Background: This study is an extension of a 28- week, randomized, double-blind, placebo-controlled study of memantine in 252 patients with moderate to severe Alzheimer disease. Objective: To evaluate long-term memanti...Background: This study is an extension of a 28- week, randomized, double-blind, placebo-controlled study of memantine in 252 patients with moderate to severe Alzheimer disease. Objective: To evaluate long-term memantine treatment in moderate to severe Alzheimer disease. Design, Setting, and Patients: Open-label, 24- week extension trial. Raters remained blind to the patients’ initial study treatment. Patients (n=175) were enrolled from the previous double-blind study in an outpatient setting. Intervention: Twenty mg of memantine was given daily. Main Outcome Measures: Efficacy assessments from the double-blind study were continued and safety parameters were monitored. Results: Patients who switched to memantine treatment from their previous placebo therapy experienced a significant benefit in all main efficacy assessments (functional, global, and cognitive) relative to their mean rate of decline with placebo treatment during the double-blind period (P < .05). The completion rate for the extension phase of the study was high (78% ) and the favorable adverse event profile for memantine therapy was similar to that seen in the double-blind study. Conclusion: These results extend previous findings that demonstrated the efficacy and safety of memantine in the treatment of patients with moderate to severe Alzheimer disease.展开更多
Process of warm tube hydroforming was experimentally investigated for forming an AZ31B magnesium alloy tubular part with a large expansion ratio. Effects of temperature on the mechanical properties and formability wer...Process of warm tube hydroforming was experimentally investigated for forming an AZ31B magnesium alloy tubular part with a large expansion ratio. Effects of temperature on the mechanical properties and formability were studied by uniaxial tensile test and hydraulic bulge test. Total elongation increases with temperature up to 250℃, but uniform elongation and maximum expansion ratio get the highest value at 175℃. Different axial feeding amounts were applied in experiments to determine the reasonable loading path. A preform with useful wrinkles was then realized and the tubular part with an expansion ratio of 50% was formed. Finally, mechanical condition to produce useful wrinkles is deduced and the result illustrates that useful wrinkles are easier to be obtained for tube with higher strain hardening coefficient value and tubular part with smaller expansion ratio.展开更多
文摘Background: This study is an extension of a 28- week, randomized, double-blind, placebo-controlled study of memantine in 252 patients with moderate to severe Alzheimer disease. Objective: To evaluate long-term memantine treatment in moderate to severe Alzheimer disease. Design, Setting, and Patients: Open-label, 24- week extension trial. Raters remained blind to the patients’ initial study treatment. Patients (n=175) were enrolled from the previous double-blind study in an outpatient setting. Intervention: Twenty mg of memantine was given daily. Main Outcome Measures: Efficacy assessments from the double-blind study were continued and safety parameters were monitored. Results: Patients who switched to memantine treatment from their previous placebo therapy experienced a significant benefit in all main efficacy assessments (functional, global, and cognitive) relative to their mean rate of decline with placebo treatment during the double-blind period (P < .05). The completion rate for the extension phase of the study was high (78% ) and the favorable adverse event profile for memantine therapy was similar to that seen in the double-blind study. Conclusion: These results extend previous findings that demonstrated the efficacy and safety of memantine in the treatment of patients with moderate to severe Alzheimer disease.
基金Project(NCET-07-0237) supported by New Century Excellent Talents Program in Chinese University
文摘Process of warm tube hydroforming was experimentally investigated for forming an AZ31B magnesium alloy tubular part with a large expansion ratio. Effects of temperature on the mechanical properties and formability were studied by uniaxial tensile test and hydraulic bulge test. Total elongation increases with temperature up to 250℃, but uniform elongation and maximum expansion ratio get the highest value at 175℃. Different axial feeding amounts were applied in experiments to determine the reasonable loading path. A preform with useful wrinkles was then realized and the tubular part with an expansion ratio of 50% was formed. Finally, mechanical condition to produce useful wrinkles is deduced and the result illustrates that useful wrinkles are easier to be obtained for tube with higher strain hardening coefficient value and tubular part with smaller expansion ratio.
