Pharmacokinetics of Moclobemide Sustained Release Tablets after Multiple Oral Dose Administration in Healthy Volunteers

To investigate the pharmacokinetic characteristics of moclobemide sustainedrelease tablets after multiple oral dose administration in healthy Chinese volunteers. MethodsMoclobemide sustained release tablets were given as a multiple oral dose regimen of 300 mg oncedaily for five consecutive days to 12 healthy volunteers. The concentrations of moclobemide inplasma were determined by reversed-phase high performance liquid chromatography. The partialpharmacokinetic parameters were calculated using 3p97 pharmacokinetic program. Results Theconcentration-time profile fitted an one-compartment model best. The steady-state pharmacokineticparameters of moclobemide sustained release tablets after multiple oral doses were as follows:C_(max) was (1 950 +- 156) μg· L^(-1), T_(max) was (6.00 +-1.55) h, T_(1/2(kel)) was (3.14 +-0.12)h, AUC_(ss 0-24) was (22 836 +- 1 842) μg·h· L^(-1), MRT was (7.68+-0.36) h, CL/F_((s)) was(20.2+-2.1) L·h^(-1), and V/F_((c)) was (91.4+-9.4) L, respectively. No marked adverse events werenoted during this study. Conclusion The formulation has a sustained-release effect and goodtolerance in the healthy volunteers, which provides useful information for clinical practice.

Application of system dynamics for assessment of sustainable performance of construction projects

Sustainable performance is expected to become a major factor when examining the feasibility of a construction project in terms of its life cycle performance. The study on which this paper is based developed a simulation model, using system dy- namics methodology, to assess the sustainable performance of projects. Three major factors are used to examine project sus- tainable performance (PSP): the sustainability of economic development (E), the sustainability of social development (S), and the sustainability of environmental development (En). Sustainable development ability (SDA) was used as a prototype to evaluate the degree of sustainable performance. The simulation software ‘ithink’ was used to help with the application of the model to a real life case. This paper explains and demonstrates the procedures used to develop the model and finally offers an approach for assessing the feasibility of a construction project in terms of its sustainable performance.

Finite element model for linear-elastic mixed mode loading using adaptive mesh strategy

An adaptive mesh finite element model has been developed to predict the crack propagation direction as well as to calculate the stress intensity factors （SIFs）, under linear-elastic assumption for mixed mode loading application. The finite element mesh is generated using the advancing front method. In order to suit the requirements of the fracture analysis, the generation of the background mesh and the construction of singular elements have been added to the developed program. The adaptive remeshing process is carried out based on the posteriori stress error norm scheme to obtain an optimal mesh. Previous works of the authors have proposed techniques for adaptive mesh generation of 2D cracked models. Facilitated by the singular elements, the displacement extrapolation technique is employed to calculate the SIK The fracture is modeled by the splitting node approach and the trajectory follows the successive linear extensions of each crack increment. The SlFs values for two different case studies were estimated and validated by direct comparisons with other researchers work.

Network models for molecular kinetics and their initial applications to human health

Molecular kinetics underlies all biological phenomena and, like many other biological processes, may best be understood in terms of networks. These networks, called Markov state models （MSMs）, are typically built from physical simulations. Thus, they are capable of quantitative prediction of experiments and can also provide an intuition for complex couformational changes. Their primary application has been to protein folding; however, these technologies and the insights they yield are transferable. For example, MSMs have already proved useful in understanding human diseases, such as protein misfolding and aggregation in Alzheimer＇s disease.

The application of nanotechnology in the improvement of dental composite resins

In this paper, nanotechnology for the improvement of dental composite resins has been reviewed in the background of the existing shortcomings, focusing on the improvement for polymerization shrinkage, anti-bacterial properties and mechanical properties of composite resins. The results show that the use of nanotechnology and nano materials can be an effective method to improve the performance of dental composite resins in a various ways. At last, the paper also discusses the perspective about the dental composite resins.

