“全球器官捐献和移植概览”（Global Observatory on Donation and Transplantation，GODT）是应2004年第57次世界卫生大会有关持续审查全球同种异体器官移植相关实践、安全、质量、功效、流行病学和伦理组织决议的要求建设的，“全球...“全球器官捐献和移植概览”（Global Observatory on Donation and Transplantation，GODT）是应2004年第57次世界卫生大会有关持续审查全球同种异体器官移植相关实践、安全、质量、功效、流行病学和伦理组织决议的要求建设的，“全球器官捐献和移植数据库”（Global Data in Organ Donation and Transplantation）是其中一个信息平台，旨在收集、分析、评估WHO成员国器官捐献和移植方面的立法、组织机构和年度数据。展开更多
Use and effects of liver specific antigen in orthotopic liver transplantations were researched in this study. Group I:syngeneic control (Wistar to Wistar); Group II:acute rejection (SD to Wistar ); Group III: Thym...Use and effects of liver specific antigen in orthotopic liver transplantations were researched in this study. Group I:syngeneic control (Wistar to Wistar); Group II:acute rejection (SD to Wistar ); Group III: Thymic inoculation of SD rat LSA day 7 before transplantation. The observation of common situation and survival time, rejection grades, NF κB activity of splenocytes and IL 2mRNA expression of grafted liver were used to analyze acute rejection severity and immune state of animals in different groups. The common situation of group I was very well after transplantation and no signs of rejection were found. Recipients of group II lost body weight progressively. All dead within day 9 to day 13 posttransplantation; median survival time was 10.7 ±0.51 days. It was an optimal acute rejection control. As for group III, 5 out of 6 recipients survived for a long time and common situation was remarkably better than that of group II. Its rejection grades were significantly lower than that of group II( P <0.05). NF κB activity was only detected in group I at day 5 and day 7 after transplantation, whereas high activity of NF κB was detected at all time points in groupII and the low NF κB activity detected in group III was significantly lower than that of group II ( P <0.05). No IL 2mRNA expression was detected at any time point in group I,whereas high level expression was detected at all time points in group II and the low level expression only detected at day 3 in group III was significantly lower than that of group II ( P <0.05). Conclusion: LSA is an important transplantation antigen which is involved directly in the immunorejection of liver transplantation. We report here for the first time that intrathymic inoculation of LSA can alleviate the rejection of liver allotransplantation; and that grafts can survive for a long time thereby, thus leading to a novel way to achieve liver transplantation immunotolerance.展开更多
文摘“全球器官捐献和移植概览”（Global Observatory on Donation and Transplantation，GODT）是应2004年第57次世界卫生大会有关持续审查全球同种异体器官移植相关实践、安全、质量、功效、流行病学和伦理组织决议的要求建设的，“全球器官捐献和移植数据库”（Global Data in Organ Donation and Transplantation）是其中一个信息平台，旨在收集、分析、评估WHO成员国器官捐献和移植方面的立法、组织机构和年度数据。
文摘Use and effects of liver specific antigen in orthotopic liver transplantations were researched in this study. Group I:syngeneic control (Wistar to Wistar); Group II:acute rejection (SD to Wistar ); Group III: Thymic inoculation of SD rat LSA day 7 before transplantation. The observation of common situation and survival time, rejection grades, NF κB activity of splenocytes and IL 2mRNA expression of grafted liver were used to analyze acute rejection severity and immune state of animals in different groups. The common situation of group I was very well after transplantation and no signs of rejection were found. Recipients of group II lost body weight progressively. All dead within day 9 to day 13 posttransplantation; median survival time was 10.7 ±0.51 days. It was an optimal acute rejection control. As for group III, 5 out of 6 recipients survived for a long time and common situation was remarkably better than that of group II. Its rejection grades were significantly lower than that of group II( P <0.05). NF κB activity was only detected in group I at day 5 and day 7 after transplantation, whereas high activity of NF κB was detected at all time points in groupII and the low NF κB activity detected in group III was significantly lower than that of group II ( P <0.05). No IL 2mRNA expression was detected at any time point in group I,whereas high level expression was detected at all time points in group II and the low level expression only detected at day 3 in group III was significantly lower than that of group II ( P <0.05). Conclusion: LSA is an important transplantation antigen which is involved directly in the immunorejection of liver transplantation. We report here for the first time that intrathymic inoculation of LSA can alleviate the rejection of liver allotransplantation; and that grafts can survive for a long time thereby, thus leading to a novel way to achieve liver transplantation immunotolerance.
