The present study depicts the therapeutic effect of Zygophyllum cornutum methanolic extract (ZCME) on metabolic disturbances, oxidative stress in heart and myocardium histological changes in streptozotocin (STZ)-i...The present study depicts the therapeutic effect of Zygophyllum cornutum methanolic extract (ZCME) on metabolic disturbances, oxidative stress in heart and myocardium histological changes in streptozotocin (STZ)-induced diabetic rats. Three days after diabetes induction, ZCME was administered orally for six weeks (700 mg/kg bw/day). Serum glucose and lipid profile were evaluated. Reduced glutathione (GSH), catalase (CAT) and thiobarbituric acid reactive substances (TBARS) were measured in heart tissue. The results showed increased levels of blood glucose, total cholesterol (TC), LDL cholesterol (LDL-C) and triglyceride (TG) in the diabetic rats. On the other hand, the level of HDL cholesterol (HDL-C) decreased. Compared to the control normal rats, the level of TBARS in heart tissue was markedly increased while GSH and CAT were significantly modified in the diabetic rats. Oral administration of ZCME has normalized serum glucose and lipid profile. TBARS were significantly reduced in heart while CAT and GSH were markedly normalized. Myocardium sections showed the absence of histological changes observed in the diabetic rats. The study suggests that Zygophyllum cornutum may provide a useful therapeutic option in the reversal of metabolic disturbances and oxidative stress-induced cardiac dysfunction in diabetes mellitus.展开更多
A recently emerging family of smart materials,photostrictive materials,exhibit large photostriction under uniform illumination of high-energy light.This photostriction mechanism arises from a superposition phenomenon ...A recently emerging family of smart materials,photostrictive materials,exhibit large photostriction under uniform illumination of high-energy light.This photostriction mechanism arises from a superposition phenomenon of photovoltaic and converse piezoelectric effects.A photostrictive type of opto-electromechanical actuator activated by high-energy lights can introduce actuation and control effects without hard-wired connections.The control light intensity applied to the actuator is proportional to the transverse velocity at a positioned point,which is measured by a laser vibrometer.In this paper,photostrictive films are numerically analyzed to evaluate their use as wireless actuators for future remote vibration control of flexible structures.A novel opto-electromechanical solid shell finite element formulation is developed for accurate analysis of the multiple physics effects of photovoltaic,pyroelectric and thermal expansion of photostrictive materials.Available experimental data and analytical solutions have been used to verify the present finite element results.The simulation in this study demonstrates that the present formulation is very reliable,accurate and also computationally efficient and that the use of photostrictive actuators can provide good controllability of structural vibration.展开更多
Objective: To validate the hypothesis that there exists an optimal axial compression stress range to enhance tibial fracture healing.Methods: Rabbits with a surgically induced V-shaped tibial fracture were separated...Objective: To validate the hypothesis that there exists an optimal axial compression stress range to enhance tibial fracture healing.Methods: Rabbits with a surgically induced V-shaped tibial fracture were separated into 2 main groups: the control group (C Group, n=6) without application of any axial compression stress stimulation postoperatively and the stimulation group ( S Group, n=90). The S Group was further divided into 20 subgroups (S11 to S54) in terms of 5 axial compression stress stimulation levels (112.8 kPa, 289.8kPa, 396.5 kPa, 472.7 kPa, and 602.3 kPa) and 4 experimental endpoints (1, 3, 5 and 8 weeks after operation). A custom made circular external fixator was used to provide the axial compression stress of the fracture sites. Based on X-ray observation, a fracture healing scoring system was created to evaluate the fracture healing process.Results: At 8 weeks after operation, there existed a "⌒-shape" relationship between healing score and axial compression stress stimulation level of fracture site. The optimal axial compression stress stimulation ranged from 289.8 kPa to 472.7 kPa, accompanying the best fracture healing, i.e. the fracture line became indistinct or almost disappeared, and a lot of callus jointed the two fracture ends. Meanwhile, at 5 weeks after operation, corresponding to the relatively low healing scores, there was a fracture healing performance similar to that at 8 weeks. Besides, at 1 or 3 weeks after operation, for all the axial compression stress levels (0-602.3 kPa), no obvious healing effect was found.Conclusions: It is implied from the stated X-ray observation results in this study that the potential optimal axial compression stress stimulation and optimal fracture healing time are available. The axial compression stress level of 289.8-472.7 kPa and fracture healing time of more than 8 weeks jointly comprise the optimal axial compression stress stimulation conditions to enhance tibial fracture healing.展开更多
