探索相位幅度耦合和复杂网络方法在酒精依赖患者事件相关电位的脑网络机制研究中的应用。以开源的76例酒精依赖患者和45例健康对照在延迟匹配样本范式中的事件相关电位为研究对象。首先对数据进行预处理,然后使用调制指数方法,计算所有...探索相位幅度耦合和复杂网络方法在酒精依赖患者事件相关电位的脑网络机制研究中的应用。以开源的76例酒精依赖患者和45例健康对照在延迟匹配样本范式中的事件相关电位为研究对象。首先对数据进行预处理,然后使用调制指数方法,计算所有导联对间theta-gamma、alpha-gamma相位幅度耦合(TGC、AGC)强度,构建因果脑网络,并计算网络密度为0.3时的脑网络图论参数。此外,还计算导联内theta、alpha、beta、gamma节律小波包能量,以及疲劳因子,数据以四分位数表示50%(25%, 75%)。结果表明,只有非靶刺激时两组之间的耦合强度有显著差异。酒精依赖患者多个导联对间的TGC、AGC均显著降低(分别占比15.29%、1.29%,均P<0.05),平均耦合强度显著降低,以TGC尤为明显[TGC:0.014(0.011, 0.018) vs 0.012(0.010, 0.014),P=0.002;AGC:0.012(0.010, 0.014) vs 0.011(0.010, 0.012),P=0.005]。在TGC网络中,酒精依赖患者的特征路径长度[84.13(60.96, 110.33) vs 104.24(86.93, 118.98),P=0.005]、直径[222.40(154.78, 254.39) vs 253.39(207.82, 307.99),P=0.003]显著增加,平均聚类系数[0.013(0.010, 0.019) vs 0.009(0.008, 0.012),P<0.001]、全局效率[0.014(0.011, 0.016) vs 0.011(0.010, 0.013),P<0.001]、平均局部效率[0.017(0.013, 0.022) vs 0.013(0.011, 0.017),P<0.001]、传递性[0.011(0.008, 0.016) vs 0.008(0.007, 0.010),P<0.001]均显著降低。AGC网络的结果与TGC网络的结果相似,但是其直径无统计学差异。酒精依赖患者多个导联的theta、alpha、beta节律小波包能量显著降低(分别占比95.08%、100%、50.82%,均P<0.05),部分导联的疲劳因子显著降低(占比45.90%,均P<0.05)。在非靶刺激试验时,酒精依赖患者的皮层兴奋性增强,大脑抑制控制能力减弱,TGC和AGC脑网络的功能分离和整合能力降低,脑网络拓扑组织紊乱。展开更多
In this paper, the dynamic effect of oceanic upwelling on the intensity of E1 Nifio-Southern Oscilla tion （ENSO） is studied using a simple coupled model （Zebiak-Cane Model）. The term balance analysis in the temper...In this paper, the dynamic effect of oceanic upwelling on the intensity of E1 Nifio-Southern Oscilla tion （ENSO） is studied using a simple coupled model （Zebiak-Cane Model）. The term balance analysis in the temperature variability equation shows that the anomalous upwelling of the mean vertical temperature gradient and the mean advection of the anomalous meridional tem perature gradient are the two of most important factors that determine the intensity of ENSO events, in which the ＂vertical oceanic heat flux＂ in the eastern equatorial Pa cific （EEP） is the primary influencing factor. The lag cor relation between ＂vertical heat flux （VHF）＂ and ENSO intensity shows that the highest correlation occurs when the former leads the latter by one to two weeks. The VHF is positively correlated with the background thermocline strength in the EEP, and an increase of both could result in strong ENSO variability. Comparison of the forced and coupled experiments suggests that the coupled process can affect both the intensity and freauencv of ENSO.展开更多
文摘探索相位幅度耦合和复杂网络方法在酒精依赖患者事件相关电位的脑网络机制研究中的应用。以开源的76例酒精依赖患者和45例健康对照在延迟匹配样本范式中的事件相关电位为研究对象。首先对数据进行预处理,然后使用调制指数方法,计算所有导联对间theta-gamma、alpha-gamma相位幅度耦合(TGC、AGC)强度,构建因果脑网络,并计算网络密度为0.3时的脑网络图论参数。此外,还计算导联内theta、alpha、beta、gamma节律小波包能量,以及疲劳因子,数据以四分位数表示50%(25%, 75%)。结果表明,只有非靶刺激时两组之间的耦合强度有显著差异。酒精依赖患者多个导联对间的TGC、AGC均显著降低(分别占比15.29%、1.29%,均P<0.05),平均耦合强度显著降低,以TGC尤为明显[TGC:0.014(0.011, 0.018) vs 0.012(0.010, 0.014),P=0.002;AGC:0.012(0.010, 0.014) vs 0.011(0.010, 0.012),P=0.005]。在TGC网络中,酒精依赖患者的特征路径长度[84.13(60.96, 110.33) vs 104.24(86.93, 118.98),P=0.005]、直径[222.40(154.78, 254.39) vs 253.39(207.82, 307.99),P=0.003]显著增加,平均聚类系数[0.013(0.010, 0.019) vs 0.009(0.008, 0.012),P<0.001]、全局效率[0.014(0.011, 0.016) vs 0.011(0.010, 0.013),P<0.001]、平均局部效率[0.017(0.013, 0.022) vs 0.013(0.011, 0.017),P<0.001]、传递性[0.011(0.008, 0.016) vs 0.008(0.007, 0.010),P<0.001]均显著降低。AGC网络的结果与TGC网络的结果相似,但是其直径无统计学差异。酒精依赖患者多个导联的theta、alpha、beta节律小波包能量显著降低(分别占比95.08%、100%、50.82%,均P<0.05),部分导联的疲劳因子显著降低(占比45.90%,均P<0.05)。在非靶刺激试验时,酒精依赖患者的皮层兴奋性增强,大脑抑制控制能力减弱,TGC和AGC脑网络的功能分离和整合能力降低,脑网络拓扑组织紊乱。
基金supported by the National Natural Science Foundation of China (Grant Nos. 40976007 and 41176002)the Special Fund for Meteorological Scientific Research in the Public Interest of China Meteorological Administration (Grant No. GYHY201006022)the Norwegian Research Council through the East Asian DecCen Project (Grant No. 193690/S30)
文摘In this paper, the dynamic effect of oceanic upwelling on the intensity of E1 Nifio-Southern Oscilla tion （ENSO） is studied using a simple coupled model （Zebiak-Cane Model）. The term balance analysis in the temperature variability equation shows that the anomalous upwelling of the mean vertical temperature gradient and the mean advection of the anomalous meridional tem perature gradient are the two of most important factors that determine the intensity of ENSO events, in which the ＂vertical oceanic heat flux＂ in the eastern equatorial Pa cific （EEP） is the primary influencing factor. The lag cor relation between ＂vertical heat flux （VHF）＂ and ENSO intensity shows that the highest correlation occurs when the former leads the latter by one to two weeks. The VHF is positively correlated with the background thermocline strength in the EEP, and an increase of both could result in strong ENSO variability. Comparison of the forced and coupled experiments suggests that the coupled process can affect both the intensity and freauencv of ENSO.
