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新疆西昆仑喀拉阿特河一带玛尔坎雀库塞山组的厘定
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作者 高永利 《新疆地质》 CAS CSCD 2015年第2期190-194,共5页
新疆西昆仑喀拉阿特河一带前人确立的下二叠统(未分)中发现一套火山岩夹碳酸盐岩、碎屑岩沉积建造,与上覆昆盖依套组呈断层接触,与下伏喀拉阿特河组呈平行不整合接触。该套地层在岩石组合、生物面貌、沉积环境、接触关系等方面独立成组... 新疆西昆仑喀拉阿特河一带前人确立的下二叠统(未分)中发现一套火山岩夹碳酸盐岩、碎屑岩沉积建造,与上覆昆盖依套组呈断层接触,与下伏喀拉阿特河组呈平行不整合接触。该套地层在岩石组合、生物面貌、沉积环境、接触关系等方面独立成组,灰岩内采集狭体贝(未定种)Stenoscisma sp.;小戟贝(未定种)Chonetinella sp.;韦勒贝(未定种)Wellerella sp.;扇房贝(未定种)Rhipidomella sp.;股窗贝(未定种)Crurithyris sp.;印度胡斯台贝Hustedia indica(Waagen);胡斯台贝(未定种)Hustedia sp.;扭曲虫Plectogyra sp.;拟犬齿珊瑚Paracania sp.等,时代为早二叠世,故将其从下二叠系(未分)解体出,厘定为玛尔坎雀库塞山组。该套地层单位的确立,为区域填图、建立岩石地层单位,及本区地层划分和区域对比提供了新依据。 展开更多
关键词 西昆仑 喀拉阿特河 二叠系 玛尔坎雀库塞山组 地层划分与对比
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马尔库塞对马克思“巴黎手稿”解读的贡献 被引量:5
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作者 张秀琴 《北京大学学报(哲学社会科学版)》 CSSCI 北大核心 2016年第2期52-58,共7页
马尔库塞是第一个对1932年公开出版的"巴黎手稿"进行及时解读的人,并由此掀开了接下来西方学界的"巴黎手稿热"。马尔库塞对马克思巴黎手稿的解读贡献可分为早期和后期两个阶段:早期阶段,以其《历史唯物主义的基础》... 马尔库塞是第一个对1932年公开出版的"巴黎手稿"进行及时解读的人,并由此掀开了接下来西方学界的"巴黎手稿热"。马尔库塞对马克思巴黎手稿的解读贡献可分为早期和后期两个阶段:早期阶段,以其《历史唯物主义的基础》(1932)首次认定了巴黎手稿之于历史唯物主义的重要性,以及异化劳动概念在马克思关于人的本质观中的重要意义,正是这样的认定,日后成就了整个西方马克思主义人本主义一派对于巴黎手稿的基本解读格局;后期阶段,马尔库塞以其《自然与革命》(1972)中对巴黎手稿的再解读,引入了一种介于人本主义马克思主义和海德格尔主义马克思主义之间的解读范式,即以存在主义化的"自然"概念的引入和"感受"异化批判为视角,将历史唯物主义重建工作由异化劳动引向异化感受领域。马尔库塞的解读贡献,在巴黎手稿的历史地位确认及其基本内容认定等方面,不仅肇始了整个人本主义西方马克思主义对马克思巴黎手稿的基本判断,而且还试图伴随着20世纪中后期西方学界对于巴黎手稿的持续讨论,尝试着将精神分析学的和存在主义的方法引入这一论证。时至今日,我们在国际语境中探讨马克思的巴黎手稿的相关议题,无不受马尔库塞所开创的这一解读先河的影响。 展开更多
关键词 马克思 巴黎手稿 马尔库塞 历史唯物主义
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19世纪初对美国扩张的抵制与特库姆塞联盟的形成
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作者 张鹏 《上饶师范学院学报》 2018年第2期85-92,共8页
美国建国初期,对西部印第安人部落实行的扩张主义政策,给印第安人带来了严重的生存危机、社会危机与精神文化危机。因此,敌视与抵制逐渐成为大部分印第安人部落对待美国扩张的主流态度。他们抵制美国扩张的方式主要体现在两个方面:一是... 美国建国初期,对西部印第安人部落实行的扩张主义政策,给印第安人带来了严重的生存危机、社会危机与精神文化危机。因此,敌视与抵制逐渐成为大部分印第安人部落对待美国扩张的主流态度。他们抵制美国扩张的方式主要体现在两个方面:一是精神文化方面,试图通过回归印第安人原有的宗教信仰与生活方式来摆脱对美国白人文明的依赖;一是政治军事方面,试图团结所有印第安人部落,构建政治军事联盟来抵制美国扩张。此外,这一时期英国对印第安人抵制美国扩张的支持也起到比较重要的作用。这些因素最终促成特库姆塞联盟的形成。印第安人抵制美国扩张是特库姆塞联盟形成的社会基础,而特库姆塞联盟的形成则是印第安人抵制美国扩张的结果。该联盟的形成过程,反映了美国建国初期白人与印第安人持续冲突的内在逻辑,以及印第安人适应社会环境变化的主动性。 展开更多
关键词 美国的扩张 联盟 坦斯夸塔瓦 英国
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库雷-楚佳古堰塞湖的湖岸堤反映的湖面波动历史
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作者 姜胜凡 刘维明 赖忠平 《四川地质学报》 2021年第1期19-26,共8页
阿尔泰山高能洪水是地球上已知的最大的陆地淡水排放,洪水起源于库雷-楚佳盆地,至少发生过3次规模较大的高能洪水,卡通河下游广泛存在的洪水沉积物和库雷-楚佳盆地内的沙波等洪水沉积物,提供了大量的洪水证据。同时盆地内广泛存在大量... 阿尔泰山高能洪水是地球上已知的最大的陆地淡水排放,洪水起源于库雷-楚佳盆地,至少发生过3次规模较大的高能洪水,卡通河下游广泛存在的洪水沉积物和库雷-楚佳盆地内的沙波等洪水沉积物,提供了大量的洪水证据。同时盆地内广泛存在大量的湖岸堤,如库雷盆地东南部和楚佳盆地北部,表明了库雷-楚佳冰堰湖复杂的湖面波动历史。本研究利用遥感解译、ArcGIS工具和Python编程对盆地内的湖岸堤进行海拔标定和库容计算,共解译湖岸堤123级,其中,楚佳盆地湖岸堤75级,库雷盆地55级,第一级湖岸堤海拔1534m,库容3.64km^(3);最高湖岸堤海拔2112m,代表湖泊的历史最高水位,库容691.322km^(3)。 展开更多
关键词 雷-楚佳古堰 湖岸堤 遥感解译 晚更新世
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青海省格尔木市小库赛湖北一带1:5万航磁异常特征及找矿前景
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作者 付厚起 《世界有色金属》 2018年第8期121-121,123,共2页
研究区位于柴达木盆地西南缘,昆仑山脉北坡腹地。大地构造位置属秦祁昆晚加里东造山系东昆仑造山带伯喀里克-香日德元古宙古陆块体和雪山峰-布尔汗达造山亚带两个三级构造单元。区内共圈出11处1:5万航磁异常,经地面物探异常查证及工程验... 研究区位于柴达木盆地西南缘,昆仑山脉北坡腹地。大地构造位置属秦祁昆晚加里东造山系东昆仑造山带伯喀里克-香日德元古宙古陆块体和雪山峰-布尔汗达造山亚带两个三级构造单元。区内共圈出11处1:5万航磁异常,经地面物探异常查证及工程验证,初步分析认为本区有较好的找矿前景。 展开更多
关键词 库塞湖北 1:5万航磁 找矿前景
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Fabrication and Characteristics of a Si-Based Single Electron Transistor 被引量:2
