傅自应副省长会见美国华人生物医药科技协会访问团

在中国的传统佳节中秋节前夕,江苏省政府副省长傅自应亲切会见美国华人生物医药科技协会（以下简称CBA）会长魏紫萍一行。省侨办主任王华、副主任孙彬等陪同会见。宾主双方就CBA与江苏开展生物医药人才项目合作、引进海外人才创业环境及2015年在南京召开国际生物医药交流洽谈会暨CBA年会等事项进行了广泛的交谈。

略论扬琴演奏的弹与打

一 名应副实 “打扬琴”已经成为扬琴演奏中的一种通常性说法,人们往往说:“某某扬琴打得不错”。“请你再打一首曲子听听”。“打扬琴”、“敲扬琴”或者“砸扬琴”等等,好象习以为常,而“弹扬琴”却很少听到。这种“打扬琴”的说法到底起于何时、何地、何人?一时难于考证。是否早在国外和传入我国以后,曾有人将击弦乐器的扬琴列入打击乐器组呢?这有待于专家研究,但是,从扬琴演奏艺术来说,究竟是说“打”还是“弹”更名副其实、更有利于演奏艺术的发展呢? 一种乐器的名称,往往是由该乐器以何种手段而发音来决定的,例如,各种弦乐器都是以弓和弦的接触、磨擦发音的,故称之为拉提琴、拉二胡等等;

浙江元明清名诗人评传

一、传略溶字洁躬,一字鉴躬,号秋岳,又号倦圃,嘉兴人。明崇祯丁丑进士,选庶吉士,改御史謇谔,有直声,中朝贵人多侧目。明亡清室召罗才俊,顺治间溶以先朝遗逸应副御史户部侍郎,出为广东布政使,左迁山西阳和道,裁缺归里。迨康熙戊午,巳未间,天子思得宏博之士,备顾问大臣,有举秋岳应诏者。是时彼已归隐林泉、仰屋著书,三微不起矣。卒年八十三岁。溶肆力于文章,尤工尺牍,长笺短幅人共宝之。

对《岭外代答》一处失误的辨证

南宋周去非所著《岭外代答》,其中有关广西盐业的记述,为研究宋代广西盐业史者提供了重要的史料,经学者印证认为它符合或接近实际,但笔者发现其中也有一点失实之处。 《岭外代答》卷五《广右漕计》云:“盐场滨海,以舟运于廉州石康仓,客贩西盐者,自廉州陆运至郁林州,而后可以舟运。……自改行官卖……乃置十万仓于郁林州,官以牛车自廉州石康仓运盐贮之。

来信照登

感谢竺雄扬同志纠正我的一个错误结论,即“了”在古汉语中的使用问题.至于“了”在现代汉语中的用法,尚有商榷之处.我们认为从简从俗为好.“了”在作时态助词时,它前面的形容词还是具备动词特点的,故原则上不必把动词和形容词分成两类归纳.

Structure Determination of By-product in Grignard Reaction for Preparing Mifepristone Derivatives

Aim To determine the structure of the by-product produced in Grignard reaction for preparing mifepristone derivatives, and elucidate the reaction mechanism.Methods The structure of the by-product was determined with elemental analysis, one- and two-dimension spectra NMR (DEPT, 1H-1Hcosy, HMQC, HMBC) and compared with those of mifepristone.Results The main by-product was 11,17-di-addition product of Grignard reagent of N, N-dimethylamino phenyl bromide.Conclusion This is the first complete assignment of 1H NMR and 13C NMR of compound (3).

