常减压技术的创新

本文重点介绍了常减压装置的类型、工艺技术状况和技术特点、介绍了两种不同的常减压工艺流程、提出了常减压技术的创新及应用。

C^(++)中共享数据的保护方法

在分析破坏数据安全性原因的基础上,通过对C++面向对象程序设计中常类型和常成员的深入研究,提出了将既需要共享、又需要防止改变的数据声明为常量,并探讨了常引用、常对象和用const修饰的对象成员的使用方法,实现对C++面向对象程序设计中共享数据的保护。

Interannual variations of North Equatorial Current transport in the Pacific Ocean during two types of El Ni?o

Interannual variations of Pacific North Equatorial Current （NEC） transport during eastern- Pacific E1 Nifios （EP-EI Nifios） and central-Pacific E1 Nifios （CP-E1 Nifios） are investigated by composite analysis with European Centre for Medium-Range Weather Forecast Ocean Analysis/Reanalysis System 3. During EP-E1 Nifio, NEC transport shows significant positive anomalies from the developing to decay phases, with the largest anomalies around the mature phase. During CP-EI Nifio, however, the NEC transport only shows positive anomalies before the mature phase, with much weaker anomalies than those during EP-El Nifio. The NEC transport variations are strongly associated with variations of the tropical gyre and wind forcing in the tropical North Pacific. During EP-E1 Nifio, strong westerly wind anomalies and positive wind stress curl anomalies in the tropical North Pacific induce local upward Ekman pumping and westward-propagating upwelling Rossby waves in the ocean, lowering the sea surface height and generating a cyclonic gyre anomaly in the western tropical Pacific. During CP-E1 Nifio, however, strength of the wind and associated Ekman pumping velocity are very weak. Negative sea surface height and cyclonic flow anomalies are slightly north of those during EP El Nino.

Abnormal Phenomena of Volume Strain before Large Earthquakes

This paper studies the imminent anomalies observed by the Sacks volume strainmeter in Erzhangying station and Tiantanghe station before 80 earthquakes with Ms≥ 7. 0 which took place from January 2011 to April 2014 all over the world. Then, preconditions for anomaly identification are put forward for complex earthquake cases. Statistical results show that volume strain observation has a better earthquake reflecting ability for earthquakes with magnitudes larger than 7. 0 and epicentral distance within 8000kin. In addition, these results also reflect that the volume strain observation can better reflect precursory anomalies of such earthquakes. Based on categorization and description of those anomalies, we divide the anomalies into three types, that is, earth tide distortion type, abrupt change type and slow earthquake type. Furthermore, the paper makes a statistical analysis of these types and preliminarily discusses their mechanical properties as well. According to research, volume strain anomaly has an indicative significance to future strong earthquakes in the world.

lncRNA HOST2、miR-181a在卵巢上皮癌中的表达及临床意义

目的探讨非编码长链RNA人卵巢癌特异性转录本2(lncRNA HOST2)和miR-181a在卵巢上皮癌(EOC)中的表达及临床意义。方法收集2017年1月至2018年6月期间72例EOC患者和60例良性卵巢肿瘤患者行外科手术后的新鲜组织,液氮保存。采用实时荧光定量PCR(QPCR)检测组织中HOST2和miR-181a表达,分析两者表达及其与EOC临床病理特征的关系。受试者工作特征(ROC)曲线评价HOST2和miR-181a诊断EOC的效能。结果与良性卵巢肿瘤组织比较,EOC中HOST2在表达水平为1.261±0.436,miR-181a的表达水平为0.768±0.271,差异有统计学意义(P<0.05)。Spearman相关性分析显示,EOC组织中HOST2和miR-181a表达呈负相关性(r=-0.530,P<0.001)。HOST2和miR-181a诊断EOC的AUC分别为0.643(95%CI:0.548~0.739,P=0.005)和0.687(95%CI:0.595~0.779,P=0.001),联合诊断的AUC为0.739(95%CI:0.653~0.824,P=0.001)。HOST2表达与FIGO分期和淋巴结转移有关(P<0.05),miR-181a表达与肿瘤直径、FIGO分期和淋巴结转移有关(P<0.05)。结论EOC中HOST2表达上调,miR-181a表达下调,两者联合检测可提高EOC的诊断率。

