AIM:To evaluate the therapeutic effects of itopride vs other drugs(placebo,domperidone,mosapride) for functional dyspepsia(FD).METHODS:Randomized controlled trials(RCTs) of itopride for FD were retrieved from database...AIM:To evaluate the therapeutic effects of itopride vs other drugs(placebo,domperidone,mosapride) for functional dyspepsia(FD).METHODS:Randomized controlled trials(RCTs) of itopride for FD were retrieved from databases.Relevant information was extracted and analyzed,using the relative risk(RR) and weighted mean deviation,as appropriate.A random or fixed effect model was used,based on the heterogeneity of the included articles,and visual inspection of funnel plots was used to evaluate publication bias.RESULTS:Nine RCTs enrolling 2620 FD cases were included;1372 cases received itopride treatment and 1248 cases received placebo or other drugs(control groups).Compared with control groups,itopride had superior RR values of 1.11 [95%CI:(1.03,1.19),P = 0.006],1.21 [95%CI:(1.03,1.44),P = 0.02],and1.24 [95%CI:(1.01,1.53),P = 0.04] for global patient assessment,postprandial fullness,and early satiety,respectively.For the Leeds Dyspepsia Questionnaire score,the weighted mean deviation was-1.38 [95%CI:(-1.75,-1.01),P < 0.01].The incidence of adverse effects was similar in the itopride and control groups.The funnel plots for all indicators showed no evidence of publication bias.CONCLUSION:Itopride has good efficacy in terms of global patients assessment,postprandial fullness,and early satiety in the treatment of patients with FD and shows a low rate of adverse reactions.Itopride can greatly improve FD syndromes-score.展开更多
A model that rapidly predicts the density components of raw coal is described.It is based on a threegrade fast float/sink test.The recent comprehensive monthly floating and sinking data are used for comparison.The pre...A model that rapidly predicts the density components of raw coal is described.It is based on a threegrade fast float/sink test.The recent comprehensive monthly floating and sinking data are used for comparison.The predicted data are used to draw washability curves and to provide a rapid evaluation of the effect from heavy medium induced separation.Thirty-one production shifts worth of fast float/sink data and the corresponding quick ash data are used to verify the model.The results show a small error with an arithmetic average of 0.53 and an absolute average error of 1.50.This indicates that this model has high precision.The theoretical yield from the washability curves is 76.47% for the monthly comprehensive data and 81.31% using the model data.This is for a desired cleaned coal ash of 9%.The relative error between these two is 6.33%,which is small and indicates that the predicted data can be used to rapidly evaluate the separation effect of gravity separation equipment.展开更多
基金Supported by The Natural Science Foundation of Zhejiang Province of China,No. LY12H29002Traditional Chinese Medicine Science Foundation of Zhejiang Province of China,No. 2011ZB032
文摘AIM:To evaluate the therapeutic effects of itopride vs other drugs(placebo,domperidone,mosapride) for functional dyspepsia(FD).METHODS:Randomized controlled trials(RCTs) of itopride for FD were retrieved from databases.Relevant information was extracted and analyzed,using the relative risk(RR) and weighted mean deviation,as appropriate.A random or fixed effect model was used,based on the heterogeneity of the included articles,and visual inspection of funnel plots was used to evaluate publication bias.RESULTS:Nine RCTs enrolling 2620 FD cases were included;1372 cases received itopride treatment and 1248 cases received placebo or other drugs(control groups).Compared with control groups,itopride had superior RR values of 1.11 [95%CI:(1.03,1.19),P = 0.006],1.21 [95%CI:(1.03,1.44),P = 0.02],and1.24 [95%CI:(1.01,1.53),P = 0.04] for global patient assessment,postprandial fullness,and early satiety,respectively.For the Leeds Dyspepsia Questionnaire score,the weighted mean deviation was-1.38 [95%CI:(-1.75,-1.01),P < 0.01].The incidence of adverse effects was similar in the itopride and control groups.The funnel plots for all indicators showed no evidence of publication bias.CONCLUSION:Itopride has good efficacy in terms of global patients assessment,postprandial fullness,and early satiety in the treatment of patients with FD and shows a low rate of adverse reactions.Itopride can greatly improve FD syndromes-score.
基金National Natural Science Foundation of China (No. 51174202)Doctoral Fund of Ministry of Education of China (No. 20100095110013)
文摘A model that rapidly predicts the density components of raw coal is described.It is based on a threegrade fast float/sink test.The recent comprehensive monthly floating and sinking data are used for comparison.The predicted data are used to draw washability curves and to provide a rapid evaluation of the effect from heavy medium induced separation.Thirty-one production shifts worth of fast float/sink data and the corresponding quick ash data are used to verify the model.The results show a small error with an arithmetic average of 0.53 and an absolute average error of 1.50.This indicates that this model has high precision.The theoretical yield from the washability curves is 76.47% for the monthly comprehensive data and 81.31% using the model data.This is for a desired cleaned coal ash of 9%.The relative error between these two is 6.33%,which is small and indicates that the predicted data can be used to rapidly evaluate the separation effect of gravity separation equipment.