Kinetics of Burning Side Reaction in the Liquid-phase Oxidation of p-Xylene

During the liquid-phase oxidation of p-xylene,over-oxidation of reactant,intermediates and solvent to carbon dioxide and carbon monoxide is generally known as the burning side reaction.Batch and semi-continuous experiments were carried out,and the experimental data of the burning side reaction were analyzed and reported in this paper.The results showed that the rates of burning side reactions were proportional to the rates of the main reaction,but decreased with the increasing concentrations of reactant and intermediates.The inter-stimulative and competitive relationship between the burning side reaction and the main reaction was confirmed,and the rates of the burning side reaction could be described with some key indexes of the main reaction.According to the mechanism of the side reactions and the kinetics model of main reaction which were proposed and tested in the previous papers,a kinetic model of the burning side reactions involving some key indexes of the main reaction was developed,and the parameters were determined by data fitting of the COx rate curves.The obtained kinetic model could describe the burning side reactions adequately.

Second-generation direct-acting-antiviral hepatitis C virus treatment: Efficacy, safety, and predictors of SVR12

AIM To gather data on the antiviral efficacy and safety of second generation direct acting antiviral(DAA) treatment with respect to sustained virological response(SVR) 12 wk after conclusion of treatment, and to determine predictors of SVR12 in this setting.METHODS Two hundred and sixty patients treated with SOF combination partners PR(n = 51), R(n = 10), SMV(n = 30), DCV(n = 81), LDV(n = 73), or 3D(n = 15).144/260 were pre-treated, 89/260 had liver cirrhosis, 56/260 had portal hypertension with platelets < 100/nL, 25/260 had a MELD score ≥ 10 and 17/260 were postliver transplantation patients. 194/260 had HCV GT1, 44/260 HCV GT3.RESULTS Two hundred and forty/256(93.7%) patients achieved SVR12(m ITT); 4/260 were lost to follow-up. SVR12 rates for subgroups were: 92% for SOF/DCV, 93% for each SOF/SMV, SOF/PR, 94% for SOF/LDV, 100% for 3D, 94% for pretreated, 87% for liver cirrhosis, 82% for patients with platelets < 100/n L, 88% post-liver transplantation, 95% for GT1 a, 93% for GT1 b, 90% for GT3, 100% for GT2, 4, and 6. 12 patients suffered from relapse, 6 prematurely discontinued treatment, of which 4 died. Negative predictors of SVR12 were a platelet count < 100/nL, MELD score ≥ 10(P < 0.0001), liver cirrhosis(P = 0.005) at baseline. In Interferonfree treatment GT3 had significantly lower SVR rates than GT1(P = 0.016). Side effects were mild. CONCLUSION Excellent SVR12 rates and the favorable side-effect profile of DAA-combination therapy can be well translated into "real-world". Patients with advanced liver disease, signs of portal hypertension, especially with platelets < 100/n L and patients with GT3 are in special need for further research efforts to overcome comparatively higher rates of virological failure.

MOUSE ANTIBODY RESPONSE FOLLOWING REPETITIVE INJECTIONS OF GAMMA－IRRADIATED HUMAN PLACENTA COLLAGEN

Injectable bovine collagen has been used clinically for years. But both the necessity of repeated injections to maintain corrections and the question of adverse allergic reactions developing from the use of a xenogenic collagen have been an area of serious concern. To overoome these adverse effects, we have developed injectable collagen preparations from human placenta. Gamma irradiation was used for sterilization and crosslinkins of the collagen.We observed the mouse immune respose to gamma-irradiated human placenta soluble and insoluble collagen following multiple injections. After six injections of these materials, no total IgG level increase was found, nor was antibody specifically directed against human collagen found.Mouse antibody levels were also observed following Zyderm II and Zyplast repetitive injections and following repetitive implantations of coated vicryl and chromic gut. No humoral immune response was found in this heterologous type system.

Finite element analysis of contact fatigue and bending fatigue of a theoretical assembling straight bevel gear pair

The aim of this work is to propose a 3D FE model of a theoretical assembling straight bevel gear pair to analyze the contact fatigue on the tooth surface and the bending fatigue in the tooth root. Based on the cumulative fatigue criterion and the stress-life equation, the key meshing states of the gear pair were investigated for the contact fatigue and the bending fatigue. Then, the reliability of the proposed model was proved by comparing the calculation result with the simulation result. Further study was performed to analyze the variation of the contact fatigue stress and the bending fatigue stress under different loads. Furthermore, the roles of the driving pinion and the driven gear pair were evaluated in the fatigue life of the straight bevel gear pair and the main fatigue failure mode was determined for the significant gear. The results show that the fatigue failure of the driving pinion is the main fatigue failure for the straight bevel gear pair and the bending fatigue failure is the main fatigue failure for the driving pinion.