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作者 卢刚 陈治明 +1 位作者 王建农 葛惟昆 《Journal of Semiconductors》 EI CAS CSCD 北大核心 2002年第3期246-250,共5页
Si based single electron transistor (SET) is fabricated successfully on p type SIMOX substrate,based on electron beam (EB) lithography,reactive ion etching (RIE) and thermal oxidation.In particular,using thermal oxi... Si based single electron transistor (SET) is fabricated successfully on p type SIMOX substrate,based on electron beam (EB) lithography,reactive ion etching (RIE) and thermal oxidation.In particular,using thermal oxidation and etching off the oxide layer,a one dimensional Si quantum wire can be converted into several quantum dots inside quantum wire in connection with the source and drain regions.The differential conductance (d I ds /d V ds ) oscillations and the Coulomb staircases in the source drain current ( I ds ) are shown clearly dependent on the source drain voltage at 5 3K.The I ds V gs (gate voltage) oscillations are observed from the I ds V gs characteristics as a function of V gs at different temperatures and various values of V ds .For a SET whose total capacitance is about 9 16aF,the I ds V gs oscillations can be observed at 77K. 展开更多
关键词 single electron transistor Coulomb blockade single electron tunneling quantum dot electron beam lithography
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A Model of a Single Electron Transistor of Metallic Tunneling Junctions and Its Validation
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作者 张立辉 李志刚 +2 位作者 康晓辉 谢常青 刘明 《Journal of Semiconductors》 EI CAS CSCD 北大核心 2005年第7期1323-1327,共5页
Based on the orthodox theory,a model of a single electron transistor (SET) of metallic tunneling junctions is built using the master equation method. Several parameters of the device, such as capacitance, resistance... Based on the orthodox theory,a model of a single electron transistor (SET) of metallic tunneling junctions is built using the master equation method. Several parameters of the device, such as capacitance, resistance and temperature,are input into the model and thus the I-V curves are attained. These curves are consistent with those from other experiments; therefore, the model is verified. However, there still exists a difference between simulated results and experimental results,mainly comes from the stationary case of the master equation. In other words, precision of simulated results would be increased if the transient case of the master equation is considered. Moreover, the current increases exponentially at higher drain voltages, which is due to the fact that the barrier suppression is caused by the image charge potential. 展开更多
关键词 single electron transistor orthodox theory coulomb blockade quantum tunnelling
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“冷门”的作品 “冷门”的演奏 听中国爱乐乐团音乐季一场音乐会有感
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作者 景作人 《视听技术》 2004年第5期75-76,共2页
中国爱乐乐团新音乐季的节目表我去年就已拿到,在整个节目中我最早锁定的就是今年3月26日的音乐会,因为这场音乐会中有我最想听的库塞维茨基《升f小调低音提琴协奏曲》和巴托克《中提琴协奏曲》。
关键词 中国爱乐乐团 音乐季 库塞维茨基 《低音提琴协奏曲》 音乐欣赏 《牧神午后》
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Quantum Effects of Mesoscopic Inductance and Capacity Coupling Circuits 被引量:2
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作者 LIU Jian-Xin AN Zhan-Yuan SONG Yong-Hua 《Communications in Theoretical Physics》 SCIE CAS CSCD 2006年第6期1126-1130,共5页
