急性缺血性脑卒中溶栓治疗中磁敏感加权成像PVS变化及临床应价值

目的 研究急性缺血性脑卒中溶栓治疗中磁敏感加权成像突出血管征(PVS)变化及临床应价值。方法 选择2020年03月-2022年11月医院诊疗的62例急性缺血性脑卒中患者进行研究,采用随机法将患者分成对照组(单纯双联抗血小板治疗,n=24)、研究组(支架植入+双联抗血小板治疗,n=38),两组患者均进行磁敏感加权成像(SWI)检查,并对比两组患者治疗前后突出血管征(PVS)、血压、血小板计数(PLT)、空腹血糖、同型半胱氨酸(HCY)、低密度脂蛋白(LDL)等指标变化,对比分析两组脑微出血(CMBs)发生情况,并记录CMBs部位及数目,分析CMBs严重程度与PVS的相关性。结果 治疗后,两组空腹血糖、HCY、LDL、PLT均下降,其中研究组LDL下降程度更明显(P值<0.05);治疗后两组空腹血糖、HCY、PLT比较无统计学差异(P值>0.05);研究组与对照组CMBs发生率、CMBs数目、CMBs发生部位比较未见显著差异(P值>0.05);治疗后两组PVS均显著降低(P值<0.05),但两组治疗后PVS比较无明显差异(P值>0.05);以Pearson法分析发现两组患者CMBs数目均与其PVS呈明显正相关(r研究组CMBs数目=0.813,r对照组CMBs数目=0.810,P值<0.001)。结论 不同溶栓治疗的ASI患者PVS下降程度不同,且SWI能有效监测不同溶栓治疗后ASI患者CMBs发生情况,对临床ASI预后保障提供辅助性指导。

肾综合征出血热患者CT表现及改变及临床应用价值研究

目的分析肾综合征出血热患者CT表现及改变及临床应用价值。方法回顾分析本院2014年1月至2019年10月收治的134例肾综合征出血热患者作为研究对象,其中轻型31例,中型68例,重型27例,危重型8例。对患者所得图像进行分析,观察记录肾综合征出血热患者肾脏和其他脏器改变情况,以及不同类型患者肾脏和其他脏器发生损害比例情况。结果随着病情的加重,患者脏器损伤情况越严.重,轻型、.中型患者均以脾脏肿大最多,分别占3870%,4117%;27例重型患者均出现胸腔积液情况,而危重型患脏器损伤情况最为严重。双肾肿大患者,MSCT图像上可见为对称性增大,前后经增大情况明显,肾实质增厚,密度为不均匀,皮质期为低密度;胸、腹腔积液患者体内积液随患者病情变化,在多尿期随着患者的尿量增加,其积液逐渐减少、消退。结论肾综合征出血热患者CT有一定特征性表现,通过CT检查可反映出患者肾脏早期改变,可为患者早期诊断及病情变化提供参考,临床使用价值高。

延续性护理结合膳食护理在妊娠糖尿病患者中的应用价值

目的分析与研究延续性护理结合膳食护理在妊娠糖尿病患者中的应用价值。方法研究对象为2020年11月—2021年11月本辖区管理的80例妊娠糖尿病患者,随机分组,2组均为40例。对照组接受常规护理干预,观察组接受延续性护理结合膳食护理干预,对2组进行1个月的护理干预。比较2组血糖水平、自护能力、遵医行为及不良妊娠结局发生情况。结果干预后,观察组空腹血糖及餐后2h血糖水平均显著低于对照组(P<0.05);观察组自护能力评分显著高于对照组(P<0.05);观察组遵医行为显著优于对照组(P<0.05)。观察组不良妊娠结局发生率显著低于对照组(P<0.05)。结论对妊娠糖尿病患者采用延续性护理结合膳食护理效果确切,有助于纠正患者血糖水平,强化其遵医行为及自护能力,减少并发症发生风险,值得临床推广应用。

从道义逻辑看“是”与“应该是”的关系

休谟所提出的"是"与"应当"(ought to)问题其实是"是"与"应当是"的关系问题,其中包括两个问题:事实判断如何与价值判断相推,实然判断如何与应然判断相推。如果认为应当即必然有价值,允许即可能有价值,这样虽然"是"与"应当是"不能直接相推,但"A是应当的"可以推出"A是有价值的"可以推出"A是允许的"。

