With the acceleration of society’s aging process,the widespread phenomenon of polypharmacy among the elderly has become a significant concern.This research aimed to analyze potential inappropriate medication among 17...With the acceleration of society’s aging process,the widespread phenomenon of polypharmacy among the elderly has become a significant concern.This research aimed to analyze potential inappropriate medication among 178 inpatients in the geriatric general department of our hospital from January 2022 to September 2022.The participants were randomly assigned to an observation group and a control group.The observation group received pharmaceutical intervention,whereas the control group did not.The objective was to explore the impact of pharmaceutical intervention on polypharmacy in this population.The results revealed that after pharmaceutical intervention,there were no significant differences in medication adherence,medication appropriateness index(MAI),quantity of medicine,and potentially inappropriate medication(PIM)in the control group compared to before the intervention(P>0.05).However,the observation group showed significant improvement(P<0.05).The proportion of patients with good adherence increased from 57%to 78%,and the percentage of patients with MAI scores over 10 decreased from 60%to 40%.Moreover,there was a reduction in the number of medications prescribed,with only 47%of patients receiving more than five different types compared to the initial rate of 64%.Additionally,the occurrence of PIM declined from an initial rate of 64%to just 44%,surpassing that observed in the control group.Therefore,the implementation of pharmaceutical intervention can effectively enhance medication adherence and appropriateness among elderly patients,mitigate the risk of PIM,and promote rational medicine utilization.展开更多
The definition of a drought index is the foundation of drought research.However,because of the complexity of drought,there is no a unified drought index appropriate for different drought types and objects at the same ...The definition of a drought index is the foundation of drought research.However,because of the complexity of drought,there is no a unified drought index appropriate for different drought types and objects at the same time.Therefore,it is crucial to determine the regional applicability of various drought indices.Using terrestrial water storage obtained from the Gravity Recovery And Climate Experiment,and the observed soil moisture and streamflow in China,we evaluated the regional applicability of seven meteorological drought indices:the Palmer Drought Severity Index(PDSI),modified PDSI(PDSI_CN) based on observations in China,self-calibrating PDSI(scPDSI),Surface Wetness Index(SWI),Standardized Precipitation Index(SPI),Standardized Precipitation Evapotranspiration Index(SPEI),and soil moisture simulations conducted using the community land model driven by observed atmospheric forcing(CLM3.5/ObsFC).The results showed that the scPDSI is most appropriate for China.However,it should be noted that the scPDSI reduces the value range slightly compared with the PDSI and PDSI_CN;thus,the classification of dry and wet conditions should be adjusted accordingly.Some problems might exist when using the PDSI and PDSI_CN in humid and arid areas because of the unsuitability of empiricalparameters.The SPI and SPEI are more appropriate for humid areas than arid and semiarid areas.This is because contributions of temperature variation to drought are neglected in the SPI,but overestimated in the SPEI,when potential evapotranspiration is estimated by the Thornthwaite method in these areas.Consequently,the SPI and SPEI tend to induce wetter and drier results,respectively.The CLM3.5/ObsFC is suitable for China before 2000,but not for arid and semiarid areas after 2000.Consistent with other drought indices,the SWI shows similar interannual and decadal change characteristics in detecting annual dry/wet variations.Although the long-term trends of drought areas in China detected by these seven drought indices during 1961-2013 are consistent,obvious differences exist among the values of drought areas,which might be attributable to the definitions of the drought indices in addition to climatic change.展开更多
基金Hospital Pharmacy Research Foundation of Guangdong(Grant No.2022A14)。
文摘With the acceleration of society’s aging process,the widespread phenomenon of polypharmacy among the elderly has become a significant concern.This research aimed to analyze potential inappropriate medication among 178 inpatients in the geriatric general department of our hospital from January 2022 to September 2022.The participants were randomly assigned to an observation group and a control group.The observation group received pharmaceutical intervention,whereas the control group did not.The objective was to explore the impact of pharmaceutical intervention on polypharmacy in this population.The results revealed that after pharmaceutical intervention,there were no significant differences in medication adherence,medication appropriateness index(MAI),quantity of medicine,and potentially inappropriate medication(PIM)in the control group compared to before the intervention(P>0.05).However,the observation group showed significant improvement(P<0.05).The proportion of patients with good adherence increased from 57%to 78%,and the percentage of patients with MAI scores over 10 decreased from 60%to 40%.Moreover,there was a reduction in the number of medications prescribed,with only 47%of patients receiving more than five different types compared to the initial rate of 64%.Additionally,the occurrence of PIM declined from an initial rate of 64%to just 44%,surpassing that observed in the control group.Therefore,the implementation of pharmaceutical intervention can effectively enhance medication adherence and appropriateness among elderly patients,mitigate the risk of PIM,and promote rational medicine utilization.
基金supported by the National Basic Research Program of China(Grant No.2012CB956201)the National Natural Science Foundation of China(Grant Nos.41275085,41530532 & 41305062)+1 种基金the National Key Technology R&D Program of China(Grant No.2013BAC10B02)China Special Fund for Meteorological Research in the Public Interest(Grant No.GYHY201506001-1)
文摘The definition of a drought index is the foundation of drought research.However,because of the complexity of drought,there is no a unified drought index appropriate for different drought types and objects at the same time.Therefore,it is crucial to determine the regional applicability of various drought indices.Using terrestrial water storage obtained from the Gravity Recovery And Climate Experiment,and the observed soil moisture and streamflow in China,we evaluated the regional applicability of seven meteorological drought indices:the Palmer Drought Severity Index(PDSI),modified PDSI(PDSI_CN) based on observations in China,self-calibrating PDSI(scPDSI),Surface Wetness Index(SWI),Standardized Precipitation Index(SPI),Standardized Precipitation Evapotranspiration Index(SPEI),and soil moisture simulations conducted using the community land model driven by observed atmospheric forcing(CLM3.5/ObsFC).The results showed that the scPDSI is most appropriate for China.However,it should be noted that the scPDSI reduces the value range slightly compared with the PDSI and PDSI_CN;thus,the classification of dry and wet conditions should be adjusted accordingly.Some problems might exist when using the PDSI and PDSI_CN in humid and arid areas because of the unsuitability of empiricalparameters.The SPI and SPEI are more appropriate for humid areas than arid and semiarid areas.This is because contributions of temperature variation to drought are neglected in the SPI,but overestimated in the SPEI,when potential evapotranspiration is estimated by the Thornthwaite method in these areas.Consequently,the SPI and SPEI tend to induce wetter and drier results,respectively.The CLM3.5/ObsFC is suitable for China before 2000,but not for arid and semiarid areas after 2000.Consistent with other drought indices,the SWI shows similar interannual and decadal change characteristics in detecting annual dry/wet variations.Although the long-term trends of drought areas in China detected by these seven drought indices during 1961-2013 are consistent,obvious differences exist among the values of drought areas,which might be attributable to the definitions of the drought indices in addition to climatic change.
