Based on the consideration of longitudinal warp caused by shear lag effects on concrete slabs and bottom plates of steel beams,shear deformation of steel beams and interface slip between steel beams and concrete slabs...Based on the consideration of longitudinal warp caused by shear lag effects on concrete slabs and bottom plates of steel beams,shear deformation of steel beams and interface slip between steel beams and concrete slabs,the governing differential equations and boundary conditions of the steel-concrete composite box beams under lateral loading were derived using energy-variational method.The closed-form solutions for stress,deflection and slip of box beams under lateral loading were obtained,and the comparison of the analytical results and the experimental results for steel-concrete composite box beams under concentrated loading or uniform loading verifies the closed-form solution.The investigation of the parameters of load effects on composite box beams shows that:1) Slip stiffness has considerable impact on mid-span deflection and end slip when it is comparatively small;the mid-span deflection and end slip decrease significantly with the increase of slip stiffness,but when the slip stiffness reaches a certain value,its impact on mid-span deflection and end slip decreases to be negligible.2) The shear deformation has certain influence on mid-span deflection,and the larger the load is,the greater the influence is.3) The impact of shear deformation on end slip can be neglected.4) The strain of bottom plate of steel beam decreases with the increase of slip stiffness,while the shear lag effect becomes more significant.展开更多
The mechanical size effect of nanostructured,dual-phase CrCoNi medium-entropy alloy(MEA)was investigated by combining in-situ micro-compression testing with post-mortem electron microscopy analysis.The alloy possesses...The mechanical size effect of nanostructured,dual-phase CrCoNi medium-entropy alloy(MEA)was investigated by combining in-situ micro-compression testing with post-mortem electron microscopy analysis.The alloy possesses a superior yield strength up to~4 GPa,primarily due to its hierarchical microstructure including column nanograins,preferred orientation,a high density of planar defects and the presence of the hexagonal close packed(HCP)phase.While the yield strength of the alloy has shown sizeindependency,the deformation behaviour was strongly dependent on the sample size.Specifically,with decreasing the pillar diameters,the dominant deformation mode changed from highly localized and catastrophic shear banding to apparently homogeneous deformation with appreciable plasticity.This transition is believed to be governed by the sizedependent critical stress required for a shear band traversing the pillar and mediated by the competition between shearinduced softening and subsequent hardening mechanisms.In addition,an unexpected phase transformation from HCP to face-centered cubic(FCC)was observed in the highly localized deformation zones,leading to strain softening that contributed to accommodating plasticity.These findings provide insights into the criticality of sample dimensions in influencing mechanical behaviors of nanostructured metallic materials used for nanoelectromechanical systems.展开更多
In this study, the role of melanopsin-expressing retinal ganglion cells （mRGCs） in the glaucoma-induced depressive behavioral response pattern was investigated. The CFP-D2 transgenic glaucoma animal model from five ...In this study, the role of melanopsin-expressing retinal ganglion cells （mRGCs） in the glaucoma-induced depressive behavioral response pattern was investigated. The CFP-D2 transgenic glaucoma animal model from five age groups was used in this study. Immunohistochemical labeling, quantitative analysis of mRGC morphology, open field test （OFT）, and statistical analysis were used. In comparison with C57 BL/6 mice, the age-matched CFP-D2 mice had significantly elevated intraocular pressure （lOP）. We observed parallel morphological changes in the retina, including a reduction in the density of cyan fluorescent protein- （CFP） expressing cells （cells mm^-2 at 2 months of age, 1309±26; 14 months, 878±30, P〈0.001）, mRGCs （2 months, 48_＋3; 14 months, 19±4, P〈0.001）, Brn3b-expressing RGCs （2 months, 1283±80; 14 months, 950±31, P〈0.001）, Brn-3b expressing mRGCs （5 months, 50.17%±5.5%; 14 months, 12.61%±3.8%, P〈0.001）, and reduction in the dendritic field size of mRGCs （mm^2 at 2 months, 0.077±0.015; 14 months, 0.065±0.015, P〈0.05）. CFP-D2 mice had hyperactive locomotor activity patterns based on OFT findings of the total distance traveled, number of entries into the center, and time spent in the center of the testing apparatus. The glaucoma induced hyperactive response pattern could be associated with dysfunctional mRGCs, most likely Brn-3b-positive mRGCs in CFP-D2 mice.展开更多
基金Projects(51078355,50938008) supported by the National Natural Science Foundation of ChinaProject(094801020) supported by the Academic Scholarship for Doctoral Candidates of the Ministry of Education,China+1 种基金Project(CX2011B093) supported by the Doctoral Candidate Research Innovation Project of Hunan Province, ChinaProject(20117Q008) supported by the Central University Basic Scientific Research Business Expenses Special Fund of China
文摘Based on the consideration of longitudinal warp caused by shear lag effects on concrete slabs and bottom plates of steel beams,shear deformation of steel beams and interface slip between steel beams and concrete slabs,the governing differential equations and boundary conditions of the steel-concrete composite box beams under lateral loading were derived using energy-variational method.The closed-form solutions for stress,deflection and slip of box beams under lateral loading were obtained,and the comparison of the analytical results and the experimental results for steel-concrete composite box beams under concentrated loading or uniform loading verifies the closed-form solution.The investigation of the parameters of load effects on composite box beams shows that:1) Slip stiffness has considerable impact on mid-span deflection and end slip when it is comparatively small;the mid-span deflection and end slip decrease significantly with the increase of slip stiffness,but when the slip stiffness reaches a certain value,its impact on mid-span deflection and end slip decreases to be negligible.2) The shear deformation has certain influence on mid-span deflection,and the larger the load is,the greater the influence is.3) The impact of shear deformation on end slip can be neglected.4) The strain of bottom plate of steel beam decreases with the increase of slip stiffness,while the shear lag effect becomes more significant.
