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饱和冻结黏土在常应变率下的单轴抗压强度 被引量:28
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作者 李海鹏 林传年 +1 位作者 张俊兵 朱元林 《岩土工程学报》 EI CAS CSCD 北大核心 2004年第1期105-109,共5页
冻土作为一种复杂的多相介质,其强度受多方面因素的影响。通过三种不同干密度饱和冻结黏土在常应变率下的单轴抗压强度试验,得出了饱和冻结黏土的单轴抗压强度受温度、应变率、破坏时间及干密度等因素的影响规律,并分别建立了以温度、... 冻土作为一种复杂的多相介质,其强度受多方面因素的影响。通过三种不同干密度饱和冻结黏土在常应变率下的单轴抗压强度试验,得出了饱和冻结黏土的单轴抗压强度受温度、应变率、破坏时间及干密度等因素的影响规律,并分别建立了以温度、应变率(或破坏时间)及干密度为变量的强度预报方程。 展开更多
关键词 饱和冻结黏土 单轴抗压强度 常应变 应变 干密度
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饱和冻结粉土在常应变率下的单轴抗压强度 被引量:13
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作者 张俊兵 李海鹏 +1 位作者 林传年 朱元林 《岩石力学与工程学报》 EI CAS CSCD 北大核心 2003年第z2期2865-2870,共6页
在常应变率下对饱和冻结兰州粉土(黄土)进行了单轴抗压强度试验。通过对试验资料的分析,得出如下规律:(1) 抗压强度对温度十分敏感,它随着温度降低以幂函数的形式增加。(2) 在一定应变率范围内抗压强度对应变率变化反应也比较敏感,它以... 在常应变率下对饱和冻结兰州粉土(黄土)进行了单轴抗压强度试验。通过对试验资料的分析,得出如下规律:(1) 抗压强度对温度十分敏感,它随着温度降低以幂函数的形式增加。(2) 在一定应变率范围内抗压强度对应变率变化反应也比较敏感,它以幂函数的形式随着应变率的增加而增加。(3) 在一定破坏时间范围内抗压强度随着破坏时间的增长同样以幂函数规律减小。(4) 在应变率及温度相同条件下,干容重大的粉土抗压强度高于干容重小的粉土抗压强度,二者的差异程度主要受应变率的影响。 展开更多
关键词 土力学 冻结粉土 单轴抗压强度 常应变
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基于DSR Time-Sweep的沥青常应变疲劳演化规律分析 被引量:11
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作者 朱洪洲 范世平 卢章天 《重庆交通大学学报(自然科学版)》 CAS 北大核心 2018年第2期29-34,共6页
为了研究沥青疲劳特性在常应变模式下的演化规律,采用动态剪切流变仪(DSR),在应变控制模式下对70#基质沥青和SBS改性沥青进行连续加载疲劳试验,获得基于复数剪切模量(G~*)、耗散能变化率(DR)和累计耗散能比(DER)三种物理指标对应的疲劳... 为了研究沥青疲劳特性在常应变模式下的演化规律,采用动态剪切流变仪(DSR),在应变控制模式下对70#基质沥青和SBS改性沥青进行连续加载疲劳试验,获得基于复数剪切模量(G~*)、耗散能变化率(DR)和累计耗散能比(DER)三种物理指标对应的疲劳曲线,并通过疲劳曲线分析沥青疲劳破坏过程。试验结果表明:70#基质沥青的疲劳曲线变化有规律,能较好的表征沥青疲劳破坏过程,确定沥青疲劳寿命;耗散能变化率无法用于表征SBS改性沥青疲劳破坏规律;在相同分析方法中,SBS改性沥青疲劳寿命优于70#基质沥青;随着应变增加,两种沥青疲劳寿命均下降。 展开更多
关键词 道路工程 疲劳性能 动态剪切流变仪 沥青 常应变
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地质体材料剪切带内部的常剪切应变点及速度分布分析 被引量:2
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作者 王学滨 《防灾减灾工程学报》 CSCD 2009年第4期368-375,共8页
对于峰后线性应变软化的地质体材料,剪切带内部的总剪切应变等于弹性剪切应变(由经典弹性理论描述)及由微结构效应而引起的局部塑性剪切应变(由非局部理论或梯度塑性理论描述)之和。若剪切应力—塑性剪切应变曲线的斜率的绝对值(称之为... 对于峰后线性应变软化的地质体材料,剪切带内部的总剪切应变等于弹性剪切应变(由经典弹性理论描述)及由微结构效应而引起的局部塑性剪切应变(由非局部理论或梯度塑性理论描述)之和。若剪切应力—塑性剪切应变曲线的斜率的绝对值(称之为软化模量)小于剪切弹性模量的两倍,则在剪切带的任一剖面内存在两个总剪切应变不依赖于剪切应力的点,称之为常剪切应变点。在这两个点上,弹性剪切应变的降低和局部塑性剪切应变的增加处于平衡状态,总剪切速度达到它的最大值或最小值。在两个常剪切应变点之间,局部总速度随剪切应力率的降低而增加。剪切带内部的局部总速度分布是非线性的,这与通常采用的剪切带内部速度的线性分布假定(忽略微结构效应)不同。 展开更多
关键词 地质体材料 剪切带 剪切应变 速度分布 局部化 梯度塑性理论
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基于混合常应力-光滑应变单元的极限分析方法 被引量:7
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作者 周锡文 刘锋涛 +2 位作者 戴北冰 张澄博 张金鹏 《岩土力学》 EI CAS CSCD 北大核心 2022年第6期1660-1670,共11页
