In rolling process, the rolling force is an important parameter. The precision of the predicted rolling force will directly affect the precision of the finished product. By using adaptive control theory and fusing the...In rolling process, the rolling force is an important parameter. The precision of the predicted rolling force will directly affect the precision of the finished product. By using adaptive control theory and fusing the measured and predicted data, the precision of the predicted rolling force is gradually improved. This system has been used in plant for more than one year, and the result of the application shows that the system has steady and reliable performance, and high precision.展开更多
[Objective] To study the remediation efficiency of red mud on Pb, Zn and Cd in the heavy metal contaminated paddy soil of mine area, to clarify its remediation mechanism and fertilizer efficiency on heavy metal contam...[Objective] To study the remediation efficiency of red mud on Pb, Zn and Cd in the heavy metal contaminated paddy soil of mine area, to clarify its remediation mechanism and fertilizer efficiency on heavy metal contaminated soil. [Method] The soil incubation experiment was conducted to study the effect of red mud on the pH values and electrical conductivity (EC), and the remediation efficiency of red mud on lead (Pb), zinc (Zn) and cadmium (Cd) in heavy metal contaminated soil. [Result] Red mud addition reduced the content of exchangeable Pb, Zn and Cd in the soil significantly. Compared with the control, when incubated for 30, 60 and 90 d with the red mud dosage of 4% (W/W), the exchangeable Pb content was decreased by 39.25%, 41.38% and 50.19%; exchangeable Zn content was decreased by 49.26%, 57.32% and 47.16%; and exchangeable Cd content was decreased by 19.53%, 24.06% and 25.70%, respectively. The application of red mud had significant impact on the share of Pb, Zn and Cd contents in five forms, and different amounts of red mud application all reduced the proportion of exchangeable Pb, Zn and Cd to the total Pb, Zn and Cd. In addition, the proportion of exchangeable Pb, Zn and Cd to total Pb, Zn and Cd decreased with the increasing amount of red mud addition. [Conclusion] The study provided references for reasonable application of red mud and reduction of heavy metal pollution in paddy soil.展开更多
Current dynamic finite element model updating methods are not efficient or restricted to the problem of local optima. To circumvent these, a novel updating method which integrates the meta-model and the genetic algori...Current dynamic finite element model updating methods are not efficient or restricted to the problem of local optima. To circumvent these, a novel updating method which integrates the meta-model and the genetic algorithm is proposed. Experimental design technique is used to determine the best sampling points for the estimation of polynomial coefficients given the order and the number of independent variables. Finite element analyses are performed to generate the sampling data. Regression analysis is then used to estimate the response surface model to approximate the functional relationship between response features and design parameters on the entire design space. In the fitness evaluation of the genetic algorithm, the response surface model is used to substitute the finite element model to output features with given design parameters for the computation of fitness for the individual. Finally, the global optima that corresponds to the updated design parameter is acquired after several generations of evolution. In the application example, finite element analysis and modal testing are performed on a real chassis model. The finite element model is updated using the proposed method. After updating, root-mean-square error of modal frequencies is smaller than 2%. Furthermore, prediction ability of the updated model is validated using the testing results of the modified structure. The root-mean-square error of the prediction errors is smaller than 2%.展开更多
In order to establish the relationship between the measured dynamic response and the health status of long-span bridges, a double-layer model updating method for steel-concrete composite beam cable-stayed bridges is p...In order to establish the relationship between the measured dynamic response and the health status of long-span bridges, a double-layer model updating method for steel-concrete composite beam cable-stayed bridges is proposed. Measured frequencies are selected as the first-layer reference data, and the mass of the bridge deck, the grid density, the modulus of concrete and the ballast on the side span are modified by using a manual tuning technique. Measured global positioning system (GPS) data is selected as the second-layer reference data, and the degradation of the integral structure stiffness EI of the whole bridge is taken into account for the second-layer model updating by using the finite element iteration algorithm. The Nanpu Bridge in Shanghai is taken as a case to verify the applicability of the proposed model updating method. After the first-layer model updating, the standard deviation of modal frequencies is smaller than 7%. After the second-layer model updating, the error of the deflection of the mid-span is smaller than 10%. The integral structure stiffness of the whole bridge decreases about 20%. The research results show a good agreement between the calculated response and the measured response.展开更多
