Alterations in oxidative phosphorylation resulting from mitochondriai dysfunction have long been hypothesized to be involved in tumorigenesis. Mitochondria have recently been shown to play an important role in regulat...Alterations in oxidative phosphorylation resulting from mitochondriai dysfunction have long been hypothesized to be involved in tumorigenesis. Mitochondria have recently been shown to play an important role in regulating both programmed cell death and cell proliferation. Furthermore, mitochondrial DNA （mtDNA） mutations have been found in various cancer cells. However, the role of these mtDNA mutations in tumorigenesis remains largely unknown. This review focuses on basic mitochondrial genetics, mtDNA mutations and consequential mitochondrial dysfunction associated with cancer. The potential molecular mechanisms, mediating the pathogenesis from mtDNA mutations and mitochondrial dysfunction to tumorigenesis are also discussed.展开更多
The activity of tritiated water has been standardized by two liquid scintillation counting methods:The CIEMAT/NIST method with the54Mn-standard efficiency tracing and the triple-to-double coincidence ratio(TDCR)method...The activity of tritiated water has been standardized by two liquid scintillation counting methods:The CIEMAT/NIST method with the54Mn-standard efficiency tracing and the triple-to-double coincidence ratio(TDCR)method.The samples were prepared with Ultima Gold TM AB liquid scintillation cocktail in low-potassium glass vials.In the application of the CIEMAT/NIST method,the computer program EMILIA was used to calculate the efficiency of3H and54Mn according to the KL1L2L3M atomic rearrangement model.And the detection efficiency of the TDCR counter was calculated using TDCR07 code,which makes it possible to allow for the potential asymmetry between the three photomultiplier tubes.The influence of stopping power and k B factor is discussed in the paper.When a power approach is adopted for the stopping power for electrons below 1ke V and k B is chosen to be 0.0075 cm/Me V,the relative deviation will be only 0.3%between the two methods.展开更多
Using broadband seismic records from regional networks, we determined the focal mechanisms and depths of 37 earthquakes in the 2013 M7.0 Lushan earthquake sequence(3.4≤Mw≤5.1) by fitting the three-component waveform...Using broadband seismic records from regional networks, we determined the focal mechanisms and depths of 37 earthquakes in the 2013 M7.0 Lushan earthquake sequence(3.4≤Mw≤5.1) by fitting the three-component waveform data. The results show that the earthquakes are predominantly thrust events, with occasional strike-slip mechanisms. Most earthquakes occurred at depths of 10–20 km. We derived the regional distribution of the average stress field in this area using the damped linear inversion method and the focal mechanisms obtained in this study. The inversion results suggest that the Lushan region and the adjacent area are mostly under compression. The orientations of the maximum principal axes trend NW-SE, with some local differences in the stress distribution at different depths. Compared with the distribution of the stress field in the Wenchuan earthquake area, the stress field in the southwest section of the Longmenshan Fault zone(LFZ) share similar characteristics, predominantly thrust faulting with a few strike-slip events and the maximum compression axes being perpendicular to the LFZ.展开更多
文摘Alterations in oxidative phosphorylation resulting from mitochondriai dysfunction have long been hypothesized to be involved in tumorigenesis. Mitochondria have recently been shown to play an important role in regulating both programmed cell death and cell proliferation. Furthermore, mitochondrial DNA （mtDNA） mutations have been found in various cancer cells. However, the role of these mtDNA mutations in tumorigenesis remains largely unknown. This review focuses on basic mitochondrial genetics, mtDNA mutations and consequential mitochondrial dysfunction associated with cancer. The potential molecular mechanisms, mediating the pathogenesis from mtDNA mutations and mitochondrial dysfunction to tumorigenesis are also discussed.
基金supported by the National Natural Science Foundation of China(Grant Nos.91126002 and 11405071)the National Science and Technology Major Project of China(Grant No.2012ZX06004-005)
文摘The activity of tritiated water has been standardized by two liquid scintillation counting methods:The CIEMAT/NIST method with the54Mn-standard efficiency tracing and the triple-to-double coincidence ratio(TDCR)method.The samples were prepared with Ultima Gold TM AB liquid scintillation cocktail in low-potassium glass vials.In the application of the CIEMAT/NIST method,the computer program EMILIA was used to calculate the efficiency of3H and54Mn according to the KL1L2L3M atomic rearrangement model.And the detection efficiency of the TDCR counter was calculated using TDCR07 code,which makes it possible to allow for the potential asymmetry between the three photomultiplier tubes.The influence of stopping power and k B factor is discussed in the paper.When a power approach is adopted for the stopping power for electrons below 1ke V and k B is chosen to be 0.0075 cm/Me V,the relative deviation will be only 0.3%between the two methods.
基金supported by the National Natural Science Foundation of China(Grant No.41104032)the Special Project Seismic Commonwealth Research(Grant No.201308013)
文摘Using broadband seismic records from regional networks, we determined the focal mechanisms and depths of 37 earthquakes in the 2013 M7.0 Lushan earthquake sequence(3.4≤Mw≤5.1) by fitting the three-component waveform data. The results show that the earthquakes are predominantly thrust events, with occasional strike-slip mechanisms. Most earthquakes occurred at depths of 10–20 km. We derived the regional distribution of the average stress field in this area using the damped linear inversion method and the focal mechanisms obtained in this study. The inversion results suggest that the Lushan region and the adjacent area are mostly under compression. The orientations of the maximum principal axes trend NW-SE, with some local differences in the stress distribution at different depths. Compared with the distribution of the stress field in the Wenchuan earthquake area, the stress field in the southwest section of the Longmenshan Fault zone(LFZ) share similar characteristics, predominantly thrust faulting with a few strike-slip events and the maximum compression axes being perpendicular to the LFZ.
