By means of solvent extraction and repeated chromatography on silica gel, Sephadex LH-20, HPLC, and preparative TLC, the ethanol extract of the stems of Homalium ceylanicum（Flacourtiaceae/Salicaceae sensu lato） was ...By means of solvent extraction and repeated chromatography on silica gel, Sephadex LH-20, HPLC, and preparative TLC, the ethanol extract of the stems of Homalium ceylanicum（Flacourtiaceae/Salicaceae sensu lato） was chemically investigated, which led to the isolation of 13 constituents, including five lignans（1–5） and three isocoumarins（6–8）. Based on the spectroscopic analysis and comparison of its 1H NMR and 13C NMR data with those in literatures, their structures were identified as（–）-5＇-methoxyisolariciresinol 3α-O-β-D-glucopyranoside（1）,（＋）-lyoniresinol 3α-O-β-D-glucopyranoside（2）,（＋）-isolarisiresinol 3α-O-β-Dglucopyranoside（3）,（–）-isolarisiresinol 3α-O-β-D-glucopyranoside（4）, icariside E5（5）, 3-phenylisocoumarin（6）, homalicine（7）,（–）-dihydrohomalicine（8）, friedelin（9）, 4-hydroxybenzoic acid（10）, catechol（11）, methyl-α-arabinofuranoside（12）, and uridine（13）. All isolates except compounds 6–8 were described from this genus for the first time. Compound 6 was isolated from this species for the first time.展开更多
基金Program for Changjiang Scholar and Innovative Tea m in University(Grant No.985-2-063-112)
文摘By means of solvent extraction and repeated chromatography on silica gel, Sephadex LH-20, HPLC, and preparative TLC, the ethanol extract of the stems of Homalium ceylanicum（Flacourtiaceae/Salicaceae sensu lato） was chemically investigated, which led to the isolation of 13 constituents, including five lignans（1–5） and three isocoumarins（6–8）. Based on the spectroscopic analysis and comparison of its 1H NMR and 13C NMR data with those in literatures, their structures were identified as（–）-5＇-methoxyisolariciresinol 3α-O-β-D-glucopyranoside（1）,（＋）-lyoniresinol 3α-O-β-D-glucopyranoside（2）,（＋）-isolarisiresinol 3α-O-β-Dglucopyranoside（3）,（–）-isolarisiresinol 3α-O-β-D-glucopyranoside（4）, icariside E5（5）, 3-phenylisocoumarin（6）, homalicine（7）,（–）-dihydrohomalicine（8）, friedelin（9）, 4-hydroxybenzoic acid（10）, catechol（11）, methyl-α-arabinofuranoside（12）, and uridine（13）. All isolates except compounds 6–8 were described from this genus for the first time. Compound 6 was isolated from this species for the first time.