极限分析是岩土工程稳定性评价的重要方法之一。传统的有限元极限分析方法,采用低阶三角形单元时需要引入速度间断面并采用特殊网格布局,或者采用高阶三角形单元等措施来克服体积锁定问题和提高数值精度。在光滑有限元法(smoothed finit... 极限分析是岩土工程稳定性评价的重要方法之一。传统的有限元极限分析方法,采用低阶三角形单元时需要引入速度间断面并采用特殊网格布局,或者采用高阶三角形单元等措施来克服体积锁定问题和提高数值精度。在光滑有限元法(smoothed finite element method,简称SFEM)的基础上,提出了一种基于新型混合常应力-光滑应变单元的极限分析方法(mixed constant stress-smoothed strain element limit analysis,简称MCSE-LA方法)。在服从关联流动法则和Mohr-Coulomb屈服准则的基础上,MCSE-LA方法最终将数值极限分析转化为以应力和极限荷载乘子为基本未知量的二阶锥规划(second orderconeprogramming,简称SOCP)问题。MCSE-LA方法具有形式简单、优化变量相对较少和无需显式的写出塑性内能耗散函数的优点,并且根据凸锥优化的对偶理论,可以从对偶问题中获得速度场和塑性乘子等信息。此外,还采用基于最大塑性剪应变率的网格自适应加密算法,该算法在塑性区细化网格,显著提高了新数值极限分析方法的计算效率和精度。最后通过边坡稳定分析的结果对比,验证了MCSE-LA方法的计算精度和效率均高于传统的有限元极限分析方法。 展开更多
关键词 数值极限分析 应力-光滑应变混合单元 二阶锥规划 自适应网格加密
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黄土的连续加荷固结试验的有限元分析
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作者 刘婵 何文昌 张乾乾 《山西建筑》 2024年第17期67-69,共3页
应用常应变率模型对重塑黄土进行有限元分析。通过不同的应变率模型试验,结果表明试样中竖向有效应力的增长速度随着应变率的增大而增大。应变率越大,加载后期最终的有效应力值也越大;孔压的上升速度越快,达到相同压缩量孔压所产生的幅... 应用常应变率模型对重塑黄土进行有限元分析。通过不同的应变率模型试验,结果表明试样中竖向有效应力的增长速度随着应变率的增大而增大。应变率越大,加载后期最终的有效应力值也越大;孔压的上升速度越快,达到相同压缩量孔压所产生的幅值也越大,常应变率试验中孔压缓慢上升中途并未出现水压力消散的现象。常应变率试验在加载初期试样不同深度的水平面有效应力分布均匀,克服了常规固结试验中加荷瞬时,有效应力分布不均造成的试样压缩的不均匀这个缺点。与室内固结试验结果进行了比较分析,结果表明所采用的数值分析方法能较好地模拟黄土的固结试验过程,对揭示土体固结变形有一定的实际意义。 展开更多
关键词 常应变 土体固结 有效应力 孔隙水压力
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非均匀边坡稳定的光滑有限元极限分析 被引量:1
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作者 卢亮 刘锋涛 王延伟 《土木工程》 2024年第5期721-732,共12页
非均匀层状边坡稳定是岩土工程中的重要问题之一。基于理想塑性上限和下限的极限分析方法是分析此类问题的常用方法之一。近期提出的基于混合常应力–光滑应变单元的极限分析方法(MCSE-LA)在克服体积锁定和计算性能(精度、效率以及收敛... 非均匀层状边坡稳定是岩土工程中的重要问题之一。基于理想塑性上限和下限的极限分析方法是分析此类问题的常用方法之一。近期提出的基于混合常应力–光滑应变单元的极限分析方法(MCSE-LA)在克服体积锁定和计算性能(精度、效率以及收敛性)方面已被证明比传统有限元极限分析方法具有一定的优势,并且可以同时获得极限状态下的应力场和速度场。基于此,首先通过与经典有限元极限分析对比分析,验证MCSE-LA在非均匀边坡稳定分析中的可行性;其次,针对含软弱层边坡进行参数分析,发现软弱层的黏聚力对安全系数的影响更显著,而软弱层的摩擦角则对破坏机构特征的影响更明显;同时说明自适应的MCSE-LA可以较好地分析实际边坡的稳定性,为边坡工程的稳定性评价提供了一种有效的方法。 展开更多
关键词 非均匀边坡 稳定性 极限分析 混合应力–光滑应变单元
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基于两级光滑边域混合单元的弹塑性二阶锥规划方法 被引量:1
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作者 刘锋涛 周锡文 +2 位作者 张澄博 戴北冰 莫红艳 《岩土工程学报》 EI CAS CSCD 北大核心 2023年第5期1045-1053,共9页
弹塑性增量分析的数学规划方法是分析岩土工程变形和强度问题的有效途径之一,在处理非光滑屈服面、接触和多屈服面等复杂问题时具有独特的优势。为进一步简化计算和克服体积锁定问题,在广义Hellinger-Reissner(GHR)变分原理的基础上,提... 弹塑性增量分析的数学规划方法是分析岩土工程变形和强度问题的有效途径之一,在处理非光滑屈服面、接触和多屈服面等复杂问题时具有独特的优势。为进一步简化计算和克服体积锁定问题,在广义Hellinger-Reissner(GHR)变分原理的基础上,提出一种新型混合常应力-两级光滑边域的三节点三角形单元,在关联流动法则和Mohr-Coulomb屈服准则条件下,将弹塑性增量问题转化为标准的二阶锥规划问题,并将黏-摩擦接触条件转化为锥约束条件引入到弹塑性增量分析的二阶锥规划问题中,随后采用高效的原对偶内点算法对其进行求解。最后将新方法用于岩土工程中两类经典问题的弹塑性数值分析。结果表明:新方法在计算效率、收敛性和精度方面均优于传统六节点三角形混合单元。 展开更多
