Coherence analysis is a powerful tool in seismic interpretation for imaging geological discontinuities such as faults and fractures. However, subtle faults or fractures of one stratum are difficult to be distinguished...Coherence analysis is a powerful tool in seismic interpretation for imaging geological discontinuities such as faults and fractures. However, subtle faults or fractures of one stratum are difficult to be distinguished on coherence sections (time slices or profiles) due to interferences from adjacent strata, especially these with strong reflectivity. In this paper, we propose a coherence enhancement method which applies local histogram specification (LHS) techniques to enhance subtle faults or fractures in the coherence cubes. Unlike the traditional histogram specification (HS) algorithm, our method processes 3D coherence data without discretization. This method partitions a coherence cube into many sub-blocks and self-adaptively specifies the target distribution in each block based on the whole distribution of the coherence cube. Furthermore, the neighboring blocks are partially overlapped to reduce the edge effect. Applications to real datasets show that the new method enhances the details of subtle faults and fractures noticeably.展开更多
Optical coherence tomography(OCT) is an optical imaging modality that performs high-resolution,cross-sectional,subsurface tomographic imaging of the microstructure of tissues.The physical principle of OCT is similar t...Optical coherence tomography(OCT) is an optical imaging modality that performs high-resolution,cross-sectional,subsurface tomographic imaging of the microstructure of tissues.The physical principle of OCT is similar to that of B-mode ultrasound imaging,except that it uses infrared light waves rather than acoustic waves.The in vivo resolution is 10-25 times better(about 10 μm) than with high-frequency ultrasound imaging,but the depth of penetration is limited to 1-3 mm,depending upon tissue structure,depth of focus of the probe used,and pressure applied to the tissue surface.In the last decade,OCT technology has evolved from an experimental laboratory tool to a new diagnostic imaging modality with a wide spectrum of clinical applications in medical practice,including the gastrointestinal(GI) tract and pancreatic-biliary ductal system.OCT imaging from the GI tract can be done in humans by using narrow-diameter,catheter-based probes that can be inserted through the accessory channel of either a conventional front-view endoscope,for investigating the epithelial structure of the GI tract,or a side-view endoscope,inside a standard transparent ERCP catheter,for investigating the pancreatico-biliary ductal system.Esophagus and the esophago-gastric junction has been the most widely investigated organ so far;more recently,also duodenum,colon and pancreatico-biliary ductal system have been extensively investigated.OCT imaging of the gastro-intestinal wall structure is characterized by a multiple-layer architecture that permits an accurate evaluation of the mucosa,lamina propria,muscularis mucosae,andpart of the submucosa.The technique may be,therefore,used to identify pre-neoplastic conditions of the GI tract,such as Barrett's epithelium and dysplasia,and evaluate the depth of penetration of early-stage neoplastic lesions.OCT imaging of the pancreatic and biliary ductal system could improve the diagnostic accuracy for ductal epithelial changes and the differential diagnosis between neoplastic and non-neoplastic lesions.展开更多
AIM:To demonstrate the feasibility of optical coherence tomography(OCT)imaging in differentiating cervical inlet patch(CIP)from normal esophagus,Barrett'sesophagus(BE),normal stomach and duodenum. METHODS:This stu...AIM:To demonstrate the feasibility of optical coherence tomography(OCT)imaging in differentiating cervical inlet patch(CIP)from normal esophagus,Barrett'sesophagus(BE),normal stomach and duodenum. METHODS:This study was conducted at the Veterans Affairs Boston Healthcare System(VABHS).Patients undergoing standard esophagogastroduodenoscopy at VABHS,including one patient with CIP,one representative patient with BE and three representative normal subjects were included.White light video endoscopy was performed and endoscopic 3D-OCT images were obtained in each patient using a prototype OCT system.The OCT imaging probe passes through the working channel of the endoscope to enable simultaneous video endoscopy and 3D-OCT examination of the human gastrointestinal(GI)tract.Standard hematoxylin and eosin(H and E)histology was performed on biopsy or endoscopic mucosal resection specimens in order to compare and validate the 3D-OCT data. RESULTS:CIP was observed from a 68-year old male with gastroesophageal reflux disease.The CIP region appeared as a pink circular lesion in the upper