Objective:To improve the diagnosis and therapeutic effect of occurrence and development of hyponatremia and disorder of acid-base balance among patients with hepatic encephalopathy(HE) by elucidating the regularity an...Objective:To improve the diagnosis and therapeutic effect of occurrence and development of hyponatremia and disorder of acid-base balance among patients with hepatic encephalopathy(HE) by elucidating the regularity and mechanism,as well as its influence on prognosis.Methods:327 HE patients admitted to our hospital from January 1990 to June 2010 were enrolled.Meanwhile 316 patients hospitalized in the medical department of the same hospital were chosen as the control group.Patients in both groups were given the same methods to measure arterial blood gas parameters(pH value,PaCO2,[HCO3-],TCO2,BE and SaO2),blood biochemistry([Na+],[K+],[Cl-]),liver function,kidney function and blood glucose,serum sodium,and thereupon tocalculate the anion gap(AG) and the potential [HCO3-],and acid-base balance disorder.Results:Among the 327 HE patients,hyponatremia was found in 188 cases(57.4%),of whom 132 patients died(70.2%).While among the 316 patients in control group,68 presented with hyponatremia(21.5%),and 19 died(27.9%).The incidence and mortality were significantly different between the two groups(P<0.001).All the 327 patients presented with different degrees of acid-base balance disorder and 178 died(54.4%),in whom 164(50.2%) belonged to simple acid-base balance disorder and 74(45.1%) died,136(41.6%) were dual acid-base balance disorder and 80(58.8%) died,27(8.2%) were triple acid-base disturbance and 24(88.9%) died.Whereas in the control group only 83 patients(26.2%) were recognized as simple and dual acid-base balance disorder,and 18(21.7%) died.There was higher incidence of acid-base balance disorder and mortality rate in HE group than control one(P<0.001).Conclusion:Hyponatremia is valuable to judge HE patients' prognosis.The key parameters in the judgment and evaluation on acid-base balance disorder among HE patients are the change of pH values and serum electrolyte values.When pH value ≤ 7.30 or > 7.55,it generally suggests a poor prognosis.展开更多
MGAC (Motion Geometric Active Contours), a new variational framework of geometric active contours to track multiple nonrigid moving objects in the clutter background in image sequences is presented. This framework, in...MGAC (Motion Geometric Active Contours), a new variational framework of geometric active contours to track multiple nonrigid moving objects in the clutter background in image sequences is presented. This framework, incorporating with the motion edge information, consists of motion detection and tracking stages. At the motion detection stage, the motion edge map provides an approximate edge map of the moving objects. Then, a tracking stage, merely using the static edge information, is considered to improve the motion detection result. Force field regularization method is used to extend the capture range of the edge attraction force field in both stages. Experiments demonstrate that the proposed framework is valid for tracking multiple nonrigid objects in the clutter background.展开更多
The maintaining overheads of Distributed Hash Table (DHT) topology have recently received considerable attention. This paper presents a novel SHT (Session Heterogeneity Topology) model, in which DHT is reconstructed w...The maintaining overheads of Distributed Hash Table (DHT) topology have recently received considerable attention. This paper presents a novel SHT (Session Heterogeneity Topology) model, in which DHT is reconstructed with session hetero- geneity. SHT clusters nodes by means of session heterogeneity among nodes and selects the stable nodes as the participants of DHT. With an evolving process, this model gradually makes DHT stable and reliable. Therefore the high maintaining overheads for DHT are effectively controlled. Simulation with real traces of session distribution showed that the maintaining overheads are reduced dramatically and that the data availability is greatly improved.展开更多
On March 16–17, 2008, a sea fog occurred in Dianbai in the west of Guangdong Province and was accompanied by a high-pressure synoptic system. Using comprehensive observation datasets, this study analyzes the evolutio...On March 16–17, 2008, a sea fog occurred in Dianbai in the west of Guangdong Province and was accompanied by a high-pressure synoptic system. Using comprehensive observation datasets, this study analyzes the evolution of liquid water content during this sea fog and investigates the relationships between liquid water content and the average diameters and count densities of fog droplets, air temperature, wind speed and turbulence exchanges. The main results are presented as follows. (1) The sea fog showed a quasi-periodic oscillation characteristic, i.e., it developed, disappeared and then developed again. (2) During the sea fog, the number of fog droplets changed significantly while the changes in average diameter of the fog droplets were relatively small. The development and disappearance of the sea fog correlated significantly with the fog droplet numbers. (3) The air-cooling mechanism played a significant role in sea fog formation and development. However, the influences of this mechanism were not evident during fog persistence. (4) During sea fog formation, weak turbulence exchanges were helpful for fog formation. During sea fog development and persistence, liquid water content increased when turbulence exchanges weakened, and vice versa. The changes in turbulence exchanges were closely related to the quasi-periodic oscillations observed in sea fog presence.展开更多