关键词 弹塑性增量分析 二阶锥规划 应力-光滑应变混合单元 两级光滑边域
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软材料的SHPB实验设计 被引量:57
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作者 卢芳云 W.Chen D.J.Frew 《爆炸与冲击》 EI CAS CSCD 北大核心 2002年第1期15-19,共5页
通过对SHPB实验中加载波波形进行控制设计 ,实现软材料试样在加载过程中的应力平衡和常应变率加载 ,从而保证SHPB实验的前提条件。采用这种方法研究了两种材料的高应变率本构 ,实验结果表明 :设计的方法是行之有效的。
关键词 软材料 SHPB实验 加载波整形 应力平衡 常应变率加载 材料科学 一维应力波
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岩土类材料率相关性及硬化-软化特性模型研究 被引量:2
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作者 王小平 夏雄 《岩土力学》 EI CAS CSCD 北大核心 2011年第11期3283-3287,共5页
岩土类材料具有显著的率相关性,其应力-应变关系全过程一般表现为硬化-软化特征,研究如何描述这两类特征具有重要的意义。基于岩土类材料的物理变形机制分析,考虑到其结构性特征,采用弹黏塑性本构模型,引入反映材料结构变化的可变结构... 岩土类材料具有显著的率相关性,其应力-应变关系全过程一般表现为硬化-软化特征,研究如何描述这两类特征具有重要的意义。基于岩土类材料的物理变形机制分析,考虑到其结构性特征,采用弹黏塑性本构模型,引入反映材料结构变化的可变结构黏滞系数及其演化方程,并将其嵌入到弹黏塑性本构模型中去,建立能够反映材料结构变化的弹黏塑性本构模型。利用玄武岩常规三轴常应变率试验结果对所建立的模型进行试验验证,结果表明:所建立的弹黏塑本构模型能够完整、合理地描述岩土类材料应力-应变关系全过程以及材料本构关系的率相关性,同时还能够反映材料的峰值强度、残余强度特征。 展开更多
关键词 率相关性 硬化-软化 结构黏滞系数 弹黏塑性模型 常应变率试验
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APPLICATION OF 2-D MOIRE INTERFEROMETRYOF STICKING FILM IN HUMAN TIBIA MEASUREMENT
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作者 张桂琴 羡若凯 《Transactions of Tianjin University》 EI CAS 1999年第1期68-71,共4页
This paper makes use of the method of testing and measuring the human body tibia by using2-D moire interferometry of sticking film. hased on the J'--y direction moire patterns recorded synchronously by 2-D optical... This paper makes use of the method of testing and measuring the human body tibia by using2-D moire interferometry of sticking film. hased on the J'--y direction moire patterns recorded synchronously by 2-D optical path,the elastic constant,strain and displacement of the tibia are measured.Compared with the electric measuring method the error is samll and the sensitivity is high. 展开更多
关键词 2-D moire interferometry of sticking film elastic constant strain and displacement
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Theoretical Study on Mechanism and Kinetics of Reaction of O(^3p) with Propane 被引量:1
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作者 荆富强 曹剑炜 +3 位作者 刘小君 胡煜峰 马海涛 边文生 《Chinese Journal of Chemical Physics》 SCIE CAS CSCD 2016年第4期430-436,I0001,共8页
