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乙型肝炎病毒遗传异质性对干扰素应答性的影响 被引量:3
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作者 兰林 王宇明 《世界华人消化杂志》 CAS 2002年第6期696-698,共3页
迄今IFN-α仍是治疗乙型肝炎的主要抗病毒药物,但其总体疗效并不理想。究其原因,HBV基因组的多样性可能是重要原因之一。HBV种群具有高度的异质性,存在着多种不同的血清型、基因型及变异株,即使在单个感染个体内,也可能包含异质性的HBV... 迄今IFN-α仍是治疗乙型肝炎的主要抗病毒药物,但其总体疗效并不理想。究其原因,HBV基因组的多样性可能是重要原因之一。HBV种群具有高度的异质性,存在着多种不同的血清型、基因型及变异株,即使在单个感染个体内,也可能包含异质性的HBV病毒群体(准种)。研究发现不同的HBV株对IFN-α治疗的敏感性不同,个体内准种的异质性程度也对扰素治疗的应答性有影响。因此,正确深入地认知和分析HBV遗传异质性,对阐明影响IFN-α治疗的病毒学因素有着重要的意义。 展开更多
关键词 乙型肝炎病毒 遗传异质 干扰素 应签性 影响
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All-optical scheme for detecting the possible Majorana signature based on QD and nanomechanical resonator systems 被引量:4
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作者 CHEN HuaJun ZHU KaDi 《Science China(Physics,Mechanics & Astronomy)》 SCIE EI CAS CSCD 2015年第5期2-15,共14页
Majorana fermions(MFs) are exotic particles that are their own anti-particles. Currently, the search for MFs occurring as quasiparticle excitations in condensed matter systems has attracted widespread interest, becaus... Majorana fermions(MFs) are exotic particles that are their own anti-particles. Currently, the search for MFs occurring as quasiparticle excitations in condensed matter systems has attracted widespread interest, because of their importance in fundamental physics and potential applications in topological quantum computation based on solid-state devices. Motivated by recent experimental progress towards the detection and manipulation of MFs in hybrid semiconductor/superconductor heterostructures, in this review, we present a novel proposal to probe MFs in all-optical domain. We introduce a single quantum dot(QD), a hybrid quantum dot-nanomechanical resonators(QD-NR) system, and a carbon nanotube(CNT) resonator implanted in a single electron spin system with optical pump-probe technology to detect MFs, respectively. With this scheme, a possible Majorana signature is investigated via the probe absorption spectrum and nonlinear optical Kerr effect, and the coupling strength between MFs and the QD or the single electron spin is also determined. In the hybrid QD-NR system, vibration of the NR will enhance the nonlinear optical effect, which makes the MFs more sensitive for detection. In the CNT resonator with a single electron, the single electron spin can be considered as a sensitive probe, and the CNT resonator behaved as a phonon cavity is robust for detecting of MFs. This optical scheme will provide another method for the detection MFs and will open the door for new applications ranging from robust manipulation of MFs to quantum information processing based on MFs. 展开更多
关键词 Majorana fermions QD nanomechanical resonator carbon nanotube resonator optical pump-probe technology
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