The Nucleosides Contents and Their Variation in Natural Cordyceps sinensis and Cultured Cordyceps Mycelia

Aim: To compare the contents of nucleosides from natural Cordyceps sinensis and cultured Cordyceps mycelia, and to study the effect of humidity and heat on the content of nucleosides. Methods: The contents of nucleosides were determined by using high performance capillary electrophoresis (HPCE). Beckman P/ACE System 5010 apparatus equipped with a UV detector and a Beckman untreated fused-silica capillary (57 cm 75 mm, 50 cm effective length) was used. Before sample injection, the capillary was rinsed with 1 molL-1 sodium hydroxide solution and running buffer for 5 min, respectively. A voltage of 20 kV was applied for the separation. Pressure injection was 586 kPa for 6 seconds, and the wavelength of detector was 254 nm. The running time was 20 min at 20 oC. The effect of humidity and heat on the contents of nucleosides from natural Cordyceps sinensis and cultured Cordyceps mycelia was observed for 1, 3, 5 and 10 days at temperature 40 oC, and relative humidity 75%. Results: The content of nucleosides from natural Cordyceps sinensis was higher than that from cultured Cordyceps mycelia. But the contents of nucleosides from freshly collected natural Cordyceps sinensis were very low, even below the limit of quantitation. The contents of nucleosides from natural Cordyceps sinensis were significantly increased by humidity and heat, but this phenomenon was not observed in cultured Cordyceps mycelia. Conclusion: There are differences between the nucleosides from natural Cordyceps sinensis and cultured Cordyceps mycelia. The nucleosides in natural Cordyceps sinensis may be derived from the degradation of nucleic acids. This implies that adenosine being used for the quality control of natural Cordyceps sinensis may have to be reconsidered.

Overview of Pharmacological & Ecological Research of Scirpus tabernaemontani Gmel

On the basis of extensive literature search, the species, ingredients, pharmacology, clinical applications, ecological value and cultivation techniques of Scirpus tabemaemontani Gmel have been reviewed, to provide scientific data for further research ＆ development.

Clinical Application and Pharmaceutical Values of Levant Cotton Root

Levant cotton root is a folk traditional herb with a long history in China. This article gave a brief introduction on recent research work related to main com- position, pharmacologic effect and clinical application of levant cotton root and pro- posed existing problems and countermeasures for pharmaceutical industrialization.

红色家书融入高校思想政治教育的路径探析

红色家书深刻记录了中国共产党领导中国人民谋求民族独立、人民解放的艰辛历程,为培养有理想、有本领、有担当的时代新人提供了价值标准和内在动力。将红色家书融入高校思想政治教育的主渠道可以通过:坚持理论性和实践性相结合;优化和创新红色家书的传播方式,坚持主导性与主体性相结合;将红色家书融入校园文化建设,坚持显性和隐性教育相结合三个角度进行探索,以增强高校思想政治教育的实效性。

Isolation and Identification of a Taxol-producing Endophytic Fungus Identified from Taxus media

[Objective] The aim was to isolate and identify a taxol-producing endophytic fungus from Taxus media. [Method] 32 strains of endophytic fungi were identified form the inner bark of T. media,and their fermentation products were detected by high performance liquid chromatography (HPLC). [Result] Through the screening,a strain of taxol-producing endophytic fungi M57 was obtained,which could produce 45-50 μg/L of taxol,and M57 was defined as Rhizopus sp. through morphological observation and 18S rDNA sequence analysis. [Conclusion] The finding of Rhizopus sp. M57 provided a promising strain for producing taxol with taxol-producing fungi fermentation process.

Advances in Pharmaceutical and Ecological Value of Sagina japonica(Sw.) Ohwi

Sagina japonica（Sw.） Ohwi is a traditional medicinal herb for the treatment of lacquer dermatitis, and its medicinal and ecological value needs to be further developed. Based on broad literature search, this paper summarized the identification, composition, pharmacology, clinical applications, ecological value, and cultivation technologies of S. japonica（Sw.） Ohwi, aiming at providing scientific information for further research and development of S. japonica（Sw.） Ohwi.