Using the quantum theory for a mesoscopic circuit based on the discretenes of electric charges, the finitedifference Schrodinger equation of the non-dlssipative mesoscopic inductance and capacity coupling circuit is a... Using the quantum theory for a mesoscopic circuit based on the discretenes of electric charges, the finitedifference Schrodinger equation of the non-dlssipative mesoscopic inductance and capacity coupling circuit is achieved. The Coulomb blockade effect, which is caused by the discreteness of electric charges, is studied. Appropriately choose the components in the circuits, the finlte-dlfference Schrodinger equation can be divided into two Mathieu equations in representation." With the WKBJ method, the currents quantum fluctuations in the ground states of the two circuits are calculated. The results show that the currents quantum zero-point fluctuations of the two circuits are exist and correlated. 展开更多
关键词 mesoscopic circuit Mathieu equation quantum effect
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Kosik's Dialectics of Concrete Totality
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作者 Denko Skalovski 《Journal of Philosophy Study》 2015年第6期273-281,共9页
Setting out from the categories of totality and histori(ci)sm in Kosik's Dialectics of the Concrete, we look at the relationship between theory and praxis: empty, abstract totality versus concrete, reified and ali... Setting out from the categories of totality and histori(ci)sm in Kosik's Dialectics of the Concrete, we look at the relationship between theory and praxis: empty, abstract totality versus concrete, reified and alienated practice (Lukacs, Habermas, Honneth); a bad totality, in which the real polydimensional subject is replaced by the one-dimensional, mythologized, fetishized, and economistically reduced "subject" of consummation (Marcuse, Baudrillard). The dialectics of concrete totality implies a marxistic critique of the ethical and juristic universalism, in the context of the "positive" side of globalization and political unilateralism, as a concrete, militant, hegemonistic, post-colonial, and neo-imperial practice (Apel, Habermas, Chomsky, Zinoviev); globalization as totali(tari)zation, the "last man," the "end of history," and the "end" of dialectics in its neo-liberal, eschatological, empty ideological "realization" (Hegel, Marx, Fukuyama, Arendt); the totality of the (invariable) being as a pseudo-concrete and pseudo-dialectical ontologistic speculation (Heidegger): A "return" to a concrete history and a return of the "positive" dialectics as a critical awareness, mind, and method in the discourse "game" of human's cognitive, creative, and practical powers. The assumption of Kosik's humanism is a synchrony of nature and history in the "absolute" totality of human's concrete existence (Lukacs, Goldmann, Adorno, Sartre, Kosik). 展开更多
关键词 TOTALITY history nature DIALECTICS CONCRETE GLOBALIZATION MORAL REIFICATION
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Society and State in Marcuse and Hegel
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作者 Stefan Gandler 《Journal of Philosophy Study》 2014年第1期55-67,共13页
