Understanding and characterization of pain and other sensory symptoms are among the most important issues in the diagnosis and assessment of patient with gastrointestinal disorders. Methods to evoke and assess experim...Understanding and characterization of pain and other sensory symptoms are among the most important issues in the diagnosis and assessment of patient with gastrointestinal disorders. Methods to evoke and assess experimental pain have recently developed into a new area with the possibility for multimodal stimulation （e.g., electrical, mechanical, thermal and chemical stimulation） of different nerves and pain pathways in the human gut. Such methods mimic to a high degree the pain experienced in the clinic. Multimodal pain methods have increased our basic understanding of different peripheral receptors in the gut in health and disease. Together with advanced muscle analysis, the methods have increased our understanding of receptors sensitive to mechanical, chemical and temperature stimuli in diseases, such as systemic sclerosis and diabetes. The methods can also be used to unravel central pain mechanisms, such as those involved in allodynia, hyperalgesia and referred pain. Abnormalities in central pain mechanisms are often seen in patients with chronic gut pain and hence methods relying on multimodal pain stimulation may help to understand the symptoms in these patients. Sex differences have been observed in several diseases of the gut, and differences in central pain processing between males and females have been hypothesized using multimodal pain stimulations. Finally, multimodal methods have recently been used to gain more insight into the effect of drugs against pain in the GI tract. Hence, the multimodal methods undoubtedly represents a major step forward in the future characterization and treatment of patients with various diseases of the gut.展开更多
The development of cleaning optics and deposition-mitigating techniques is a key factor in the construction and operation of optical diagnostics in ITER. The cleaning of optical surface by pulsed radiation from a fibe...The development of cleaning optics and deposition-mitigating techniques is a key factor in the construction and operation of optical diagnostics in ITER. The cleaning of optical surface by pulsed radiation from a fiber laser is an effective method that can recover optical properties of the mirror surface. The possibility of cleaning metallic mirrors from films with complex composition by pulsed radiation from a fiber laser has been experimentally researched. It has been shown that the high initial reflection characteristics of optical elements can be recovered by choosing regimes of radiation effect on the deposited surface. Efficient cleaning is ensured by radiation with the power density of less than 107 W/cm2. At this relatively low power density, pollutions are removed in a solid phase and the thermal effect on the mirror is insignificant. Preliminary experiments of the metal mirrors cleaning by fiber laser radiation have demonstrated the possibility of hardware implementation techniques.展开更多
The objective of the present study was to determine the effect of different sources of dietary fibre on the oxidative stress induced by a high fat diet in laboratory rats. Thirty two laboratory rats were penned indivi...The objective of the present study was to determine the effect of different sources of dietary fibre on the oxidative stress induced by a high fat diet in laboratory rats. Thirty two laboratory rats were penned individually and divided into four groups： CONT （high fat diet）, G （70 g guar gum/kg）, P （70 g apple pectin/kg） and WB （155 g wheat bran/kg）. After 11 or 13 days of treatment DNA damage of blood leukocytes was measured by Comet assay and lipid peroxidation was studied by determining the malondialdehyde （MDA） concentration in liver and in urine. In comparison with group CONT, the degree of DNA damage was significantly lower in group WB. In groups G and P DNA damage was also reduced but not significantly. Similar results were also obtained for the liver MDA concentration. All three studied groups showed reduced liver MDA concentrations but only group WB was significant compared to group CONT. In comparison with group CONT, the groups WB and P had significantly reduced 24-hour urine MDA excretion, hut not group G. The results of the experiment confirmed that wheat bran intake effectively reduces oxidative stress induced by a high fat diet.展开更多
The exact solution of Sehrodinger equation corresponding to a baryonic system is the main interest in the present work. We take into account both quadratic and Coulomb terms in the potential relation. Next, after pres...The exact solution of Sehrodinger equation corresponding to a baryonic system is the main interest in the present work. We take into account both quadratic and Coulomb terms in the potential relation. Next, after presenting an exact solution, we have calculated the spin and isospin effects in both ground and excited states. The results are comparable with experimental data.展开更多
Depression is a chronic,recurring and potentially life-threatening illness that affects up to 20%of the population across the world.Despite its prevalence and considerable impact on human,little is known about its pat...Depression is a chronic,recurring and potentially life-threatening illness that affects up to 20%of the population across the world.Despite its prevalence and considerable impact on human,little is known about its pathogenesis.One of the major reasons is the restricted availability of validated animal models due to the absence of consensus on the pathology and etiology of depression.Besides,some core symptoms such as depressed mood,feeling of worthlessness,and recurring thoughts of death or suicide,are impossible to be modeled on laboratory animals.Currently,the criteria for identifying animal models of depression rely on either of the 2 principles：actions of known antidepressants and responses to stress.This review mainly focuses on the most widely used animal models of depression,including learned helplessness,chronic mild stress,and social defeat paradigms.Also,the behavioral tests for screening antidepressants,such as forced swimming test and tail suspension test,are also discussed.The advantages and major drawbacks of each model are evaluated.In prospective,new techniques that will be beneficial for developing novel animal models or detecting depression are discussed.展开更多
The interaction between CO2 laser and polyformaldehyde(POM)is quite important in the research of laser irradiation effects and mechanisms.At this time,the accuracy of the existing mass-ablation models for POM irradiat...The interaction between CO2 laser and polyformaldehyde(POM)is quite important in the research of laser irradiation effects and mechanisms.At this time,the accuracy of the existing mass-ablation models for POM irradiated by CO2 laser is poor compared with the experimental data.Based on the energy distribution deposited in the POM target,the active area excited by laser is divided into four slices,the ablation slice(the temperature-rising slice,the perturbation slice,and the undisturbed slice),and a slicing response model for the mass ablation of POM induced by pulsed CO2 laser irradiation in vacuum is developed.A formula is deduced to predict the ablated mass areal density from the model and is verified with data from several studies and our own experiments.The results show that our model fits the experimental data quite well before the shielding effect of ablation products becomes notable.The applicability of the model to other materials and the mass ablation in atmosphere are also briefly explored.展开更多