A common problem in rabbit production is the occurrence of digestive disorders just after weaning, and fiber is well known to be bcncficiai for rabbit gastrointestinal health. In order to test the hypothesis that w...A common problem in rabbit production is the occurrence of digestive disorders just after weaning, and fiber is well known to be bcncficiai for rabbit gastrointestinal health. In order to test the hypothesis that whether the good points of fiber increases with its dietary content, three isoenergetic and isonitrogenous diets and ninety mixed-sex New Zealand rabbits weaned 35-d-old were used. The results can be concluded as following： （1） Average daily feed intake （ADFI） tended to increase （i〉=0.058） while average daily gain （ADG） （p=0.001） and feed conversion ratio （FCR） （p〈0.001） deteriorated with increasing dietary ADF content. The highest morbidity was observed in the rabbits fed the highest dietary ADF concentration. （2）A decreasing coefficient of total tract apparent digestibility （CTTAD） of dry matter （DM） and crude protein （CP） was obtained with the increase of dietary fiber level （p〈0.001 and =0.003）. （3） A significant negative effect of treatments on sucrase and maltase activities in the jejunum was observed （p=0.001 and 0.003）. （4） The volatile fatty acid （VFA） concentration （p=0.011） and butyric acid （% total VFA） （P=0.001） dropped while the NH3-N concentration （P〈0.001）, pH （P=0.004） and acetic acid （% total VFA） （P〈0.001） increased with increasing dietary ADF. It was concluded that high fiber level was unfavorable to the rabbits in the first two weeks after weaning.展开更多
DNA methylation is one of the most signaficant epigenetic events which greatly influence gene activation, gene imprinting, chromatin stability, and so on. The level of methylation in genome and certain regions should ...DNA methylation is one of the most signaficant epigenetic events which greatly influence gene activation, gene imprinting, chromatin stability, and so on. The level of methylation in genome and certain regions should be in a normal range, because any variation would cause physiological dysfunction. In account of essential roles of DNA methylation in the living system, the detection of methylation in both overall genome and specific positions has drawn great interest. So far many biological and chemical methods have been developed to detect DNA methylation. Herein, we summerize some novel methods mainly based on chemical modification and analytic methods in DNA detection.展开更多
文摘Objective:To improve the diagnosis and therapeutic effect of occurrence and development of hyponatremia and disorder of acid-base balance among patients with hepatic encephalopathy(HE) by elucidating the regularity and mechanism,as well as its influence on prognosis.Methods:327 HE patients admitted to our hospital from January 1990 to June 2010 were enrolled.Meanwhile 316 patients hospitalized in the medical department of the same hospital were chosen as the control group.Patients in both groups were given the same methods to measure arterial blood gas parameters(pH value,PaCO2,[HCO3-],TCO2,BE and SaO2),blood biochemistry([Na+],[K+],[Cl-]),liver function,kidney function and blood glucose,serum sodium,and thereupon tocalculate the anion gap(AG) and the potential [HCO3-],and acid-base balance disorder.Results:Among the 327 HE patients,hyponatremia was found in 188 cases(57.4%),of whom 132 patients died(70.2%).While among the 316 patients in control group,68 presented with hyponatremia(21.5%),and 19 died(27.9%).The incidence and mortality were significantly different between the two groups(P<0.001).All the 327 patients presented with different degrees of acid-base balance disorder and 178 died(54.4%),in whom 164(50.2%) belonged to simple acid-base balance disorder and 74(45.1%) died,136(41.6%) were dual acid-base balance disorder and 80(58.8%) died,27(8.2%) were triple acid-base disturbance and 24(88.9%) died.Whereas in the control group only 83 patients(26.2%) were recognized as simple and dual acid-base balance disorder,and 18(21.7%) died.There was higher incidence of acid-base balance disorder and mortality rate in HE group than control one(P<0.001).Conclusion:Hyponatremia is valuable to judge HE patients' prognosis.The key parameters in the judgment and evaluation on acid-base balance disorder among HE patients are the change of pH values and serum electrolyte values.When pH value ≤ 7.30 or > 7.55,it generally suggests a poor prognosis.