In the 40s and the 50s of the last century existed a largely shared conviction amongst the majority of social scientists in the US regarding the explanation of the theoretical philosophical roots of National Socialism... In the 40s and the 50s of the last century existed a largely shared conviction amongst the majority of social scientists in the US regarding the explanation of the theoretical philosophical roots of National Socialism. Contrarily to European writers, who searched its philosophical origins in irrational philosophical traditions, in the US, they relied upon the perception that Hegel's Philosophy of State was the most relevant ideological basis of National Socialism. Hegel's idea for the need of a strong state, seemed to clearly support the hypothesis. Herbert Marcuse, exiled in the United States, bad to confront himself with this conviction that academic colleague shared. This theoretical hypothesis was in tune to the Zeitgeist and the political context, in which anticommunism was growing stronger by the day and where the cold war was developing. Associating Hegel and National Socialism implied, for most of the hypothesis defenders yet another vantage point: it could discredit also Marx, for the tights links between his philosophical thinking and Hegel's one. For Marcuse this hypothesis was even more problematic knowing that in Germany, national socialist philosophers had rejected Hegel from the very first day their party came to power. In this article we try to analyze Marcuse's respective philosophical argument. The point of departure of this reconstruction is the philosophical interpretation of Hegel's theory of the State. Further than the historical context, the debate on Hegel and his theory of the State, is very relevant for today's debates, dominated by neoliberal ideologies, which often are starting from similar theoretical errors than the mentioned. In both cases exists a lack of understanding of the classic bourgeois content within the concept of the State, based on the French Revolution. 展开更多
关键词 Georg Wilhelm Friedrich Hegel Herbert Marcuse STATE SOCIETY
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Research on effect of clogging process on permeability of loose dam foundation of plateau reservoir
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作者 XU Wenming ZHAO Shuyun WANG Gangcheng 《Global Geology》 2012年第4期291-296,共6页
Taking Zhuoyu reservoir in Shannan of Tibet as the test site,the authors collected soil samples for laboratory analysis,and devised infiltration-clogging equipment for laboratory test to research the effect of cloggin... Taking Zhuoyu reservoir in Shannan of Tibet as the test site,the authors collected soil samples for laboratory analysis,and devised infiltration-clogging equipment for laboratory test to research the effect of clogging process on permeability of loose dam foundation of plateau reservoir.Through laboratory test,the soil can cause clogging effect by itself,and the effect of clogging is relative to the water pressure.The clogging effect can be caused obviously by adding fine particles,and the clogging effect of the particles with 0.063-0.25 mm diameter is best,which verifies the rationality of the optimal diameter interval.It provides the realistic significance for the anti-seepage of the plateau reservoir dam foundation. 展开更多
关键词 clogging test clogging effect PERMEABILITY diameter interval
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Laszlo Marton's Three Short Novels as a Translational Challenge
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作者 Marko Cudic 《Sino-US English Teaching》 2016年第7期573-585,共13页