esophagus under white light endoscopy.OCT imaging over the CIP region showed columnar epithelium structure,which clearly contrasted the squamous epithelium structure from adjacent normal esophagus.3D-OCT images obtained from other representative patients demonstrated distinctive patterns of the normal esophagus,BE,normal stomach,and normal duodenum bulb.Microstructures,such as squamous epithelium,lamina propria, muscularis mucosa,muscularis propria,esophageal glands,Barrett's glands,gastric mucosa,gastric glands, and intestinal mucosal villi were clearly observed with OCT and matched with H and E histology.These results demonstrated the feasibility of using OCT to evaluate GI tissue morphology in situ and in real-time. CONCLUSION:We demonstrate in situ evaluation of CIP microstructures using 3D-OCT,which may be a useful tool for future diagnosis and follow-up of patients with CIP.展开更多
The parallel spectral-domain optical coherence tomography(PSDOCT) is described for highspeed optical coherence tomography(OCT) without lateral scanning. In this setup, the self-elimination of auto-correlation(AC...The parallel spectral-domain optical coherence tomography(PSDOCT) is described for highspeed optical coherence tomography(OCT) without lateral scanning. In this setup, the self-elimination of auto-correlation(AC) interference algorithm was used for eradicating the AC interference and ghost images. However, when performed in free space OCT, this algorithm still generated a weak DC component. The algorithm was improved by adding the background intensity part to compensate for the mutual interference between object and reference arms. The results demonstrate that the DC component can be eradicated. Compared with conventional QCT and complex Fourier-domain optical coherence to- mography, the advantages of PSDOCT with the improved algorithm in free space are that it has no moving parts to generate consecutive phase shift, the structure of the object can be reconstructed immediately and automatically, and the speed is approximately 16 times faster than those of the other two in the same case.展开更多
Background Different stems implantation in ST-segmem elevation myocardial infarction (STEMI) patients may influence the long term prognosis by affecting vessel healings after stenting. The aim of this study was to e...Background Different stems implantation in ST-segmem elevation myocardial infarction (STEMI) patients may influence the long term prognosis by affecting vessel healings after stenting. The aim of this study was to evaluate the vessel healings after implantation of drug elming stems (DES) with biodegradable or durable polymer or of bare-metal stems (BMS) in patients with ache STEMI. Methods This study included 50 patients, who underwem follow up angiogram and optical coherence tomography (OCT) assessment about one year after percutaneous coronary intervemion (PCI) for STEMI. According to the initial stems types, these patients were classified to durable (n = 19) or biodegradable polymer sirolimus-eluting stems (n = 15), or BMS (n = 16) groups. The conditions of stem struts coverage and malapposi- tion were analyzed with OCT technique. Results A total of 9003 struts were analyzed: 3299, 3202 and 2502 from durable or biodegradable polymer DES, or BMS, respectively. Strut coverage rate (89.0%, 94.9% and 99.3%, respectively), malapposition presence (1.7%, 0.03% and 0 of struts, respectively) and average intimal thickness over struts (76 ± 12 μm, 161 ± 30 μm and 292 ± 29 μm, respectively) were significantly differem among different stent groups (all P 〈 0.001). Conclusions Vessel healing status in STEMI patients is superior after implantation of biodegradable polymer DES than durable polymer DES, while both are inferior to BMS.展开更多
In the last ten years, the D_InSAR (Differential Interferometric Synthetic Aperture Radar) technique has proved very useful; it has been a new space observation technique with great potential. Investigating seismic fo...In the last ten years, the D_InSAR (Differential Interferometric Synthetic Aperture Radar) technique has proved very useful; it has been a new space observation technique with great potential. Investigating seismic focus rupture information using D_InSAR is a scientific issue to which more attention is being paid. In this paper, the basic theory of seismic focus dislocation models is discussed briefly. Based on a map of the interferometric deformation field of the Zhangbei_Shangyi earthquake from Jan.10, 1998, and applying the seismic focus dislocation model within elastic half_space medium; some geometrical and kinematical characteristics of the main seismic fault are deduced. Results were as follows: the seismic break surface of the Zhangbei_Shangyi earthquake is left_slip and thrust fault, striking in SEE_NWW 272°with dip angle 46°; rupture direction is unilateral faulting from SEE to NWW; length of rupture zone is 9km, width is 8km, and depth is 8km, the displacement vector of three directions are 290mm, 560mm and 0mm.展开更多