The reaction of C3H8+O(^3p)→C3HT+OH is investigated using ab initio calculation and dynamical methods. Electronic structure calculations for all stationary points are obtained using a dual-level strategy. The geo... The reaction of C3H8+O(^3p)→C3HT+OH is investigated using ab initio calculation and dynamical methods. Electronic structure calculations for all stationary points are obtained using a dual-level strategy. The geometry optimization is performed using the unrestricted second-order Moller-Plesset perturbation method and the single-point energy is computed us- ing the coupled-cluster singles and doubles augmented by a perturbative treatment of triple excitations method. Results indicate that the main reaction channel is C3Hs+O(^3p)→i- C3HT+OH. Based upon the ab initio data, thermal rate constants are calculated using the variational transition state theory method with the temperature ranging from 298 K to 1000 K. These calculated rate constants are in better agreement with experiments than those reported in previous theoretical studies, and the branching ratios of the reaction are also calculated in the present work. Furthermore, the isotope effects of the title reaction are calculated and discussed. The present work reveals the reaction mechanism of hydrogenabstraction from propane involving reaction channel competitions is helpful for the understanding of propane combustion. 展开更多
关键词 Reaction mechanism Thermal rate constant Variational transition state theory Isotope effect
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A tetragonal tungsten bronze-type photocatalyst:Ferro-paraelectric phase transition and photocatalysis
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作者 范大勇 种瑞峰 +3 位作者 范峰滔 王秀丽 李灿 冯兆池 《Chinese Journal of Catalysis》 SCIE EI CAS CSCD 北大核心 2016年第8期1257-1262,共6页
Although ferroelectrics have potential applications in photocatalysis due to their highly efficient charge separation, their mechanism of charge separation is still unknown. A ferroelectric Sr0.7Ba0.3Nb2O6 (SBN‐70)... Although ferroelectrics have potential applications in photocatalysis due to their highly efficient charge separation, their mechanism of charge separation is still unknown. A ferroelectric Sr0.7Ba0.3Nb2O6 (SBN‐70) semiconductor with a low ferro‐paraelectric phase transition (65℃) was studied. The photocatalytic activity for H2 production by ferroelectric and paraelectric SBN‐70 was examined. The spontaneous polarization in the ferroelectric phase strongly affected the photocata‐lytic performance and parallel ferroelectric domains significantly promoted photogenerated charge separation to result in better photocatalytic H2 production. This knowledge provides an important basis for the fabrication of ferroelectric photocatalysts with improved charge separation ability. 展开更多
