Objective To examine whether the polymorphisms of endothelial nitric oxide synthase (eNOS) gene are associated with the susceptibility to high altitude pulmonary edema (HAPE) in Chinese railway construction workers at...Objective To examine whether the polymorphisms of endothelial nitric oxide synthase (eNOS) gene are associated with the susceptibility to high altitude pulmonary edema (HAPE) in Chinese railway construction workers at Qinghai-Tibet where the altitude is over 4 500 m above sea level. Methods A case-control study was conducted including 149 HAPE patients in the construction workers and 160 healthy controls randomly recruited from their co-workers, matching the patients in ethnicity, age, sex, lifestyle, and working conditions. Three polymorphisms of eNOS gene, T-786C in promoter, 894G/T in exon 7, and 27bp variable number tandem repeat (VNTR) in intron 4, were genotyped using polymerase chain reaction (PCR) and confirmed with DNA sequencing. Results The frequencies of 894T allele and heterozygous G/T of the 894G/T variant were significantly higher in HAPE patients group than in the control group (P=0.0028 and P=0.0047, respectively). However, the frequencies of the T-786C in promoter and the 27bp VNTR in intron 4 were not significantly different between the two groups. Haplotypic analysis revealed that the frequencies of two haplotypes (H3,T-T-b, b indicates 5 repeats of 27 bp VNTR; H6, C-G-a, a indicates 4 repeats of 27 bp VNTR) were significantly higher in HAPE patients (both P<0.0001). On the contrary, the frequencies of H1 (T-G-b) and H2 (T-G-a) were lower in HAPE patients than in healthy controls (both P<0.001). Conclusions Two haplotypes (T-T-b and C-G-a) may be strongly associated with susceptibility to HAPE. Compared with the individual alleles of eNOS gene, the interaction of multiple genetic markers within a haplotype may be a major determinant for the susceptibility to HAPE.展开更多
My camera lens is so illusionary that the authenticity of the Forbidden City is fading away. And my perspective is as narrow as an awl which slowly stings into the profundity of history... —Li
The seismic characteristics of four typical mortise-tenon joints of Chinese southern traditional timber frame buildings were researched, including Yanwei mortise-tenon joint （including dropping Yanwei mortise-tenon j...The seismic characteristics of four typical mortise-tenon joints of Chinese southern traditional timber frame buildings were researched, including Yanwei mortise-tenon joint （including dropping Yanwei mortise-tenon joint）, Shizigutou mortise-tenon joint, Ban mortise-tenon joint and Mantou mortise-tenon joint. Experiments on thirteen specimens were carried out. Failure modes, hysteresis curves, skeleton curves and rotational stiffness were studied. The results provided a theoretical basis for seismic research, protection and maintenance of Chinese southern traditional timber flame buildings.展开更多
As one of the most important plantations,Chinese fir has drawn more and more attention from domestic wood researchers.And as the development and increasing of plantation resource of Chinese fir,research and developmen...As one of the most important plantations,Chinese fir has drawn more and more attention from domestic wood researchers.And as the development and increasing of plantation resource of Chinese fir,research and development of the product will become a hot point.In this paper,we chose 1 571 pieces of structural lumbers from 4 areas to research grading.After sawing,drying and dressing,the lumbers were separated into 3 main grades by GB50005-2003 Code for Design of Timber Structures,namely SS,No.1 and No.2.The conclusions are that knot as the maximum strength reduced defect(MSRD)is a main character in the lumber,the visual quality of Fujian structural lumbers is polarized,and the applicability of visual grading to the lumber is poor,so we hold the point that we should adjust the grading rules to gain a better grading result.展开更多
基金Supported by National Natural Science Foundation of China (30393130, 30470651)National Basic Research Program of China (973 Program) (2006BAI19B07, 2006CB504103)National Key Laboratory Specific Fund (2060204)
文摘Objective To examine whether the polymorphisms of endothelial nitric oxide synthase (eNOS) gene are associated with the susceptibility to high altitude pulmonary edema (HAPE) in Chinese railway construction workers at Qinghai-Tibet where the altitude is over 4 500 m above sea level. Methods A case-control study was conducted including 149 HAPE patients in the construction workers and 160 healthy controls randomly recruited from their co-workers, matching the patients in ethnicity, age, sex, lifestyle, and working conditions. Three polymorphisms of eNOS gene, T-786C in promoter, 894G/T in exon 7, and 27bp variable number tandem repeat (VNTR) in intron 4, were genotyped using polymerase chain reaction (PCR) and confirmed with DNA sequencing. Results The frequencies of 894T allele and heterozygous G/T of the 894G/T variant were significantly higher in HAPE patients group than in the control group (P=0.0028 and P=0.0047, respectively). However, the frequencies of the T-786C in promoter and the 27bp VNTR in intron 4 were not significantly different between the two groups. Haplotypic analysis revealed that the frequencies of two haplotypes (H3,T-T-b, b indicates 5 repeats of 27 bp VNTR; H6, C-G-a, a indicates 4 repeats of 27 bp VNTR) were significantly higher in HAPE patients (both P<0.0001). On the contrary, the frequencies of H1 (T-G-b) and H2 (T-G-a) were lower in HAPE patients than in healthy controls (both P<0.001). Conclusions Two haplotypes (T-T-b and C-G-a) may be strongly associated with susceptibility to HAPE. Compared with the individual alleles of eNOS gene, the interaction of multiple genetic markers within a haplotype may be a major determinant for the susceptibility to HAPE.
文摘My camera lens is so illusionary that the authenticity of the Forbidden City is fading away. And my perspective is as narrow as an awl which slowly stings into the profundity of history... —Li
基金supported by the National Natural Science Foundation of China(Grant No.51008059)China Postdoctoral Science Special Foundation(Grant No.201003543)
文摘The seismic characteristics of four typical mortise-tenon joints of Chinese southern traditional timber frame buildings were researched, including Yanwei mortise-tenon joint （including dropping Yanwei mortise-tenon joint）, Shizigutou mortise-tenon joint, Ban mortise-tenon joint and Mantou mortise-tenon joint. Experiments on thirteen specimens were carried out. Failure modes, hysteresis curves, skeleton curves and rotational stiffness were studied. The results provided a theoretical basis for seismic research, protection and maintenance of Chinese southern traditional timber flame buildings.
文摘As one of the most important plantations,Chinese fir has drawn more and more attention from domestic wood researchers.And as the development and increasing of plantation resource of Chinese fir,research and development of the product will become a hot point.In this paper,we chose 1 571 pieces of structural lumbers from 4 areas to research grading.After sawing,drying and dressing,the lumbers were separated into 3 main grades by GB50005-2003 Code for Design of Timber Structures,namely SS,No.1 and No.2.The conclusions are that knot as the maximum strength reduced defect(MSRD)is a main character in the lumber,the visual quality of Fujian structural lumbers is polarized,and the applicability of visual grading to the lumber is poor,so we hold the point that we should adjust the grading rules to gain a better grading result.