Theory and application of rock burst prevention using deep hole high pressure hydraulic fracturing

In order to analyze the mechanism of deep hole high pressure hydraulic fracturing, nonlinear dynamic theory, damage mechanics, elastic-plastic mechanics are used, and the law of crack propagation and stress transfer under two deep hole hydraulic fracturing in tectonic stress areas is studied using seepage-stress coupling models with RFPA simulation software. In addition, the effects of rock burst control are tested using multiple methods, either in the stress field or in the energy field. The research findings show that with two deep holes hydraulic fracturing in tectonic stress areas, the direction of the main crack propagation under shear-tensile stress is parallel to the greatest principal stress direction. High-pressure hydraulic fracturing water seepage can result in the destruction of the coal structure, while also weakening the physical and mechanical properties of coal and rock. Therefore the impact of high stress concentration in hazardous areas will level off, which has an effect on rock burst prevention and control in the region.

Simulation study of coal mine safety investment based on system dynamics

To generate dynamic planning for coal mine safety investment, this study applies system dynamics to decision-making, classifying safety investments by accident type. It validates the relationship between safety investments and accident cost, by structurally analyzing the causality between safety investments and their influence factors. Our simulation model, based on Vensim software, conducts simulation analysis on a series of actual data from a coalmine in Shanxi Province. Our results indicate a lag phase in safety investments, and that increasing pre-phase safety investment reduces accident costs. We found that a 24% increase in initial safety investment could help reach the target accident costs level 14 months earlier. Our simulation test included nine kinds of variation trends of accident costs brought by different investment ratios on accident prevention. We found an optimized ratio of accident prevention investments allowing a mine to reach accident cost goals 4 months earlier, without changing its total investment.

Research on theory and application of landslide model test

In this paper, a theory of landslide model testing and application in Three Gorges reservoir area were introduced.Based on geo-mechanical model tests, the similarity ratio of similar material parameters, component of similar material and the boundary friction coefficient of the 2D earth landslide model test were derived and stated by theoretical and experimental methods.A model test of the Qianjiangping landslide in Three Gorges reservoir area reveal a two-step trigger mechanism of coexistence between retrogressive landslide and thrust load caused land-slide.

Simulation of Liquid Argon Flow along a Nanochannel： Effect of Applied Force

Liquid argon flow along a nanochannel is studied using molecular dynamics (MD) simulation in this work.Large-scale Atomic/Molecular Massively Parallel Simulator (LAMMPS) is used as the MD simulator.The effects of reduced forces at 0.5,1.0 and 2.0 on argon flow on system energy in the form of system potential energy,pressure and velocity profile are described.Output in the form of three-dimensional visualization of the system at steady-state condition using Visual Molecular Dynamics (VMD) is provided to describe the dynamics of the argon atoms.The equilibrium state is reached after 16000 time steps.The effects on system energy,pressure and velocity profile due to reduced force of 2.0 (F2) are clearly distinguishable from the other two lower forces where sufficiently high net force along the direction of the nanochannel for F2 renders the attractive and repulsive forces between the argon atoms virtually non-existent.A reduced force of 0.5 (F0.5) provides liquid argon flow that approaches Poiseuille (laminar) flow as clearly shown by the n-shaped average velocity profile.The extension of the present MD model to a more practical application affords scientists and engineers a good option for simulation of other nanofluidic dynamics processes.

The Application of Ecosystem Dynamic Model in Xiamen Bay

This paper is to establish a nitrogen and phosphorus nutrients cycle-based numerical model of ecological dynamics for Xiamen Bay on the basis of the existing three-dimensional barocline hydrodynamic model. The calculation results show that the estuarine district of Jiulongjiang estuary has the highest inorganic nitrogen concentration followed by the West Harbor, which demonstrates that Jiulongjiang River is the main input source of inorganic nitrogen in Xiamen Bay. The West Harbor has relatively high concentration of nutrients caused by the huge land pollution emission and its own poor water exchange capacity; while the distribution rules of phytoplankton biomass correspond with those of phosphates, demonstrating Xiamen Bay＇s phytoplankton controlled by phosphorus; the haloplankton biomass differs slightly, presenting the gradual reduction from the interior part to the exterior part of the bay.

Clinical application of hepatic CT perfusion

Complicated changes occur in hemodynamics of hepatic artery and vein, and portal vein under various kinds of pathologic status hepatic blood supply. This because of distinct double article reviews the clinical application of hepatic computed tomography perfusion in some liver diseases.

