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骨折内固定术后延迟感染34例报告 被引量:3
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作者 鲍宜周 张玉武 傅元贵 《骨与关节损伤杂志》 1998年第3期168-169,共2页
我们自1985年~1996年共进行四肢骨折内固定手术2892例。术后发生延迟感染34例,占同期内固定的1.18%,均经综合疗法治愈,报告如下。 1 临床资料 1.1 一般资料 本组34例中,男29例,女5例,年龄11~50岁。损伤原因:辗压伤19例,高处坠伤8例... 我们自1985年~1996年共进行四肢骨折内固定手术2892例。术后发生延迟感染34例,占同期内固定的1.18%,均经综合疗法治愈,报告如下。 1 临床资料 1.1 一般资料 本组34例中,男29例,女5例,年龄11~50岁。损伤原因:辗压伤19例,高处坠伤8例,重物砸伤5例,皮带绞伤2例。开放性骨折23例,按Gustilo氏分类:Ⅰ型4例,Ⅱ型13例,Ⅲ_A5例,Ⅲ_c1例。11例闭合性骨折中,7例为粉碎性骨折,4例病人肢体有较重的软组织损伤伴皮肤擦伤水泡形成。发生于小腿19例,手部5例,股部及前臂各4例,足部2例。23例开放性骨折病人首次手术距受伤时间为8h内18例,8~12h4例,12h以上1例。11例闭合性骨折首次手术距受伤时间为3d~12周。发生延迟感染的时间为术后20~135d。 展开更多
关键词 四肢骨折 骨折固定术 延迟感染 病例报告
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13例术后延迟感染防治体会 被引量:1
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作者 吕诗武 《中国热带医学》 CAS 2008年第7期1177-1177,共1页
目的探讨四肢骨折内固定术后延迟感染的原因及防治方法。方法2003年1月~2007年12月,共收治骨折内固定术患者812例,术后发生延迟感染13例,通过细菌培养及药敏合理应用抗菌素,伤口换药,病灶清除,开放引流、冲洗以及对易感染倾向者积极治... 目的探讨四肢骨折内固定术后延迟感染的原因及防治方法。方法2003年1月~2007年12月,共收治骨折内固定术患者812例,术后发生延迟感染13例,通过细菌培养及药敏合理应用抗菌素,伤口换药,病灶清除,开放引流、冲洗以及对易感染倾向者积极治疗。结果发生延迟感染的主要原因有污染组织清除不彻底、切口内异物存留、手术适应证及内固定物选择不当患肢血循环障碍等。13例发生延迟感染时间为术后21~62d,经过积极治疗感染患者均得到治愈。其中浅部发生感染治愈平均时间为12d,深部发生感染治愈平均时间为32d。结论骨折术后延迟感染重在预防,早期发现,及时治疗,可不取出内固定物,疗效好。 展开更多
关键词 延迟感染 防治
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老年肺部感染消散延迟的原因与对策 被引量:3
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作者 何礼贤 《实用老年医学》 CAS 2004年第1期13-14,共2页
关键词 肺部感染消散延迟 原因 对策 消散延迟性肺炎
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复杂网络上同时考虑感染延迟和非均匀传播的SIR模型 被引量:6
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作者 赵敬 夏承遗 +1 位作者 孙世温 王莉 《智能系统学报》 CSCD 北大核心 2013年第2期128-134,共7页
为了能更有效地分析和理解传染性疾病的传播,提出了一个新颖的SIR模型,在这个传播模型里同时考虑了影响疾病传播行为的2个因素:感染延迟和非均匀传播.基于平均场理论和大量的数值仿真,给出了疾病传播临界值的解析公式,并发现感染延迟和... 为了能更有效地分析和理解传染性疾病的传播,提出了一个新颖的SIR模型,在这个传播模型里同时考虑了影响疾病传播行为的2个因素:感染延迟和非均匀传播.基于平均场理论和大量的数值仿真,给出了疾病传播临界值的解析公式,并发现感染延迟和非均匀传播对临界值影响截然不同:感染延迟能够在很大程度上减小传播阈值,促进疾病在人群中的传播;而非均匀传播能够增大传播临界值,阻碍疾病的大规模传播.当前的研究结果有助于深入理解真实复杂系统中的疾病传播行为,充分考虑感染延迟、传播机制和实际人群的拓扑结构等因素在疾病传播中的作用,从而为制定有效的传染病预防和控制措施提供理论依据. 展开更多
关键词 感染延迟 非均匀传播 临界值 复杂网络 SIR模型
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基于银行间网络的流动性风险传染机制研究 被引量:6
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作者 姚登宝 《安徽大学学报(哲学社会科学版)》 CSSCI 北大核心 2017年第4期130-137,共8页
