In this paper, we propose a Packet Cache-Forward(PCF) method based on improved Bayesian outlier detection to eliminate out-of-order packets caused by transmission path drastically degradation during handover events in...In this paper, we propose a Packet Cache-Forward(PCF) method based on improved Bayesian outlier detection to eliminate out-of-order packets caused by transmission path drastically degradation during handover events in the moving satellite networks, for improving the performance of TCP. The proposed method uses an access node satellite to cache all received packets in a short time when handover occurs and forward them out in order. To calculate the cache time accurately, this paper establishes the Bayesian based mixture model for detecting delay outliers of the entire handover scheme. In view of the outliers' misjudgment, an updated classification threshold and the sliding window has been suggested to correct category collections and model parameters for the purpose of quickly identifying exact compensation delay in the varied network load statuses. Simulation shows that, comparing to average processing delay detection method, the average accuracy rate was scaled up by about 4.0%, and there is about 5.5% cut in error rate in the meantime. It also behaves well even though testing with big dataset. Benefiting from the advantage of the proposed scheme in terms of performance, comparing to conventional independent handover and network controlled synchronizedhandover in simulated LEO satellite networks, the proposed independent handover with PCF eliminates packet out-of-order issue to get better improvement on congestion window. Eventually the average delay decreases more than 70% and TCP performance has improved more than 300%.展开更多
Objective： The prognosis of patients with nasopharyngeal carcinoma （NPC） depends on the stage of the disease at diagnosis. Unfortunately, at diagnosis, most of patients have locally advanced, non-metastatic stage I...Objective： The prognosis of patients with nasopharyngeal carcinoma （NPC） depends on the stage of the disease at diagnosis. Unfortunately, at diagnosis, most of patients have locally advanced, non-metastatic stage III or IVa disease. The study was to evaluate the efficacy and toxicities of cisplatin plus 5-fluorouracil combined with concurrent radiotherapy for locally advanced nasopharyngeal carcinoma. Methods： Sixty-six patients with locally advanced nasopharyngeal carcinoma received chemotherapy of cisplatin plus 5-fluorouracil jointing concurrent radiotherapy; concurrent radiotherapy started on day 1 in the first cycle of chemotherapy of PF, 5-fluorouraci1500 mg/m^2 intravenous infusion on days 1-5, cisplatin 80 mg/m2 intravenous infusion on days 1-3, 21 days for a cycle, a total of three cycles; nasopharyngeal lesions and positive lymph node were given a total amount of 70 Gy, prophylactic neck radiation were given the amount of 50 Gy, radiotherapy five times a week, Gy/f. Results： All patients who can be evaluated, the response rate （RR） was 100%; 1-, 3- and 5-year overall survival （OS） were 100%, 86.4%, 21.2%, respectively; 3-year, 5-year disease-free survival （DFS） were 72.7% and 18.2%, respective- ly; the average survival time and median survival time were 49.0 months and 48.5 months, respectively; the average survival time and median survival time of DFS were 46.1 months and 46.5 months, respectively. Conclusion： For patients with locally advanced nasopharyngeal carcinoma, who accepted RT combining concurrent chemotherapy of cisplatin plus 5-fluorouracil, clinical efficacy is satisfaction and toxicities could be tolerated.展开更多
基金supported by National High Technology Research and Development Program of China(863 Program,No.2014AA7011005)National Nature Science Foundation of China(No.91438120)
文摘In this paper, we propose a Packet Cache-Forward(PCF) method based on improved Bayesian outlier detection to eliminate out-of-order packets caused by transmission path drastically degradation during handover events in the moving satellite networks, for improving the performance of TCP. The proposed method uses an access node satellite to cache all received packets in a short time when handover occurs and forward them out in order. To calculate the cache time accurately, this paper establishes the Bayesian based mixture model for detecting delay outliers of the entire handover scheme. In view of the outliers' misjudgment, an updated classification threshold and the sliding window has been suggested to correct category collections and model parameters for the purpose of quickly identifying exact compensation delay in the varied network load statuses. Simulation shows that, comparing to average processing delay detection method, the average accuracy rate was scaled up by about 4.0%, and there is about 5.5% cut in error rate in the meantime. It also behaves well even though testing with big dataset. Benefiting from the advantage of the proposed scheme in terms of performance, comparing to conventional independent handover and network controlled synchronizedhandover in simulated LEO satellite networks, the proposed independent handover with PCF eliminates packet out-of-order issue to get better improvement on congestion window. Eventually the average delay decreases more than 70% and TCP performance has improved more than 300%.
文摘Objective： The prognosis of patients with nasopharyngeal carcinoma （NPC） depends on the stage of the disease at diagnosis. Unfortunately, at diagnosis, most of patients have locally advanced, non-metastatic stage III or IVa disease. The study was to evaluate the efficacy and toxicities of cisplatin plus 5-fluorouracil combined with concurrent radiotherapy for locally advanced nasopharyngeal carcinoma. Methods： Sixty-six patients with locally advanced nasopharyngeal carcinoma received chemotherapy of cisplatin plus 5-fluorouracil jointing concurrent radiotherapy; concurrent radiotherapy started on day 1 in the first cycle of chemotherapy of PF, 5-fluorouraci1500 mg/m^2 intravenous infusion on days 1-5, cisplatin 80 mg/m2 intravenous infusion on days 1-3, 21 days for a cycle, a total of three cycles; nasopharyngeal lesions and positive lymph node were given a total amount of 70 Gy, prophylactic neck radiation were given the amount of 50 Gy, radiotherapy five times a week, Gy/f. Results： All patients who can be evaluated, the response rate （RR） was 100%; 1-, 3- and 5-year overall survival （OS） were 100%, 86.4%, 21.2%, respectively; 3-year, 5-year disease-free survival （DFS） were 72.7% and 18.2%, respective- ly; the average survival time and median survival time were 49.0 months and 48.5 months, respectively; the average survival time and median survival time of DFS were 46.1 months and 46.5 months, respectively. Conclusion： For patients with locally advanced nasopharyngeal carcinoma, who accepted RT combining concurrent chemotherapy of cisplatin plus 5-fluorouracil, clinical efficacy is satisfaction and toxicities could be tolerated.