A direct self-repairing control approach is proposed for helicopter via quantum control techniques and adaptive compensator when some complex faults occur. For a linear varying-parameter helicopter control system, the...A direct self-repairing control approach is proposed for helicopter via quantum control techniques and adaptive compensator when some complex faults occur. For a linear varying-parameter helicopter control system, the model reference adaptive control law is designed and an adaptive compensator is used for improving its self-re- pairing capability. To enhance anti-interference capability of helicopter, quantum control feedforward is added be- tween fault and disturbance. Simulation results illustrate the effectiveness and feasibility of the approach.展开更多
The forbidden pitch "dip" in the critical dimension (CD) through the pitch curve is a well-known optical proximity effect. The CD and CD process window near the "dip",usually found near a pitch range of 1.1 to 1...The forbidden pitch "dip" in the critical dimension (CD) through the pitch curve is a well-known optical proximity effect. The CD and CD process window near the "dip",usually found near a pitch range of 1.1 to 1.4 wavelength/ NA (numerical aperture),is smaller when compared with other pitches. This is caused by inadequate imaging contrast for an unequal line and space grating. Although this effect is relatively well-known, its relationship with typical process condition parameters,such as the effective image blur caused by the photo-acid diffusion during the post exposure bake or the aberration in the imaging lens, has not been systematically studied. In this paper, we will examine the correlation between the image blur and the effect on the CD, including the decrease in the CD value (the depth of the "dip") and the CD process window. We find that both the decrease in the CD value and the focus latitude near the forbidden pitch correlate very well with the effective Gaussian image blur. Longer effective diffusion length correlates well with a smaller process window and a deeper CD "dip". We conclude that the dip depth is very sensitive to the change in image contrast.展开更多
Objective: A new indirect composite restorative system with water combingpressure, light, and heat was introduced for the fabrication of inlays and onlays. Methods: Fifteendefected teeth were selected for composite re...Objective: A new indirect composite restorative system with water combingpressure, light, and heat was introduced for the fabrication of inlays and onlays. Methods: Fifteendefected teeth were selected for composite resin inlay and onlay fabrication with Tescera ATL unitequipment. The clinical trial was carried out for 3 months. Results: After 3 months test, 7parameters were checked, 15 Tescera inlays and onlays were demonstrated that exceptional esthetics,all 7 parameters were good and the patients were very satisfied. Conclusion: inlays , which weremade with Tescera ATL restorative system, are esthetics; physical properties of materials areimproved highly, and have a long-lasting durability. This restorative system is worthy to be usedand further studied in dental practice.展开更多
Nation-membrane-based proton exchange fuel cells (PEMFCs) typically operate at below 100 ℃. However, H3PO4-doped polybenzimidazole (PBI)-based PEMFCs can operate at 100-200 ℃. This is advantageous because of acc...Nation-membrane-based proton exchange fuel cells (PEMFCs) typically operate at below 100 ℃. However, H3PO4-doped polybenzimidazole (PBI)-based PEMFCs can operate at 100-200 ℃. This is advantageous because of accelerated reaction rates and enhanced tolerance to poisons such as CO and S02, which can arise from reformed gas or the atmosphere. However, the strong adsorption of phosphoric anions on the Pt surface dramatically decreases the electrocatalytic activity. This study exploits the "third-body effect", in which a small amount of organic molecules are pre-adsorbed on the Pt surface to inhibit the adsorption of phosphoric anions. Pre-adsorbate species inhibit the ad- sorption of phosphoric anions, but can also partially occlude active sites. Thus, the optimum pre-adsorbate coverage is studied by correlating the oxygen reduction reaction (ORR) activity of Pt with pre-adsorbate coverage on the Pt surface. The influence of the pre-adsorbate molecule length is investigated using the organic amines, butylamine, octylamine, and dodecylamine, in both 0.1 mol/L HCI04 and 0.1 mol/L H3P04. Such amines readily bond to the Pt surface. In aqueous HCI04 electrolyte, the ORR activity of Pt decreases monotonically with increasing pre-adsorbate coverage. In aqueous