关键词 PHOTOCATALYSIS Ferro-paraelectric phase transition Sr0.7Ba0.3Nb2O6 Anomalous photovoltaic effect Temperature-dependent photolumi-nescence excitation spectrum
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Abnormal Phenomena of Volume Strain before Large Earthquakes 被引量:1
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作者 Wu Lijun Chen Zhengwei +3 位作者 Li Hangu Xu Lei An Bayaer Xu Shunqiang 《Earthquake Research in China》 CSCD 2015年第3期373-385,共13页
This paper studies the imminent anomalies observed by the Sacks volume strainmeter in Erzhangying station and Tiantanghe station before 80 earthquakes with Ms≥ 7. 0 which took place from January 2011 to April 2014 al... This paper studies the imminent anomalies observed by the Sacks volume strainmeter in Erzhangying station and Tiantanghe station before 80 earthquakes with Ms≥ 7. 0 which took place from January 2011 to April 2014 all over the world. Then, preconditions for anomaly identification are put forward for complex earthquake cases. Statistical results show that volume strain observation has a better earthquake reflecting ability for earthquakes with magnitudes larger than 7. 0 and epicentral distance within 8000kin. In addition, these results also reflect that the volume strain observation can better reflect precursory anomalies of such earthquakes. Based on categorization and description of those anomalies, we divide the anomalies into three types, that is, earth tide distortion type, abrupt change type and slow earthquake type. Furthermore, the paper makes a statistical analysis of these types and preliminarily discusses their mechanical properties as well. According to research, volume strain anomaly has an indicative significance to future strong earthquakes in the world. 展开更多
关键词 Large earthquakes Volume strain The earth tide distortion Abruptchange Slow earthquakes Earthquake case study
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The South China Sea throughflow: linkage with local monsoon system and impact on upper thermal structure of the ocean 被引量:2
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作者 刘钦燕 王东晓 谢强 《Chinese Journal of Oceanology and Limnology》 SCIE CAS CSCD 2012年第6期1001-1009,共9页
