Purpose: To assess the role of serum anticardiolipin IgG antibody and fasting plasma homocysteine levels as risk factors for retinal vascular occlusive diseas e in Thai patients. Methods: This is a retrospective, case...Purpose: To assess the role of serum anticardiolipin IgG antibody and fasting plasma homocysteine levels as risk factors for retinal vascular occlusive diseas e in Thai patients. Methods: This is a retrospective, case-control study. Forty -one consecutive patients with recent onset of retinal vascular occlusive disea seswere enrolled. In conjunctionwith a routine laboratory work up, serum anticar diolipin IgG antibody and plasma homocysteine were evaluated. Ninety volunteers without a history of retinal vascular occlusive disease were chosen as controls. Results: In general, mean levels of anticardiolipin IgG antibody and homocystei ne did not differ between the patients and controls. However, when the groupswit hout a history of underlying systemic diseases were compared, there were statist ically significant differences in the anticardiolipin IgG antibody level between patients and controls (mean 12.24±8.66 and 7.70 ±6.69 GPL units/ml, respectiv ely) with a P value of 0.024. Conclusions: No association was found between plas ma homocysteine level and retinal vascular occlusion in our patient population. A high level of anticardiolipin IgG antibody is shown to be a risk factor only i n patients without a history of underlying systemic diseases. The effect of anti cardiolipin IgG antibody on the development of retinal vascular occlusive diseas e appears to be limited and may not be a major cause.展开更多
文摘Purpose: To assess the role of serum anticardiolipin IgG antibody and fasting plasma homocysteine levels as risk factors for retinal vascular occlusive diseas e in Thai patients. Methods: This is a retrospective, case-control study. Forty -one consecutive patients with recent onset of retinal vascular occlusive disea seswere enrolled. In conjunctionwith a routine laboratory work up, serum anticar diolipin IgG antibody and plasma homocysteine were evaluated. Ninety volunteers without a history of retinal vascular occlusive disease were chosen as controls. Results: In general, mean levels of anticardiolipin IgG antibody and homocystei ne did not differ between the patients and controls. However, when the groupswit hout a history of underlying systemic diseases were compared, there were statist ically significant differences in the anticardiolipin IgG antibody level between patients and controls (mean 12.24±8.66 and 7.70 ±6.69 GPL units/ml, respectiv ely) with a P value of 0.024. Conclusions: No association was found between plas ma homocysteine level and retinal vascular occlusion in our patient population. A high level of anticardiolipin IgG antibody is shown to be a risk factor only i n patients without a history of underlying systemic diseases. The effect of anti cardiolipin IgG antibody on the development of retinal vascular occlusive diseas e appears to be limited and may not be a major cause.