For the diagnosis of glaucoma,optical coherence tomography(OCT)is a noninvasive imaging technique for the assessment of retinal layers.To accurately segment intraretinal layers in an optic nerve head(ONH)region,we pro...For the diagnosis of glaucoma,optical coherence tomography(OCT)is a noninvasive imaging technique for the assessment of retinal layers.To accurately segment intraretinal layers in an optic nerve head(ONH)region,we proposed an automatic method for the segmentation of three intraretinal layers in eye OCT scans centered on ONH.The internal limiting membrane,inner segment and outer segment,Bruch’s membrane surfaces under vascular shadows,and interaction of multiple high-reflectivity regions in the OCT image can be accurately segmented through this method.Then,we constructed a novel spatial-gradient continuity constraint,termed spatial-gradient continuity constraint,for the correction of discontinuity between adjacent image segmentation results.In our experiment,we randomly selected 20 B-scans,each annotated three retinal layers by experts.Signed distance errors of?0.80μm obtained through this method are lower than those obtained through the state-of-art method(?1.43μm).Meanwhile,the segmentation results can be used as bases for the diagnosis of glaucoma.展开更多
HIGH-VOLTAGE electrical injuries can result in a variety of ocular complications. Cataract and macular edema are the most common injuries.Other injuries include punctate keratopathy,uveitis,macular hole,subretinal mac...HIGH-VOLTAGE electrical injuries can result in a variety of ocular complications. Cataract and macular edema are the most common injuries.Other injuries include punctate keratopathy,uveitis,macular hole,subretinal macular haemorrhage,and choroidal atrophy.We report a case that optical coherence tomography (OCT) and multifocal electro- retinogram (mfERG) clearly demonstrated the bilateral macular lesions following electrical injury, while the fundus examination was nearly normal.展开更多
Here we present the case of a 79-year-old woman who complained of acute abdominal pain,vomiting and diarrhoea.Laboratory exams demonstrated a severe metabolic imbalance.Abdominal X-rays showed bowel overdistension and...Here we present the case of a 79-year-old woman who complained of acute abdominal pain,vomiting and diarrhoea.Laboratory exams demonstrated a severe metabolic imbalance.Abdominal X-rays showed bowel overdistension and pneumatosis of the stomach wall.Abdominal tomography revealed infarction of the stomach,duodenum and small bowel due to thrombosis of the celiacomesenteric trunk.Exploratory laparotomy revealed ischemia of the liver,spleen infarction and necrosis of the gastro-intestinal tube(from the stomach up to the first third of the transverse colon).No further surgical procedures were performed.The patient died the following day.To our knowledge,this is the first reported case about severe gastro-intestinal ischemia due to thrombosis of the celiacomesenteric trunk,a rare anatomic variation of the gastrointestinal vascularisation.展开更多
Objective To provide novel spectral domain optical coherence tomography (SD OCT) findings of Vogt-Koyanagi-Harada (VKH) disease as well as new insights into the pathogenesis of this disease. Methods Detailed SD OCT an...Objective To provide novel spectral domain optical coherence tomography (SD OCT) findings of Vogt-Koyanagi-Harada (VKH) disease as well as new insights into the pathogenesis of this disease. Methods Detailed SD OCT and fluorescein angiography (FA) findings of 18 consecutive VKH patients (11 women and 7 men) from December 2007 to April 2009 who were in acute uveitic stage at presentation were reviewed. All the patients had been followed up for at least 6 months with reevaluation(s) of SD OCT performed in 10 patients. Results Intraretinal cysts were found to be located in various layers of the outer retina. In addition to the photoreceptor layer, they could also be found between the outer plexiform layer and the outer nuclear layer, or spanning the external limiting membrane. On FA, intraretinal cysts could be hypofluorescent, normofluorescent, or hyperfluorescent. Some intraretinal cysts had a characteristic FA pattern, in which a small round hypofluorescent area was surrounded by a ring of hyperfluorescence (donut-shaped dye pooling). Subretinal fibrinoid deposit appeared in acute uveitic stage in two severe VKH patients and seemed to develop from subretinal exudates and evolved into typical subretinal fibrosis. Gradual transfiguration/migration and progressive proliferation/pigmentation of the subretinal fibrinoid deposit/subretinal fibrosis was observed in one patient. Conclusions Intraretinal cysts could form in various layers of the outer retina and may result from extension of choroidal inflammation. Subretinal fibrosis may develop from subretinal exudates in VKH patients and may cause substantial visual impairment.展开更多