Comparing irinotecan/cisplatin with etoposide/cisplatin in patients with ED-SCLC: A meta-analysis of efficacy and toxicity

Objective： Irinotecan in combination with cisplatin for extensive-stage disease small-ceU lung cancer （ED-SCLC） patients has gained wide interest. Varying results for this treatment underpin the need for a synthesis of evidence. Methods： We conducted a literature-based meta-analysis to quantify the magnitude of the benefit comparing irinotecan in combination with cisplatin （IP） with etoposide in combination with cisplatin （EP） in ED-SCLC patients. The primary outcome was overall survival （OS） and progression-free survival （PFS）; secondary outcomes included overall response rate, 1- and 2-year survival rates, disease control rate and toxicity. Results： Four trials including 1,541 patients were identified in the analysis. No positive results （P〈0.05） were seen： OS （HR=0.85, CI95%=0.71-1.01; P=-0.08） with high heterogeneity （Chi2=7.76, dr=-3 [P=-0.05]; I2=61%）, PFS （HR=0.91, CI95%=0.74-1.28; P=-0.36） with high heterogeneity （Chi2=11.96, df=3 [P=-0.008]; I2=75%）, overall response rate（OR=1.16; CI95%=0.79-1.70; P=0.45）, disease control rate （OR=1.01; CI95%=0.74-1.38; P=0.95）, 1-year survival rate （OR = 1.30; CI95%=0.98-1.72; P=0.07） and 2-year survival rate （OR=1.97; CI95%=0.95-4.09; P=-0.07）. Fewer patients who received IP suffered severe hematologic toxicities （grade≥3）, such as neutropenia, thrombocytopenia and leucopenia. However, severe non-hematologic toxicities （grade≥3）, such as diarrhea, nausea, vomiting, fatigue, anorexia, and dehydration, were more common among patients who received IP. Conclusion： IP does not lengthen the overall survival or progression-free survival compared with EP in patients with ED-SCLC Fewer patients receiving IP had grade ≥ 3 hematological toxicities of nentropenia, leucopenia and thrombocytopenia, but more had grade≥3 diarrhea, nausea, vomiting, fatigue, anorexia and dehydration.

Calculation method of sliding ratios for conjugate-curve gear pair and its application

The calculation method of sliding ratios for conjugate-curve gear pair, generated based on the theory of conjugate curves,is proposed. The theoretical model of conjugate-curve gear drive is briefly introduced. The general calculation formulas of sliding ratios are developed according to the conjugate curves. The applications to the circular arc gears based on conjugate curves and the novel involute-helix gears are studied. A comparison on the sliding coefficient with the conventional corresponding gear drive is also carried out. The influences of gear parameters such as spiral parameter, gear ratio and modulus on the sliding ratios of gear drive are discussed. Brief description of manufacturing method for conjugate-curve gear pair is given. The research results show that the sliding ratios of gear pair become smaller with the increase of spiral parameter and gear ratio, respectively. And it will be greater with the increase of modulus for the tooth profiles. The meshing characteristics of conjugate-curve gears are further reflected and the optimization design of tooth profiles with high performance may be obtained.

Application of sinomenine in rheumatic diseases

Sinomenine is widely used in a variety of rheumatic diseases, and more and more attention has been paid to theadverse reaction in allergic reactions, digestive tract, blood, circulatory and nervous system. The application ofsinomenine in rheumatoid diseases and its side effects were reviewed here, which may provide a reference for thesafe and effective application of sinomenine preparations.