This paper deals with the problems encountered while translating the book of short novels M. L., a gyilkos (The Murderer L. M.), written by the contemporary Hungarian author Lazlo Marton (b. 1959). One of the most... This paper deals with the problems encountered while translating the book of short novels M. L., a gyilkos (The Murderer L. M.), written by the contemporary Hungarian author Lazlo Marton (b. 1959). One of the most important reasons why the translator of this book (who also happens to be the author of this paper) has chosen to translate into Serbian this particular book, and not some other, more famous work of Marton, lies in the thematic, geocultural, and historical parallels with the Serbian context, which form the main fabular line of these short stories. The other, from the perspective of this paper, even more relevant reason for this translational choice can be found in the non-everyday challenge that Marton's hardly translatable style and language pose to the translator. This kind of a situation almost requires that the translator sacrifices formal fidelity to the original text and tries to find more creative solutions; in other words, it suggests choosing the principle of the so-called dynamic equivalence over the formal equivalence principle. In this respect, a special problem is the need to translate the so-called "talking names", a narrative trick with a great tradition in Hungarian literature. The aim of this paper is to try to answer, with the use of a representative corpus of examples, the following question: Is it possible and where can we draw limits in this author-translation related field of play, and what should be the level of consistency allowed to the translator, i.e., to what extent can he/she become the "coauthor"of the translated work? 展开更多
关键词 translation challenge dynamic equivalence translating names
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Evolution on the Water Quality in Sergipe Hinterland Reservoirs, Northeast Brazil
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作者 Carlos Alexandre Borges Garcia Anairam Piedade de Souza Melol +6 位作者 Helenice Leite Garcia Cristiane da CunhaNascimento Silvanio Silvario Lopes da Costa Maria Caroline Silva Mendonaa Jose do Patrocinio Hora Alves Marcus Aure1io Soares Cruz Rennan Geovanny Oliveira Araujo 《Journal of Environmental Science and Engineering(B)》 2017年第7期345-351,共7页
Population growth has consequences for intense use of aquatic ecosystems. Samples were taken, between 2013 and 2014, in the reservoirs "Algodoeiro" and "Gloria" in Sergipe, Brazil. TSI (Trophic State Index) and ... Population growth has consequences for intense use of aquatic ecosystems. Samples were taken, between 2013 and 2014, in the reservoirs "Algodoeiro" and "Gloria" in Sergipe, Brazil. TSI (Trophic State Index) and WQI (Water Quality Index) were used. It was determined the parameters such as conductivity, dissolved oxygen, total nitrogen, total phosphorus and chlorophyll. TSI has been applied, in "Algodoeiro", which was classified as mesotrophic. With the increase of rainfall in 2014, this reservoir changed its condition to eutrophic. "Gloria" reservoir was already classified in super-eutrophication. Regarding the WQI, the reservoirs were classified in Class IV, indicating a critically degraded condition. 展开更多
关键词 Water quality environmental degradation limnological studies TSI (Trophic State Index) RWQI (Reservoir WaterQuality Index).