Optical coherence tomography(OCT) is a noninvasive,high-resolution,high-potential imaging method that has recently been introduced into medical investigations.A growing number of studies have used this technique in th...Optical coherence tomography(OCT) is a noninvasive,high-resolution,high-potential imaging method that has recently been introduced into medical investigations.A growing number of studies have used this technique in the field of gastroenterology in order to assist classical analyses.Lately,3D-imaging and Doppler capabilities have been developed in different configurations,which make this type of investigation more attractive.This paper reviews the principles and characteristics of OCT and Doppler-OCT in connection with analyses of the detection of normal and pathological structures,and with the possibility to investigate angiogenesis in the gastrointestinal tract.展开更多
Recent advancements in the endoscopic imaging of Barrett's esophagus can be used to probe a wide range of optical properties that are altered with neoplastic progression.This review summarizes relevant changes in ...Recent advancements in the endoscopic imaging of Barrett's esophagus can be used to probe a wide range of optical properties that are altered with neoplastic progression.This review summarizes relevant changes in optical properties as well as imaging approaches that measures those changes.Wide-field imaging approaches include narrow-band imaging that measures changes in light scattering and absorption,and autofluorescence imaging that measure changes in endogenous fluorophores.High-resolution imaging approaches include optical coherence tomography,endocytoscopy,confocal microendoscopy,and high-resolution microendoscopy.These technologies,some coupled with an appropriate contrast agent,can measure differences in glandular morphology,nuclear morphology,or vascular alterations associated with neoplasia.Advances in targeted contrast agents are further discussed.Studies that have explored these technologies are highlighted;as are the advantages and limitations of each.展开更多
AIM: To assess each layer of the optical coherence tomography (OCT) image of the esophageal wall with reference to the histological structure, METHODS: Resected specimens of fresh pig esophagus was used as a model...AIM: To assess each layer of the optical coherence tomography (OCT) image of the esophageal wall with reference to the histological structure, METHODS: Resected specimens of fresh pig esophagus was used as a model for the esophageal wall. We injected cyanoacrylate adhesive into the specimens to create a marker, and scanned them using a miniature OCT probe. The localization of these markers was assessed in the OCT images. Then we compared the OCT-imaged morphology with the corresponding histological section, guided by the cyanoacrylate adhesive markers. We prepared a second set of experiments using nylon sutures as markers. RESULTS: The OCT image of the esophageal specimen has a clear five-layered morphology. First, it consisted of a relatively less reflective layer; second, a more reflective layer; third, a less reflective layer; fourth, a more reflective layer; and fifth, a less reflective layer. Comparing the OCT images with marked histological sections showed that the first layer corresponded to stratified squamous epithelium; the second to lamina propria; the third to muscularis mucosa; fourth, submucosa; and fifth, muscularis propria with deeper structures of the esophageal wa CONCLUSION: We demonstrated that the OCT image of the normal esophageal wall showed a five- layered morphology, which corresponds to histological esophageal wall components.展开更多
Objectives To investigate image characteristics and thickness of the retinal nerve fiber layer (RNFL) in normal and glaucomatous eyes using optical coherence tomography (OCT), and analyze the relationship between RNFL...Objectives To investigate image characteristics and thickness of the retinal nerve fiber layer (RNFL) in normal and glaucomatous eyes using optical coherence tomography (OCT), and analyze the relationship between RNFL thickness and visual field index.Methods Eighty-three normal persons (150 eyes) and 83 patients with primary open angle glaucoma (POAG, 149 eyes) underwent OCT examinations with 3.4 mm diameter circle scan to calculate the RNFL thickness. Statistical analysis was used to compare differences in RNFL thickness in quadrants and means between the normal and glaucomatous groups and the different stages of POAG. Linear