Creep and Shrinkage Effects on the Bond-Slip Characteristics and Ultimate Strength of Composite Slabs

Composite one-way concrete slabs with profiled steel sheeting as permanent formwork are commonly used in the construction industry. The steel sheeting supports the wet concrete of a cast-in-situ reinforced or post-tensioned concrete slab and, after the concrete sets, acts as external reinforcement. In this type of slab, longitudinal shear failure between the concrete and the steel sheeting is the most common type of failure at the ultimate load stage. Design codes require the experimental evaluation of the longitudinal shear capacity of each type of steel decking using full-scale tests. This paper presents the results of the short-term testing up to failure of two types of profiled steel decking that are commonly used in the construction industry in Australia. Fourteen full-scale, simply-supported slabs were tested in four-point bending with shear spans of either span/4 or span/6. Four slabs were tested at age of 28 days and the other 10 slabs were subjected to drying shrinkage and various levels of sustained loads for a period of at least 6 months prior to testing to failure. The effects of creep and drying shrinkage on the load carrying capacity and deformation of the slabs at ultimate loads are presented and discussed. The bond-slip relationship of each slab is determined from the test data and the values of maximum longitudinal shear stress calculated using different methods are described and compared.

Skulls Symmetry of ＂White Rasquera＂ Goat

Three common categories of bilateral asymmetry have been described： directional asymmetry, antisymmetry, and FA （fluctuating asymmetry）. FA is the most subtle of the three types of asymmetry, and differs from the patterns of the others in that paired structures tend to be symmetric in size. The analysis of FA allows to estimate the influence of stress factors on animal development and enables evaluation of resistance to stress. The aim of this work was to estimate the symmetry of skulls of a contemporary pure goat breed, as there is currently no study of FA as an estimate of individual quality for domestic goats. For this purpose, 11 landmarks were digitized in two dimensions from the crania of 24 adult goats （12 males and 12 females） belonging to the ＂White Rasquera＂ breed. The skulls showed nearly perfect bilateral symmetry. The low detected values of FA in skulls revealed a weak influence of developmental stress on this goat contemporary population and its strong ability to compensate stress.

Perception Survey of Carbon Monoxide Risk in Rabat-Sale-Zemmour-Zaer Populations

Carbon monoxide （CO） intoxication is one of the most common types of poisoning in the modem world. To better tailor messages and communication needs to the public, a perception survey of CO and his risk was conducted among the population of Rabat-Sale-Zemmour-Zaer. The authors included 400 people in this survey. The demographic characteristics of the respondents consisted of： 85.0% female, 92.9% adults, 29.7% had a high level of education, 49.6% unemployed, 89.5% were home owners and 53.9% lived in apartments. Water heaters were present in the homes of 91.0% of respondents and 6.5% of them used gas. Gas was used as fuel in 45.4% of cases. For water heaters, 20.8% had an exhaust duct, 9.9% were serviced regularly and 47.5% were installed in a well ventilated area. Regarding the media, television was the medium that allowed 73.4% of the CO to know, regardless of age, sex and level of education among the 94.3% of who ever heard of this deadly gas before the survey.

Similarity Reductions of Nearly Concentric KdV Equation

Basing on the direct method developed by Clarkson and Kruskal, the nearly concentric Korteweg-de Vries （ncKdV） equation can be reduced to three types of （1＋1）-dimensional variable coefficients partial differential equations （PDEs） and three types of variable coefficients ordinary differential equation. Furthermore, three types of （1＋1）-dimensional variable coefficients PDEs are all reduced to constant coefficients PDEs by some transformations.

