目的观察玻璃体腔注射康柏西普联合Ahmed青光眼阀植入及广泛视网膜光凝对新生血管性青光眼(NVG)的治疗效果。方法选择2014年10月至2015年10月徐州医科大学附属淮安医院眼科收治药物无法控制眼压的NVG患者26例26眼,先给予患眼玻璃体腔注...目的观察玻璃体腔注射康柏西普联合Ahmed青光眼阀植入及广泛视网膜光凝对新生血管性青光眼(NVG)的治疗效果。方法选择2014年10月至2015年10月徐州医科大学附属淮安医院眼科收治药物无法控制眼压的NVG患者26例26眼,先给予患眼玻璃体腔注射康柏西普0.05 m L,于注药1周后行Ahmed青光眼阀植入术,并于术后及时行眼底荧光血管造影及视网膜激光光凝。结果注药后2~7 d,24眼新生血管全部消退,2眼残留少许血管;治疗前眼压38.0~59.5 mm Hg,平均(48.38±9.16)mm Hg,联合治疗(注药+AGV植入术+PRP)后1个月眼压(11.56±3.43)mm Hg,3个月眼压(12.16±3.37)mm Hg,6个月眼压(12.69±2.52)mm Hg,与治疗前比较差异均有统计学意义(P<0.05);联合治疗后最佳矫正视力≥0.1者7眼,视力0.01~0.09者16眼,与治疗前视力比较,差异有统计学意义(P<0.05)。结论联合治疗新生血管性青光眼安全有效。展开更多
Purpose: Iris neovascularization (INV) and anterior chamber angle neovascularization after radiotherapy for uveal melanoma may lead to neovascular glaucoma and enucleation. However, neovascularization of the anterior ...Purpose: Iris neovascularization (INV) and anterior chamber angle neovascularization after radiotherapy for uveal melanoma may lead to neovascular glaucoma and enucleation. However, neovascularization of the anterior ocular segment may respond favorably to treatment with panretinal photocoagulation. The purpose of this study was to evaluate the frequency, interval to development, and predisposing factors of anterior ocular segment neovascularization following iodine 125 (I125)- brachytherapy for uveal melanoma. Design: Retrospective, interventional, consecutive case series. Participants: Sixty- five patients (65 eyes), consecutively treated with I125 brachytherapy for uveal melanoma from 1995 through 2000 and followed up after radiation therapy for 24 months or more. Methods: Clinical findings and ultrasonography characteristics as well as treatment parameters were analyzed. Main Outcome Measures: The frequency of INV was determined and the interval to development of INV as well as the predisposing factors were analyzed statistically. Results: In 15 of 65 eyes (23% ), INV was detected after I125 brachytherapy at a mean± standard deviation of 26.66± 11.63 months (median, 24 months; range, 9- 48 months). Risk factors displaying the stronger correlation with INV were greater maximal tumor height (P< 0.01), greater tumor vascularity (P< 0.01), and disinsertion of horizontal rectus muscles (P=0.01). Conclusions: After I125 brachytherapy for choroidal melanoma, INV developed in 23% of eyes and was correlated with larger tumor size, greater tumor vascularity, and disinsertion of a horizontal rectus muscle.展开更多
文摘目的观察玻璃体腔注射康柏西普联合Ahmed青光眼阀植入及广泛视网膜光凝对新生血管性青光眼(NVG)的治疗效果。方法选择2014年10月至2015年10月徐州医科大学附属淮安医院眼科收治药物无法控制眼压的NVG患者26例26眼,先给予患眼玻璃体腔注射康柏西普0.05 m L,于注药1周后行Ahmed青光眼阀植入术,并于术后及时行眼底荧光血管造影及视网膜激光光凝。结果注药后2~7 d,24眼新生血管全部消退,2眼残留少许血管;治疗前眼压38.0~59.5 mm Hg,平均(48.38±9.16)mm Hg,联合治疗(注药+AGV植入术+PRP)后1个月眼压(11.56±3.43)mm Hg,3个月眼压(12.16±3.37)mm Hg,6个月眼压(12.69±2.52)mm Hg,与治疗前比较差异均有统计学意义(P<0.05);联合治疗后最佳矫正视力≥0.1者7眼,视力0.01~0.09者16眼,与治疗前视力比较,差异有统计学意义(P<0.05)。结论联合治疗新生血管性青光眼安全有效。
文摘Purpose: Iris neovascularization (INV) and anterior chamber angle neovascularization after radiotherapy for uveal melanoma may lead to neovascular glaucoma and enucleation. However, neovascularization of the anterior ocular segment may respond favorably to treatment with panretinal photocoagulation. The purpose of this study was to evaluate the frequency, interval to development, and predisposing factors of anterior ocular segment neovascularization following iodine 125 (I125)- brachytherapy for uveal melanoma. Design: Retrospective, interventional, consecutive case series. Participants: Sixty- five patients (65 eyes), consecutively treated with I125 brachytherapy for uveal melanoma from 1995 through 2000 and followed up after radiation therapy for 24 months or more. Methods: Clinical findings and ultrasonography characteristics as well as treatment parameters were analyzed. Main Outcome Measures: The frequency of INV was determined and the interval to development of INV as well as the predisposing factors were analyzed statistically. Results: In 15 of 65 eyes (23% ), INV was detected after I125 brachytherapy at a mean± standard deviation of 26.66± 11.63 months (median, 24 months; range, 9- 48 months). Risk factors displaying the stronger correlation with INV were greater maximal tumor height (P< 0.01), greater tumor vascularity (P< 0.01), and disinsertion of horizontal rectus muscles (P=0.01). Conclusions: After I125 brachytherapy for choroidal melanoma, INV developed in 23% of eyes and was correlated with larger tumor size, greater tumor vascularity, and disinsertion of a horizontal rectus muscle.
