Objective:Gemcitabine,used as single agent for elderly patients with non-small cell lung cancer (NSCLC),was demonstrated effective in this population based on phase II studies.The aim of this study was to summarize al...Objective:Gemcitabine,used as single agent for elderly patients with non-small cell lung cancer (NSCLC),was demonstrated effective in this population based on phase II studies.The aim of this study was to summarize all those phase II studies with the hope to get a comprehensive understanding of gemcitabine efficacy.Methods:The PubMed database was used to search all the papers on NSCLC associated with gemcitabine used as single agent in the first line setting till to March 31st,2010.And the medians and their 95% CI of overall response rate (ORR),disease control rate (DCR),progression free survival (PFS),and overall survival (OS) were calculated.Results:1.There were 7 papers including 410 patients with performance status (PS) ≤ 2 and advanced stage collected.2.The dose-intensities of gemcitabine were 843.75 mg/m 2 /week-1125 mg/m 2 /week in the 4-week schedule,and 666.7 mg/m 2 /week in the 3-week schedule.3.The median age was 73.8 (95% CI was 72.44,75.16) years old;36.1% (95% CI:31.4%,40.7%) of patients with stage IIIB and 60.5% (95% CI:55.8%,65.2%) of patients with stage IV;35.9% (95% CI:31.2%,40.5%) patients were adenocarcinomas and 43.7% (95% CI:38.9%,48.5%) patients were squamous cell carcinomas (SCCs).4.The ORR,DCR,PFS/TTP,and OS were 22.3% (95% CI:18.2%,26.5%),58.4% (95% CI:53.5%,63.4%),3.6 (95% CI:2.9,5.15) months and 6.68 (95% CI:5.4,8.11) months,respectively.Conclusion:Gemcitabine as single agent applied in this special population was effective and can be well tolerated under different doses and usage.展开更多
Objective: The aim of the study was to analyze the incidence, mortality and their impact factors and changing trends of malignant tumors in 2010 in the residents of Hai’an county, Jiangsu Province, China. Methods: Us...Objective: The aim of the study was to analyze the incidence, mortality and their impact factors and changing trends of malignant tumors in 2010 in the residents of Hai’an county, Jiangsu Province, China. Methods: Using the information of incidence, death registration information database and population data of malignant tumors in 2010 in the residents of Hai’an county, the incidence, mortality, accumulation incidence rates, and truncated incidence rate of malignant tumors were statistically analyzed. Results: The crude incidence, China standardized and world standardized incidence rates of malignant tumors in 2010 in Hai’an county were 281.53 per 100000 persons, 174.96 per 100 000 persons, and 175.14 per 100000 persons, respectively. The cumulative incidence rate from aged 0 to 64 years, the cumulative incidence rate from aged 0 to 74 years and the truncated incidence rate from aged 35 to 64 years were 6.85%, 15.39%, and 193.26 per 100000 persons, respectively. The rough mortality rate, China standardized and world standardized incidence rates were 234.11 per 100000 persons, 145.30 per 100000 persons, and 144.77 per 100000 persons, respectively. The top five cancers in the spectrum of cancer incidence were respectively esophageal cancer, lung cancer, stomach cancer, liver cancer, and colorectal cancer. The top four cancers in the spectrum of cancer death were consistent with the spectrum of cancer incidence. The 5th cancer in the spectrum of cancer death was pancreatic cancer. The incidence and mortality of various age groups were at a low level before 35-year-old age group. The incidence of female was slightly higher than that of male. But the incidence and mortality from the age group of 50 showed "suddenly" upward trend with age. The incidence and mortality of male were significantly higher than those of female. The ratios of male to female of incidence and mortality were 1.52:1 and 1.67:1, respectively. Conclusion: Residents over the age of 50, especially males, are high-risk groups who are exposed to certain risk factors. They should be the key objects of prevention and treatment of malignant tumors.展开更多
基金Support by a grant from Major Science and Technology Project of"National Significant New Drug Creation"(No. 2008ZX09312-002)
文摘Objective:Gemcitabine,used as single agent for elderly patients with non-small cell lung cancer (NSCLC),was demonstrated effective in this population based on phase II studies.The aim of this study was to summarize all those phase II studies with the hope to get a comprehensive understanding of gemcitabine efficacy.Methods:The PubMed database was used to search all the papers on NSCLC associated with gemcitabine used as single agent in the first line setting till to March 31st,2010.And the medians and their 95% CI of overall response rate (ORR),disease control rate (DCR),progression free survival (PFS),and overall survival (OS) were calculated.Results:1.There were 7 papers including 410 patients with performance status (PS) ≤ 2 and advanced stage collected.2.The dose-intensities of gemcitabine were 843.75 mg/m 2 /week-1125 mg/m 2 /week in the 4-week schedule,and 666.7 mg/m 2 /week in the 3-week schedule.3.The median age was 73.8 (95% CI was 72.44,75.16) years old;36.1% (95% CI:31.4%,40.7%) of patients with stage IIIB and 60.5% (95% CI:55.8%,65.2%) of patients with stage IV;35.9% (95% CI:31.2%,40.5%) patients were adenocarcinomas and 43.7% (95% CI:38.9%,48.5%) patients were squamous cell carcinomas (SCCs).4.The ORR,DCR,PFS/TTP,and OS were 22.3% (95% CI:18.2%,26.5%),58.4% (95% CI:53.5%,63.4%),3.6 (95% CI:2.9,5.15) months and 6.68 (95% CI:5.4,8.11) months,respectively.Conclusion:Gemcitabine as single agent applied in this special population was effective and can be well tolerated under different doses and usage.
文摘Objective: The aim of the study was to analyze the incidence, mortality and their impact factors and changing trends of malignant tumors in 2010 in the residents of Hai’an county, Jiangsu Province, China. Methods: Using the information of incidence, death registration information database and population data of malignant tumors in 2010 in the residents of Hai’an county, the incidence, mortality, accumulation incidence rates, and truncated incidence rate of malignant tumors were statistically analyzed. Results: The crude incidence, China standardized and world standardized incidence rates of malignant tumors in 2010 in Hai’an county were 281.53 per 100000 persons, 174.96 per 100 000 persons, and 175.14 per 100000 persons, respectively. The cumulative incidence rate from aged 0 to 64 years, the cumulative incidence rate from aged 0 to 74 years and the truncated incidence rate from aged 35 to 64 years were 6.85%, 15.39%, and 193.26 per 100000 persons, respectively. The rough mortality rate, China standardized and world standardized incidence rates were 234.11 per 100000 persons, 145.30 per 100000 persons, and 144.77 per 100000 persons, respectively. The top five cancers in the spectrum of cancer incidence were respectively esophageal cancer, lung cancer, stomach cancer, liver cancer, and colorectal cancer. The top four cancers in the spectrum of cancer death were consistent with the spectrum of cancer incidence. The 5th cancer in the spectrum of cancer death was pancreatic cancer. The incidence and mortality of various age groups were at a low level before 35-year-old age group. The incidence of female was slightly higher than that of male. But the incidence and mortality from the age group of 50 showed "suddenly" upward trend with age. The incidence and mortality of male were significantly higher than those of female. The ratios of male to female of incidence and mortality were 1.52:1 and 1.67:1, respectively. Conclusion: Residents over the age of 50, especially males, are high-risk groups who are exposed to certain risk factors. They should be the key objects of prevention and treatment of malignant tumors.