建立流动性风险传染模型,理解流动性风险传染的内在机理,有助于金融监管部门及时采取措施缓释风险和缓解危机,维护金融系统的稳定发展。在SIR模型中引入感染延迟时间,运用复杂网络理论构建银行间流动性风险传染的复杂动力学模型,并通过... 建立流动性风险传染模型,理解流动性风险传染的内在机理,有助于金融监管部门及时采取措施缓释风险和缓解危机,维护金融系统的稳定发展。在SIR模型中引入感染延迟时间,运用复杂网络理论构建银行间流动性风险传染的复杂动力学模型,并通过理论推导和数值仿真等方法系统分析流动性风险在银行间传染的演化规律,结果表明:在BA无标度网络中,银行间网络的关联性越强,越容易感染流动性风险;延长感染延迟时间可以减小流动性风险传染的概率、速度和范围;提高银行间网络的密集程度能够促进流动性风险的传染效应。因此,系统性重要银行应建立流动性资产动态储备机制,非系统性重要银行需要建立资产结构和业务规模的动态管理机制,监管部门应构建银行间流动性风险的动态分层监管模式,提高整个金融系统的稳定性。 展开更多
关键词 流动性风险 SIR模型 感染延迟时间 银行间网络 金融危机
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Analysis of the delayed approach to the management of infected pancreatic necrosis 被引量:15
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作者 Nilesh Doctor Sujith Philip +2 位作者 Vidhyachandra Gandhi Maharra Hussain Savio G Barreto 《World Journal of Gastroenterology》 SCIE CAS CSCD 2011年第3期366-371,共6页
AIM: To analyze outcomes of delayed single-stage necrosectomy after early conservative management of patients with infected pancreatic necrosis (IPN) associated with severe acute pancreatitis (SAP). METHODS: Between J... AIM: To analyze outcomes of delayed single-stage necrosectomy after early conservative management of patients with infected pancreatic necrosis (IPN) associated with severe acute pancreatitis (SAP). METHODS: Between January 1998 and December 2009, data from patients with SAP who developed IPN and were managed by pancreatic necrosectomy were analyzed. RESULTS: Fifty-nine of 61 pancreatic necrosectomies were performed by open surgery and 2 laparoscopically. In 55 patients, single-stage necrosectomy could be performed (90.2%). Patients underwent surgery at a median of 29 d (range 13-46 d) after diagnosis of acute pancreatitis. Sepsis and multiple organ failure accounted for the 9.8% mortality rate. Pancreatic fistulae (50.8%) predominantly accounted for the morbidity. The median hospital stay was 23 d, and the median interval for return to regular activities was 110 d.CONCLUSION: This series supports the concept of delayed single-stage open pancreatic necrosectomy for IPN. Advances in critical care, antibiotics and interventional radiology have played complementary role in improving the outcomes. 展开更多
关键词 NECROSECTOMY Infected necrosis PANCREAS Severe acute pancreatitis INFLAMMATION
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髋关节置换术后慢性隐匿性假体周围感染的诊断与治疗 被引量:11