correlation and regression analysis were used to show the correlation between RNFL thickness and visual field index of 115 eyes in glaucomatous patients. Reproducibility, sensitivity and specificity of RNFL measurements using OCT were evaluated.Results RNFL thickness measured by OCT in normal subjects was thicker in superior and inferior, less in temporal, and thinnest in nasal quadrants. The curve showed double peaks. RNFL of glaucomatous patients showed local thinning or defect, diffuse thinning, or both. The mean RNFL thicknesses of the normal group in the temporal, superior, nasal and infeior quadrants were 90.1 ± 10.8 lμm, 140.4 ± 10.5μm, 85.2 ± 14.0 μm, and 140.4 + 9.7 μm, respectively with a mean of 114.2 ± 6.0 μm. The numbers for the glaucomatous group were respectively 56.0 ± 31.0 μm, 81.0 ± 36.3 μm, 47.1 ± 27.5 μm, and 73.4 ±38.4 μm for the four quadrants, with a mean of 64.6 ± 28.8 μm. There was a significant difference in RNFL thickness between the normal and glaucomatous groups (P < 0.000), and the three stages (early,developing and late) of glaucornatous groups (P < 0.000). There was a close negative relationship between RNFL thickness and visual field index ( r = - 0.796, P < 0.0001 ). The sensitivity and specificity of RNFL thickness in POAG measured using OCT were 93.3% and 92.0%, respectively.Conclusions OCT can quantitatively measure RNFL thickness differences between normal persons and glaucomatous patients. RNFL thickness gradually decreases while visual field defect increases with the development of POAG.展开更多
基金sponsored by Important National Science and Technology Specific Projects of China (Grant No.2008ZX05023-005-011 and No. 2008ZX05040-003)the National 973 Program of China (Grant No. 2006CB202208)
文摘Coherence analysis is a powerful tool in seismic interpretation for imaging geological discontinuities such as faults and fractures. However, subtle faults or fractures of one stratum are difficult to be distinguished on coherence sections (time slices or profiles) due to interferences from adjacent strata, especially these with strong reflectivity. In this paper, we propose a coherence enhancement method which applies local histogram specification (LHS) techniques to enhance subtle faults or fractures in the coherence cubes. Unlike the traditional histogram specification (HS) algorithm, our method processes 3D coherence data without discretization. This method partitions a coherence cube into many sub-blocks and self-adaptively specifies the target distribution in each block based on the whole distribution of the coherence cube. Furthermore, the neighboring blocks are partially overlapped to reduce the edge effect. Applications to real datasets show that the new method enhances the details of subtle faults and fractures noticeably.
文摘Optical coherence tomography(OCT) is an optical imaging modality that performs high-resolution,cross-sectional,subsurface tomographic imaging of the microstructure of tissues.The physical principle of OCT is similar to that of B-mode ultrasound imaging,except that it uses infrared light waves rather than acoustic waves.The in vivo resolution is 10-25 times better(about 10 μm) than with high-frequency ultrasound imaging,but the depth of penetration is limited to 1-3 mm,depending upon tissue structure,depth of focus of the probe used,and pressure applied to the tissue surface.In the last decade,OCT technology has evolved from an experimental laboratory tool to a new diagnostic imaging modality with a wide spectrum of clinical applications in medical practice,including the gastrointestinal(GI) tract and pancreatic-biliary ductal system.OCT imaging from the GI tract can be done in humans by using narrow-diameter,catheter-based probes that can be inserted through the accessory channel of either a conventional front-view endoscope,for investigating the epithelial structure of the GI tract,or a side-view endoscope,inside a standard transparent ERCP catheter,for investigating the pancreatico-biliary ductal system.Esophagus and the esophago-gastric junction has been the most widely investigated organ so far;more recently,also duodenum,colon and pancreatico-biliary ductal system have been extensively investigated.OCT imaging of the gastro-intestinal wall structure is characterized by a multiple-layer architecture that permits an accurate evaluation of the mucosa,lamina propria,muscularis mucosae,andpart of the submucosa.The technique may be,therefore,used to identify pre-neoplastic conditions of the GI tract,such as Barrett's epithelium and dysplasia,and evaluate the depth of penetration of early-stage neoplastic lesions.OCT imaging of the pancreatic and biliary ductal system could improve the diagnostic accuracy for ductal epithelial changes and the differential diagnosis between neoplastic and non-neoplastic lesions.
