为了验证逆康普顿机制的主导过程以及主导过程中软光子的起源,通过文献收集了75个平谱射电类星体(Flat-Spectrum Radio Quasar,FSRQ)多波段的(准)同时数据,并利用对数抛物线函数拟合了频谱能量分布,分析同步峰流量与逆康普顿峰之比和多...为了验证逆康普顿机制的主导过程以及主导过程中软光子的起源,通过文献收集了75个平谱射电类星体(Flat-Spectrum Radio Quasar,FSRQ)多波段的(准)同时数据,并利用对数抛物线函数拟合了频谱能量分布,分析同步峰流量与逆康普顿峰之比和多普勒因子的关系,运用自举法(Bootstrapping)计算了样本的种子因子(Seed Factor,SF)分布,用于调查软光子的起源。分析结果如下:(1)在轻子模型框架下,整个样本与子样本log[U B(νFν)EC/U ext(νFν)syn]和logδ的显著相关性表明,平谱射电类星体的高能辐射优先由外康普顿过程主导。(2)对于相对低同步峰的峰频种群,观测的种子因子分布与理论上尘埃环(Dust Torus,DT)的种子因子范围相交,表明逆康普顿过程中的软光子很可能由尘埃环主导;而对于相对高同步峰的峰频种群,观测的种子因子超过了宽线区(Broad-Line Region,BLR)或尘埃环种子因子的范围,因此无法确定软光子的来源。展开更多
利用支持向量机(Support Vector Machine,SVM)、随机森林(Random Forest,RF)、集成学习(Ensemble Learning,EM)和多层感知机(Multi-Layer Perceptron,MLP)将罗马5期耀变体多波段目录(The 5th edition of the Roma-BZCAT Multifrequency ...利用支持向量机(Support Vector Machine,SVM)、随机森林(Random Forest,RF)、集成学习(Ensemble Learning,EM)和多层感知机(Multi-Layer Perceptron,MLP)将罗马5期耀变体多波段目录(The 5th edition of the Roma-BZCAT Multifrequency Catalogue of Blazars,5BZCAT)中227个不确定类型的耀变体(Blazars of Uncertain type,BZUs)分为蝎虎天体候选体和平谱射电类星体候选体,并通过特征工程和网格搜索方法提高分类准确率。综合4种分类器的分类结果,将判别概率阈值设为0.8,得到33个蝎虎天体候选体和119个平谱射电类星体候选体。展开更多
研究了69个平谱射电类星体(Flat Spectrum Radio Quasars)的近红外射线光度与宽线区光度之间的关系,发现它们之间存在较强的相关性。在排除了红移的影响后,两者的相关性变的非常微弱。这表明平谱射电类星体的近红外辐射与宽线区辐射可...研究了69个平谱射电类星体(Flat Spectrum Radio Quasars)的近红外射线光度与宽线区光度之间的关系,发现它们之间存在较强的相关性。在排除了红移的影响后,两者的相关性变的非常微弱。这表明平谱射电类星体的近红外辐射与宽线区辐射可能具有不同的物理辐射机制。还讨论了近红外光度与中心超大质量黑洞质量之间的相关性。展开更多
Aim To establish a LC-MS method for determining the concentration of nifedipine in human plasma and to evaluate the pharmacokinetic characteristics of nifedipine sustained-release tablets. Methods A XB-C18 （5 μm, 4....Aim To establish a LC-MS method for determining the concentration of nifedipine in human plasma and to evaluate the pharmacokinetic characteristics of nifedipine sustained-release tablets. Methods A XB-C18 （5 μm, 4.6 mm ×150 mm） column and a mobile phase of methanol： 0.01 mol·L^-1ammonium acetate （60：40, V/V） were used to separate nifedipine, the detections was accuracy under atmosperic pressure electronic spray ionization （AP-ESI） mode and ion mass spectrum （m/z） of 314.9 [M＋H]^＋ for nifedipine, and 320.8 [M＋H]^＋ for lorazepam （Internal Standard, IS）. Results The linear range of nifedipine was 0.3 - 80 ng·mL^-1 （ r = 0.9997）, and the limit of quantitation （LOQ） was 0.3 ng·mL^-1. The nifedipine pharmacokinetic parameters after a single dose of 20 mg nifedipine sustained-release tablets test （T） or reference （R） were as the followings, t1/2 （6.73 ± 2.00） h and （7.04 ± 2.18） h, Tmax （4.28 ± 0.70） h and （4.48 ± 0.70） h, Cmax（39.66 ± 10.58） ng·mL^-1 and （40.19 ± 10.97） ng·mL^-1, AUC0-36 （391.63 ± 108.55） ng·mL^-1·h and （387.57 ± 121.51） ng·mL^-1·h, and AUC0-∞ （408.28 ± 121.16） ng·mL^-1·h and （406.15 ± 133.13） ng·mL^-1·h. The relative bioavailability of nifedipine sustained-release tablets （test） was （103.02 ± 13.93） %. Conclusion LC-MS method for the determination of concentrations of nifedipine in human plasma was sensitive and accurate, and could be used in nifedipine bioavailability and pharmacokinetic studies.展开更多
Stress response of a tension leg platform （TLP） in extreme environments was investigated in this paper. A location on one of the gussets was selected as the object point, where directional stresses were numerically ...Stress response of a tension leg platform （TLP） in extreme environments was investigated in this paper. A location on one of the gussets was selected as the object point, where directional stresses were numerically simulated and also experimentally verified by a strain gage. Environmental loading and the platform＇s structural strength were analyzed in accordance with industrial standards, utilizing linear wave theory and the finite element method （FEM）. The fast Fourier transform technique was used to calculate the stress response amplitude operators （RAO） from the records of measurements. A comparison was performed between the stress RAO of the numerical simulation and that of the actual measurements. The results indicated that the stress RAO of the numerical simulation fitted well with measured data at specified wave headings with different periods.展开更多