Predictive value of ^(18)F-fluorodeoxyglucose PET/CT for transarterial chemolipiodolization of hepatocellular carcinoma

AIM： To investigate the correlation of 18F-fluorodeoxy- glucose （18F-FDG） positron emission tomography （PET） with clinical features and the prediction of treatment response. METHODS： A total of 83 hepatocellular carcinoma （HCC） patients undergoing 18F-FDG PET before transar- terial chemolipiodolization with systemic chemo-infusion between October, 2006 and May, 2009 were retrospec-tively enrolled. The patients included 68 men and 15 women （mean age, 60 ~ 10.7 years）. The effect of 18F- FDG-monitored PET uptake on clinical features and on the evaluated treatment response was ascertained with modified Response Evaluation Criteria in Solid Tumors. The PET parameters of maximal standardized uptake value of the tumor （Tsuvmax）, the ratio of the tumor maximal standardized uptake value （SUV） to the liver maximal SUV （Tsuvmax/Lsuwax） and the ratio of tumor maximal SUV to the liver mean SUV （msuvmax/LSUVrnean） were tested as predictive factors. RESULTS： Among the 3 SUV parameters, the TSUV- =maxdLsuvmean ratio （cutoff value of 1.90） was significantly associated with tumor burden including tumor size, tu- mor number, α-fetoprotein levels and tumor stage （P 〈 0.001, P = 0.008, P = 0.011, P 〈 0.001, respectively）. The objective response rates in patients with a high SUV ratio （≥ 1.90） were significantly better than those with a low SUV ratio （〈 1.90） （P = 0.020）. The overall survival rates of patients exhibiting a low Tsuvmax/Lsu- Vmean ratio （〈 1.90） and those with a high SUV ratio （≥1.90） was 38.2 and 10.3 mo, respectively （P 〈 0.01）. However, the time to progression showed no significant difference between the groups （P = 0.15）. CONCLUSION： 18F-FDG PET can be an important predictor of HCC treatment. In particular, the Tsuvmax/ Lsuwean ratio （cutoff value of 1.90） can provide useful information in treatment prognosis for HCC patients treated with Iocoregional therapy.

The value of gastroenterultrasound developer in diagnosis of the stomach tumor

Objective: To study the value of gastroenterultrasound developer in diagnosis of the stomach tumor. Methods: 38 patients who diagnosed as stomach tumor by gastroscopy were chosen, and their images before and after by using gastroenterultrasound developer were compared. Results: The difference between the detectable rate of stomach tumor before and after by using gastroenterultrasound developer was significant (P < 0.01). Conclusion: Gastroenterultrasound developer has a high diagnostic value in diagnosis of the stomach tumor.

Clinical study of stomach neoplasm CT perfusion imaging

Objection:The purpose of this study is preliminarily to discuss stomach perfusion imaging technique with Multi-slice CT and its clinical application value in stomach neoplasm.Methods:Fifteen patients with known stomach neoplasm performed perfusion imaging with 4 or 16 slice CT.Performing perfusion imaging in central slice of neoplasm,using CT cine scan,slice thick 10 mm/2i;with high pressure syringe,injecting quickly from right elbow-front vein,dosage 45-50 mL,injec-tion rate 3.5-4.0 mL/s,scanning delay time 5 s,scanning total time 45 s.We performed perfusion CT post-processing using pancreatic mode of perfusion CT software.Blood flow(BF),blood volume(BV),mean transit time(MTT),and permeability surface(PS) of gastric wall and tumor were computed for every case.Results:BF,BV,MTT and PS of gastric tumor were 116.68 ± 90.09 mL/(min·100 g),9.57 ± 8.12 mL/100 g,10.07 ± 7.74 s,20.78 ± 19.68 mL/(min·100g),respectively.The P values for each CT perfusion parameters between gastric tumor and normal gastric wall were 0.001,0.021,0.155 and 0.031,respectively.Conclusion:Perfusion CT can provide hemodynamics of gastric tumors and play a key role in the diagnosis of gastric tumors.It's clinical application prospect will be fully broad.