H3P04 electrolyte, the ORR activity of Pt initially increases and then decreases with in- creasing pre-adsorbate coverage. The maximum ORR activity in H3P04 occurs at a pre-adsorbate coverage of around 20%. The effect of molecular length of the pre-adsorbate is negligible, but its coverage strongly affects the degree to which phosphoric anion adsorption is inhibited. Butylamine adsorbs to Pt at partial active sites, which decreases the electrochemically active surface area. Ad- sorbed butylamine may also modify the electronic structure of the Pt surface. The ORR activity in the phosphoric acid electrolyte remains relatively low, even when using the pre-adsorbate modified Pt/C catalysts. Further development of the catalyst and electrolyte is required before the commercialization of H3PO4-PBl-based PEMFCs can be realized.展开更多
Equipment plays an important role in open pit mining industry and its cost competence at efficient operation and maintenance techniques centered on reliability can lead to significant cost reduction.The application of...Equipment plays an important role in open pit mining industry and its cost competence at efficient operation and maintenance techniques centered on reliability can lead to significant cost reduction.The application of optimal maintenance process was investigated for minimizing the equipment breakdowns and downtimes in Sungun Copper Mine.It results in the improved efficiency and productivity of the equipment and lowered expenses as well as the increased profit margin.The field operating data of 10 trucks are used to estimate the failure and maintenance profile for each component,and modeling and simulation are accomplished by using reliability block diagram method.Trend analysis was then conducted to select proper probabilistic model for maintenance profile.Then reliability of the system was evaluated and importance of each component was computed by weighted importance measure method.This analysis led to identify the items with critical impact on availability of overall equipment in order to prioritize improvement decisions.Later,the availability of trucks was evaluated using Monte Carlo simulation and it is revealed that the uptime of the trucks is around 11000 h at 12000 operation hours.Finally,uncertainty analysis was performed to account for the uncertainty sources in data and models.展开更多
The electrocatalytic oxidation of methanol was studied over Ni, Co and Cu binary or ternary alloys on graphite electrodes in a NaOH solution (0.1 mol/L). The catalysts were prepared by cycling the graphite electrode...The electrocatalytic oxidation of methanol was studied over Ni, Co and Cu binary or ternary alloys on graphite electrodes in a NaOH solution (0.1 mol/L). The catalysts were prepared by cycling the graphite electrode in solutions containing Ni, Cu and Co ions at cathodic potentials. The synergistic effects and catalytic activity of the modified electrodes were investigated by cyclic voltammetry (CV), chronoamperometry CCA) and electrochemical impedance spectroscopy (EIS). It was found that, in the presence of methanol, the modified Ni-based ternary alloy electrode (G/NiCuCo) exhibited a significantly higher response for methanol oxidation compared to the other samples. The anodic peak currents showed a linear dependency on the square root of the scan rate, which is a characteristic of a diffusion controlled process. During CA studies, the reaction exhibited Cottrellin behavior and the diffusion coefficient of methanol was determined to be 6.25× 10-6 cm2/s and the catalytic rate constant, K, for methanol oxidation was found to be 40×107 cm3/Cmol.s). EIS was used to investigate the catalytic oxidation of methanol on the surface of the modified electrode.展开更多
Objective To investigate the active components and mechanism of Sanao Decoction(三拗汤,SAD)in treating chronic cough based on network pharmacology and molecular docking.Methods Active components and their targets were...Objective To investigate the active components and mechanism of Sanao Decoction(三拗汤,SAD)in treating chronic cough based on network pharmacology and molecular docking.Methods Active components and their targets were obtained from the Traditional Chinese Medicine Systems and Pharmacology Database and Analysis Platform(TCMSP),Bioinformatics Analysis Tool for Molecular mech ANism of Traditional Chinese Medicine(BATMAN-TCM)database,and the literature.The component-target regulatory network and protein-protein interaction(PPI)network were constructed by Cytoscape 3.7.2,and a bioinformatics analysis was performed to identify the significant pathways and their relevant targets.Molecular docking of the core active components and relevant targets was performed.Results A total of 98 active components of SAD and the corresponding 113 drug targets were identified.The component-target regulatory network and PPI network were successfully established.Results of the bioinformatics analysis indicated that 2281 Gene Ontology(GO)terms were enriched in chronic cough,including 2062 terms were in biological processes,77 in cellular components,and 142 in molecular functions,and top 20 significant pathways in Kyoto Encyclopedia of Genes and Genomes(KEGG)analysis.Molecular docking study demonstrated that quercetin,luteolin,kaempferol,and naringenin were in good agreement with the corresponding targets.Conclusion The active compounds of SAD,such as quercetin,luteolin,kaempferol,and naringenin,may act on AKT1,MAPK1,RELA,EGFR,and Bcl-2 and regulate the PI3 K-Akt signaling pathway,AGE-RAGE signaling pathway,and fluid shear stress and atherosclerosis pathway to exert the effects of anti-inflammatory,anti-airway remodeling,anti-oxidant stress effects,and repair airway damage,thus treating chronic cough.展开更多
