We present a novel incremental algorithm for non-slicing floorplans based on the corner block list representation. The horizontal and vertical adjacency graphs are derived from the packing of the initial floorplanning...We present a novel incremental algorithm for non-slicing floorplans based on the corner block list representation. The horizontal and vertical adjacency graphs are derived from the packing of the initial floorplanning results. Based on the critical path and the accumulated slack distances we define,we choose the best position for insertion and do a series of operations incrementally, such as deleting modules, adding modules, and resizing modules quickly. This incremental floorplanning algorithm has a very high speed less than 1μm,which is one of the most important measures in this research. The algorithm preserves the original good performances on area and wire length. It can also supply other tools with good physical estimates for area, wire length, and other performance guidelines.展开更多
Retinoic acid level in the retina/choroid is altered in induced myopia models.All-trans-retinol dehydrogenase(RDH8) is an important enzyme of retinoic acid metabolism.This study aimed to investigate the association of...Retinoic acid level in the retina/choroid is altered in induced myopia models.All-trans-retinol dehydrogenase(RDH8) is an important enzyme of retinoic acid metabolism.This study aimed to investigate the association of the RDH8 gene with high myopia.Three single nucleotide polymorphisms(SNPs) [RDH851(rs2233789) ,RDH8E5a(rs1644731) ,and RDH855b(rs3760753) ]were selected,based on the linkage disequilibrium pattern of RDH8 from a previous study,and genotyped for 160 Han Chinese nuclear families with highly myopic(-10 diopters or worse) offspring as well as in an independent group with 166 highly myopic cases(-10 diopters or worse) and 211 controls. Family-based association analysis was performed using the family-based association test(FBAT) package,and genotype relative risk(GRR) was calculated using the GenAssoc program.Population-based association analysis was performed using Chi-square test.These SNPs were in linkage equilibrium with each other.SNPs RDH851(rs2233789) and RDH8E5a(rs1644731) both did not show association with high myopia.SNP RDH855b(rs3760753) demonstrated significant association(P=0.0269) with a GRR of 0.543(95%confidence interval=0.304-0.968,P=0.038) .The association became statistically insignificant,however,after multiple comparison correction.Haplotype analysis did not show a significant association either.Population-based association analysis also showed no significant association(P>0.05) .Our family-and population-based data both suggest that the RDH8 gene is unlikely to be associated with high myopia in Chinese.展开更多
We study the transport properties of a superconductor-quantum spin Hall insulator-superconductor Josephson junction both in the absence and in the presence of a DC bias voltage. As the system is predicted to host Majo...We study the transport properties of a superconductor-quantum spin Hall insulator-superconductor Josephson junction both in the absence and in the presence of a DC bias voltage. As the system is predicted to host Majorana fermions at its interfaces,the Andreev bond states are supposed to exhibit a distinct 4π periodicity in the superconducting phase difference, namely the fractional Josephson effect. Using the non-equilibrium Green's function method, we calculate the current and the related current noise based on a tight-binding Hamiltonian. Our direct results show that the fractional Josephson effect can not be seen in equilibrium junctions. While in non-equilibrium junctions, this effect can be confirmed by the multiple Andreev reflections induced peaks of the non-equilibrium noise, which appear at discrete frequencies ω = ne V with n being an integer number.展开更多
文摘We present a novel incremental algorithm for non-slicing floorplans based on the corner block list representation. The horizontal and vertical adjacency graphs are derived from the packing of the initial floorplanning results. Based on the critical path and the accumulated slack distances we define,we choose the best position for insertion and do a series of operations incrementally, such as deleting modules, adding modules, and resizing modules quickly. This incremental floorplanning algorithm has a very high speed less than 1μm,which is one of the most important measures in this research. The algorithm preserves the original good performances on area and wire length. It can also supply other tools with good physical estimates for area, wire length, and other performance guidelines.
基金Project supported by the National Natural Science Foundation of China(No.30600693)the Qianjiang Talent Project of Zhejiang Province(No.2010R10068)the Hong Kong Polytechnic University(No.J-BB7P),China
文摘Retinoic acid level in the retina/choroid is altered in induced myopia models.All-trans-retinol dehydrogenase(RDH8) is an important enzyme of retinoic acid metabolism.This study aimed to investigate the association of the RDH8 gene with high myopia.Three single nucleotide polymorphisms(SNPs) [RDH851(rs2233789) ,RDH8E5a(rs1644731) ,and RDH855b(rs3760753) ]were selected,based on the linkage disequilibrium pattern of RDH8 from a previous study,and genotyped for 160 Han Chinese nuclear families with highly myopic(-10 diopters or worse) offspring as well as in an independent group with 166 highly myopic cases(-10 diopters or worse) and 211 controls. Family-based association analysis was performed using the family-based association test(FBAT) package,and genotype relative risk(GRR) was calculated using the GenAssoc program.Population-based association analysis was performed using Chi-square test.These SNPs were in linkage equilibrium with each other.SNPs RDH851(rs2233789) and RDH8E5a(rs1644731) both did not show association with high myopia.SNP RDH855b(rs3760753) demonstrated significant association(P=0.0269) with a GRR of 0.543(95%confidence interval=0.304-0.968,P=0.038) .The association became statistically insignificant,however,after multiple comparison correction.Haplotype analysis did not show a significant association either.Population-based association analysis also showed no significant association(P>0.05) .Our family-and population-based data both suggest that the RDH8 gene is unlikely to be associated with high myopia in Chinese.
基金supported by the National Key Basic Research Program of China(Grant Nos.2015CB921102,and 2014CB920901)the National Key R and D Program of China(Grant No.2017YFA0303301)+2 种基金the National Natural Science Foundation of China(Grants Nos.11574007,11574245,11534001,and 11474085)the Natural Science Foundation of Jiangsu Province(Grant No.BK20160007)the Key Research Program of the Chinese Academy of Sciences(Grant No.XDPB08-4)
文摘We study the transport properties of a superconductor-quantum spin Hall insulator-superconductor Josephson junction both in the absence and in the presence of a DC bias voltage. As the system is predicted to host Majorana fermions at its interfaces,the Andreev bond states are supposed to exhibit a distinct 4π periodicity in the superconducting phase difference, namely the fractional Josephson effect. Using the non-equilibrium Green's function method, we calculate the current and the related current noise based on a tight-binding Hamiltonian. Our direct results show that the fractional Josephson effect can not be seen in equilibrium junctions. While in non-equilibrium junctions, this effect can be confirmed by the multiple Andreev reflections induced peaks of the non-equilibrium noise, which appear at discrete frequencies ω = ne V with n being an integer number.
