/min/m2. TC （Total-Cholesterol） （-31%）, LDLC （LDL-Cholesterol） （-42%）, TG （triglycerides） （-36.8%） levels, and nonHDLC （non HDLC holesterol） （-41%） and TC/HDLC ratio （-40%） were significantly reduced （P 〈 0.001）. GFR （＋2.5%） increased significantly. No significant changes were observed in HDLC （＋13%）. Group B was of 744 patients, 69% （males： 514）, 31% （females： 230） （median age： 70 ± 13 years）, and moderate stage Ill CKD （GFR： 38 ± 12 mL/min/l.73m2）. After 24 months the change of HDLC （＋3.5%） was not significant, while TC （-27%）, TG （-32%）, LDLC （-33%）, non-HDLC （33.4%）, TC/HDLC （-30%）, and GFR （＋2.1%） were statistically significant （P 〈 0.001）. Group C consisted of 180 patients, 51.6% （males： 93）, 48.3% （females： 87） （median age： 72±11 years）, with severe stage IV CKD （GFR： 19 mL/min/l.73m2）. HDLC （＋13%） was not significant, while TC （-32%）, TG （-38%）, LDLC （-35%）, non-HDLC （-38.5%）, TC/HDLC （-40%）, and GFR （＋2.1%） were statistically significant （P 〈 0.001）. An effective but safe lipid-lowering therapy in patients with CKD, may be crucial to prevent cardiovascular events. The treatment with Dill stat~ combined with diet is to be started as soon as possible in patients with CKD in order of improving lipid and lipoprotein profile, and reducing the progression of renal damage.
基金supported by the National Science Foundation of China(No.41404070)China Geological Survey(No.DD20160102-02)
文摘Chile is a very important country that forms part of the Andean metallogenic belts. The Atacama and Domeyko fault systems in northern Chile control the tectonic- magmatic activities that migrate eastward and the types of mineral resources. In this paper, we processed and interpreted aeromagnetic data from northern Chile using reduction to pole, upward field continuation, the second derivative calculation in the vertical direction, inclination angle calculation, and analytical signal amplitude analysis. We revealed the locations and planar distribution characteristics of the regional deep faults along the NNE and NS directions. Furthermore, we observed that the major reasons for the formation of the tectonic-magmatic rocks belts were the nearly parallel deep faults distributed from west to east and multiple magmatic activities along these faults. We ascertained the locations of volcanic mechanisms and the relationships between them using these regional deep faults. We deduced the spatial distributions of the basic-intermediate, basic, and acidic igneous rocks, intrusive rocks, and sedimentary sequences. We showed the linear positive magnetic anomalies and magnetic anomaly gradient zones by slowly varying the background, negative magnetic anomaly field, which indicated the presence of strong magmatic activities in these regional deep faults; it also revealed the favorable areas of copper and polymetallic mineralization. This study provides some basic information for further research on the geology, structural characteristics, and mineral resource prospecting in northern Chile.
文摘Inflammatory bowel disease (IBD), in particular Crohn's disease refractory to conventional therapy, fistulizing Crohn's disease and chronic active ulcerative colitis, generally respond well to anti-tumor necrosis factor (TNF) therapy. However, serious side effects do occur, necessitating careful monitoring of therapy. Potential side effects of anti-TNF therapy include opportunistic infections, which show a higher incidence when concomitant immunosuppression is used. Furthermore, antibody formation against anti-TNF is associated with decreased efficacy and an increased frequency of infusion reactions. The hypothesis of a slightly increased risk of lymphomas in IBD patients treated with anti TNF-therapy is debatable, since most studies lack the specific design to properly address this issue. Alarmingly, the occurrence of hepatosplenic T-cell lymphomas coincides with combined immunosuppressive therapy. Despite the potential serious side effects, anti-TNF therapy is an effective and relatively safe treatment option for refractory IBD. Future research is needed to answer important questions, such as the long-term risk of malignancies, safety during pregnancy, when to discontinue and when to switch anti-TNF therapy, as well as to determine the balance between therapeutic and toxic effects.
基金funded by the project "Demonstration of typical changes of vulne rability of disasters in urban-rural fringe:a case study of seismic disaster in the Beijing-Tianjin-Tangshan region" of National Natural Science Foundation (Grant No.40771011)
文摘An earthquake measuring 5.1 on the Richter scale struck Wen'an county,Hebei Province on July 4,2006. No casualties have been reported,with only slight damage. The disaster level of this event is the slightest on the M4.9～5.1 events record tally since the CCDSN (China Center of Digital Seismic Network) was built in 1999. The epicenter intensity of this earthquake was low,while in areas like Beijing,which is 100km far away,abnormal high intensity zones appeared. This article discusses the reasons behind this abnormal phenomenon,with the diagrams of intensity isolines drawn by the intense seismic stations and networks in the capital circle area as references,as well as the seismogenic mechanism in the source,the seismic histories,the geological structures and the ray pathways of seismic waves in areas within 150km around the epicenter. It was concluded that the special dynamic and geological situations were the main causes for the lower intensity degree and slight damage in the epicenter area,but higher intensity in the surrounding areas.
文摘The relation between the United States and the Democratic People＇s Republic of Korea （DPRK） is of substantial strategic prominence in the security landscape of Northeast Asia. The longstanding incompatibility between the two countries can be illuminated by drawing on three factors： the conflict of interest in the DPRK-ROK unification; the strategic interests of the nuclearization and the denuclearization-normalization dilemma; the Sino-U.S. dual power structure in Northeast Asia. In addressing these issues, this paper discusses the possibility of achieving diplomatic normalization between the U.S. and DPRK by examining in a comparative framework the feasibility of existing mechanisms. The paper concludes that unconventional mechanism is required to establish the initial momentum for a necessary political breakthrough, especially in light of the Trump phenomenon. Specifically, the author proposes a stepwise model to assist the diplomatic reconciliation and to further promote the restoration of peace, security and stability in Northeast Asia.
文摘It has been found in our past studies that the installation of asymmetric plate at the inlet of inducer is effective for the suppression of cavitation surge phenomenon.In the present study,the suction performance of 2-bladed helical inducer with an inlet asymmetric plate is experimentally investigated.It is observed that the suction performance in large flow rate conditions is not significantly influenced by the asymmetric plate,whereas the head of inducer with the asymmetric plate increases just before the head breakdown in partial flow conditions.To understand the mechanism of this additional head,the flow measurements and the numerical simulations are carried out.It is found that the circumferential component of absolute velocity at the exit of inducer slightly increases with the development of cavitation in both cases with and without the inlet asymmetric plate,indicating the increase of the theoretical head.The theoretical head increase with the inlet asymmetric plate is also confirmed by the unsteady numerical simulations,suggesting that the additional head is achieved through the increase of the theoretical head with the change of the exiting flow from the inducer associated with some amount of cavitation.