文摘The present study depicts the therapeutic effect of Zygophyllum cornutum methanolic extract (ZCME) on metabolic disturbances, oxidative stress in heart and myocardium histological changes in streptozotocin (STZ)-induced diabetic rats. Three days after diabetes induction, ZCME was administered orally for six weeks (700 mg/kg bw/day). Serum glucose and lipid profile were evaluated. Reduced glutathione (GSH), catalase (CAT) and thiobarbituric acid reactive substances (TBARS) were measured in heart tissue. The results showed increased levels of blood glucose, total cholesterol (TC), LDL cholesterol (LDL-C) and triglyceride (TG) in the diabetic rats. On the other hand, the level of HDL cholesterol (HDL-C) decreased. Compared to the control normal rats, the level of TBARS in heart tissue was markedly increased while GSH and CAT were significantly modified in the diabetic rats. Oral administration of ZCME has normalized serum glucose and lipid profile. TBARS were significantly reduced in heart while CAT and GSH were markedly normalized. Myocardium sections showed the absence of histological changes observed in the diabetic rats. The study suggests that Zygophyllum cornutum may provide a useful therapeutic option in the reversal of metabolic disturbances and oxidative stress-induced cardiac dysfunction in diabetes mellitus.
基金supported by the National Natural Science Foundation of China (Grant Nos. 10872090, 50830201)NUAA Research Funding (Grant No. NJ2010011)
文摘A recently emerging family of smart materials,photostrictive materials,exhibit large photostriction under uniform illumination of high-energy light.This photostriction mechanism arises from a superposition phenomenon of photovoltaic and converse piezoelectric effects.A photostrictive type of opto-electromechanical actuator activated by high-energy lights can introduce actuation and control effects without hard-wired connections.The control light intensity applied to the actuator is proportional to the transverse velocity at a positioned point,which is measured by a laser vibrometer.In this paper,photostrictive films are numerically analyzed to evaluate their use as wireless actuators for future remote vibration control of flexible structures.A novel opto-electromechanical solid shell finite element formulation is developed for accurate analysis of the multiple physics effects of photovoltaic,pyroelectric and thermal expansion of photostrictive materials.Available experimental data and analytical solutions have been used to verify the present finite element results.The simulation in this study demonstrates that the present formulation is very reliable,accurate and also computationally efficient and that the use of photostrictive actuators can provide good controllability of structural vibration.
基金This work was supported by grants from the Chongqing Academician Foundation (No. 1998-93), the National Natural Science Foundation of China (No. 30122202 and No. 30928005) and the Third Military Medical University Research Foundation (No. 2009 XHG16),
文摘Objective: To validate the hypothesis that there exists an optimal axial compression stress range to enhance tibial fracture healing.Methods: Rabbits with a surgically induced V-shaped tibial fracture were separated into 2 main groups: the control group (C Group, n=6) without application of any axial compression stress stimulation postoperatively and the stimulation group ( S Group, n=90). The S Group was further divided into 20 subgroups (S11 to S54) in terms of 5 axial compression stress stimulation levels (112.8 kPa, 289.8kPa, 396.5 kPa, 472.7 kPa, and 602.3 kPa) and 4 experimental endpoints (1, 3, 5 and 8 weeks after operation). A custom made circular external fixator was used to provide the axial compression stress of the fracture sites. Based on X-ray observation, a fracture healing scoring system was created to evaluate the fracture healing process.Results: At 8 weeks after operation, there existed a "⌒-shape" relationship between healing score and axial compression stress stimulation level of fracture site. The optimal axial compression stress stimulation ranged from 289.8 kPa to 472.7 kPa, accompanying the best fracture healing, i.e. the fracture line became indistinct or almost disappeared, and a lot of callus jointed the two fracture ends. Meanwhile, at 5 weeks after operation, corresponding to the relatively low healing scores, there was a fracture healing performance similar to that at 8 weeks. Besides, at 1 or 3 weeks after operation, for all the axial compression stress levels (0-602.3 kPa), no obvious healing effect was found.Conclusions: It is implied from the stated X-ray observation results in this study that the potential optimal axial compression stress stimulation and optimal fracture healing time are available. The axial compression stress level of 289.8-472.7 kPa and fracture healing time of more than 8 weeks jointly comprise the optimal axial compression stress stimulation conditions to enhance tibial fracture healing.