Objective: The aim of this study was to evaluate the value of the application of anterolateral thigh flap in postoperative repairing of vulva tumor. Methods: Anterolateral thigh flap with the descending branch of th...Objective: The aim of this study was to evaluate the value of the application of anterolateral thigh flap in postoperative repairing of vulva tumor. Methods: Anterolateral thigh flap with the descending branch of the lateral circumflex femoral artery and the pedicle of anterolaterat thigh cutaneous nerve was used in primary repairing of the defect from postoperative vulva tumor, the sizes of the flaps ranged from 10 cm ×14 cm-14 cm× 20 cm. Results: All flaps survived, during a follow-up of 2 to 12 months, the appearance of the flaps was satisfactory with sensitive function without local recurrences. Conclusion: Anterelateral thigh flap has fairly long vessel pedicle, wider vessel diameter, and is in the covert area. Anterolateral thigh flap with sensory nerve is the ideal choice for postoperative repairing of vulva tumor.展开更多
The modified couple stress theory(MCST)is applied to analyze axisymmetric bending and buckling behaviors of circular microplates with sinusoidal shear deformation theory.The differential governing equations and bounda...The modified couple stress theory(MCST)is applied to analyze axisymmetric bending and buckling behaviors of circular microplates with sinusoidal shear deformation theory.The differential governing equations and boundary conditions are derived through the principle of minimum total potential energy,and expressed in nominal form with the introduced nominal variables.With the application of generalized differential quadrature method(GDQM),both the differential governing equations and boundary conditions are expressed in discrete form,and a set of linear equations are obtained.The bending deflection can be obtained through solving the linear equations,while buckling loads can be determined through solving general eigenvalue problems.The influence of material length scale parameter and plate geometrical dimensions on the bending deflection and buckling loads of circular microplates is investigated numerically for different boundary conditions.展开更多
文摘In rolling process, the rolling force is an important parameter. The precision of the predicted rolling force will directly affect the precision of the finished product. By using adaptive control theory and fusing the measured and predicted data, the precision of the predicted rolling force is gradually improved. This system has been used in plant for more than one year, and the result of the application shows that the system has steady and reliable performance, and high precision.
基金Supported by the National Natural Science Foundation of China(50874046)the National High-tech Research and Develop Program of China(863 Program)(2010AA065203)the Science and Technology Project of Education Bureau of Hunan Province,China(08A032)~~
文摘[Objective] To study the remediation efficiency of red mud on Pb, Zn and Cd in the heavy metal contaminated paddy soil of mine area, to clarify its remediation mechanism and fertilizer efficiency on heavy metal contaminated soil. [Method] The soil incubation experiment was conducted to study the effect of red mud on the pH values and electrical conductivity (EC), and the remediation efficiency of red mud on lead (Pb), zinc (Zn) and cadmium (Cd) in heavy metal contaminated soil. [Result] Red mud addition reduced the content of exchangeable Pb, Zn and Cd in the soil significantly. Compared with the control, when incubated for 30, 60 and 90 d with the red mud dosage of 4% (W/W), the exchangeable Pb content was decreased by 39.25%, 41.38% and 50.19%; exchangeable Zn content was decreased by 49.26%, 57.32% and 47.16%; and exchangeable Cd content was decreased by 19.53%, 24.06% and 25.70%, respectively. The application of red mud had significant impact on the share of Pb, Zn and Cd contents in five forms, and different amounts of red mud application all reduced the proportion of exchangeable Pb, Zn and Cd to the total Pb, Zn and Cd. In addition, the proportion of exchangeable Pb, Zn and Cd to total Pb, Zn and Cd decreased with the increasing amount of red mud addition. [Conclusion] The study provided references for reasonable application of red mud and reduction of heavy metal pollution in paddy soil.
