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基础胰岛素制剂的区别:对延长作用机制的理解有助于解释制剂间的差异 被引量:7
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作者 张化冰 《药品评价》 CAS 2019年第21期7-10,32,共5页
所有胰岛素在靶组织水平具有相同的作用机制,故通过不同延长作用时间的机制实现时间-作用曲线的差异,导致药物在皮下组织间隙的过程和进入循环的吸收速率不同。基于不同延长作用时间的机制和导致的临床作用曲线的差异,2019年5月发表在Ad... 所有胰岛素在靶组织水平具有相同的作用机制,故通过不同延长作用时间的机制实现时间-作用曲线的差异,导致药物在皮下组织间隙的过程和进入循环的吸收速率不同。基于不同延长作用时间的机制和导致的临床作用曲线的差异,2019年5月发表在Adv Ther杂志上的文章“基础胰岛素制剂的区别:对延长作用机制的理解有助于解释制剂间的差异”对几种基础胰岛素制剂进行比较。通过综合利用这些知识,在确定哪种治疗方案最大程度满足每位患者的需求时,医疗保健专业人员和支付方可以做出知情和明智的决策。本文对该篇文章进行中文摘译,同时,特邀杨文英教授对此文做一点评。 展开更多
关键词 基础胰岛素 低血糖 药效学 药代动力学 延长作用 第二代长效胰岛素
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32磷标记供体白细胞静脉注射预处理对兔同种皮肤移植存活的延长作用
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作者 刘长年 马腾骧 +3 位作者 王梓清 张欣 李玉芝 刘耀晨 《中华器官移植杂志》 CAS 1984年第2期54-57,后插1,共5页
关键词 标记 供体 白细胞 静脉注射 预处理 同种皮肤移植 延长作用 INTRAVENOUS Injection
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复合微量元素对四膜虫寿命影响的研究 被引量:3
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作者 刘汴生 刘永烈 +2 位作者 袁彬 彭涛 李颖 《老年医学与保健》 CAS 1997年第2期52-55,70,F003,共6页
目的为探索复合微量元素对四膜虫寿命的延长作用,车文进行了系统的实验研究。方法选用上海株(S1)克隆的四膜虫置于8组复合微量元素胰蛋白胨培养液中持续孵育,定期用光镜计数,相差显微镜观察其形态及活力,电镜观察其超微结构。结果... 目的为探索复合微量元素对四膜虫寿命的延长作用,车文进行了系统的实验研究。方法选用上海株(S1)克隆的四膜虫置于8组复合微量元素胰蛋白胨培养液中持续孵育,定期用光镜计数,相差显微镜观察其形态及活力,电镜观察其超微结构。结果长寿地区“微量元素谱”8631组和8632组使四膜虫生存期延长到246天,明显高于对照组(60天)和其它微量元素组(120-180无)。结论长寿地区“微量元素谱”(Mn、Mo、Se.F.Sr、Zn)能显著延长四膜虫的寿命。 展开更多
关键词 复合微量元素 四膜虫 寿命 延长作用
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Component changes of calcium and phosphorus in osteogenesis by lengthening procedures in adult canines
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作者 王兵 刘贻运 +1 位作者 郑介柏 陈国勋 《Chinese Journal of Traumatology》 CAS 2003年第1期32-36,共5页
Objective: To explore chemical component changes of dog bone at different lengthening time and in different bone regions of interest, and to evaluate the mineralization during Ilizarov lengthening process. Methods: Th... Objective: To explore chemical component changes of dog bone at different lengthening time and in different bone regions of interest, and to evaluate the mineralization during Ilizarov lengthening process. Methods: The ash weight, the concentrations of calcium, phosphorus and the calcium/phosphorus ratio were measured at different intervals (2, 4, 6, 8, 12 weeks) since lengthening and the lengthened part was compared with a control area at each interval. Results: The ash weight, the concentrations of calcium and phosphorus in the lengthened area differed at all development time. The calcium/phosphorus (Ca/P) ratio in the lengthened region remained significantly lower than that in the control region up to 12 weeks after the lengthening. Conclusions: These results suggest that also other inorganic ions play an important role in the mineralization process and that they become relatively more important since 8 weeks after the lengthening. 展开更多
关键词 Bone lengthening CALCIUM PHOSPHORUS Calcium/phosphorus ratio
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Intrinsic exchange bias effect in strain-engineered single antiferromagnetic LaMnO3 films 被引量:1
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作者 Guowei Zhou Huihui Ji +2 位作者 Yuhao Bai Zhiyong Quan Xiaohong Xu 《Science China Materials》 SCIE EI CSCD 2019年第7期1046-1052,共7页
In this work, epitaxial growth of LaMnO3 thin films on different substrates using pulsed laser deposition under tensile and compressive strain was studied. The intrinsic exchange bias effect was observed in the single... In this work, epitaxial growth of LaMnO3 thin films on different substrates using pulsed laser deposition under tensile and compressive strain was studied. The intrinsic exchange bias effect was observed in the single A-type antiferromagnetic LaMnO3 films no matter whether the tensile or compressive strain was supplied by the substrates. Due to the lattice mismatch between the film and different substrates, the intense strain can induce MnO6 octahedral rotation in the bottom region of the film neighboring the substrate, which leads to the distortion of MnO6 octahedron and the net magnetic behavior. However, the upper part maintains the original A-type antiferromagnetic order due to strain relaxation. The exchange bias effect in single films is attributed to the coupling between the bottom canted magnetic part and the upper antiferromagnetic region. The observation of exchange bias in single films on different substrates enables the emergence of a new class of biasing components in spintronics, which are based on strain-engineering. 展开更多
关键词 magnetic insulating state exchange bias Mn06 octahedral rotation strain and interface effects magnetic properties
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