文摘MGAC (Motion Geometric Active Contours), a new variational framework of geometric active contours to track multiple nonrigid moving objects in the clutter background in image sequences is presented. This framework, incorporating with the motion edge information, consists of motion detection and tracking stages. At the motion detection stage, the motion edge map provides an approximate edge map of the moving objects. Then, a tracking stage, merely using the static edge information, is considered to improve the motion detection result. Force field regularization method is used to extend the capture range of the edge attraction force field in both stages. Experiments demonstrate that the proposed framework is valid for tracking multiple nonrigid objects in the clutter background.
基金Projects supported by the Science & Technology Committee of Shanghai Municipality Key Technologies R & D Project (No.03dz15027) and the Science & Technology Committee of ShanghaiMunicipality Key Project (No. 025115032), China
文摘The maintaining overheads of Distributed Hash Table (DHT) topology have recently received considerable attention. This paper presents a novel SHT (Session Heterogeneity Topology) model, in which DHT is reconstructed with session hetero- geneity. SHT clusters nodes by means of session heterogeneity among nodes and selects the stable nodes as the participants of DHT. With an evolving process, this model gradually makes DHT stable and reliable. Therefore the high maintaining overheads for DHT are effectively controlled. Simulation with real traces of session distribution showed that the maintaining overheads are reduced dramatically and that the data availability is greatly improved.
基金Natural Science Foundation of China (40675013)Foundation project of Nanjing University of Information Science & TechnologyProject on natural science for universities and colleges in Jiangsu province
文摘On March 16–17, 2008, a sea fog occurred in Dianbai in the west of Guangdong Province and was accompanied by a high-pressure synoptic system. Using comprehensive observation datasets, this study analyzes the evolution of liquid water content during this sea fog and investigates the relationships between liquid water content and the average diameters and count densities of fog droplets, air temperature, wind speed and turbulence exchanges. The main results are presented as follows. (1) The sea fog showed a quasi-periodic oscillation characteristic, i.e., it developed, disappeared and then developed again. (2) During the sea fog, the number of fog droplets changed significantly while the changes in average diameter of the fog droplets were relatively small. The development and disappearance of the sea fog correlated significantly with the fog droplet numbers. (3) The air-cooling mechanism played a significant role in sea fog formation and development. However, the influences of this mechanism were not evident during fog persistence. (4) During sea fog formation, weak turbulence exchanges were helpful for fog formation. During sea fog development and persistence, liquid water content increased when turbulence exchanges weakened, and vice versa. The changes in turbulence exchanges were closely related to the quasi-periodic oscillations observed in sea fog presence.
文摘A common problem in rabbit production is the occurrence of digestive disorders just after weaning, and fiber is well known to be bcncficiai for rabbit gastrointestinal health. In order to test the hypothesis that whether the good points of fiber increases with its dietary content, three isoenergetic and isonitrogenous diets and ninety mixed-sex New Zealand rabbits weaned 35-d-old were used. The results can be concluded as following： （1） Average daily feed intake （ADFI） tended to increase （i〉=0.058） while average daily gain （ADG） （p=0.001） and feed conversion ratio （FCR） （p〈0.001） deteriorated with increasing dietary ADF content. The highest morbidity was observed in the rabbits fed the highest dietary ADF concentration. （2）A decreasing coefficient of total tract apparent digestibility （CTTAD） of dry matter （DM） and crude protein （CP） was obtained with the increase of dietary fiber level （p〈0.001 and =0.003）. （3） A significant negative effect of treatments on sucrase and maltase activities in the jejunum was observed （p=0.001 and 0.003）. （4） The volatile fatty acid （VFA） concentration （p=0.011） and butyric acid （% total VFA） （P=0.001） dropped while the NH3-N concentration （P〈0.001）, pH （P=0.004） and acetic acid （% total VFA） （P〈0.001） increased with increasing dietary ADF. It was concluded that high fiber level was unfavorable to the rabbits in the first two weeks after weaning.
基金the National Natural Science Foundation of China (90813031, 30973605, 21072155 & 20802055)National Key Foundation for Infectious Diseases (Protection and treatment of AIDs, virus hepatitis, 2008ZX10003-005)+1 种基金Open funding of the State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, the Chinese Academy of Sciences, the Fundamental Research Funds for the Central Universitiesthe 111 Project
文摘DNA methylation is one of the most signaficant epigenetic events which greatly influence gene activation, gene imprinting, chromatin stability, and so on. The level of methylation in genome and certain regions should be in a normal range, because any variation would cause physiological dysfunction. In account of essential roles of DNA methylation in the living system, the detection of methylation in both overall genome and specific positions has drawn great interest. So far many biological and chemical methods have been developed to detect DNA methylation. Herein, we summerize some novel methods mainly based on chemical modification and analytic methods in DNA detection.