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作者 甄平 李旭升 +1 位作者 田琦 常彥峰 《中国矫形外科杂志》 CAS CSCD 北大核心 2015年第19期1729-1733,共5页
[目的]探讨髋关节置换术后假体周围隐匿性感染的诊断及外科治疗方法。[方法]回顾性分析2011年5月-2014年10月连续收治12例髋关节人工关节置换术后假体周围慢性隐匿性感染患者的临床资料,男10例,女2例;年龄56-75岁,平均60.5岁。12例患者... [目的]探讨髋关节置换术后假体周围隐匿性感染的诊断及外科治疗方法。[方法]回顾性分析2011年5月-2014年10月连续收治12例髋关节人工关节置换术后假体周围慢性隐匿性感染患者的临床资料,男10例,女2例;年龄56-75岁,平均60.5岁。12例患者均表现为髋关节疼痛,首发症状距初次关节置换手术的时间6-15个月,平均9.5个月。本组病例无全身和局部感染症状及体征,C反应蛋白和血沉无明显增高,X线片6例关节假体-骨界面可见透光带,2例半髋置换可见明显的髋臼上缘骨质磨损。10例行关节穿刺细菌培养,12例术中均进行关节周围软组织标本细菌培养及冰冻切片快速病理检查。术中行假体取出,抗生素骨水泥间隔体置入及术后全身抗感染治疗,二期关节翻修。[结果]12例患者一期手术假体均顺利取出,术中均未见明显脓性分泌物,但假体柄取出后股骨髓腔内可见炎性坏死组织。术中髋周软组织标本快速冰冻切片结果每高倍视野中性粒细胞计数平均12个(8-15个/高倍视野),术后病理报告均诊断为化脓性炎症。10例术中标本细菌培养结果为阴性,2例细菌培养为金黄色葡萄球菌。关节翻修术后平均随访时间为16.6个月(5-24个月),髋关节Harris评分由术前(62.5±8.2)分(59-75分)提高至末次随访时(91.6±3.8)分(88-95分),差异有统计学意义(t=20.2,P=0.000)。[结论]假体周围隐匿性感染临床表现不典型,常规辅助检查方法不能对假体周围感染提供有价值的诊断依据,术中冰冻病理检查能做出快速、准确诊断。 展开更多
关键词 关节置换 假体周围感染 延迟感染 隐匿性 术中冰冻病理检查
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Dynamics of a diffusion-driven HBV infection model with capsids and time delay 被引量:5
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作者 Kalyan Manna 《International Journal of Biomathematics》 2017年第5期27-44,共18页
In this paper, a diffusive hepatitis B virus (HBV) infection model with a discrete time delay is presented and analyzed, where the spatial mobility of both intracellular capsid covered HBV DNA and HBV and the intrac... In this paper, a diffusive hepatitis B virus (HBV) infection model with a discrete time delay is presented and analyzed, where the spatial mobility of both intracellular capsid covered HBV DNA and HBV and the intracellular delay in the reproduction of infected hepatocytes are taken into account. We define the basic reproduction number R0 that determines the dynamical behavior of the model. The local and global stability of the spatially homogeneous steady states are analyzed by using the linearization technique and the direct Lyapunov method, respectively. It is shown that the susceptible uninfected steady state is globally asymptotically stable whenever R0 ≤i and is unstable whenever R0 〉1. Also, the infected steady state is globally asymptotically stable when R0 〉 1. Finally, numerical simulations are carried out to illustrate the results obtained. 展开更多
关键词 HBV infection diffusion DELAY global stability Lyapunov function numer- ical simulation.
