目的:探讨早期贲门癌近端胃切除后两种不同消化道重建方式对患者术后生活质量的影响.方法:将105例早期贲门癌患者按消化道重建方法采用单盲随机原则分为观察组(食管胃前壁吻合联合幽门成形)(55例)和对照组(食管胃后壁吻合联合唇式包埋)...目的:探讨早期贲门癌近端胃切除后两种不同消化道重建方式对患者术后生活质量的影响.方法:将105例早期贲门癌患者按消化道重建方法采用单盲随机原则分为观察组(食管胃前壁吻合联合幽门成形)(55例)和对照组(食管胃后壁吻合联合唇式包埋)(50例),术后随访6 mo,比较两组手术时间,住院时间,术后反流性食管炎、吻合口狭窄情况.结果:两组均达到临床治愈.观察组和对照组手术时间,术后住院时间比较差异无统计学意义(151.00 min±6.03 min vs 149.00min±7.02 min,16.15 d±3.13 d vs 15.27 d±3.06 d,P>0.05);观察组发生反流性食管炎和吻合口狭窄的比例明显低于对照组[18.2%(10/55)vs 56.0%(28/50)、1.8%(1/55)vs 22.0%(11/50)](P<0.05).结论:近端胃切除术后消化道重建采用食管胃前壁吻合联合幽门成形是比较理想的方法.展开更多
Abstract:Objective To investigate the correlation among vacA genotypes, cagA gene, VacA, serum CagA antibodies of Helicobacter pylori (H. pylori) and gastroduodenal diseases. Methods vacA genotypes and cagA gene of 62...Abstract:Objective To investigate the correlation among vacA genotypes, cagA gene, VacA, serum CagA antibodies of Helicobacter pylori (H. pylori) and gastroduodenal diseases. Methods vacA genotypes and cagA gene of 62 H. pylori strains isolated from patients with chronic gastritis, peptic ulcer and gastric cancer were tested by polymerase chain reaction, and Hela cell assay for VacA activity in vitro. Serum CagA antibodies were measured by EIA method in the same patients.Results All 62 H. pylori strains possessed the vacA gene and vacA genotypes of all strains were type s1a/m2. Total positive rate of cagA gene was 56.45%; the positive rates of cagA gene of H. pylori strains isolated from patients with chronic gastritis, peptic ulcer and gastric cancer were 55.56%, 54.17% and 63.64%, respectively (P>0.05). The total positive rate of VacA was 37.10%; the positive rates of VacA produced by H. pylori strains isolated from patients with chronic gastritis, peptic ulcer and gastric cancer were 33.33%, 29.17% and 63.64%, respectively (P>0.05). The positive rates of CagA antibodies in patients with chronic gastritis, peptic ulcer and gastric cancer were 70.37%, 79.17% and 40.00%, respectively (P>0.05). The total positive rate of CagA antibodies was 68.85%.Conclusion There was no correlation among cagA gene and vacA genotypes of H. pylori, VacA, serum CagA antibodies and various gastroduodenal diseases.展开更多
文摘目的:探讨早期贲门癌近端胃切除后两种不同消化道重建方式对患者术后生活质量的影响.方法:将105例早期贲门癌患者按消化道重建方法采用单盲随机原则分为观察组(食管胃前壁吻合联合幽门成形)(55例)和对照组(食管胃后壁吻合联合唇式包埋)(50例),术后随访6 mo,比较两组手术时间,住院时间,术后反流性食管炎、吻合口狭窄情况.结果:两组均达到临床治愈.观察组和对照组手术时间,术后住院时间比较差异无统计学意义(151.00 min±6.03 min vs 149.00min±7.02 min,16.15 d±3.13 d vs 15.27 d±3.06 d,P>0.05);观察组发生反流性食管炎和吻合口狭窄的比例明显低于对照组[18.2%(10/55)vs 56.0%(28/50)、1.8%(1/55)vs 22.0%(11/50)](P<0.05).结论:近端胃切除术后消化道重建采用食管胃前壁吻合联合幽门成形是比较理想的方法.
文摘Abstract:Objective To investigate the correlation among vacA genotypes, cagA gene, VacA, serum CagA antibodies of Helicobacter pylori (H. pylori) and gastroduodenal diseases. Methods vacA genotypes and cagA gene of 62 H. pylori strains isolated from patients with chronic gastritis, peptic ulcer and gastric cancer were tested by polymerase chain reaction, and Hela cell assay for VacA activity in vitro. Serum CagA antibodies were measured by EIA method in the same patients.Results All 62 H. pylori strains possessed the vacA gene and vacA genotypes of all strains were type s1a/m2. Total positive rate of cagA gene was 56.45%; the positive rates of cagA gene of H. pylori strains isolated from patients with chronic gastritis, peptic ulcer and gastric cancer were 55.56%, 54.17% and 63.64%, respectively (P>0.05). The total positive rate of VacA was 37.10%; the positive rates of VacA produced by H. pylori strains isolated from patients with chronic gastritis, peptic ulcer and gastric cancer were 33.33%, 29.17% and 63.64%, respectively (P>0.05). The positive rates of CagA antibodies in patients with chronic gastritis, peptic ulcer and gastric cancer were 70.37%, 79.17% and 40.00%, respectively (P>0.05). The total positive rate of CagA antibodies was 68.85%.Conclusion There was no correlation among cagA gene and vacA genotypes of H. pylori, VacA, serum CagA antibodies and various gastroduodenal diseases.