AN ANALYSIS ON THE ACCIDENT OF PNEUMOTHORAX INDUCED BY INCORRECT ACUPUNCTURE TREATMENT

Acupuncture induced pneumothorax is a rarely seen clinical accident. In the present paper, the authors analyze its causes of onset, clinical manifestations and measures for prevention and management.

Comparison of two different kinds of regimens in treatment of advanced non-small cell lung cancer

Objective： The aim of this study was to analyze and compare the recent efficacy and toxicity of a three-drug platinum-based regimen （A regimen）： [cisplatin （DDP） ＋ gemcitabine （GEM） ＋ vinorelbine （NVB）] and a two-drug combination without a platinum drug （B regimen）： GEM ＋ NVB, which were used to treat 55 advanced non-small cell lung cancer （NSCLC） patients, in a bid to provide a guidance for clinical treatment. Methods： Twenty-four cases of advanced NSCLC （stage Ill-IV） patients were treated with A regimen （DDP 35 mg/m^2 d1-3; GEM 1250 mg/m^2 d1, 8 ）. The other 31 cases were treated with B （GEM 1250 mg/m^2 d1,8; NVB 25 mg/m^2 d1, 8 ）. Repeat every 3 weeks for 6 courses. Results： In A regimen group, the overall response rate was 45.8% （CR ＋ PR = 11）, median response time was 5.5 months, median survival time was 11 months and 1-year survival rate was 41.7%. In B regimen group, the overall response rate was 48.4% （CR ＋ PR = 15） and median response time, survival time and 1-year survival rate were respectively 6.5 and 10 months and 41.9%. The major toxicities were nausea/vomiting, myelosuppression in A regimen group, myelosuppression and phlebitis in B regimen group, respectively. Conclusion： A regimen and B regimen for advanced NSCLC have similar response rate （P 〉 0.05）. B regimen, a two-drug combination without a platinum drug is of less toxicity and more safety than A regimen, a three-drug platinum-based regimen and is recommended to be a regimen in the first-line treatment for advanced NSCLC.

Effects of three-dimensional conformal radiotherapy on the esophageal carcinoma

Objective： Radiation therapy is an important component of the multidisciplinary management of esophageal carcinoma. Three-dimensional conformal radiation therapy requires the precise definition of the target volume. We aimed to compare the treatment results and radiation toxicities between three-dimensional conformal radiotherapy （3D-CRT） and conventional radiotherapy （CR） for patients with cervical and thoracic esophageal carcinoma. Methods： From June 2004 to December 2006, a random study was performed on 106 patients treated with 3D-CRT or CR, 53 patients in each group. The patients in CR group received conventional radiotherapy in 2.0 Gy/f, 5 f/week and total dose was 66-70 Gy in 6.5 or 7 weeks. The patients in 3D-CRT group were treated by 3D-CRT in 2.0 Gy/f, 5 f/week and total dose was 64-70 Gy in 6 weeks. The local control rates, survival rates and radiation toxicities for the two groups were investigated. Results： The 1-year and 3-year local control rates were 83.0% and 60.4% in 3D-CRT group and 64.2% （x^2 = 4.853, P = 0.028） and 32.1% （x^2 = 9.812, P = 0.002） in CR group. The 1-year and 3-year survival rates were 73.6% and 50.9% in 3D-CRT group and 54.7% （x^2 = 4.102, P = 0.043） and 32.1% （x^2 = 3.886, P = 0.049） in CR group. Between the two groups, there was no significant difference in radiation toxicities. Conclusien： The 1-year and 3-year local control rates and survival rates of patients with esophageal carcinoma treated by 3D-CRT is superior to CR. However, longer-term results and radiation toxicity need further study which involves more patients and prolonged follow-up.