基金Supported by The VA Boston Healthcare System and NIH grants R01-CA75289-14,to Fujimoto JG and Mashimo HK99-EB010071-01A1,to Zhou C+2 种基金Air Force Office of Scientific Research contract FA9550-10-1-0063,to Fujimoto JGMedical Free Electron Laser Program contract FA9550-10-1-0551,to Fujimoto JGthe MIT/CIMIT Medical Engineering Fellowship,to Tsai TH
文摘AIM:To demonstrate the feasibility of optical coherence tomography(OCT)imaging in differentiating cervical inlet patch(CIP)from normal esophagus,Barrett'sesophagus(BE),normal stomach and duodenum. METHODS:This study was conducted at the Veterans Affairs Boston Healthcare System(VABHS).Patients undergoing standard esophagogastroduodenoscopy at VABHS,including one patient with CIP,one representative patient with BE and three representative normal subjects were included.White light video endoscopy was performed and endoscopic 3D-OCT images were obtained in each patient using a prototype OCT system.The OCT imaging probe passes through the working channel of the endoscope to enable simultaneous video endoscopy and 3D-OCT examination of the human gastrointestinal(GI)tract.Standard hematoxylin and eosin(H and E)histology was performed on biopsy or endoscopic mucosal resection specimens in order to compare and validate the 3D-OCT data. RESULTS:CIP was observed from a 68-year old male with gastroesophageal reflux disease.The CIP region appeared as a pink circular lesion in the upper esophagus under white light endoscopy.OCT imaging over the CIP region showed columnar epithelium structure,which clearly contrasted the squamous epithelium structure from adjacent normal esophagus.3D-OCT images obtained from other representative patients demonstrated distinctive patterns of the normal esophagus,BE,normal stomach,and normal duodenum bulb.Microstructures,such as squamous epithelium,lamina propria, muscularis mucosa,muscularis propria,esophageal glands,Barrett's glands,gastric mucosa,gastric glands, and intestinal mucosal villi were clearly observed with OCT and matched with H and E histology.These results demonstrated the feasibility of using OCT to evaluate GI tissue morphology in situ and in real-time. CONCLUSION:We demonstrate in situ evaluation of CIP microstructures using 3D-OCT,which may be a useful tool for future diagnosis and follow-up of patients with CIP.
文摘The parallel spectral-domain optical coherence tomography(PSDOCT) is described for highspeed optical coherence tomography(OCT) without lateral scanning. In this setup, the self-elimination of auto-correlation(AC) interference algorithm was used for eradicating the AC interference and ghost images. However, when performed in free space OCT, this algorithm still generated a weak DC component. The algorithm was improved by adding the background intensity part to compensate for the mutual interference between object and reference arms. The results demonstrate that the DC component can be eradicated. Compared with conventional QCT and complex Fourier-domain optical coherence to- mography, the advantages of PSDOCT with the improved algorithm in free space are that it has no moving parts to generate consecutive phase shift, the structure of the object can be reconstructed immediately and automatically, and the speed is approximately 16 times faster than those of the other two in the same case.
文摘Background Different stems implantation in ST-segmem elevation myocardial infarction (STEMI) patients may influence the long term prognosis by affecting vessel healings after stenting. The aim of this study was to evaluate the vessel healings after implantation of drug elming stems (DES) with biodegradable or durable polymer or of bare-metal stems (BMS) in patients with ache STEMI. Methods This study included 50 patients, who underwem follow up angiogram and optical coherence tomography (OCT) assessment about one year after percutaneous coronary intervemion (PCI) for STEMI. According to the initial stems types, these patients were classified to durable (n = 19) or biodegradable polymer sirolimus-eluting stems (n = 15), or BMS (n = 16) groups. The conditions of stem struts coverage and malapposi- tion were analyzed with OCT technique. Results A total of 9003 struts were analyzed: 3299, 3202 and 2502 from durable or biodegradable polymer DES, or BMS, respectively. Strut coverage rate (89.0%, 94.9% and 99.3%, respectively), malapposition presence (1.7%, 0.03% and 0 of struts, respectively) and average intimal thickness over struts (76 ± 12 μm, 161 ± 30 μm and 292 ± 29 μm, respectively) were significantly differem among different stent groups (all P 〈 0.001). Conclusions Vessel healing status in STEMI patients is superior after implantation of biodegradable polymer DES than durable polymer DES, while both are inferior to BMS.
文摘In the last ten years, the D_InSAR (Differential Interferometric Synthetic Aperture Radar) technique has proved very useful; it has been a new space observation technique with great potential. Investigating seismic focus rupture information using D_InSAR is a scientific issue to which more attention is being paid. In this paper, the basic theory of seismic focus dislocation models is discussed briefly. Based on a map of the interferometric deformation field of the Zhangbei_Shangyi earthquake from Jan.10, 1998, and applying the seismic focus dislocation model within elastic half_space medium; some geometrical and kinematical characteristics of the main seismic fault are deduced. Results were as follows: the seismic break surface of the Zhangbei_Shangyi earthquake is left_slip and thrust fault, striking in SEE_NWW 272°with dip angle 46°; rupture direction is unilateral faulting from SEE to NWW; length of rupture zone is 9km, width is 8km, and depth is 8km, the displacement vector of three directions are 290mm, 560mm and 0mm.
