伊立替康载药微球肝动脉栓塞治疗不可手术切除的结直肠癌肝转移的效果分析

目的分析伊立替康载药微球肝动脉栓塞治疗不可手术切除的结直肠癌肝转移的临床效果。方法50例不可手术切除的结直肠癌肝转移患者,随机分为实验组和对照组,各25例。实验组采用伊立替康载药微球肝动脉栓塞治疗,对照组采用全身化疗。分析比较两组患者的近期疗效、生存情况及并发症发生情况。结果实验组患者完全缓解(CR)率、部分缓解(PR)率、疾病稳定(SD)率、疾病进展(PD)率、客观缓解率(ORR)和疾病控制率(DCR)分别为4.0%、56.0%、20.0%、20.0%、60.0%、80.0%;对照组患者的CR率、PR率、SD率、PD率、ORR和DCR分别为0、16.0%、40.0%、44.0%、16.0%、56.0%;实验组ORR显著高于对照组,差异具有统计学意义(P<0.05);两组DCR比较差异无统计学意义(P>0.05)。两组患者1、2年生存率比较差异无统计学意义(P>0.05);实验组患者3年生存率高于对照组,差异有统计学意义(P<0.05)。实验组患者贫血、血小板降低、呕吐、乏力和肝功能异常发生率均显著低于对照组,差异具有统计学意义(P<0.05);两组患者白细胞减少、恶心、疼痛和腹泻发生率比较差异无统计学意义(P>0.05)。结论伊立替康载药微球肝动脉栓塞治疗不可手术切除的结直肠癌肝转移的临床效果较全身化疗显著,其不良反应相对较少,临床可推广使用。

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Enhanced release of the poorly soluble drug itraconazole loaded in ordered mesoporous silica

It is known that the energy of the amorphous state of itraconazole loaded in ordered mesoporous materials is high relative to that of the crystalline state and is responsible for enhanced solubility and dissolution rate. We investigated the effects of particle size(0.7–5μm), mesostructure(2D p6 mm, cubic Ia-3d and cubic Fm-3m) and pore size(2.2–15.4 nm) of mesoporous silicas on the release performance of itraconazole. Results indicated that the release performance was not influenced by the particle sizes tested here, that the release performance increased with increasing pore diameter due to the lower probability of drug molecules colliding to recrystallize in large pores, and that the release performance was decreased in the cage-type pore structure(Fm-3m) compared to that in the cylindrical pore structures(p6mm and Ia-3d) because of the small entrance to the cagelike pores that retards the drug release.