长效干扰素与常规干扰素治疗慢性乙肝60例临床对比观察

目的探讨长效干扰素治疗慢性乙型肝炎的临床效果。方法选取我院收治的60例慢性乙肝患者,将其随机均分为对照组和试验组,每组30例。对照组患者接受常规干扰素进行治疗,试验组患者接受长效干扰素进行治疗,对2组患者的乙型肝炎病毒脱氧核糖核酸(HBV-DNA)和乙型肝炎e抗原(HBe Ag)转阴率进行对比,并观察患者的不良反应。结果对照组、试验组患者的HBV-DNA转阴率分别为23.3%,56.7%;对照组、试验组患者HBe Ag转阴率分别为26.7%,63.3%,2组比较差异具有统计学意义(P<0.05);2组患者不良反应情况较为相似,没有统计学差异(P<0.05)。结论长效干扰素较常规干扰素治疗慢性乙型肝炎的临床效果更好。

对LFM信号的几种干扰样式比较

LFM信号具有很强的抗干扰能力,常规干扰很难对它产生干扰效果。研究分析了预加重调频干扰和混沌调频干扰,推导了这几种干扰样式的干扰算法,通过仿真验证2种干扰样式的可行性,并与常规干扰样式进行对比,发现预加重调频干扰和混沌调频干扰具有很好的干扰效果。

乙肝病毒对α干扰素的反应与其基因型相关:A型对α干扰素的敏感性高于D型

Background an aims: Current interferon alfa (IFN) treatment of chronic hepatitis B has limited efficacy. The role of hepatitis B virus (HBV) genotypes for response to IFN was investigated. Patients and methods: HBV genotypewas determined by direct sequencing of the HBV Xgene in 165 consecutive patientswith chronic replicative hepatitis B treated with standard IFN. HBV genotype A or D was found in 144 cases. Results: Sustained response (six months after treatment) to standard IFN therapy was higher in HBV genotype A compared with HBV genotype D infected patients (49%v 26%; p < 0.005). Sustained response to IFN was 46%versus 24%(p < 0.03) in hepatitis B e antigen (HBeAg) positive hepatitis (n = 99) and 59%versus 29%(p < 0.05) in HBeAg negative hepatitis (n = 45) for HBV genotype A compared with HBV genotype D. HBeAg status had no negative impact on IFN response. Multivariate logistic regression identified HBV genotype A and high pretreatment alanine aminotransferase levels (> 2x upper limit of normal) as independent positive predictive parameters of IFN response. Conclusions: The present study indicates that HBV genotypes A and D are important and independent predictors of IFN responsiveness in chronic hepatitis B. HBV genotype adapted treatment regimens may further improve treatment efficacy in chronic hepatitis B.

血液制品无菌生产工艺验证-培养基灌装试验

目的通过无菌灌装胰酪胨大豆肉汤培养基来验证血液制品无菌生产工艺的有效性和安全性。方法按正常分装程序进行无菌灌装,同时在灌装过程中模拟最快灌装速度、最多工作人员数量、最大灌装数量、最长工作时间、常规干扰试验和非常规干扰试验。结果通过模拟灌装过程中的最快灌装速度、最多工作人员数量、最大灌装数量、最长工作时间、常规干扰试验和非常规干扰试验,分装后的培养基孵放后无微生物生长。结论无菌灌装胰酪胨大豆肉汤培养基的验证过程及结果可以证明血液制品无菌生产工艺的控制是有效的和安全的。

Swinging up a Real-Time Inverted Pendulum System

In this study, a real-time control of the cart inverted pendulum system was developed using Mamdani type Fuzzy Logic Controller. Swing-up and stabilization of the inverted pendulum were implemented directly in a Fuzzy Logic Controller. The fuzzy logic controller was designed in the Matlab-Simulink environment and applied into in a Quasar controller board. Swing-up algorithm brings the pendulum near to its inverted position in 5 seconds from downward position. External forces were applied on the inverted pendulum to test the robustness of the fuzzy logic controller under internal as well as external disturbances. The inverted pendulum system showed an acceptable robustness to the external and internal disturbances.

四旋翼飞行仿真器的姿态控制

针对多变量控制系统对扰动敏感的问题,以携带多个配重的四旋翼飞行仿真器为研究平台,分别设计了线性二次型和粒子群优化LQR两种控制系统,模拟实际工作中旋翼机的姿态控制。在MATLAB/Simulink里建立控制系统模型,结合实时控制工具箱进行实验。结果表明,在保证控制系统性能和鲁棒性均较好的情况下,对于常规及突变性干扰,两种控制器均可有效提高多变量控制系统的抗扰能力,且粒子群优化LQR控制比LQR控制响应快、超调小,稳定性高。

长效干扰素治疗乙肝的临床疗效评价

探究慢性乙型肝炎临床治疗采取长效干扰素的治疗效果。方法:选取2018年1月到2019年6月,本院收治的患者资料62例作为研究对象,分别分为观察组和对照组,每一个小组为31例。对照组使用常规的干扰素临床治疗慢性乙型肝炎,观察组使用长效的干扰素临床治疗慢性乙型肝炎,经过实验的对比我们可以知道两组的实验结果显示临床治疗效果差异非常大。结果:观察组患者HBV-DNA率、 HBeAg阴转率高于对照组(P<0.05),不良反应与对照组无显著差异(P>0.05)。结论:由此结果可以知道临床治疗上对于慢性乙型肝炎患者,长期的使用长效干扰素的治疗效果会更好,并且患者的不良反应会比较小,对患者的危害不大,安全性能相对于其他的药物这个安全性能更高,可以被患者接受,值得大家去推广。