The tendency of South China Sea throughflow (SCSTF) variation associated with the local monsoon system, and its impact on upper-layer thermal structure, are studied using the Simple Ocean Data Assimilation (SODA) data... The tendency of South China Sea throughflow (SCSTF) variation associated with the local monsoon system, and its impact on upper-layer thermal structure, are studied using the Simple Ocean Data Assimilation (SODA) dataset, combined with Ishii reanalysis data. Luzon Strait Transport (LST) is measured and used as an index for studying the SCSTF variation. Results show that LST had an increasing tendency over the last 50 years, mainly in summer and fall. The increasing tendency was 0.017 1 Sv/a in summer and 0.027 4 Sv/a in fall, as estimated by SODA, and 0.018 0Sv/a in summer and 0.018 9 Sv/a in fall, as estimated by "Island Rule" theory. LST increased by 0.53Sv in JJA (June-July-August) and 0.98Sv in SON (September-October-November) after climate shift, as inferred by SODA data. The average LST anomaly in JJA and SON is strongly related to the local monsoon system, especially to variability of the meridional wind stress anomaly after application of a 3-year running mean, with correlation coefficients 0.57 and 0.51, respectively. In addition to the basin-scale wind forcing, the local northeasterly wind stress anomaly in the SCS can push Pacific water entering the SCS more readily in JJA and SON after climate shift, and an SCSTF-associated cooling effect may favor subsurface cooling more frequently after climate shift. 展开更多
关键词 South China Sea throughflow (SCSTF) local monsoon system subsurface temperature cooling
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非常规三角形板元(TRUNC元)的新列式及其质量矩阵和几何刚度矩阵——非常规单元系列(Ⅰ) 被引量:2
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作者 罗恩 葛爱民 李纬华 《数值计算与计算机应用》 CSCD 2007年第2期150-160,共11页
国际有限元权威Argyris所创立的TRUNC元是一个精度高的优秀板元.本文提出了构造TRUNC元的刚度矩阵的新列式,它是对Argyris列式的重要改进.与Argyris列式相比,本文的新列式的精度更高,结构更简单,计算量更小和编程更容易.为了使TRUNC... 国际有限元权威Argyris所创立的TRUNC元是一个精度高的优秀板元.本文提出了构造TRUNC元的刚度矩阵的新列式,它是对Argyris列式的重要改进.与Argyris列式相比,本文的新列式的精度更高,结构更简单,计算量更小和编程更容易.为了使TRUNC元能用于薄板的动力与稳定分析中,本文用作者所提出的新列式方法,建立了TRUNC元的两种新的质量矩阵和几何刚度矩阵. 展开更多
关键词 三角形非规板元(TRUNC元) 质量矩阵 几何刚度矩阵 列式 广义常应变 广义变应变
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非常规四边形板元(QUUNC元)——非常规单元系列(Ⅲ)
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作者 朱慧坚 刘淼 +1 位作者 罗恩 李纬华 《数值计算与计算机应用》 CSCD 2007年第4期298-305,共8页
本文提出一种非常规四边形板元(QUUNC元).这种新单元的刚度矩阵采用作者所提出的新列式方法来构造.因此,与已有四边形板元相比,QUUNC元的结构更简单,计算量更少和编程更容易.
