Objective： To observe the effects of acupuncture-moxibustion on symptoms, signs, and Th1/Th2 cytokine, and regulation on Th1/Th2 in patients with perennial allergic rhinitis（PAR） to provide experimental basis for a...Objective： To observe the effects of acupuncture-moxibustion on symptoms, signs, and Th1/Th2 cytokine, and regulation on Th1/Th2 in patients with perennial allergic rhinitis（PAR） to provide experimental basis for acupuncture treating allergic rhinitis and investigate the mechanism. Methods： Thirty patients with allergic rhinitis were treated with acupuncture-moxibustion, and 30 healthy cases were the control. Clinical symptoms, signs, and nasal mucosa were observed, and contents of IL-4, IFN-γ, and granulocyte-macrophage colony stimulating factor （GM-CSF） in the supernatant of peripheral blood monocyte cultured with PHA by ELISA, before treatment, after one course of treatment, and after two courses of treatment. Results： Before the treatment, the contents of IL-4, and GM-CSF were higher （P〈0.01） and IFN-γ was lower （P〈0.01） in the PAR cases than in the control cases. In the PAR cases, the content of GM-CSF was positive correlation with that of IL-4 （P〈0.01）, and negative correlation with IFN-7 （P〈0.01）. After the treatment, contents of IL-4 and GM-CSF were lowed （P〈0.01）, content of IFN-γ was increased （P〈0.05）, and all IL-4, GM-CSF and IFN-γ had no difference compared with those in the control cases. Conclusion： Acupuncture- moxibustion could improve the symptoms and signs in PAR patients, enhance the immune function. It may be achieved by regulating the expression of Th1 and Th2, correcting the imbalance of Th1/Th2.展开更多
文摘Objective： To observe the effects of acupuncture-moxibustion on symptoms, signs, and Th1/Th2 cytokine, and regulation on Th1/Th2 in patients with perennial allergic rhinitis（PAR） to provide experimental basis for acupuncture treating allergic rhinitis and investigate the mechanism. Methods： Thirty patients with allergic rhinitis were treated with acupuncture-moxibustion, and 30 healthy cases were the control. Clinical symptoms, signs, and nasal mucosa were observed, and contents of IL-4, IFN-γ, and granulocyte-macrophage colony stimulating factor （GM-CSF） in the supernatant of peripheral blood monocyte cultured with PHA by ELISA, before treatment, after one course of treatment, and after two courses of treatment. Results： Before the treatment, the contents of IL-4, and GM-CSF were higher （P〈0.01） and IFN-γ was lower （P〈0.01） in the PAR cases than in the control cases. In the PAR cases, the content of GM-CSF was positive correlation with that of IL-4 （P〈0.01）, and negative correlation with IFN-7 （P〈0.01）. After the treatment, contents of IL-4 and GM-CSF were lowed （P〈0.01）, content of IFN-γ was increased （P〈0.05）, and all IL-4, GM-CSF and IFN-γ had no difference compared with those in the control cases. Conclusion： Acupuncture- moxibustion could improve the symptoms and signs in PAR patients, enhance the immune function. It may be achieved by regulating the expression of Th1 and Th2, correcting the imbalance of Th1/Th2.