Attenuation-type and failure-type curve models on accumulated pore water pressure in saturated normal consolidated clay

Based on dynamic triaxial test results of saturated soft clay, similarities of variations between accumulated pore water pressure and accumulated deformation were analyzed. The Parr＇s equation on accumulated deformation was modified to create an attenuation-type curve model on accumulated pore water pressure in saturated normal consolidation clay. In this model, dynamic strength was introduced and a new parameter called equivalent dynamic stress level was added. Besides, based on comparative analysis on variations between failure-type and attenuatiun-type curves, a failure-type curve model was created on accumulated pore water pressure in saturated normal consolidation clay. Two models can take cycle number, coupling of static and dynamic deviator stress, and consolidation way into consideration. The models are verified by test results. The correlation coefficients are more than 0.98 for optimization of test results based on the two models, and there is good agreement between the optimized and test curves, which shows that the two models are suitable to predict variations of accumulated pore water pressure under different loading cases and consolidation ways. In order to improve prediction accuracy, it is suggested that loading cases and consolidation ways should be consistent with in-situ conditions when dynamic triaxial tests are used to determine the constants in the models.

The Saturation Model and Its Application on Partition Equilibria for Main Types of Heterogeneous Systems

Within the model, a definition of novel saturation and dilution degree is presented. A novel expression of equilibrium constant is derived by including interactions between components to reversible processes running between the components particles under a dynamic equilibrium. For partition equilibria, three types of basic processes are proposed and corresponding partition isotherms were derived. The isotherms are applied to the components partition between two phases for main heterogenous systems types. For construction and prediction ternary phase diagrams, a new method, the Component Binding by Saturation Model （CBSM） method, is proposed. Applying the partition isotherms derived, new extraction, evaporation and adsorption isotherms are expressed. Directly, or after an approximation, from the new adsorption isotherms, well-known adsorption isotherms are obtained.

The ANOVA-Type Inference in Linear Mixed Model with Skew-Normal Error

Linear mixed effect models with skew-normal errors and distribution-free random effects are considered. The ANOVA-type F-tests are proposed to test the significance of random effects and the hypothesis on fixed effects of interest, respectively. Both tests are proved to be exact F-tests under this model, and the exact confidence interval for fixed effects of interest is derived. Simulation results are given to study the powers of ANOVA-type tests.

New progress in active immunotherapy targeting to amyloid beta

Alzheimer's disease(AD) is one of the most common types of dementia whose hallmarks include neurofibrillary tangles and senile plaques. The latter are mainly composed of amyloid-β proteins(Aβ), and it's suggested that Aβ may be the causative factor in AD pathogenesis. Immunotherapy targeting Aβ for preventing aggregation of Aβ and mildly clearing amyloid plaques has been a hot topic since 1999. Although the first clinical trial of Aβ vaccine, AN-1792, failed in phase II, its results suggested some key points in the design of Aβ vaccines. Avoiding the possible toxic Aβ specific T cell response and inducing a Th2 type cellular immune response may be beneficial for Aβ immunotherapy. Many associations and research groups are working on Aβ vaccine and some progress has been made in recent years. In this review, we have provided a detailed summary of past Aβ vaccines, which have been sorted by the immunogen, and we also discuss some recent progress and future perspectives.

Kindler syndrome protein Kindlin-1 is mainly expressed in adult tissues originating from ectoderm/endoderm

Mutations of integrin-interacting protein Kindlin-1 cause Kindler syndrome and deregulation of Kindlin-1 is implicated in human cancers. The Kindlin-1-related diseases are confined in limited tissue types. However, Kindlin-1 tissue distribution and the dogma that governs Kindlin-1 expression in normal human body are elusive. This study examined Kindlin-1 expression in normal human adult organs, human and mouse embryonic organs by immunohistochemical analyses. We identified a general principle that the level of Kindlin-1 expression in tissues is tightly correlated with the corresponding germ layers from which these tissues originate. We compared the expression of Kindlin-1 with Kindlin-2 and found that Kindlin-1 is highly expressed in epithelial tissues derived from ectoderm and endoderm, whereas Kindlin-2 is mainly expressed in mesoderm-derived tissues. Likewise, Kindlin-1 was also found highly expressed in endoderm/ectoderm-derived tissues in human and mouse embryos. Our findings indicate that Kindlin-1 may play an importance role in the development of endoderm/ectoderm related tissues.

A New Generalization of Hardy-Hilbert’s Type Inequality with Multi-Parameters

In this paper, by introducing some parameters and estimating the weight coefficients, we give a new generalization of Hardy-Hilbert’s type inequality with the best constant factor. As applications, we consider its equivalent form and obtain some recent results, which are special cases of our results.