Clinical application value of bone turnover markers in non-small-cell lung cancer patients with bone metastases

Objective:The purpose of this study was to assess the clinical application value of bone turnover markers in non-small-cell lung cancer(NSCLC) patients with bone metastases.Including diagnosing bone metastases,detecting bone metastatic spread.Methods:Alkaline phosphatase(AKP),β-C-terminal telopeptide of type I collagen(β-CTx),osteocalcin(OST) and bone alkaline phosphatase(BALP) were measured in 76 patients with bone metastases from NSCLC and 44 normal people.Results:The level of AKP,β-CTx and BALP in patients with bone metastasis was significantly higher than in the normal people.Significant correlation was observed among bone turnover markers.The levels of BALP and OST were significantly correlated with the extent of bone metastasis.The patients with high-level CTx and low-level BALP had higher risk of pathologic fracture.Conclusion:In NSCLC patients with bone metastases,bone turnover markers can help to make diagnosis and evaluate the severity.It will have a wide range of use in clinical practice.

Application of Computed Tomographic Colonography in Diagnosis of Colonic Polyps

Objective To assess the clinical values of computed tomographic colonography （CTC） in diagnosis of colonic polyps. Methods Forty-two patients who were clinically suspicious of colonic polyps or underwent colonic polyps screening received examinations with both CTC and conventional colonoscopy. Sixteen- or 64-slice spiral computed tomography and professional imaging processing techniques were used for evaluation. Per-polyp and per-patient results were analyzed. Those by per-polyp were subsequently divided into ≥10 mm group, 5-10 mm group, and ≤5 mm group. Sensitivity, positive predictive value （PPV）, specificity, negative predictive value （NPV）, and accuracy were calculated using statistical method for diagnostic studies, with conventional colonoscopy as a gold standard. Results Ninety and 61 polyps were found by CTC and conventional colonoscopy, respectively. The per-polyp sensitivity/PPV were 80.3%/55.6% in total, and 100%/92.9%, 93.8%/65.2%, and 68.8%/ 41.5% in the ≥10 mm group, 5-10 mm group, and ≤5 turn group, respectively. The per-patient sensitivity, PPV, specificity, NPV, and accuracy were 97.1%, 89.5%, 42.9%, 75.0%, and 88.1%, respectively. Conclusion CTC can clearly reveal the morphology of colonic polyps and be used as a routine monitoring method for the clinical diagnosis of polyps.

The diagnostic evaluation of fine needle aspiration cytology of thyroid and its clinical application

Objective:The aim of the study was to investigate the diagnostic value of fine needle aspiration cytology (FNAC) and its clinical application.Methods:From April 2009 to February 2011,thyroid FNAC were performed in a total of 186 patients with thyroid nodule or mass in our hospital and 78 of those 186 patients subsequently underwent thyroidectomy.The FNAC findings were compared with the results of the corresponding histological diagnosis.Results:The results of thyroid FNAC for 186 patients showed that,(1) 166 cases of benign lesions,the detection rate was 89.24% (166/186),including 96 cases of nodular colloid goiter (51.61%),28 cases of simple colloid goiter (15.05%),38 cases of Hashimoto's thyroiditis (HT) (20.43%) and 4 cases of thyroid adenoma (2.15%);(2) 4 cases of suspicious malignant lesion,the detection rate was 2.15% (4/186);(3) 16 cases of malignant tumor,the detection rate was 8.60% (16/186).Seventy eight patients including malignant (16),suspicious malignant (4),HT (20) and nodular colloid goiters (38) cases diagnosed by FNAC were performed operation with thyroidectomy and the postoperative histopathologic results showed that there were 2 cases HT combined thyroid papillary carcinoma in HT 20 cases by FNAC,15 cases of thyroid papillary carcinoma and 1 case of follicular carcinoma in 16 cases of malignant tumor by FNAC and 4 case of thyroid papillary carcinoma in 4 cases of suspicious malignant by FNAC.Conclusion:Thyroid FNAC is a valuable and reliable method for the diagnosis of the thyroid nodules or mass or even most diffuse thyroid diseases.Diagnosis of HT and thyroid papillary carcinoma can be made by thyroid FNAC.There was larger hint value for nodular colloid goiter and simple colloid goiter according to thyroid FNAC.

