目的探讨2型糖尿病合并骨质疏松的危险因素。方法选择2019年9月—2022年9月在厦门医学院附属第二医院内分泌科住院的2型糖尿病患者分为非骨质疏松组和骨质疏松组。对两组的临床资料和实验室数据进行单因素分析。将单因素分析中有统计学...目的探讨2型糖尿病合并骨质疏松的危险因素。方法选择2019年9月—2022年9月在厦门医学院附属第二医院内分泌科住院的2型糖尿病患者分为非骨质疏松组和骨质疏松组。对两组的临床资料和实验室数据进行单因素分析。将单因素分析中有统计学意义以及临床经验考虑相关的影响因素纳入多因素二元Logistic回归模型中进行分析。结果两组的性别、年龄、身体质量指数(body mass index,BMI)、吸烟、高血压、同型半胱氨酸(homocysteine,Hcy)、尿微量白蛋白肌酐比值(urine albumin creatinine ratio,UACR)差异有统计学意义(P<0.05)。二元Logistic回归分析显示,女性、年龄大、吸烟、合并高血压、尿微量白蛋白肌酐比值为2型糖尿病合并骨质疏松的危险因素(OR>1,P<0.05),高BMI为保护因素(OR<1,P<0.05)。结论2型糖尿病合并骨质疏松的危险因素众多,其中女性、年龄大、吸烟、合并高血压、高尿微量白蛋白肌酐比值为危险因素,高BMI为保护因素。展开更多
Bedding structural planes significantly influence the mechanical properties and stability of engineering rock masses.This study conducts uniaxial compression tests on layered sandstone with various bedding angles(0...Bedding structural planes significantly influence the mechanical properties and stability of engineering rock masses.This study conducts uniaxial compression tests on layered sandstone with various bedding angles(0°,15°,30°,45°,60°,75°and 90°)to explore the impact of bedding angle on the deformational mechanical response,failure mode,and damage evolution processes of rocks.It develops a damage model based on the Logistic equation derived from the modulus’s degradation considering the combined effect of the sandstone bedding dip angle and load.This model is employed to study the damage accumulation state and its evolution within the layered rock mass.This research also introduces a piecewise constitutive model that considers the initial compaction characteristics to simulate the whole deformation process of layered sandstone under uniaxial compression.The results revealed that as the bedding angle increases from 0°to 90°,the uniaxial compressive strength and elastic modulus of layered sandstone significantly decrease,slightly increase,and then decline again.The corresponding failure modes transition from splitting tensile failure to slipping shear failure and back to splitting tensile failure.As indicated by the modulus’s degradation,the damage characteristics can be categorized into four stages:initial no damage,damage initiation,damage acceleration,and damage deceleration termination.The theoretical damage model based on the Logistic equation effectively simulates and predicts the entire damage evolution process.Moreover,the theoretical constitutive model curves closely align with the actual stress−strain curves of layered sandstone under uniaxial compression.The introduced constitutive model is concise,with fewer parameters,a straightforward parameter determination process,and a clear physical interpretation.This study offers valuable insights into the theory of layered rock mechanics and holds implications for ensuring the safety of rock engineering.展开更多
文摘目的探讨2型糖尿病合并骨质疏松的危险因素。方法选择2019年9月—2022年9月在厦门医学院附属第二医院内分泌科住院的2型糖尿病患者分为非骨质疏松组和骨质疏松组。对两组的临床资料和实验室数据进行单因素分析。将单因素分析中有统计学意义以及临床经验考虑相关的影响因素纳入多因素二元Logistic回归模型中进行分析。结果两组的性别、年龄、身体质量指数(body mass index,BMI)、吸烟、高血压、同型半胱氨酸(homocysteine,Hcy)、尿微量白蛋白肌酐比值(urine albumin creatinine ratio,UACR)差异有统计学意义(P<0.05)。二元Logistic回归分析显示,女性、年龄大、吸烟、合并高血压、尿微量白蛋白肌酐比值为2型糖尿病合并骨质疏松的危险因素(OR>1,P<0.05),高BMI为保护因素(OR<1,P<0.05)。结论2型糖尿病合并骨质疏松的危险因素众多,其中女性、年龄大、吸烟、合并高血压、高尿微量白蛋白肌酐比值为危险因素,高BMI为保护因素。
基金Projects(52074299,41941018)supported by the National Natural Science Foundation of ChinaProject(2023JCCXSB02)supported by the Fundamental Research Funds for the Central Universities,China。
文摘Bedding structural planes significantly influence the mechanical properties and stability of engineering rock masses.This study conducts uniaxial compression tests on layered sandstone with various bedding angles(0°,15°,30°,45°,60°,75°and 90°)to explore the impact of bedding angle on the deformational mechanical response,failure mode,and damage evolution processes of rocks.It develops a damage model based on the Logistic equation derived from the modulus’s degradation considering the combined effect of the sandstone bedding dip angle and load.This model is employed to study the damage accumulation state and its evolution within the layered rock mass.This research also introduces a piecewise constitutive model that considers the initial compaction characteristics to simulate the whole deformation process of layered sandstone under uniaxial compression.The results revealed that as the bedding angle increases from 0°to 90°,the uniaxial compressive strength and elastic modulus of layered sandstone significantly decrease,slightly increase,and then decline again.The corresponding failure modes transition from splitting tensile failure to slipping shear failure and back to splitting tensile failure.As indicated by the modulus’s degradation,the damage characteristics can be categorized into four stages:initial no damage,damage initiation,damage acceleration,and damage deceleration termination.The theoretical damage model based on the Logistic equation effectively simulates and predicts the entire damage evolution process.Moreover,the theoretical constitutive model curves closely align with the actual stress−strain curves of layered sandstone under uniaxial compression.The introduced constitutive model is concise,with fewer parameters,a straightforward parameter determination process,and a clear physical interpretation.This study offers valuable insights into the theory of layered rock mechanics and holds implications for ensuring the safety of rock engineering.