基金This work is supported by the National 973 project (NKBRSF G19990754)the National Science Fund for Distinguished YoungScholars (10125313)+1 种基金the Fundfor Top Scholars of Guangdong Provience (Q02114)This research has made use of data fromthe University of Michigan Radio Astronomy Observatory which has been supported by the University of Michigan and the National Science Foundation
文摘利用支持向量机(Support Vector Machine,SVM)、随机森林(Random Forest,RF)、集成学习(Ensemble Learning,EM)和多层感知机(Multi-Layer Perceptron,MLP)将罗马5期耀变体多波段目录(The 5th edition of the Roma-BZCAT Multifrequency Catalogue of Blazars,5BZCAT)中227个不确定类型的耀变体(Blazars of Uncertain type,BZUs)分为蝎虎天体候选体和平谱射电类星体候选体,并通过特征工程和网格搜索方法提高分类准确率。综合4种分类器的分类结果,将判别概率阈值设为0.8,得到33个蝎虎天体候选体和119个平谱射电类星体候选体。
基金National Science Foundation of China(11733001,U1531245,11873073,U1431122,U2031112)Natural Science Foundation of Guangdong Province(2017A0303313011,2019B030302001)+2 种基金Astrophysics Key Subjects of Guangdong Province and Guangzhou CityResearch Project of Education and Teaching Reform of Hunan Province in 2018(2018436)Research Fund of Hunan Provincial Department of Education(19C1263)。
文摘收集了一个具有光学和射电偏振的blazar样本,讨论了光学和射电偏振与喷流参数之间的关系.第一,蝎虎天体(BL Lac object,BL Lac)的偏振高于平谱射电源(Flat Spectrum Radio Quasar,FSRQ)的偏振,核主导系数R和比率f都正比于本征射电和光学偏振;第二,基于该样本,可得喷流是球型的;第三,BL Lac和FSRQ具有相似的本征偏振与喷流参量(log R和f)的关系.
文摘研究了69个平谱射电类星体(Flat Spectrum Radio Quasars)的近红外射线光度与宽线区光度之间的关系,发现它们之间存在较强的相关性。在排除了红移的影响后,两者的相关性变的非常微弱。这表明平谱射电类星体的近红外辐射与宽线区辐射可能具有不同的物理辐射机制。还讨论了近红外光度与中心超大质量黑洞质量之间的相关性。
文摘Aim To establish a LC-MS method for determining the concentration of nifedipine in human plasma and to evaluate the pharmacokinetic characteristics of nifedipine sustained-release tablets. Methods A XB-C18 （5 μm, 4.6 mm ×150 mm） column and a mobile phase of methanol： 0.01 mol·L^-1ammonium acetate （60：40, V/V） were used to separate nifedipine, the detections was accuracy under atmosperic pressure electronic spray ionization （AP-ESI） mode and ion mass spectrum （m/z） of 314.9 [M＋H]^＋ for nifedipine, and 320.8 [M＋H]^＋ for lorazepam （Internal Standard, IS）. Results The linear range of nifedipine was 0.3 - 80 ng·mL^-1 （ r = 0.9997）, and the limit of quantitation （LOQ） was 0.3 ng·mL^-1. The nifedipine pharmacokinetic parameters after a single dose of 20 mg nifedipine sustained-release tablets test （T） or reference （R） were as the followings, t1/2 （6.73 ± 2.00） h and （7.04 ± 2.18） h, Tmax （4.28 ± 0.70） h and （4.48 ± 0.70） h, Cmax（39.66 ± 10.58） ng·mL^-1 and （40.19 ± 10.97） ng·mL^-1, AUC0-36 （391.63 ± 108.55） ng·mL^-1·h and （387.57 ± 121.51） ng·mL^-1·h, and AUC0-∞ （408.28 ± 121.16） ng·mL^-1·h and （406.15 ± 133.13） ng·mL^-1·h. The relative bioavailability of nifedipine sustained-release tablets （test） was （103.02 ± 13.93） %. Conclusion LC-MS method for the determination of concentrations of nifedipine in human plasma was sensitive and accurate, and could be used in nifedipine bioavailability and pharmacokinetic studies.
基金supported by the Fund of "111 Project" (Grant No.B07019) from the State Administration of Foreign Experts Affairs and the Ministry of Education of China
文摘Stress response of a tension leg platform （TLP） in extreme environments was investigated in this paper. A location on one of the gussets was selected as the object point, where directional stresses were numerically simulated and also experimentally verified by a strain gage. Environmental loading and the platform＇s structural strength were analyzed in accordance with industrial standards, utilizing linear wave theory and the finite element method （FEM）. The fast Fourier transform technique was used to calculate the stress response amplitude operators （RAO） from the records of measurements. A comparison was performed between the stress RAO of the numerical simulation and that of the actual measurements. The results indicated that the stress RAO of the numerical simulation fitted well with measured data at specified wave headings with different periods.
