Objective To investigate whether glomerular density （GD） could be an independent prognostic factor for patients of IgA nephropathy with estimated glomerular filtration rate （eGFR） of 30 to 60 ml/min per 1.73 m2, ...Objective To investigate whether glomerular density （GD） could be an independent prognostic factor for patients of IgA nephropathy with estimated glomerular filtration rate （eGFR） of 30 to 60 ml/min per 1.73 m2, or for patients with time-average proteinuria 〈 0.5 g/d. Methods A total of 173 patients with biopsy-confirmed IgA nephropathy diagnosed from January 2000 to December 2010 were included. All of these patients were followed up for more than 5 years. The endpoint was a 〉 30% of decline in eGFR from baseline after 5-year follow-up. The optimal cut-off value of GD was calculated by ROC curve. Kaplan-Meier method and Cox regression analysis was used for survival analysis. Results A 30% of decline in eGFR occurred in 14.5% of all patients. The optimal diagnostic cut-off value of GD was 1.99/mm2 （AUC = 0.90, sensitivity = 84.0%, specificity = 81.8%） determined by ROC curve. The low GD group （GD 〈 1.99 per mm2） experienced a significant increase in renal endpoint for patients with eGFR of 30 to 60 ml/min per 1.73 m2 （six patients in lower GD group, while one patient in the other group）. For patients with time-average proteinuria 〈 0.5 g/d, the lower GD group showed a higher eGFR decline from baseline （4.5±16.7 ml/min per 1.73 m2 vs. –8.1±21.4 ml/min per 1.73 m2, P = 0.038）; two patients in this group reached the endpoint, while no patients in the higher GD group did. Conclusion GD could be an independent prognostic factor for patients of IgA nephropathy with eGFR at 30 to 60 ml/min per 1.73 m2 of body surface, particularly for those with time-averaged amount of urine protein less than 0.5 g per day.展开更多
In this paper, the preliminary data from University of Michigan Radio Astronomy Observatory database （UMRAO） are used to discuss the radio spectral index properties of 8 BL Lacs. To do so, we calculated the radio sp...In this paper, the preliminary data from University of Michigan Radio Astronomy Observatory database （UMRAO） are used to discuss the radio spectral index properties of 8 BL Lacs. To do so, we calculated the radio spectral index, a （F oc va）, which was obtained by fitting the averaged flux densities in the bands （4.8 GHZ, 8 GHz, and 14.5 GHz） by binning the original for 7 d. We also calculated the time delay between the averaged lightcurves and the spectral variance. Our calculations and analysis give the following results. 1） The averaged logarithmic flux density at 8 GHz （logF） and the corresponding spectral index （or） have strong correlation for all the BL Lacs; 2） the lightcurves and the spectral variability have the similar profile for all the BL Lacs; 3） the lightcurves delay spectral variability for all sources but PKS 0735＋178, with the delay time ranging from 31 d to 125 d.展开更多
基金Supported by the Key Projects in the National Science and Technology Pillar Program During the Twelfth Five-year Plan Period(2011BAI10B03)
文摘Objective To investigate whether glomerular density （GD） could be an independent prognostic factor for patients of IgA nephropathy with estimated glomerular filtration rate （eGFR） of 30 to 60 ml/min per 1.73 m2, or for patients with time-average proteinuria 〈 0.5 g/d. Methods A total of 173 patients with biopsy-confirmed IgA nephropathy diagnosed from January 2000 to December 2010 were included. All of these patients were followed up for more than 5 years. The endpoint was a 〉 30% of decline in eGFR from baseline after 5-year follow-up. The optimal cut-off value of GD was calculated by ROC curve. Kaplan-Meier method and Cox regression analysis was used for survival analysis. Results A 30% of decline in eGFR occurred in 14.5% of all patients. The optimal diagnostic cut-off value of GD was 1.99/mm2 （AUC = 0.90, sensitivity = 84.0%, specificity = 81.8%） determined by ROC curve. The low GD group （GD 〈 1.99 per mm2） experienced a significant increase in renal endpoint for patients with eGFR of 30 to 60 ml/min per 1.73 m2 （six patients in lower GD group, while one patient in the other group）. For patients with time-average proteinuria 〈 0.5 g/d, the lower GD group showed a higher eGFR decline from baseline （4.5±16.7 ml/min per 1.73 m2 vs. –8.1±21.4 ml/min per 1.73 m2, P = 0.038）; two patients in this group reached the endpoint, while no patients in the higher GD group did. Conclusion GD could be an independent prognostic factor for patients of IgA nephropathy with eGFR at 30 to 60 ml/min per 1.73 m2 of body surface, particularly for those with time-averaged amount of urine protein less than 0.5 g per day.
基金supported by the National Natural Science Foundation of China (Grant Nos.10633010 and 11173009)the Bureau of Education of Guangzhou Municipality (Grant No.11 Sui-Jiao-Ke[2009])+3 种基金Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme(GDUPS)(2009)Yangcheng Scholar Funded Scheme(Grant No.10A027S)the Joint Laboratory for Optical Astronomy of Chinese Academy of Sciencessupported by the University of Michigan and the National Science Foundation
文摘In this paper, the preliminary data from University of Michigan Radio Astronomy Observatory database （UMRAO） are used to discuss the radio spectral index properties of 8 BL Lacs. To do so, we calculated the radio spectral index, a （F oc va）, which was obtained by fitting the averaged flux densities in the bands （4.8 GHZ, 8 GHz, and 14.5 GHz） by binning the original for 7 d. We also calculated the time delay between the averaged lightcurves and the spectral variance. Our calculations and analysis give the following results. 1） The averaged logarithmic flux density at 8 GHz （logF） and the corresponding spectral index （or） have strong correlation for all the BL Lacs; 2） the lightcurves and the spectral variability have the similar profile for all the BL Lacs; 3） the lightcurves delay spectral variability for all sources but PKS 0735＋178, with the delay time ranging from 31 d to 125 d.
