合理使用抗生素干预中应用循证药学理念的效果观察

目的探讨合理使用抗生素干预中使用循证药学理念的应用效果。方法我院于2015年下半年开始在合理使用抗生素干预中落实循证药学理念,选择2015年1~6月在本院采用抗生素治疗的65例住院患者作为观察组,另选择2016年同期本院收治的同类型患者65例作为对照组,观察两组患者使用抗生素的合理性,并监测两组患者治疗效果及用药安全性情况。结果观察组用药不合理占比(0)显著少于对照组(9.23%),组间差异P<0.05。观察组总有效率(95.38%)显著高于(84.62%),组间差异P<0.05。观察组不良反应发生率(10.77%)显著高于对照组(16,92%),组间差异P<0.05。结论循证药学理念用于合理使用抗生素干预中可有效提升用药合理性,同时有助于提高临床疗效,并降低抗生素不良反应风险,值得临床推广使用。

3种Ⅰ类切口手术预防用抗菌药物干预前后的效果分析

目的探讨干预前后3种Ⅰ类切口手术围手术期预防抗菌药物的合理使用与干预措施实施的效果。方法抽取干预前、后3种Ⅰ类切口清洁手术出院病历分别为干预前组和干预后组,各120例,进行干预前后预防用抗菌药物合理性进行对照研究。结果干预前组抗菌药物预防使用率为98.33%,干预后组抗菌药物预防使用率为23.33%(P<0.01);抗菌药物预防使用率显著下降,不合理使用抗菌药物现象明显得到改善。结论实施干预措施有效监管效果明显,可显著提高临床抗菌药物的合理使用率,降低医疗费用,为抗菌药物合理使用提供依据。

Impact of pharmaceutical intervention on the rational use of antibiotics in primary hospital

Evidence based pharmaceutical interventions focusing on the characteristics of antibiotics use in primary hospitals were investigated to optimize the use of antibiotics. Four pharmaceutical interventions were set up in this study： 1） different levels of antibiotic management system were developed; 2） usage of antibiotics was reported in a monthly journal for the entire hospital; 3） early antibiotics warning system was started; 4） communication between pharmacists and physicians was strengthened. Use of antibiotics in 2007 （before intervention） and 2008 （after intervention） in department of respiratory medicine was analyzed. Significant differences （P〈0.01） in antibiotics use before and after intervention were observed. Use of antibiotics was changed from focusing on one category of drugs to a rotation of a wide range of agents. Evidence based, sound pharmaceutical interventions were effective means to ensure the rational use of antibiotics.