基金Supported by "Det Obelske Familiefond" & "Spar Nord Fonden"
文摘Understanding and characterization of pain and other sensory symptoms are among the most important issues in the diagnosis and assessment of patient with gastrointestinal disorders. Methods to evoke and assess experimental pain have recently developed into a new area with the possibility for multimodal stimulation （e.g., electrical, mechanical, thermal and chemical stimulation） of different nerves and pain pathways in the human gut. Such methods mimic to a high degree the pain experienced in the clinic. Multimodal pain methods have increased our basic understanding of different peripheral receptors in the gut in health and disease. Together with advanced muscle analysis, the methods have increased our understanding of receptors sensitive to mechanical, chemical and temperature stimuli in diseases, such as systemic sclerosis and diabetes. The methods can also be used to unravel central pain mechanisms, such as those involved in allodynia, hyperalgesia and referred pain. Abnormalities in central pain mechanisms are often seen in patients with chronic gut pain and hence methods relying on multimodal pain stimulation may help to understand the symptoms in these patients. Sex differences have been observed in several diseases of the gut, and differences in central pain processing between males and females have been hypothesized using multimodal pain stimulations. Finally, multimodal methods have recently been used to gain more insight into the effect of drugs against pain in the GI tract. Hence, the multimodal methods undoubtedly represents a major step forward in the future characterization and treatment of patients with various diseases of the gut.
文摘The development of cleaning optics and deposition-mitigating techniques is a key factor in the construction and operation of optical diagnostics in ITER. The cleaning of optical surface by pulsed radiation from a fiber laser is an effective method that can recover optical properties of the mirror surface. The possibility of cleaning metallic mirrors from films with complex composition by pulsed radiation from a fiber laser has been experimentally researched. It has been shown that the high initial reflection characteristics of optical elements can be recovered by choosing regimes of radiation effect on the deposited surface. Efficient cleaning is ensured by radiation with the power density of less than 107 W/cm2. At this relatively low power density, pollutions are removed in a solid phase and the thermal effect on the mirror is insignificant. Preliminary experiments of the metal mirrors cleaning by fiber laser radiation have demonstrated the possibility of hardware implementation techniques.
文摘The objective of the present study was to determine the effect of different sources of dietary fibre on the oxidative stress induced by a high fat diet in laboratory rats. Thirty two laboratory rats were penned individually and divided into four groups： CONT （high fat diet）, G （70 g guar gum/kg）, P （70 g apple pectin/kg） and WB （155 g wheat bran/kg）. After 11 or 13 days of treatment DNA damage of blood leukocytes was measured by Comet assay and lipid peroxidation was studied by determining the malondialdehyde （MDA） concentration in liver and in urine. In comparison with group CONT, the degree of DNA damage was significantly lower in group WB. In groups G and P DNA damage was also reduced but not significantly. Similar results were also obtained for the liver MDA concentration. All three studied groups showed reduced liver MDA concentrations but only group WB was significant compared to group CONT. In comparison with group CONT, the groups WB and P had significantly reduced 24-hour urine MDA excretion, hut not group G. The results of the experiment confirmed that wheat bran intake effectively reduces oxidative stress induced by a high fat diet.
文摘The exact solution of Sehrodinger equation corresponding to a baryonic system is the main interest in the present work. We take into account both quadratic and Coulomb terms in the potential relation. Next, after presenting an exact solution, we have calculated the spin and isospin effects in both ground and excited states. The results are comparable with experimental data.
文摘Depression is a chronic,recurring and potentially life-threatening illness that affects up to 20%of the population across the world.Despite its prevalence and considerable impact on human,little is known about its pathogenesis.One of the major reasons is the restricted availability of validated animal models due to the absence of consensus on the pathology and etiology of depression.Besides,some core symptoms such as depressed mood,feeling of worthlessness,and recurring thoughts of death or suicide,are impossible to be modeled on laboratory animals.Currently,the criteria for identifying animal models of depression rely on either of the 2 principles：actions of known antidepressants and responses to stress.This review mainly focuses on the most widely used animal models of depression,including learned helplessness,chronic mild stress,and social defeat paradigms.Also,the behavioral tests for screening antidepressants,such as forced swimming test and tail suspension test,are also discussed.The advantages and major drawbacks of each model are evaluated.In prospective,new techniques that will be beneficial for developing novel animal models or detecting depression are discussed.
基金supported by the National Natural Science Foundation of China(Grant No.51306203)the Advancing Research Program of NUDT(Grant No.JC14-01-02)
文摘The interaction between CO2 laser and polyformaldehyde(POM)is quite important in the research of laser irradiation effects and mechanisms.At this time,the accuracy of the existing mass-ablation models for POM irradiated by CO2 laser is poor compared with the experimental data.Based on the energy distribution deposited in the POM target,the active area excited by laser is divided into four slices,the ablation slice(the temperature-rising slice,the perturbation slice,and the undisturbed slice),and a slicing response model for the mass ablation of POM induced by pulsed CO2 laser irradiation in vacuum is developed.A formula is deduced to predict the ablated mass areal density from the model and is verified with data from several studies and our own experiments.The results show that our model fits the experimental data quite well before the shielding effect of ablation products becomes notable.The applicability of the model to other materials and the mass ablation in atmosphere are also briefly explored.
