目的报道经睫状体平坦部玻璃体切割（pars plana vitrectomy，PPV）联合使用截断式袖套超声乳化探头行玻璃体腔超声乳化，处理因白内障手术异位至玻璃体腔的硬核的结果。方法临床病例回顾性研究。对2010年4月至2013年2月在解放军总医院...目的报道经睫状体平坦部玻璃体切割（pars plana vitrectomy，PPV）联合使用截断式袖套超声乳化探头行玻璃体腔超声乳化，处理因白内障手术异位至玻璃体腔的硬核的结果。方法临床病例回顾性研究。对2010年4月至2013年2月在解放军总医院眼科白内障手术引起的晶状体硬核掉入玻璃体腔的病例，在标准PPV后，使用截断式的普通超声乳化探头在前部或中部玻璃体腔对晶状体硬核及碎片行吸取和乳化，统计分析手术前后的视力、术中和术后的并发症。结果纳入研究的36例患者平均年龄（67．5±7．2）岁。白内障手术和PPV的平均时间间隔是（27．6±38．5）d（0-123d）。术后随访时间（163．5±54．5）d。术前最佳矫正视力（BCVA）〈0．2有25只眼，0．2～0．5有8只眼，0．5以上有3只眼；术后BCVA〈0．2有5只眼，0．2，0．5有23只眼，0．5以上有8只眼。术中2只眼发生医源性视网膜损伤，术后2只眼眼压偏高。结论PPV联合使用截断式的普通超声乳化探头行玻璃体腔超声乳化手术处理异位到玻璃体腔的晶状体硬核效果明显，可以提高患者的视力，没有观察到超声乳化探头相关的并发症。展开更多
OBJECTIVE： To provide existence of abnormal potential evidence for the Savda, we assessed host metabonomic responses and dynamic changes oc- curring in various diseases using 1H nuclear mag- netic resonance （NMR）-b...OBJECTIVE： To provide existence of abnormal potential evidence for the Savda, we assessed host metabonomic responses and dynamic changes oc- curring in various diseases using 1H nuclear mag- netic resonance （NMR）-based metabonomics. METHODS： Plasma samples taken from patients with complicated diseases with abnormal Savda （n= 140, including 35 cases each of diabetes, asthma, breast cancer, and cervical carcinoma） and from healthy controls （n=35） were analyzed by ~H NMR （600 MHz）, and the spectral profiles were analyzed by multivariate analysis using orthogonal projec- tion to latent structure with discriminant analysis. RESULTS： Supervised modeling of the data provid- ed very good discrimination between patients and healthy controls. Compared with ,the healthy controls, the patient groups with different disease con- ditions displayed similar metabolic changes, characterized by lower creatine, creatinine, lactate, and amino acid levels （including isoleucine, leucine, va- line, alanine, and 1-methylhistidine） and higher lip- id levels （very low-density lipoproteins and unsatu- rated lipids）. Additionally, cancer patients （breast and cervical） showed decreased myo-inositol, a-glucose, and 13-glucose, and increased pyruvate and carnitine in plasma. CONCLUSION： The data indicate that decreased ox- idative defense, liver function abnormalities, amino acid deficiencies, and energy metabolism disorders are common characteristics of complicated diseas- es, which may be related to the formation of abnor- mal Savda.展开更多
基金Supported by the Education Department Natural Science Foundation of Guizhou Province(No.2012059)United Natural Science Foundation of Guizhou Province(No.LKG[2013]14)+2 种基金National Natural Science Foundation of China(No.31100187)Governor Fund of GuizhouProvince(No.201280)Teaching Team Project in Environmental Science of Guizhou Province(No.[2012]426)~~
文摘目的报道经睫状体平坦部玻璃体切割（pars plana vitrectomy，PPV）联合使用截断式袖套超声乳化探头行玻璃体腔超声乳化，处理因白内障手术异位至玻璃体腔的硬核的结果。方法临床病例回顾性研究。对2010年4月至2013年2月在解放军总医院眼科白内障手术引起的晶状体硬核掉入玻璃体腔的病例，在标准PPV后，使用截断式的普通超声乳化探头在前部或中部玻璃体腔对晶状体硬核及碎片行吸取和乳化，统计分析手术前后的视力、术中和术后的并发症。结果纳入研究的36例患者平均年龄（67．5±7．2）岁。白内障手术和PPV的平均时间间隔是（27．6±38．5）d（0-123d）。术后随访时间（163．5±54．5）d。术前最佳矫正视力（BCVA）〈0．2有25只眼，0．2～0．5有8只眼，0．5以上有3只眼；术后BCVA〈0．2有5只眼，0．2，0．5有23只眼，0．5以上有8只眼。术中2只眼发生医源性视网膜损伤，术后2只眼眼压偏高。结论PPV联合使用截断式的普通超声乳化探头行玻璃体腔超声乳化手术处理异位到玻璃体腔的晶状体硬核效果明显，可以提高患者的视力，没有观察到超声乳化探头相关的并发症。
基金Supported by China National Natural Science Foundation Program (No.81160459)
文摘OBJECTIVE： To provide existence of abnormal potential evidence for the Savda, we assessed host metabonomic responses and dynamic changes oc- curring in various diseases using 1H nuclear mag- netic resonance （NMR）-based metabonomics. METHODS： Plasma samples taken from patients with complicated diseases with abnormal Savda （n= 140, including 35 cases each of diabetes, asthma, breast cancer, and cervical carcinoma） and from healthy controls （n=35） were analyzed by ~H NMR （600 MHz）, and the spectral profiles were analyzed by multivariate analysis using orthogonal projec- tion to latent structure with discriminant analysis. RESULTS： Supervised modeling of the data provid- ed very good discrimination between patients and healthy controls. Compared with ,the healthy controls, the patient groups with different disease con- ditions displayed similar metabolic changes, characterized by lower creatine, creatinine, lactate, and amino acid levels （including isoleucine, leucine, va- line, alanine, and 1-methylhistidine） and higher lip- id levels （very low-density lipoproteins and unsatu- rated lipids）. Additionally, cancer patients （breast and cervical） showed decreased myo-inositol, a-glucose, and 13-glucose, and increased pyruvate and carnitine in plasma. CONCLUSION： The data indicate that decreased ox- idative defense, liver function abnormalities, amino acid deficiencies, and energy metabolism disorders are common characteristics of complicated diseas- es, which may be related to the formation of abnor- mal Savda.
