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针刺对脑卒中痉挛大鼠模型大脑皮质DRD1mRNA、DRD2mRNA表达的影响 被引量:19
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作者 岳增辉 陈乐乐 +3 位作者 朱小姗 薛晓 肖硕实 关闯 《湖南中医药大学学报》 CAS 2012年第12期51-54,共4页
目的通过观察针刺对脑卒中痉挛状态大鼠大脑皮质多巴胺受体亚型(DRD1、DRD2)mRNA表达的影响,探讨针刺缓解脑卒中痉挛状态的作用机理。方法采用大脑中动脉线栓法制作大鼠脑卒中痉挛状态模型,常规手法针刺组(模型+常规手法针刺阳陵泉、曲... 目的通过观察针刺对脑卒中痉挛状态大鼠大脑皮质多巴胺受体亚型(DRD1、DRD2)mRNA表达的影响,探讨针刺缓解脑卒中痉挛状态的作用机理。方法采用大脑中动脉线栓法制作大鼠脑卒中痉挛状态模型,常规手法针刺组(模型+常规手法针刺阳陵泉、曲池)及电针组(模型+电针阳陵泉、曲池)。以神经系统损伤症状、肌张力评分评价模型和针刺疗效,RT-PCR法观察大鼠大脑皮质DRD1mRNA、DRD2mRNA的表达。结果 (1)与模型组比较,针刺可降低大鼠神经系统损伤评分及痉挛大鼠的肌张力,比较差异有显著统计学意义(P<0.01),但常规手法针刺组与电针组比较差异无统计学意义(P>0.05);(2)大脑皮质DRD1mRNA、DRD2mRNA的表达:与模型组比较,常规手法针刺组与电针组表达均明显增加,比较差异有统计学意义(P<0.05,P<0.01);常规手法针刺组与电针组比较差异无统计学意义(P>0.05);结论针刺对脑卒中痉挛性瘫痪具有较好的疗效,其作用机理可能与调节中枢神经系统大脑皮质DRD1mRNA、DRD2mRNA的表达有关;但常规手法针刺与电针差异不明显。 展开更多
关键词 脑卒中痉挛状态 常规手法 多巴胺D1受体信使核糖核酸 多巴胺D2受体信使核糖核酸
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Knee joint pain treated with scraping combined with collateral bloodletting therapy 被引量:2
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作者 Yao-yao CAI Wei-hua CHEN +2 位作者 Dan-dan HE Jia-le ZHANG 《World Journal of Acupuncture-Moxibustion》 CSCD 2018年第3期181-184,I0004,共5页
Objective: To observe the clinical efficacy of knee joint pain treated with scraping combined with collateral bloodletting therapy in comparison with the routine acupuncture techniques.Methods: From March 2017 throu... Objective: To observe the clinical efficacy of knee joint pain treated with scraping combined with collateral bloodletting therapy in comparison with the routine acupuncture techniques.Methods: From March 2017 through to September 2017, 60 outpatients of knee joint pain were collected from the Acupuncture-Moxibustion Department. They were randomly divided into the group A(treated with scraping combined with collateral bloodletting therapy) and the group B(treated with the simple needling therapy of acupuncture), 30 cases in each one. Once treatment was given every day and10 times consist of one course, two courses of treatment were required. At the end of treatment, the visual analogue scale(VAS) was adopted to evaluate the pain index, tenderness index and the overall effect of the patients in the two groups. Based on the Lysholm knee scale, the scores were compared in the patients of the two groups before and after treatment.Results: The total effective rate was 96.7% in the group A and was 86.7% in the group B, indicating the significant difference(P〈0.05). VAS value was 3.03 ± 0.62 in the group A and was 3.67 ± 0.74 in the group B after treatment, indicating that difference is statistically significant(P〈0.05). The Lysholm knee score was 89.2 ± 4.8 in the group A and was 82.4 ± 2.6 in the group B after treatment, indicating that difference is statistically significant(P〈0.05).Conclusion: The scraping combined with collateral bloodletting therapy is significant in the efficacy on knee joint pain and feasible in the clinical guidance. 展开更多
关键词 Scraping combined with collateral bloodletting therapy Knee joint pain Routine acupuncture manipulation
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