基金Projects(61672542,61573380)supported by the National Natural Science Foundation of China
文摘For the diagnosis of glaucoma,optical coherence tomography(OCT)is a noninvasive imaging technique for the assessment of retinal layers.To accurately segment intraretinal layers in an optic nerve head(ONH)region,we proposed an automatic method for the segmentation of three intraretinal layers in eye OCT scans centered on ONH.The internal limiting membrane,inner segment and outer segment,Bruch’s membrane surfaces under vascular shadows,and interaction of multiple high-reflectivity regions in the OCT image can be accurately segmented through this method.Then,we constructed a novel spatial-gradient continuity constraint,termed spatial-gradient continuity constraint,for the correction of discontinuity between adjacent image segmentation results.In our experiment,we randomly selected 20 B-scans,each annotated three retinal layers by experts.Signed distance errors of?0.80μm obtained through this method are lower than those obtained through the state-of-art method(?1.43μm).Meanwhile,the segmentation results can be used as bases for the diagnosis of glaucoma.
文摘HIGH-VOLTAGE electrical injuries can result in a variety of ocular complications. Cataract and macular edema are the most common injuries.Other injuries include punctate keratopathy,uveitis,macular hole,subretinal macular haemorrhage,and choroidal atrophy.We report a case that optical coherence tomography (OCT) and multifocal electro- retinogram (mfERG) clearly demonstrated the bilateral macular lesions following electrical injury, while the fundus examination was nearly normal.
文摘Here we present the case of a 79-year-old woman who complained of acute abdominal pain,vomiting and diarrhoea.Laboratory exams demonstrated a severe metabolic imbalance.Abdominal X-rays showed bowel overdistension and pneumatosis of the stomach wall.Abdominal tomography revealed infarction of the stomach,duodenum and small bowel due to thrombosis of the celiacomesenteric trunk.Exploratory laparotomy revealed ischemia of the liver,spleen infarction and necrosis of the gastro-intestinal tube(from the stomach up to the first third of the transverse colon).No further surgical procedures were performed.The patient died the following day.To our knowledge,this is the first reported case about severe gastro-intestinal ischemia due to thrombosis of the celiacomesenteric trunk,a rare anatomic variation of the gastrointestinal vascularisation.
文摘Objective To provide novel spectral domain optical coherence tomography (SD OCT) findings of Vogt-Koyanagi-Harada (VKH) disease as well as new insights into the pathogenesis of this disease. Methods Detailed SD OCT and fluorescein angiography (FA) findings of 18 consecutive VKH patients (11 women and 7 men) from December 2007 to April 2009 who were in acute uveitic stage at presentation were reviewed. All the patients had been followed up for at least 6 months with reevaluation(s) of SD OCT performed in 10 patients. Results Intraretinal cysts were found to be located in various layers of the outer retina. In addition to the photoreceptor layer, they could also be found between the outer plexiform layer and the outer nuclear layer, or spanning the external limiting membrane. On FA, intraretinal cysts could be hypofluorescent, normofluorescent, or hyperfluorescent. Some intraretinal cysts had a characteristic FA pattern, in which a small round hypofluorescent area was surrounded by a ring of hyperfluorescence (donut-shaped dye pooling). Subretinal fibrinoid deposit appeared in acute uveitic stage in two severe VKH patients and seemed to develop from subretinal exudates and evolved into typical subretinal fibrosis. Gradual transfiguration/migration and progressive proliferation/pigmentation of the subretinal fibrinoid deposit/subretinal fibrosis was observed in one patient. Conclusions Intraretinal cysts could form in various layers of the outer retina and may result from extension of choroidal inflammation. Subretinal fibrosis may develop from subretinal exudates in VKH patients and may cause substantial visual impairment.
基金Supported by Project number 99CP/I//2007 ANCSProject number 12-106/2008 CNMP,Romania
文摘Optical coherence tomography(OCT) is a noninvasive,high-resolution,high-potential imaging method that has recently been introduced into medical investigations.A growing number of studies have used this technique in the field of gastroenterology in order to assist classical analyses.Lately,3D-imaging and Doppler capabilities have been developed in different configurations,which make this type of investigation more attractive.This paper reviews the principles and characteristics of OCT and Doppler-OCT in connection with analyses of the detection of normal and pathological structures,and with the possibility to investigate angiogenesis in the gastrointestinal tract.