基金supported by the Australian Research Council Discovery Projects Grantpartly supported by the Fundamental Research Funds for the Central Universities(SWU118105)+1 种基金the financial support from Australia Research Council(DE170100053)the Robinson Fellowship Scheme of the University of Sydney(G200726)。
文摘The mechanical size effect of nanostructured,dual-phase CrCoNi medium-entropy alloy(MEA)was investigated by combining in-situ micro-compression testing with post-mortem electron microscopy analysis.The alloy possesses a superior yield strength up to~4 GPa,primarily due to its hierarchical microstructure including column nanograins,preferred orientation,a high density of planar defects and the presence of the hexagonal close packed(HCP)phase.While the yield strength of the alloy has shown sizeindependency,the deformation behaviour was strongly dependent on the sample size.Specifically,with decreasing the pillar diameters,the dominant deformation mode changed from highly localized and catastrophic shear banding to apparently homogeneous deformation with appreciable plasticity.This transition is believed to be governed by the sizedependent critical stress required for a shear band traversing the pillar and mediated by the competition between shearinduced softening and subsequent hardening mechanisms.In addition,an unexpected phase transformation from HCP to face-centered cubic(FCC)was observed in the highly localized deformation zones,leading to strain softening that contributed to accommodating plasticity.These findings provide insights into the criticality of sample dimensions in influencing mechanical behaviors of nanostructured metallic materials used for nanoelectromechanical systems.
基金supported by the National Basic Research Program of China (2009CB320900 to Pu MingLiang,2011CB510206 to Pu MingLiangand Gao Jie)National Natural Science Foundation of China(30831160516 to Pu MingLiang)+2 种基金NIH EY04067 (N.C. Brecha)VAMerit Review (N.C. Brecha).supported by a summer fellowship from the PKU-UCLA Joint Research Institute
文摘In this study, the role of melanopsin-expressing retinal ganglion cells （mRGCs） in the glaucoma-induced depressive behavioral response pattern was investigated. The CFP-D2 transgenic glaucoma animal model from five age groups was used in this study. Immunohistochemical labeling, quantitative analysis of mRGC morphology, open field test （OFT）, and statistical analysis were used. In comparison with C57 BL/6 mice, the age-matched CFP-D2 mice had significantly elevated intraocular pressure （lOP）. We observed parallel morphological changes in the retina, including a reduction in the density of cyan fluorescent protein- （CFP） expressing cells （cells mm^-2 at 2 months of age, 1309±26; 14 months, 878±30, P〈0.001）, mRGCs （2 months, 48_＋3; 14 months, 19±4, P〈0.001）, Brn3b-expressing RGCs （2 months, 1283±80; 14 months, 950±31, P〈0.001）, Brn-3b expressing mRGCs （5 months, 50.17%±5.5%; 14 months, 12.61%±3.8%, P〈0.001）, and reduction in the dendritic field size of mRGCs （mm^2 at 2 months, 0.077±0.015; 14 months, 0.065±0.015, P〈0.05）. CFP-D2 mice had hyperactive locomotor activity patterns based on OFT findings of the total distance traveled, number of entries into the center, and time spent in the center of the testing apparatus. The glaucoma induced hyperactive response pattern could be associated with dysfunctional mRGCs, most likely Brn-3b-positive mRGCs in CFP-D2 mice.
