目的分析自体外周血造血干细胞支持下高剂量化疗对于晚期乳腺癌化疗前后生活质量影响,为选择有效改善患者生活质量的干预措施提供依据。方法回顾性分析25例病例组行自体外周血造血干细胞支持下高剂量化疗的晚期乳腺癌患者临床资料,同期...目的分析自体外周血造血干细胞支持下高剂量化疗对于晚期乳腺癌化疗前后生活质量影响,为选择有效改善患者生活质量的干预措施提供依据。方法回顾性分析25例病例组行自体外周血造血干细胞支持下高剂量化疗的晚期乳腺癌患者临床资料,同期选取接受常规方案化疗的22例晚期乳腺癌患者为对照组。采用简明健康状况调查量表SF-36(MOS36-item short forum health survey)的缩减版本SF-12量表作为问卷调查表。在第1个时间点(T1)为治疗前,第2个时间点(T2)为第2周期高剂量化疗前和第4周期常规治疗前,第3个时间点(T3)为高剂量化疗结束3月随访时和常规剂量化疗结束后3月进行调查随访。采用t检验进行统计分析。结果高剂量化疗组和常规剂量组患者生活质量8个维度评分T2较T1均显著下降(P<0.05),T3较T1两组患者活力和社会功能维度仍显著下降(P<0.05),其他维度差异无统计学意义。T2时间点高剂量化疗组较常规剂量化疗组总体健康、生理功能、活力和社会功能维度显著下降(P<0.05),T1和T3时间点高剂量化疗组和常规剂量组差异无统计学意义。结论自体外周血造血干细胞支持下高剂量化疗导致乳腺癌患者总体健康、生理功能、活力和社会功能显著下降,但患者高剂量化疗缩短了治疗时间,使患者可更快的恢复正常生活。展开更多
OBJECTIVE To observe the dose and the complicationsfrom total body irradiation before hematopoietic stem celltransplantation.METHODS This study involved 312 patients with total bodyirradiation before hematopoietic ste...OBJECTIVE To observe the dose and the complicationsfrom total body irradiation before hematopoietic stem celltransplantation.METHODS This study involved 312 patients with total bodyirradiation before hematopoietic stem cell transplantation. Theywere entered into the treated research from May 1999 to October2005. All patients had received the irradiation from ^(60)Co of anabsorbed dose rate of (5.2 ± 1.13) cGy/min. The total dose of TBIwas 7～12 Gy, 1 f/d × 2 d. A high-dose rate group (≥10 Gy) included139 cases and a low-dose rate group (< 10 Gy) included 173 cases.RESULTS The probability of acute gastrointestinal reactionsin the high-dose rate group was more compared with that in thelow-dose rate group. The differences for other reactions, such ashematopoietic reconstitution and graft survival rate, between thetwo groups were insignificant.CONCLUSION Using fractional total body irradiation at a doserate of 5 cGy/min, with a total dose of 7～12 Gy, 1 f/d × 2 d , withthe lung receiving under 7.5 Gy is a safe and effective pretreatmentfor hematopoietic stem cell transplantation.展开更多
文摘目的分析自体外周血造血干细胞支持下高剂量化疗对于晚期乳腺癌化疗前后生活质量影响,为选择有效改善患者生活质量的干预措施提供依据。方法回顾性分析25例病例组行自体外周血造血干细胞支持下高剂量化疗的晚期乳腺癌患者临床资料,同期选取接受常规方案化疗的22例晚期乳腺癌患者为对照组。采用简明健康状况调查量表SF-36(MOS36-item short forum health survey)的缩减版本SF-12量表作为问卷调查表。在第1个时间点(T1)为治疗前,第2个时间点(T2)为第2周期高剂量化疗前和第4周期常规治疗前,第3个时间点(T3)为高剂量化疗结束3月随访时和常规剂量化疗结束后3月进行调查随访。采用t检验进行统计分析。结果高剂量化疗组和常规剂量组患者生活质量8个维度评分T2较T1均显著下降(P<0.05),T3较T1两组患者活力和社会功能维度仍显著下降(P<0.05),其他维度差异无统计学意义。T2时间点高剂量化疗组较常规剂量化疗组总体健康、生理功能、活力和社会功能维度显著下降(P<0.05),T1和T3时间点高剂量化疗组和常规剂量组差异无统计学意义。结论自体外周血造血干细胞支持下高剂量化疗导致乳腺癌患者总体健康、生理功能、活力和社会功能显著下降,但患者高剂量化疗缩短了治疗时间,使患者可更快的恢复正常生活。
文摘OBJECTIVE To observe the dose and the complicationsfrom total body irradiation before hematopoietic stem celltransplantation.METHODS This study involved 312 patients with total bodyirradiation before hematopoietic stem cell transplantation. Theywere entered into the treated research from May 1999 to October2005. All patients had received the irradiation from ^(60)Co of anabsorbed dose rate of (5.2 ± 1.13) cGy/min. The total dose of TBIwas 7～12 Gy, 1 f/d × 2 d. A high-dose rate group (≥10 Gy) included139 cases and a low-dose rate group (< 10 Gy) included 173 cases.RESULTS The probability of acute gastrointestinal reactionsin the high-dose rate group was more compared with that in thelow-dose rate group. The differences for other reactions, such ashematopoietic reconstitution and graft survival rate, between thetwo groups were insignificant.CONCLUSION Using fractional total body irradiation at a doserate of 5 cGy/min, with a total dose of 7～12 Gy, 1 f/d × 2 d , withthe lung receiving under 7.5 Gy is a safe and effective pretreatmentfor hematopoietic stem cell transplantation.
