ANCA相关性血管炎（ANCA-associated vasculitis，AAV）是以中性粒细胞异常死亡，导致血管发生坏死性炎性反应的自身免疫性疾病。主要由肉芽肿性多血管炎（granulomatosis with polyangiitis，GPA）、显微镜下多血管炎（microscopic pol...ANCA相关性血管炎（ANCA-associated vasculitis，AAV）是以中性粒细胞异常死亡，导致血管发生坏死性炎性反应的自身免疫性疾病。主要由肉芽肿性多血管炎（granulomatosis with polyangiitis，GPA）、显微镜下多血管炎（microscopic polyangiitis，MPA）和嗜酸性粒细胞肉芽肿性多血管炎（eosinophilic granulomatosis with polyangiitis，EGPA）组成。展开更多
OBJECTIVE: To study telomerase activity (TA) and its variation in bone marrow mononuclear cells from patients with myelodysplastic syndrome (MDS) at different stages in comparison with normal bone marrow cells and leu...OBJECTIVE: To study telomerase activity (TA) and its variation in bone marrow mononuclear cells from patients with myelodysplastic syndrome (MDS) at different stages in comparison with normal bone marrow cells and leukemic cells. METHODS: The TA was semi-quantitatively determined in mononuclear cells from 20 normal bone marrow samples, 21 patients with MDS at different stages and 32 cases of acute leukemia by using a polymerase chain reaction-enzyme linked immuno-sorben assay (PCR-ELISA) kit. RESULTS: The TA in normal bone marrow cells was in the range of 0 to 0.3 units (U) with a mean of 0.11 +/- 0.08 U. Among them, 3 samples were considered positive in accordance with the standard recommended by the kit's pamphlet. In bone marrow cells from patients with acute leukemia, the TA was ranging from 0 to 0.96 U with a mean value of 0.42 +/- 0.26 U. The positive rate was 78.1% which was significantly different from that in normal bone marrow (BM) (P展开更多
文摘ANCA相关性血管炎（ANCA-associated vasculitis，AAV）是以中性粒细胞异常死亡，导致血管发生坏死性炎性反应的自身免疫性疾病。主要由肉芽肿性多血管炎（granulomatosis with polyangiitis，GPA）、显微镜下多血管炎（microscopic polyangiitis，MPA）和嗜酸性粒细胞肉芽肿性多血管炎（eosinophilic granulomatosis with polyangiitis，EGPA）组成。
文摘OBJECTIVE: To study telomerase activity (TA) and its variation in bone marrow mononuclear cells from patients with myelodysplastic syndrome (MDS) at different stages in comparison with normal bone marrow cells and leukemic cells. METHODS: The TA was semi-quantitatively determined in mononuclear cells from 20 normal bone marrow samples, 21 patients with MDS at different stages and 32 cases of acute leukemia by using a polymerase chain reaction-enzyme linked immuno-sorben assay (PCR-ELISA) kit. RESULTS: The TA in normal bone marrow cells was in the range of 0 to 0.3 units (U) with a mean of 0.11 +/- 0.08 U. Among them, 3 samples were considered positive in accordance with the standard recommended by the kit's pamphlet. In bone marrow cells from patients with acute leukemia, the TA was ranging from 0 to 0.96 U with a mean value of 0.42 +/- 0.26 U. The positive rate was 78.1% which was significantly different from that in normal bone marrow (BM) (P