文摘Current dynamic finite element model updating methods are not efficient or restricted to the problem of local optima. To circumvent these, a novel updating method which integrates the meta-model and the genetic algorithm is proposed. Experimental design technique is used to determine the best sampling points for the estimation of polynomial coefficients given the order and the number of independent variables. Finite element analyses are performed to generate the sampling data. Regression analysis is then used to estimate the response surface model to approximate the functional relationship between response features and design parameters on the entire design space. In the fitness evaluation of the genetic algorithm, the response surface model is used to substitute the finite element model to output features with given design parameters for the computation of fitness for the individual. Finally, the global optima that corresponds to the updated design parameter is acquired after several generations of evolution. In the application example, finite element analysis and modal testing are performed on a real chassis model. The finite element model is updated using the proposed method. After updating, root-mean-square error of modal frequencies is smaller than 2%. Furthermore, prediction ability of the updated model is validated using the testing results of the modified structure. The root-mean-square error of the prediction errors is smaller than 2%.
基金The Special Project of the Ministry of Construction ofChina (No.20060909).
文摘In order to establish the relationship between the measured dynamic response and the health status of long-span bridges, a double-layer model updating method for steel-concrete composite beam cable-stayed bridges is proposed. Measured frequencies are selected as the first-layer reference data, and the mass of the bridge deck, the grid density, the modulus of concrete and the ballast on the side span are modified by using a manual tuning technique. Measured global positioning system (GPS) data is selected as the second-layer reference data, and the degradation of the integral structure stiffness EI of the whole bridge is taken into account for the second-layer model updating by using the finite element iteration algorithm. The Nanpu Bridge in Shanghai is taken as a case to verify the applicability of the proposed model updating method. After the first-layer model updating, the standard deviation of modal frequencies is smaller than 7%. After the second-layer model updating, the error of the deflection of the mid-span is smaller than 10%. The integral structure stiffness of the whole bridge decreases about 20%. The research results show a good agreement between the calculated response and the measured response.
基金Supported by the National Natural Science Foundation of China(61074080)the Innovation Foundation for Aeronautical Science and Technology(08C52001)~~
文摘A direct self-repairing control approach is proposed for helicopter via quantum control techniques and adaptive compensator when some complex faults occur. For a linear varying-parameter helicopter control system, the model reference adaptive control law is designed and an adaptive compensator is used for improving its self-re- pairing capability. To enhance anti-interference capability of helicopter, quantum control feedforward is added be- tween fault and disturbance. Simulation results illustrate the effectiveness and feasibility of the approach.
文摘The forbidden pitch "dip" in the critical dimension (CD) through the pitch curve is a well-known optical proximity effect. The CD and CD process window near the "dip",usually found near a pitch range of 1.1 to 1.4 wavelength/ NA (numerical aperture),is smaller when compared with other pitches. This is caused by inadequate imaging contrast for an unequal line and space grating. Although this effect is relatively well-known, its relationship with typical process condition parameters,such as the effective image blur caused by the photo-acid diffusion during the post exposure bake or the aberration in the imaging lens, has not been systematically studied. In this paper, we will examine the correlation between the image blur and the effect on the CD, including the decrease in the CD value (the depth of the "dip") and the CD process window. We find that both the decrease in the CD value and the focus latitude near the forbidden pitch correlate very well with the effective Gaussian image blur. Longer effective diffusion length correlates well with a smaller process window and a deeper CD "dip". We conclude that the dip depth is very sensitive to the change in image contrast.