Preparation and Electrochemical Application of Praseodymium Modified TiO2-NTs/SnO2-Sb Anode by Cyclic Voltammetry Method

A Pr-doped TiO2-NTs/SnO2-Sb electrode was prepared by a simple method, cyclic voltarnmetry （CV）. The methyl orange （MO）aqueous solution was selected as a simulated wastewater. The ordered microstructural TiO2-NTs substrate was synthesized by an electrochemical method to obtain large specific surface area and high space utilization. The phase structure, electrode surface morphology and electrochemical properties of electrodes were characterized by XRD, SEM and electrochemical technology, respectively. The results showed that praseo- dymium oxide was successfully doped into the SnOz-Sb film by CV method. Due to the doped Pr, the oxygen evo- lution potential increased from 2.25 V to 2.40 V. The degradation of MO was investigated by UV-vis. The Ct/C0（φ） was studied as a function to obtain the optimal parameters, such as the amount of doped Pr, current density and initial dye concentration. In addition, the degradation process followed pseudo-first-order reaction kinetics and the rate constant was 0.099 3 min-1. The result indicated that the introduction of Pr reduced the formation of oxygen vacancies or enhanced the formation of adsorbed hydroxyl radical groups on the surface, thus leading to better activity and stability.

A new improved Alopex-based evolutionary algorithm and its application to parameter estimation

In this work, focusing on the demerit of AEA (Alopex-based evolutionary algorithm) algorithm, an improved AEA algorithm (AEA-C) which was fused AEA with clonal selection algorithm was proposed. Considering the irrationality of the method that generated candidate solutions at each iteration of AEA, clonal selection algorithm could be applied to improve the method. The performance of the proposed new algorithm was studied by using 22 benchmark functions and was compared with original AEA given the same conditions. The experimental results show that the AEA-C clearly outperforms the original AEA for almost all the 22 benchmark functions with 10, 30, 50 dimensions in success rates, solution quality and stability. Furthermore, AEA-C was applied to estimate 6 kinetics parameters of the fermentation dynamics models. The standard deviation of the objective function calculated by the AEA-C is 41.46 and is far less than that of other literatures' results, and the fitting curves obtained by AEA-C are more in line with the actual fermentation process curves.

An Essential Solution of Water Entry Problems and its Engineering Applications

For solving water entry problems, a numerical method is presented, which is a CFD method based on free surface capturing method and Cartesian cut cell mesh.In this approach, incompressible Euler equations for a variable density fluid are numerically calculated by the finite volume method.Then artificial compressibility method, dual time-stepping technique and Roe's approximate Riemann solver are adopted in the numerical scheme.Finally, some application cases are designed to show the ability of the current method to cope with water entry problems in ocean engineering.

Application of Discrete Lumped Kinetic Modeling on Vacuum Gas Oil Hydrocracking

The kinetic model of vacuum gas oil （VGO） hydrocracking based on discrete lumped approach was investigated, and some improvement was put forward at the same time in this article. A parallel reaction scheme to describe the conver- sion of VGO into products （gases, gasoline, and diesel） proposed by Orochko was used. The different experimental data were analyzed statistically and then the product distribution and kinetic parameters were simulated by available data. Fur- thermore, the kinetic parameters were correlated based on the feed property, reaction temperature, and catalyst activity. An optimization code in Matlab 2011b was written to fine-me these parameters. The model had a favorable ability to predict the product distribution and there was a good agreement between the model predictions and experiment data. Hence, the ki- netic parameters indeed had something to do with feed properties, reaction temperature and catalyst activity.

Non-Noether Conserved Quantity of Poincaré-Chetaev Equations of a Generalized Classical Mechanics

In the present paper the Lie symmetrical non-Noether conserved quantity of the Poincaré Chetaev equations of a generalized classical mechanics under the general infinitesimal transformations of Lie groups is discussed. First, we establish the determining equations of Lie symmetry of the equations. Second, the Lie symmetrical non-Noether conserved quantity of the equations is deduced. Finally, an example is given to illustrate the application of the results.