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Gillnet Selectivity and Length at Maturity of Nile Tilapia (Oreochromis niloticus L.) in a Tropical Reservoir (Amerti: Ethiopia)
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作者 Mathewos Hailu 《Journal of Agricultural Science and Technology(A)》 2014年第2期135-140,共6页
The selectivity of gillnets for Oreochromis niloticus in Amerti reservoir (9°63′ N, 37°23′ E) was determined from gillnets with four mesh sizes (60, 80, 100 and 120 mm). Four selectivity models (a nor... The selectivity of gillnets for Oreochromis niloticus in Amerti reservoir (9°63′ N, 37°23′ E) was determined from gillnets with four mesh sizes (60, 80, 100 and 120 mm). Four selectivity models (a normal model assuming fixed spread, a normal model assuming that spread is proportional to mesh size, a lognormal model and a gamma model) were fitted to the data by using the share each length's catch total (SELECT) method. A total of 657 specimens of Oreochromis niloticus were caught (12.0-35.5 cm total length, TD. The sizes at first sexual maturity were 21.5 cm TL and 18.9 cm TL, respectively, for male and female Oreochromis niloticus. The lognormal selectivity curve provided the best fit to the data according to model deviance estimates with optimum selectivity of 16.66, 22.26, 27.78 and 33.38 cm TL for the 60, 80, 100 and 120 mm mesh sizes, respectively. 展开更多
关键词 GILLNET mesh selectivity Nile tilapia SELECT
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“法国理论”在法国 被引量:2
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作者 陆扬 《复旦学报(社会科学版)》 CSSCI 北大核心 2013年第2期60-66,156,共7页
"法国理论"可以理解为经过美国包装后法国各派先锋理论的总和。今天它在本土所遭遇的反思命运,也还是带着当年"美国化"的印迹,包括《法国理论》等法国学者的相关著作,被译成英文后又反馈法国,进一步促成了未必是强... "法国理论"可以理解为经过美国包装后法国各派先锋理论的总和。今天它在本土所遭遇的反思命运,也还是带着当年"美国化"的印迹,包括《法国理论》等法国学者的相关著作,被译成英文后又反馈法国,进一步促成了未必是强弩之末的"理论"话语。反思中的一个共识是理论不宜反客为主,不能替代文本和作品分析,当然后者已不复拘泥于从泰纳到朗松的文学史视野。甚至,"法国理论"被认为是批判有余,人文维度终有缺失,所以福柯、德里达这些批判大师的著作,至今还没有走进法国课堂,成为文本分析的对象。但反思中的另一个声音同样值得注意:理论是谦卑的,因为它说到底是要给人性的弱点做出解释。由此给予我们的启示,应是今天来谈"法国理论",并不是怀旧哪个业已分崩离析的黄金时代。脱离具体语境的新术语泛滥诚然不足称道,然用平和的心态来看待"理论",如今或正当其时。 展开更多
关键词 “法国理论” “索卡尔效应” 库塞 文本分析
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伊拉克的“7大金刚”
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作者 桂兵 《环球军事》 2003年第04X期36-37,共2页
当美国总统布什向萨达姆发出最后通碟时,伊拉克出乎美国意料地立刻作出回应,萨达姆不会流亡国外,美国必将以失败告终;当战争的硝烟弥漫巴格达上空时,在海湾战争中伤了元气、军事实力与美军相差悬殊的伊军并非像人们想像的那样不堪... 当美国总统布什向萨达姆发出最后通碟时,伊拉克出乎美国意料地立刻作出回应,萨达姆不会流亡国外,美国必将以失败告终;当战争的硝烟弥漫巴格达上空时,在海湾战争中伤了元气、军事实力与美军相差悬殊的伊军并非像人们想像的那样不堪一击。 展开更多
关键词 伊拉克战争 萨达姆 马基得 库塞
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Cotunneling transport in ultra-narrow gold nanowire bundles 被引量:1
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作者 Anais Loubat Walter Escoffier +5 位作者 Lise-Marie Lacroix Guillaume Viau Reasmey Tan Julian Carrey Benedicte Warot-Fonrose Bertrand Raquet 《Nano Research》 SCIE EI CAS CSCD 2013年第9期644-651,共8页
We investigate the charge transport in close-packed ultra-narrow (1.5 nm diameter) gold nanowires stabilized by oleylamine ligands. We give evidence of charging effects in the weakly coupled one-dimensional (1D) n... We investigate the charge transport in close-packed ultra-narrow (1.5 nm diameter) gold nanowires stabilized by oleylamine ligands. We give evidence of charging effects in the weakly coupled one-dimensional (1D) nanowires, monitored by the temperature and the bias voltage. At low temperature, in the Coulomb blockade regime, the current flow reveals an original cooperative multi-hopping process between 1D-segments of Au-NWs, minimising the charging energy cost. Above the Coulomb blockade threshold voltage and at high temperature, the charge transport evolves into a sequential tunneling regime between the nearest- nanowires. Our analysis shows that the effective length of the Au-NWs inside the bundle is similar to the 1D localisation length of the electronic wave function (of the order of 120 nm _+ 20 nm), but almost two orders of magnitude larger than the diameter of the nanowire. This result confirms the high structural quality of the Au-NW segments. 展开更多
关键词 ultra-narrow goldnanowires 1D nano-objects electronic transport variable cotunneling Coulomb blockade