文摘Objective: A new indirect composite restorative system with water combingpressure, light, and heat was introduced for the fabrication of inlays and onlays. Methods: Fifteendefected teeth were selected for composite resin inlay and onlay fabrication with Tescera ATL unitequipment. The clinical trial was carried out for 3 months. Results: After 3 months test, 7parameters were checked, 15 Tescera inlays and onlays were demonstrated that exceptional esthetics,all 7 parameters were good and the patients were very satisfied. Conclusion: inlays , which weremade with Tescera ATL restorative system, are esthetics; physical properties of materials areimproved highly, and have a long-lasting durability. This restorative system is worthy to be usedand further studied in dental practice.
基金supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA09030104)the National Basic Research Program of China(973 Program,2012CB215500)the Key Program of the Chinese Academy of Sciences(KGZD-EW-T08)
文摘Nation-membrane-based proton exchange fuel cells (PEMFCs) typically operate at below 100 ℃. However, H3PO4-doped polybenzimidazole (PBI)-based PEMFCs can operate at 100-200 ℃. This is advantageous because of accelerated reaction rates and enhanced tolerance to poisons such as CO and S02, which can arise from reformed gas or the atmosphere. However, the strong adsorption of phosphoric anions on the Pt surface dramatically decreases the electrocatalytic activity. This study exploits the "third-body effect", in which a small amount of organic molecules are pre-adsorbed on the Pt surface to inhibit the adsorption of phosphoric anions. Pre-adsorbate species inhibit the ad- sorption of phosphoric anions, but can also partially occlude active sites. Thus, the optimum pre-adsorbate coverage is studied by correlating the oxygen reduction reaction (ORR) activity of Pt with pre-adsorbate coverage on the Pt surface. The influence of the pre-adsorbate molecule length is investigated using the organic amines, butylamine, octylamine, and dodecylamine, in both 0.1 mol/L HCI04 and 0.1 mol/L H3P04. Such amines readily bond to the Pt surface. In aqueous HCI04 electrolyte, the ORR activity of Pt decreases monotonically with increasing pre-adsorbate coverage. In aqueous H3P04 electrolyte, the ORR activity of Pt initially increases and then decreases with in- creasing pre-adsorbate coverage. The maximum ORR activity in H3P04 occurs at a pre-adsorbate coverage of around 20%. The effect of molecular length of the pre-adsorbate is negligible, but its coverage strongly affects the degree to which phosphoric anion adsorption is inhibited. Butylamine adsorbs to Pt at partial active sites, which decreases the electrochemically active surface area. Ad- sorbed butylamine may also modify the electronic structure of the Pt surface. The ORR activity in the phosphoric acid electrolyte remains relatively low, even when using the pre-adsorbate modified Pt/C catalysts. Further development of the catalyst and electrolyte is required before the commercialization of H3PO4-PBl-based PEMFCs can be realized.
基金the support of the Maintenance Department of Mobin Co.Sungun Copper mine
文摘Equipment plays an important role in open pit mining industry and its cost competence at efficient operation and maintenance techniques centered on reliability can lead to significant cost reduction.The application of optimal maintenance process was investigated for minimizing the equipment breakdowns and downtimes in Sungun Copper Mine.It results in the improved efficiency and productivity of the equipment and lowered expenses as well as the increased profit margin.The field operating data of 10 trucks are used to estimate the failure and maintenance profile for each component,and modeling and simulation are accomplished by using reliability block diagram method.Trend analysis was then conducted to select proper probabilistic model for maintenance profile.Then reliability of the system was evaluated and importance of each component was computed by weighted importance measure method.This analysis led to identify the items with critical impact on availability of overall equipment in order to prioritize improvement decisions.Later,the availability of trucks was evaluated using Monte Carlo simulation and it is revealed that the uptime of the trucks is around 11000 h at 12000 operation hours.Finally,uncertainty analysis was performed to account for the uncertainty sources in data and models.