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Chaetocin reactivates the lytic replication of Epstein-Barr virus from latency via reactive oxygen species
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作者 Shilun Zhang Juan Yin Jiang Zhong 《Science China(Life Sciences)》 SCIE CAS CSCD 2017年第1期66-71,共6页
Oxidative stress, regarded as a negative effect of free radicals in vivo, takes place when organisms suffer from harmful stimuli. Some viruses can induce the release of reactive oxygen species (ROS) in infected cell... Oxidative stress, regarded as a negative effect of free radicals in vivo, takes place when organisms suffer from harmful stimuli. Some viruses can induce the release of reactive oxygen species (ROS) in infected cells, which may be closely related with their pathogenicity. In this report, chaetocin, a fimgal metabolite reported to have antimicrobial and cytostatic activity, was studied for its effect on the activation of latent Epstein-Barr virus (EBV) in B95-8 cells. We found that chaetocin remarkably up-regulated EBV lytic transcription and DNA replication at a low concentration (50 nmol L-l). The activation of latent EBV was accompanied by an increased cellular ROS level. N-acetyl-L-cysteine (NAC), an ROS inhibitor, suppressed chaetocin-induced EBV activation. Chaetocin had little effect on histone H3K9 methylation, while NAC also significantly reduced H3K9 methylation. These results suggested that chaetocin reactivates latent EBV primarily via ROS pathways. 展开更多
关键词 Epstein-Barr virus reactive oxygen species chaetocin
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DYNAMICS OF A NON-AUTONOMOUS HIV-1 INFECTION MODEL WITH DELAYS 被引量:1
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作者 XIA WANG SHENGQIANG LIU XINYU SONG 《International Journal of Biomathematics》 2013年第5期59-84,共26页
In this paper, following a previous paper ([32] Permanence and extinction of a non- autonomous HIV-I model with two time delays, preprint) on the permanence and extinc- tion of a delayed non-autonomous HIV-1 within-... In this paper, following a previous paper ([32] Permanence and extinction of a non- autonomous HIV-I model with two time delays, preprint) on the permanence and extinc- tion of a delayed non-autonomous HIV-1 within-host model, we introduce and investigate a delayed HIV-1 model including maximum homeostatic proliferation rate of CD4+ T- cells and varying coefficients. By applying the asymptotic analysis theory and oscillation theory, we show: (i) the system will be permanent when the threshold value R. 〉 1, and for this case we also obtain the explicit estimate of the eventual lower bound of the HIV-1 virus load; (ii) the threshold value R* 〈 1 implies the extinction of the virus. Furthermore, we obtain that the threshold dynamics is in agreement with that of the corresponding autonomous system, which extends the classic results for the system with constant coefficients. Numerical simulations are also given to illustrate our main results, and in particular, some sensitivity test of R. is established. 展开更多
关键词 NON-AUTONOMOUS HIV-1 infection delay permanence and extinction oscilla-tion theory.
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Dynamics of an infection model with two delays
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作者 Xinguo Sun Junjie Wei 《International Journal of Biomathematics》 2015年第5期295-315,共21页
In this paper, a HTLV-I infection model with two delays is considered. It is found that the dynamics of this model are determined by two threshold parameters R0 and R1, basic reproduction numbers for viral infection a... In this paper, a HTLV-I infection model with two delays is considered. It is found that the dynamics of this model are determined by two threshold parameters R0 and R1, basic reproduction numbers for viral infection and for CTL response, respectively. If R0 〈 1, the infection-free equilibrium P0 is globally asymptotically stable. If R1 〈 1 〈 R0, the asymptomatic-carrier equilibrium P1 is globally asymptotically stable. If R1 〉 1, there exists a unique HAM/TSP equilibrium P2. The stability of P2 is changed when the second delay T2 varies, that is there exist stability switches for P2. 展开更多
关键词 HTLV-I infection CTL response DELAY Lyapunov functionals global stabi-lity Hopf bifurcation.
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THE DELAYED BARBOUR'S MODEL FOR SCHISTOSOMIASIS
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作者 LONGXING QI JING-AN CUI 《International Journal of Biomathematics》 2012年第2期117-137,共21页
The transmission of schistosomiasis involves latent periods of infected hosts. In this paper, considering the latent periods of infected human, infected bovines and infected snails, we propose a delayed Barbour's mod... The transmission of schistosomiasis involves latent periods of infected hosts. In this paper, considering the latent periods of infected human, infected bovines and infected snails, we propose a delayed Barbour's model with two definitive hosts and define basic reproductive number. The stability of equilibria for the systems with and without time delays are both investigated. To study the impact of the latent periods on the transmission of schistosomiasis, some sensitivity analysis of the basic reproductive number on the three time delays are carried out. It is shown that the basic reproductive number decreases as the three time delays increase. Furthermore, the impact of the latent periods of infected snails on the system is stronger than that of the latent periods of infected human and infected bovines. Thus, to reduce the prevalence of schistosomiasis infection, prolonging the latent periods of infected snails by some measures could achieve better results than prolonging the latent periods of infected definitive hosts. 展开更多
关键词 Barbour's two-definitive-host model SCHISTOSOMIASIS basic reproductivenumber three time delays.
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