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Early use of dexamethasone increases Nr4a1 in Kupffer cells ameliorating acute liver failure in mice in a glucocorticoid receptor-dependent manner 被引量:3
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作者 Jing-wen DENG Qin YANG +10 位作者 Xiao-peng CAI Jia-ming ZHOU Wei-gao E Yan-dong AN Qiu-xian ZHENG Meng HONG Yan-li REN Jun GUAN Gang WANG Shu-jing LAI Zhi CHEN 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2020年第9期727-739,共13页
Background and objective:Acute liver failure(ALF)is a type of disease with high mortality and rapid progression with no specific treatment methods currently available.Glucocorticoids exert beneficial clinical effects ... Background and objective:Acute liver failure(ALF)is a type of disease with high mortality and rapid progression with no specific treatment methods currently available.Glucocorticoids exert beneficial clinical effects on therapy for ALF.However,the mechanism of this effect remains unclear and when to use glucocorticoids in patients with ALF is difficult to determine.The purpose of this study was to investigate the specific immunological mechanism of dexamethasone(Dex)on treatment of ALF induced by lipopolysaccharide(LPS)/D-galactosamine(D-Ga IN)in mice.Methods:Male C57 BL/6 mice were given LPS and D-Ga IN by intraperitoneal injection to establish an animal model of ALF.Dex was administrated to these mice and its therapeutic effect was observed.Hematoxylin and eosin(H&E)staining was used to determine liver pathology.Multicolor flow cytometry,cytometric bead array(CBA)method,and next-generation sequencing were performed to detect changes of messenger RNA(m RNA)in immune cells,cytokines,and Kupffer cells,respectively.Results:A mouse model of ALF can be constructed successfully using LPS/D-Ga IN,which causes a cytokine storm in early disease progression.Innate immune cells change markedly with progression of liver failure.Earlier use of Dex,at 0 h rather than 1 h,could significantly improve the progression of ALF induced by LPS/D-Ga IN in mice.Numbers of innate immune cells,especially Kupffer cells and neutrophils,increased significantly in the Dex-treated group.In vivo experiments indicated that the therapeutic effect of Dex is exerted mainly via the glucocorticoid receptor(Gr).Sequencing of Kupffer cells revealed that Dex could increase m RNA transcription level of nuclear receptor subfamily 4 group A member 1(Nr4 a1),and that this effect disappeared after Gr inhibition.Conclusions:In LPS/D-Ga IN-induced ALF mice,early administration of Dex improved ALF by increasing the numbers of innate immune cells,especially Kupffer cells and neutrophils.Gr-dependent Nr4 a1 upregulation in Kupffer cells may be an important ALF effect regulated by Dex in this process. 展开更多
关键词 GLUCOCORTICOID DEXAMETHASONE Kupffer cells Acute liver failure Nuclear receptor subfamily 4 group A member 1(Nr4a1)
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Observation of Coulomb blockade and ballistic tunneling in graphene single electron transistor
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作者 TAN ZhenBing LIU GuangTong LU Li YANG ChangLi 《Science China(Physics,Mechanics & Astronomy)》 SCIE EI CAS 2012年第1期7-10,共4页
A square graphene single electron transistor (SET) was defined with two side gates, and its transport was studied at low temperature at T = 2 K. At zero magnetic field, Coulomb blockade oscillations were clearly obs... A square graphene single electron transistor (SET) was defined with two side gates, and its transport was studied at low temperature at T = 2 K. At zero magnetic field, Coulomb blockade oscillations were clearly observed near the Dirac point of this device. At high magnetic field, in the quantum Hall regime, we observed ballistic tunneling of the carders through the graphene SET, contrary to the Coulomb blockades observed while approaching the vicinity of the Dirac point. 展开更多
关键词 GRAPHENE single electron transistor Coulomb blockade TUNNELING quantum Hall state
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