Mass Valuation and the Implementation Necessity of GIS （Geographic Information System） in Albania

In the last decade, mass valuation system is applied in Albania in addition to individual valuation system for real estate valuation. This system is used for compiling the land value map and apartments value map. Due to the lack of experience in the compilation of these maps, the methodology of valuation is based on the experiences of other countries with similar development of real estate market. The mass assessment, which is applied in determining the values for specific purposes, such as expropriation, compensation and taxes for property transfer through the methodology adopted for this aim, is analyzed in the light of the finding of issues that accompany this application. The aim of this research is to highlight the problems to provide the ways of overcoming them in order to approximate the values of map values with market values. The mass appraisal process requires effective valuation models and proper management of resources. Its accuracy depends upon the extent and quality of property data available. Because of this reason, it is recommended the usage of the GIS （geographic information system）, an automated system for collection and processing of the data necessary for valuation, as the first point of integration between two process of valuation, individual and mass valuation.

Clinical value of CTS-guided percutaneous transthoracic biopsy in elder patients with lung cancer

Objective： To evaluate the value of CTS-guided percutaneous transthoracic biopsy for the diagnosis of pulmonary lesions in elder patients. Methods： The intact data of 78 elder patients underwent percutaneous pulmonary biopsy with a spring-core biopsy needle under CTS guidance were analyzed. The diagnosis of all the cases was confirmed by pathology and follow-up. Results： Ninety-five lung biopsies were performed in 78 cases and satisfactory tissue specimens obtained in all cases, the success rate was 100%. The diagnosis for malignant tumors and benign lesions was 72 and 6, respectively. The overall accuracy rate was 100%. Pneumothorax was noted in 5 cases （6.4%） and hemoptysis seen in 10 patients （12.8%）. Conclusion： CTS-guided percutaneous transthoracic biopsy with a spring-core biopsy needle are accurate, safe and quick for pulmonary lesions in elder patients.

The applied value of modified POSSUM score in evaluating lung cancer surgery’s risk

Objective: The aim of this study was to explore the modified physiological and operative severity score for the enumeration of mortality and morbidity (POSSUM) scoring system and the relationship between predicted data and actual data of complication and surgical mortality of lung cancer radical surgery made by such score system. Methods: Retrospective analysis on the 86 cases of the clinical materials of patients with primary lung cancer radical surgery for thoracic surgery of line lung cancer in the 81st Hospital of PLA from October 2010 to October 2011 and using the POSSUM scoring system to predict the cases of postoperative complication and death toll, then making a comparison with the actual cases. Results: The POSSUM scoring system predicting 29 cases of postoperative complications, but 32 cases of practical complications, the difference between them has no statistical significance (P﹥0.05), 8 cases of predicted postoperative deaths, 2 cases of practical deaths, by comparison, there was statistical significance (P﹤0.05). Conclusion: The modified POSSUM scoring system can be used to predict the postoperative complication of lung surgery patients, but sometimes overestimates the postoperative death cases.

Using Multi-destination ZTCM to Evaluate the Recreational Values of Cultural Sights:an Application to Jiayuguan,China

This study explained the importance of environmental protection in tourism development and illustrated the relationship between recreational resource valuation and environmental consideration.We compare different models of travel cost method and reiterates long-time existing problems of multi-destination and treats of time opportunity cost(TOC).Taking Jiayuguan's cultural sights as an example,we establish an updated method called multidestination zonal tourism cost method to evaluate the recreational values(RVs) of selected three cultural sights.We divide trip packages of Jiayuguan's tourists into 11 portfolios.Each portfolio can be seen as a separate commodity,and each commodity has its own demand curve.According to demand curves we can calculate consumer surplus(CS) of different portfolios of tourist destinations and later we sum up the total travel costs(including travel expenditure and TOC) and CS to come to the RVs of each portfolio.We then apply suitable proportions to calculate the RVs between different destinations in the portfolio.In the end,we add up all the RVs calculated for the objective destination.Using this method,we draw conclusions that Jiayuguan's RV in 2006 includes national and international values,summing up to 738.4762 million yuan.The tourist expenditure,CS and TOC of Jiayuguan is proportionating 62.96,32.28 and 4.76%,respectively.This study is also an example of non-market valuation of cultural tourism resources.