A New Alpha-function for the Peng-Robinson Equation of State： Application to Natural Gas

Cubic equations of state(EOSs) are simple and easy at calculation. One way of improving the accuracy of a cubic EOS is through the modification of temperature-dependent energy parameter by using alpha-function.The industrial applications of natural gas are very wide and as a result, prediction of thermodynamic properties and phase behavior of natural gas is an important part of design for such processes. In this work we develop a newα-function for the Peng-Robinson(PR) EOS with the parameters optimized especially for natural gas components.The parameters are generalized as a linear function of acentric factor. The results are compared to the predictions from original PR EOS and other α-functions in literature. It is shown that the new α-function presents a good accuracy with the average deviation of 1.42% for natural gas components.

CATALYSIS OF POLYSTYRENE N-HYDROXYL SULFONAMIDE FOR ESTERIFICATION OF BUTANOL WITH ACETIC ANHYDRIDE

Polystyrene N-hydroxyl sulfonamide resin 1 was prepared and used to catalyze the esterification of n-butanol and acetic anhydride. The mechanism of catalytic esterification proved by IR spectra of the resins was found that O-H and N-H of the N-hydroxyl sulfonamide resin reacted with the acetic anhydride respectively to form the active intermediate polystyrene N,O-diacetyl sulfonamate which was cleaved by n-butanol to produce butyl acetate. The catalytic esterification by resin 1 was in good agreement with the kinetic model of 揵i-bi-ping-pong?mechanism.

An integrated approach to study of strata behaviour and gas flow dynamics and its application

This paper presents an advanced and integrated research approach to longwall mining-induced strata move- ment, stress changes, fractures, and gas flow dynamics with actual examples of its application from recent studies for coextraction of coal and methane development at Huainan Mining Group in China, in a deep and multi-seam mining environment. The advanced approach takes advantage of the latest techniques in Australia for mine scale geotechnical characterisation, field measurement, monitoring and numerical modelling. Key techniques described in this paper include coal mine site 3D geotechnical characterisation methods, surface deep downhole multi-point extensometers and piezometers for overburden displacement and pore pressure measurements during mining, tracer gas tests for goal gas flow patterns, and advanced numerical modelling codes for coupled coal mine strata, water and gas simulations, and longwall goaf gas ttow investigations. This integrated approach has resulted in significant insights into the complex dynamic imeraction between strata, groundwater, and gas during mining at Huainan Mining Group in recent years. Based on the lindings from the extensive field monitoring and numerical modelling studies, a three-dimensional annular-shaped over-lying zone along the perimeter of the longwall panel was identified for optimal methane drainage during mining.

Hepato-cardiovascular response and its regulation

AIM: To determine the possible existence of a hepato-cardiovascular response and its regulatory mechanism in normal rats. METHODS: Systemic hemodynamic changes following intraportal injection of latex microspheres were studied in two modified rat models of hepatic circulation, in which the extrahepatic splanchnic circulation was excluded by evisceration and the liver was perfused by systemic blood via either the portal vein (model 1) or hepatic artery (model 2) in vivo. RESULTS: In model 1, intraportal injection of two sized microspheres (15-μm and 80-μm) induced a similar decrease in mean arterial pressure, while extrahepatic portal venous occlusion induced an immediate increase in mean arterial pressure. In model 2, microsphere injection again induced a significant reduction in mean arterial pressure, aortic blood flow and aortic resistance. There were no significant differences in these parameters between liver-innervated rats and liver-denervated rats. The degrees of microsphere-induced reduction in mean arterial pressure (-38.1±1.9% in liver-innervated rats and -35.4±2.1% in liver-denervated rats, respectively) were similar to those obtained by withdrawal of 2.0 mL of blood via the jugular vein (-33.3±2.1%) (P>0.05). Injection of 2.0 mL Haemaccel in microsphere-treated rats, to compensate for the reduced effective circulating blood volume, led to a hyperdynamic state which, as compared with basal values and unlike control rats, was characterised by increased aortic blood flow (+21.6±3.3%), decreased aortic resistance (-38.1±3.5%) and reduced mean arterial pressure (-9.7±2.8%). CONCLUSION: A hepato-cardiovascular response exists in normal rats. It acts through a humoral mechanism leading to systemic vasodilatation, and may be involved in the hemodynamic disturbances associated with acute and chronic liver diseases.