基金provided by K.N.Toosi University of Technology Research Council to conduct this research
文摘The electrocatalytic oxidation of methanol was studied over Ni, Co and Cu binary or ternary alloys on graphite electrodes in a NaOH solution (0.1 mol/L). The catalysts were prepared by cycling the graphite electrode in solutions containing Ni, Cu and Co ions at cathodic potentials. The synergistic effects and catalytic activity of the modified electrodes were investigated by cyclic voltammetry (CV), chronoamperometry CCA) and electrochemical impedance spectroscopy (EIS). It was found that, in the presence of methanol, the modified Ni-based ternary alloy electrode (G/NiCuCo) exhibited a significantly higher response for methanol oxidation compared to the other samples. The anodic peak currents showed a linear dependency on the square root of the scan rate, which is a characteristic of a diffusion controlled process. During CA studies, the reaction exhibited Cottrellin behavior and the diffusion coefficient of methanol was determined to be 6.25× 10-6 cm2/s and the catalytic rate constant, K, for methanol oxidation was found to be 40×107 cm3/Cmol.s). EIS was used to investigate the catalytic oxidation of methanol on the surface of the modified electrode.
基金funding support from the National Natural Science Foundation of China(No.82174093)。
文摘Objective To investigate the active components and mechanism of Sanao Decoction(三拗汤,SAD)in treating chronic cough based on network pharmacology and molecular docking.Methods Active components and their targets were obtained from the Traditional Chinese Medicine Systems and Pharmacology Database and Analysis Platform(TCMSP),Bioinformatics Analysis Tool for Molecular mech ANism of Traditional Chinese Medicine(BATMAN-TCM)database,and the literature.The component-target regulatory network and protein-protein interaction(PPI)network were constructed by Cytoscape 3.7.2,and a bioinformatics analysis was performed to identify the significant pathways and their relevant targets.Molecular docking of the core active components and relevant targets was performed.Results A total of 98 active components of SAD and the corresponding 113 drug targets were identified.The component-target regulatory network and PPI network were successfully established.Results of the bioinformatics analysis indicated that 2281 Gene Ontology(GO)terms were enriched in chronic cough,including 2062 terms were in biological processes,77 in cellular components,and 142 in molecular functions,and top 20 significant pathways in Kyoto Encyclopedia of Genes and Genomes(KEGG)analysis.Molecular docking study demonstrated that quercetin,luteolin,kaempferol,and naringenin were in good agreement with the corresponding targets.Conclusion The active compounds of SAD,such as quercetin,luteolin,kaempferol,and naringenin,may act on AKT1,MAPK1,RELA,EGFR,and Bcl-2 and regulate the PI3 K-Akt signaling pathway,AGE-RAGE signaling pathway,and fluid shear stress and atherosclerosis pathway to exert the effects of anti-inflammatory,anti-airway remodeling,anti-oxidant stress effects,and repair airway damage,thus treating chronic cough.
文摘Objective: The aim of this study was to evaluate the value of the application of anterolateral thigh flap in postoperative repairing of vulva tumor. Methods: Anterolateral thigh flap with the descending branch of the lateral circumflex femoral artery and the pedicle of anterolaterat thigh cutaneous nerve was used in primary repairing of the defect from postoperative vulva tumor, the sizes of the flaps ranged from 10 cm ×14 cm-14 cm× 20 cm. Results: All flaps survived, during a follow-up of 2 to 12 months, the appearance of the flaps was satisfactory with sensitive function without local recurrences. Conclusion: Anterelateral thigh flap has fairly long vessel pedicle, wider vessel diameter, and is in the covert area. Anterolateral thigh flap with sensory nerve is the ideal choice for postoperative repairing of vulva tumor.
基金supported in part by the National Natural Science Foundation of China(No.12172169)the Priority Academic Program Development of Jiangsu Higher Education Institutions。
文摘The modified couple stress theory(MCST)is applied to analyze axisymmetric bending and buckling behaviors of circular microplates with sinusoidal shear deformation theory.The differential governing equations and boundary conditions are derived through the principle of minimum total potential energy,and expressed in nominal form with the introduced nominal variables.With the application of generalized differential quadrature method(GDQM),both the differential governing equations and boundary conditions are expressed in discrete form,and a set of linear equations are obtained.The bending deflection can be obtained through solving the linear equations,while buckling loads can be determined through solving general eigenvalue problems.The influence of material length scale parameter and plate geometrical dimensions on the bending deflection and buckling loads of circular microplates is investigated numerically for different boundary conditions.