Two Independent Numerical Studies Demonstrating How to Efficiently Eliminate Electrolysis Side Reactions in Magneto-Hydro-Dynamic Pumping System

In this work, a numerical study for designing a new kind of MHD （Magneto-Hydrn-Dynamic） pumps is presented. This technique makes a compromise between electrolysis prevention and high flow rate performance. This technique should eliminate electrolytic bubble generation, electrodes wear and fluid propriety modification. All these side phenomena are prevented by considering isolated electrodes. The numerical presented results in this paper demonstrate that continuous MHD pumping is possible with isolated electrodes. The MHD excitation combines a high frequency altering current with a low frequency altering magnetic field. In order to validate our results, two independent theoretical methods for computing flow rate are followed. The two presented independent approaches show that high flow rate is possible even with isolated electrodes. To overcome the problem of dimensioning this kind of pumps, a generic numerical analysis is proposed. Hence, the pump performances as functions of the external parameter are studied and tools to calculate for a given fluid and the optimal high frequency regime are provided.

The effect and side effects of Gemcitabine plus Vinorelbine in patients with triple-negative metastatic breast cancer

Objective： The aim of this study was to evaluate the anti-tumor activity and safety of Gemcitabine （GEM） combined with Vinorelbine （NVB） in patients with advanced TNABC after chemotherapy. Methods： Thirty-seven patients with immunohistochemical proved TNABC were enrolled. The patients received 21-day cycles of NVB 25mg/m^2 i.v. with GEM 1000 mg/m^2 i.v. on days 1 and 8. Results： A total of 136 cycles were given to 37 patients（median 4 cycles, ranged 2-6 cycles）. The treatment response was evaluable in all patients. Of the 37 patients, 1 received complete remission （CR）, 8 received partial remission （PR）, 20 had stable disease （SD）, 9 had progressive disease （PD）. Overall objective response （CR＋ PR） were 24.3 %. The median time to progress （TTP） was 6 months （95% CI, 4-6 months）. The median overall survival was 24 months （95% CI, 11-37 months）. The median 1-year survival rate was （66.24±8.43）%. The median 3-year survival rate was （28.77±11.96）%. The major adverse events were grade Ⅰ-Ⅱ myelosuppression, peripheral neurologic toxicities, nausea and vomiting. Some patients had rash and hepatic dysfunction. A total of 40% of patients experienced flu-like symptoms. Alopecia and diarrhea were rare. Conclusion： The combination of GEM and NVB is an effective and well tolerated regimen for the patients with TNABC.

An adaptive range-query optimization technique with distributed replicas

Replication is an approach often used to speed up the execution of queries submitted to a large dataset.A compile-time/run-time approach is presented for minimizing the response time of 2-dimensional range when a distributed replica of a dataset exists.The aim is to partition the query payload(and its range) into subsets and distribute those to the replica nodes in a way that minimizes a client's response time.However,since query size and distribution characteristics of data(data dense/sparse regions) in varying ranges are not known a priori,performing efficient load balancing and parallel processing over the unpredictable workload is difficult.A technique based on the creation and manipulation of dynamic spatial indexes for query payload estimation in distributed queries was proposed.The effectiveness of this technique was demonstrated on queries for analysis of archived earthquake-generated seismic data records.

Stability analysis of the rotating tribological pair system on circular-disc end faces

In order to study the stability of friction and contact of the rotating tribological pair system,considering the influence of the changeable factors on the stability,the system dynamics analysis model based on the Lagrange equation is firstly established.The surface contact stiffness model is determined on the basis of the fractal theory.The model of the friction torque with velocities is created by using the Stribeck friction effect.The Lyapunov indirect method is employed to explore the eigenvalue problem of the system state equation.The effects of the applied load,the fractal dimension,the fractal scaling coefficient and the Stribeck coefficient on the system stability are investigated in detail.The numerical simulation results demonstrate that the tribological pair system is prone to causing system instability at low speed,and the system instability boundary value decreases when the Stribeck coefficient decreases.The fractal dimension and the fractal scaling coefficient impact the system stability slightly when fractal dimensions are large,and the system instability can be reduced by properly increasing the surface smoothness.Moreover,the system instability evidently increases with the increase in the applied load and the Stribeck coefficient.These achievements can provide a reference and theoretical support for the analysis of the dynamic performance of the tribological pair system.