基金Supported by The National Institute of Health Grants BRP CA103830 and RO1 EB007594
文摘Recent advancements in the endoscopic imaging of Barrett's esophagus can be used to probe a wide range of optical properties that are altered with neoplastic progression.This review summarizes relevant changes in optical properties as well as imaging approaches that measures those changes.Wide-field imaging approaches include narrow-band imaging that measures changes in light scattering and absorption,and autofluorescence imaging that measure changes in endogenous fluorophores.High-resolution imaging approaches include optical coherence tomography,endocytoscopy,confocal microendoscopy,and high-resolution microendoscopy.These technologies,some coupled with an appropriate contrast agent,can measure differences in glandular morphology,nuclear morphology,or vascular alterations associated with neoplasia.Advances in targeted contrast agents are further discussed.Studies that have explored these technologies are highlighted;as are the advantages and limitations of each.
文摘AIM: To assess each layer of the optical coherence tomography (OCT) image of the esophageal wall with reference to the histological structure, METHODS: Resected specimens of fresh pig esophagus was used as a model for the esophageal wall. We injected cyanoacrylate adhesive into the specimens to create a marker, and scanned them using a miniature OCT probe. The localization of these markers was assessed in the OCT images. Then we compared the OCT-imaged morphology with the corresponding histological section, guided by the cyanoacrylate adhesive markers. We prepared a second set of experiments using nylon sutures as markers. RESULTS: The OCT image of the esophageal specimen has a clear five-layered morphology. First, it consisted of a relatively less reflective layer; second, a more reflective layer; third, a less reflective layer; fourth, a more reflective layer; and fifth, a less reflective layer. Comparing the OCT images with marked histological sections showed that the first layer corresponded to stratified squamous epithelium; the second to lamina propria; the third to muscularis mucosa; fourth, submucosa; and fifth, muscularis propria with deeper structures of the esophageal wa CONCLUSION: We demonstrated that the OCT image of the normal esophageal wall showed a five- layered morphology, which corresponds to histological esophageal wall components.
基金agrantfromtheGuangdongProvincialMainItemFoundation (No 49)
文摘Objectives To investigate image characteristics and thickness of the retinal nerve fiber layer (RNFL) in normal and glaucomatous eyes using optical coherence tomography (OCT), and analyze the relationship between RNFL thickness and visual field index.Methods Eighty-three normal persons (150 eyes) and 83 patients with primary open angle glaucoma (POAG, 149 eyes) underwent OCT examinations with 3.4 mm diameter circle scan to calculate the RNFL thickness. Statistical analysis was used to compare differences in RNFL thickness in quadrants and means between the normal and glaucomatous groups and the different stages of POAG. Linear correlation and regression analysis were used to show the correlation between RNFL thickness and visual field index of 115 eyes in glaucomatous patients. Reproducibility, sensitivity and specificity of RNFL measurements using OCT were evaluated.Results RNFL thickness measured by OCT in normal subjects was thicker in superior and inferior, less in temporal, and thinnest in nasal quadrants. The curve showed double peaks. RNFL of glaucomatous patients showed local thinning or defect, diffuse thinning, or both. The mean RNFL thicknesses of the normal group in the temporal, superior, nasal and infeior quadrants were 90.1 ± 10.8 lμm, 140.4 ± 10.5μm, 85.2 ± 14.0 μm, and 140.4 + 9.7 μm, respectively with a mean of 114.2 ± 6.0 μm. The numbers for the glaucomatous group were respectively 56.0 ± 31.0 μm, 81.0 ± 36.3 μm, 47.1 ± 27.5 μm, and 73.4 ±38.4 μm for the four quadrants, with a mean of 64.6 ± 28.8 μm. There was a significant difference in RNFL thickness between the normal and glaucomatous groups (P < 0.000), and the three stages (early,developing and late) of glaucornatous groups (P < 0.000). There was a close negative relationship between RNFL thickness and visual field index ( r = - 0.796, P < 0.0001 ). The sensitivity and specificity of RNFL thickness in POAG measured using OCT were 93.3% and 92.0%, respectively.Conclusions OCT can quantitatively measure RNFL thickness differences between normal persons and glaucomatous patients. RNFL thickness gradually decreases while visual field defect increases with the development of POAG.