关键词 规四边形板元(QUUNC元) ACM元 列式 雅可比矩阵 广义常应变 广义变应变
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Abnormal strain changes observed at Guza before the Wenchuan earthquake 被引量:11
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作者 QIU ZeHua ZHANG BaoHong +2 位作者 CHI ShunLiang TANG Lei SONG Mo 《Science China Earth Sciences》 SCIE EI CAS 2011年第2期233-240,共8页
An YRY-4 type borehole strainmeter at Guza station on the southwest end of the Longmenshan fault zone recorded anomalous changes from time to time since about one year before the Wenchuan earthquake.The anomaly is cha... An YRY-4 type borehole strainmeter at Guza station on the southwest end of the Longmenshan fault zone recorded anomalous changes from time to time since about one year before the Wenchuan earthquake.The anomaly is characterized by steps and/or asymmetrical pulses of short-periods(minutes-hours).Among about one hundred stations over the mainland of China,only Guza,the nearest one to the seismic area,observed such changes.A self-check function of the strainmeter helps confirm the credibility of the observation.The anomalous signals do not correspond to seasonal changes.The consistency in the sense of strain among long-term,anomalous interfering and coseismic changes suggests that they all resulted from the background tectonic movement.Results of an Overrun Rate Analysis further illustrate a close temporal relevance of the anomaly to the Wenchuan earthquake:its increase before,and decrease after the biggest changes during the main shock.The abnormal changes are attributed to local small-scale fractures with an evidential clue that the only Ms4.5 foreshock near Guza station on February 27,2008 produced the biggest anomalous change.By means of Wavelet Decomposition,it is revealed that longer period portion of the anomaly took place later before the main shock,consistent with the idea that scales of small fractures increase during earthquake preparation process.The anomalous strain changes are analogous to the stress changes observed before the 1976 Tangshan earthquake. 展开更多
关键词 Wenchuan earthquake earthquake precursor strain change 4-component borehole strainmeter Overrun-Rate-Analysis
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Treatment of 48 Cases of Perennial Allergic Rhinitis with Thunder-fire Moxibustion 被引量:4
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作者 蒋洁明 《Journal of Acupuncture and Tuina Science》 2010年第2期89-90,共2页
Perennial allergic rhinitis is an allergic reaction of the nasal mucosa. It is characterized by paroxysmal and repeated runny nose, sneeze, stuffy nose, rhinocnesmus and nasal mucosa edema. The author used "Doctor Z... Perennial allergic rhinitis is an allergic reaction of the nasal mucosa. It is characterized by paroxysmal and repeated runny nose, sneeze, stuffy nose, rhinocnesmus and nasal mucosa edema. The author used "Doctor ZHAO's thunder-fire moxibustion" in treating 48 cases of this disease. Now it is reported as follows. 展开更多
关键词 Moxibustion Therapy Moxa Stick Moxibustion Rhinitis Allergic Perennial
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Effects of Acupuncture-moxibustion on Monocyte Th1/Th2 Cytokine in Peripheral Blood of Patients with Perennial Allergic Rhinitis 被引量:2
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作者 郑美凤 林诚 +1 位作者 郑良朴 何芙蓉 《Journal of Acupuncture and Tuina Science》 2010年第2期85-88,共4页
Objective: To observe the effects of acupuncture-moxibustion on symptoms, signs, and Th1/Th2 cytokine, and regulation on Th1/Th2 in patients with perennial allergic rhinitis(PAR) to provide experimental basis for a... Objective: To observe the effects of acupuncture-moxibustion on symptoms, signs, and Th1/Th2 cytokine, and regulation on Th1/Th2 in patients with perennial allergic rhinitis(PAR) to provide experimental basis for acupuncture treating allergic rhinitis and investigate the mechanism. Methods: Thirty patients with allergic rhinitis were treated with acupuncture-moxibustion, and 30 healthy cases were the control. Clinical symptoms, signs, and nasal mucosa were observed, and contents of IL-4, IFN-γ, and granulocyte-macrophage colony stimulating factor (GM-CSF) in the supernatant of peripheral blood monocyte cultured with PHA by ELISA, before treatment, after one course of treatment, and after two courses of treatment. Results: Before the treatment, the contents of IL-4, and GM-CSF were higher (P〈0.01) and IFN-γ was lower (P〈0.01) in the PAR cases than in the control cases. In the PAR cases, the content of GM-CSF was positive correlation with that of IL-4 (P〈0.01), and negative correlation with IFN-7 (P〈0.01). After the treatment, contents of IL-4 and GM-CSF were lowed (P〈0.01), content of IFN-γ was increased (P〈0.05), and all IL-4, GM-CSF and IFN-γ had no difference compared with those in the control cases. Conclusion: Acupuncture- moxibustion could improve the symptoms and signs in PAR patients, enhance the immune function. It may be achieved by regulating the expression of Th1 and Th2, correcting the imbalance of Th1/Th2. 展开更多
关键词 Rhinitis Allergic Perennial Acupuncture-moxibustion Therapy IMMUNOMODULATION
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