目的:探讨重组牛碱性成纤维细胞生长因子(rb-bFGF)滴眼液与羟糖苷滴眼液对年龄相关性白内障患者术后泪膜稳定性及干眼症状的影响。方法:以我院2015-01/2016-10收治的年龄相关性白内障术后患者80例80眼为研究对象,采用随机数字表法将患...目的:探讨重组牛碱性成纤维细胞生长因子(rb-bFGF)滴眼液与羟糖苷滴眼液对年龄相关性白内障患者术后泪膜稳定性及干眼症状的影响。方法:以我院2015-01/2016-10收治的年龄相关性白内障术后患者80例80眼为研究对象,采用随机数字表法将患者均分为对照组及试验组各40例40眼,两组分别实施羟糖苷滴眼液及rb-bFGF滴眼液治疗,观察治疗后两组临床疗效、炎症相关因子[白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)]、泪液分泌试验(S I t)、泪膜破裂时间(BUT)、角膜荧光素钠染色(FL)、眼部干眼症状评分。结果:治疗后试验组总有效率90.0%,较对照组72.5%显著高,差异有统计学意义(χ~2=4.021,P<0.05);治疗前两组IL-6、TNF-α、S I t、BUT、FL评分、眼部干眼症状评分比较无明显差异(P>0.05);治疗后两组IL-6、TNF-α、S I t、FL评分、眼部干眼症状评分较治疗前明显降低,BUT明显升高(P<0.05),且治疗后试验组的各项指标变化较对照组明显,差异有统计学意义(P<0.05)。结论:在年龄相关性白内障术后患者治疗中,rb-bFGF滴眼液在调节患者炎症因子表达。展开更多
Background:This study was designed to examine if patients undergoing the same operative procedure(blepharochalasis operation)have different subjective recognition of dry eye problems depending n whether they had he op...Background:This study was designed to examine if patients undergoing the same operative procedure(blepharochalasis operation)have different subjective recognition of dry eye problems depending n whether they had he operation for cosmetic or medical reasons.Patients and Method:The study included 32 patients(25 women,7 men,mean age 57.8± 12.1 years),who underwent blepharochalasis operation between 1/2005 and 5/2005.In 17 patients(group 1)the operation was done for cosmetic reasons,in 15 patients we found a medical indication(group 2).We evaluated the subjective discomfort from the lid problems as well as the satisfaction with the operation in general and pre-or postoperative recognition of dry eye problems(all done by scales).Additionally we measured tear secretion by Schirmer’ s test and break-up time before and after operation.Results:The subjective recognition of a dry eye was stronger in group 1 than in group 2 before and after operation(p < 0.005),but objective data were nearly identically(BUT,Schirmer’ s test).Conclusion:When operated due to cosmetic reasons the stronger recognition of sicca problems(while objectively lacking)is may be caused by a stronger fixation on the lid disease itself.It seems necessary to document objective data for that reason.展开更多
文摘目的:探讨重组牛碱性成纤维细胞生长因子(rb-bFGF)滴眼液与羟糖苷滴眼液对年龄相关性白内障患者术后泪膜稳定性及干眼症状的影响。方法:以我院2015-01/2016-10收治的年龄相关性白内障术后患者80例80眼为研究对象,采用随机数字表法将患者均分为对照组及试验组各40例40眼,两组分别实施羟糖苷滴眼液及rb-bFGF滴眼液治疗,观察治疗后两组临床疗效、炎症相关因子[白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)]、泪液分泌试验(S I t)、泪膜破裂时间(BUT)、角膜荧光素钠染色(FL)、眼部干眼症状评分。结果:治疗后试验组总有效率90.0%,较对照组72.5%显著高,差异有统计学意义(χ~2=4.021,P<0.05);治疗前两组IL-6、TNF-α、S I t、BUT、FL评分、眼部干眼症状评分比较无明显差异(P>0.05);治疗后两组IL-6、TNF-α、S I t、FL评分、眼部干眼症状评分较治疗前明显降低,BUT明显升高(P<0.05),且治疗后试验组的各项指标变化较对照组明显,差异有统计学意义(P<0.05)。结论:在年龄相关性白内障术后患者治疗中,rb-bFGF滴眼液在调节患者炎症因子表达。
文摘Background:This study was designed to examine if patients undergoing the same operative procedure(blepharochalasis operation)have different subjective recognition of dry eye problems depending n whether they had he operation for cosmetic or medical reasons.Patients and Method:The study included 32 patients(25 women,7 men,mean age 57.8± 12.1 years),who underwent blepharochalasis operation between 1/2005 and 5/2005.In 17 patients(group 1)the operation was done for cosmetic reasons,in 15 patients we found a medical indication(group 2).We evaluated the subjective discomfort from the lid problems as well as the satisfaction with the operation in general and pre-or postoperative recognition of dry eye problems(all done by scales).Additionally we measured tear secretion by Schirmer’ s test and break-up time before and after operation.Results:The subjective recognition of a dry eye was stronger in group 1 than in group 2 before and after operation(p < 0.005),but objective data were nearly identically(BUT,Schirmer’ s test).Conclusion:When operated due to cosmetic reasons the stronger recognition of sicca problems(while objectively lacking)is may be caused by a stronger fixation on the lid disease itself.It seems necessary to document objective data for that reason.
